122 Works

Evidence-based expert consensus on the management of primary central nervous system lymphoma in China

Tong Chen, Yuanbo Liu, Yang Wang, Qing Chang, Jinsong Wu, Zhiliang Wang, Daoying Geng, Jin-Tai Yu, Yuan Li, Xiao-Qiu Li, Hong Chen, Dongxiao Zhuang, Jianyong Li, Bin Wang, Tao Jiang, Lanting Lyu, Yuqin Song, Xiaoguang Qiu, Wenbin Li, Song Lin, Xinghu Zhang, Dehong Lu, Junqiang Lei, Yaolong Chen & Ying Mao
Abstract Primary central nervous system lymphoma (PCNSL) is a type of central nervous system restricted non-Hodgkin lymphoma, whose histopathological diagnosis is majorly large B cell lymphoma. To provide specific, evidence-based recommendations for medical professionals and to promote more standardized, effective and safe treatment for patients with PCNSL, a panel of experts from the Chinese Neurosurgical Society of the Chinese Medical Association and the Society of Hematological Malignancies of the Chinese Anti-Cancer Association jointly developed an...

Real-time realistic computer-generated hologram with accurate depth precision and a large depth range

Chongli Zhong, Xinzhu Sang, Binbin Yan, Hui Li, Duo Chen & Xiujuan Qin
Holographic display is an ideal technology for near-eye display to realize virtual and augmented reality applications, because it can provide all depth perception cues. However, depth performance is sacrificed by exiting computer-generated hologram (CGH) methods for real-time calculation. In this paper, volume representation and improved ray tracing algorithm are proposed for real-time CGH generation with enhanced depth performance. Using the single fast Fourier transform (S-FFT) method, the volume representation enables a low calculation burden and...

Autologous stem cell transplantation in tandem with Anti-CD30 CAR T-cell infusion in relapsed/refractory CD30+ lymphoma

Peiling Zhang, Xiuxiu Yang, Yang Cao, Jue Wang, Mi Zhou, Liting Chen, Jia Wei, Zekai Mao, Di Wang, Yi Xiao, Haichuan Zhu, Shangkun Zhang, Tongcun Zhang, Yicheng Zhang, Jianfeng Zhou & Liang Huang
Abstract Background Long-term outcome is unfavourable for relapsed/refractory (r/r) lymphoma patients who are resistant to salvage chemotherapy, even after subsequent autologous stem-cell transplantation (ASCT). Although anti-CD30 chimeric antigen receptor (CAR30) T-cell therapy induces high response rates in these patients, the duration of response is relatively limited. Methods This open-label, single-center and single-arm pilot study investigated the safety and efficacy of ASCT in tandem with CAR30 T-cell infusion in r/r CD30+ lymphoma. The primary endpoint was...

Interaction of miR-200a-3p with YAP regulates cell proliferation and metastasis differentially in HPV-positive and HPV-negative cervical cancer cells

Hong Chen, Lingling Gu, Min Zhang, Huifen Chen, Hong Liao, Xueping Cao, Lu Yu & Jun Zhang
Abstract Background Although evidence has revealed that miR-200a-3p is involved in the malignant progression of various tumors, the regulatory mechanism of miR-200a-3p in the development of cervical cancer (CC) cells with different HPV statuses remains unknown. The present study was to investigate the differential effects of either miR-200a-3p or YAP on tumorous cells’ fate in vitro in HPV-negative and HPV-positive cervical cancer cell models, and to explore if the changes in proliferation, migration, and invasion...

Phylogenomics, plastome degradation and mycoheterotrophy evolution of Neottieae (Orchidaceae), with emphasis on the systematic position and Loess Plateau-Changbai Mountains disjunction of Diplandrorchis

Huan-Wen Peng, Lian Lian, Jun Zhang, Andrey S. Erst & Wei Wang
Abstract Background Mycoheterotrophy is a unique survival strategy adapted to dense forests and has attracted biologists’ attention for centuries. However, its evolutionary origin and related plastome degradation are poorly understood. The tribe Neottieae contains various nutrition types, i.e., autotrophy, mixotrophy, and mycoheterotrophy. Here, we present a comprehensive phylogenetic analysis of the tribe based on plastome and nuclear ITS data. We inferred the evolutionary shift of nutrition types, constructed the patterns of plastome degradation, and estimated...

Evolution of the CBL and CIPK gene families in Medicago: genome-wide characterization, pervasive duplication, and expression pattern under salt and drought stress

Xiao-Xia Zhang, Xiao-Long Ren, Xiao-Tong Qi, Zhi-Min Yang, Xiao-Lei Feng, Tian Zhang, Hui-Jie Wang, Peng Liang, Qi-Ying Jiang, Wen-Jun Yang, Yuan Fu, Min Chen, Zhi-Xi Fu & Bo Xu
Abstract Background Calcineurin B-like proteins (CBLs) are ubiquitous Ca2+ sensors that mediate plant responses to various stress and developmental processes by interacting with CBL-interacting protein kinases (CIPKs). CBLs and CIPKs play essential roles in acclimatization of crop plants. However, evolution of these two gene families in the genus Medicago is poorly understood. Results A total of 68 CBL and 135 CIPK genes have been identified in five genomes from Medicago. Among these genomes, the gene...

Potential contribution of early endothelial progenitor cell (eEPC)-to-macrophage switching in the development of pulmonary plexogenic lesion

Feng-Jin Shao, Xiao-Ling Guo, Jia-Xue Xu, Rui Liu, Dan-Yue Li, Qing-Hao Li, Ting Zhou, Cun Fang & Xun Tan
Abstract Background Plexiform lesions, which have a dynamic appearance in structure and cellular composition, are the histological hallmark of severe pulmonary arterial hypertension in humans. The pathogenesis of the lesion development remains largely unknown, although it may be related to local inflammation and dysfunction in early progenitor endothelial cells (eEPCs). We tested the hypothesis that eEPCs contribute to the development of plexiform lesions by differentiating into macrophages in the setting of chronic inflammation. Methods The...

Chinese Industrial Emissions Database (CIED)

Ling Tang, Min Jia, Junai Yang, Ling Li, Xin Bo & Zhifu Mi
The Chinese Industrial Emissions Database (CIED) provides inventory of particulate matter (PM), SO2 and NOX from Chinese industries from 2015 to 2018, based on direct measurements from China’s continuous emission monitoring systems (CEMS) network.

Global Phase Diagram of Bound States in the Continuum

Peng Hu, Jiajun Wang, Qiao Jiang, Jun Wang, Lei Shi, Dezhuan Han, Zhao-Qing Zhang, Che Ting Chan & Jian Zi
A global phase diagram of bound states in the continuum (BICs) in photonic-crystal slabs is obtained based on a universal classification of BICs by their different Friedrich-Wintgen origins. Previously, BICs in photonic-crystal slabs are classified into three types: single-resonance parametric, symmetry-protected and Friedrich-Wintgen BICs. Here, we show that the single-resonance parametric BICs come from the coupling between the guided resonance (GR) and Fabry-Pérot (FP) modes, and the symmetry-protected BICs from the coupling between two degenerate...

Typologies of Intergenerational Relations in Urban and Rural China: A Latent Class Analysis

Ning Wang, Maria Evandrou, Jane Falkingham & Maodi Xu
Understanding intergenerational relations in China has become increasingly important against a backdrop of rapid social and demographic transitions and an ongoing urban-rural divide. From the parental perspective, this research investigates patterns and determinants of intergenerational relations between middle-aged and older parents and their non-coresident children in urban and rural China using data from the China Health and Retirement Longitudinal Study (2018) (N = 14,616). Latent class analysis revealed three typologies of intergenerational relations found across...

Metformin alleviates bone loss in ovariectomized mice through inhibition of autophagy of osteoclast precursors mediated by E2F1

Xudong Xie, Liangcong Hu, Bobin Mi, Hang Xue, Yiqiang Hu, Adriana C. Panayi, Yori Endo, Lang Chen, Chenchen Yan, Ze Lin, Hui Li, Wu Zhou & Guohui Liu
Abstract Background Postmenopausal bone loss, mainly caused by excessive bone resorption mediated by osteoclasts, has become a global public health burden. Metformin, a hypoglycemic drug, has been reported to have beneficial effects on maintaining bone health. However, the role and underlying mechanism of metformin in ovariectomized (OVX)-induced bone loss is still vague. Results In this study, we demonstrated for the first time that metformin administration alleviated bone loss in postmenopausal women and ovariectomized mice, based...

The clinical, myopathological, and molecular characteristics of 26 Chinese patients with dysferlinopathy: a high proportion of misdiagnosis and novel variants

Ning Wang, Xu Han, Shengpu Hao, Jingzhe Han, Xiaomeng Zhou, Shuyan Sun, Jin Tang, Yanpeng Lu, Hongran Wu, Shaojuan Ma, Xueqin Song & Guang Ji
Abstract Background Dysferlinopathy is an autosomal recessive muscular dystrophy caused by pathogenic variants in the dysferlin (DYSF) gene. This disease shows heterogeneous clinical phenotypes and genetic characteristics. Methods We reviewed the clinical and pathological data as well as the molecular characteristics of 26 Chinese patients with dysferlinopathy screened by immunohistochemistry staining and pathogenic variants in DYSF genes. Results Among 26 patients with dysferlinopathy, 18 patients (69.2%) presented as Limb-girdle Muscular Dystrophy Type R2 (LGMD R2),...

LncRNA Airn alleviates diabetic cardiac fibrosis by inhibiting activation of cardiac fibroblasts via a m6A-IMP2-p53 axis

Tingwei Peng, Mingchuan Liu, Lang Hu, Dong Guo, Di Wang, Bingchao Qi, Gaotong Ren, Chenchen Hu, Feng Zhang, Hyung J. Chun, Liqiang Song, Jianqiang Hu & Yan Li
Abstract Background Cardiac fibrosis is a leading cause of cardiac dysfunction in patients with diabetes. However, the underlying mechanisms of cardiac fibrosis remain unclear. This study aimed to investigate the role of the long non-coding RNA (LncRNA) Airn in the pathogenesis of cardiac fibrosis in diabetic cardiomyopathy (DCM) and its underlying mechanism. Methods Diabetes mellitus (DM) was induced in mice by streptozotocin injection. An intramyocardial adeno-associated virus (AAV) was used to manipulate Airn expression. The...

Association between serum homocysteine and sarcopenia among hospitalized older Chinese adults: a cross-sectional study

Bing Lu, Lingyu Shen, Haiqiong Zhu, Ling Xi, Wei Wang & Xiaojun Ouyang
Abstract Objective Hyperhomocysteinemia (HHcy) is considered to increase the risk of sarcopenia (S) and remains controversial. In this study, we aimed to investigate the prevalence of S among older Chinese adults and explore whether homocysteine (Hcy) was independently associated with S. Methods This cross-sectional study was performed among older adults hospitalized in the Geriatric Hospital of Nanjing Medical University between June 2017 and December 2021. We measured all participants’ serum Hcy levels, hand grip strength,...

Combining QTL mapping and RNA-Seq Unravels candidate genes for Alfalfa (Medicago sativa L.) leaf development

Xueqian Jiang, Xijiang Yang, Fan Zhang, Tianhui Yang, Changfu Yang, Fei He, Ting Gao, Chuan Wang, Qingchuan Yang, Zhen Wang & Junmei Kang
Abstract Background Leaf size affects crop canopy morphology and photosynthetic efficiency, which can influence forage yield and quality. It is of great significance to mine the key genes controlling leaf development for breeding new alfalfa varieties. In this study, we mapped leaf length (LL), leaf width (LW), and leaf area (LA) in an F1 mapping population derived from a cultivar named ZhongmuNo.1 with larger leaf area and a landrace named Cangzhou with smaller leaf area....

Trade-off between conservation of biological variation and batch effect removal in deep generative modeling for single-cell transcriptomics

Hui Li, Davis J. McCarthy, Heejung Shim & Susan Wei
Abstract Background Single-cell RNA sequencing (scRNA-seq) technology has contributed significantly to diverse research areas in biology, from cancer to development. Since scRNA-seq data is high-dimensional, a common strategy is to learn low-dimensional latent representations better to understand overall structure in the data. In this work, we build upon scVI, a powerful deep generative model which can learn biologically meaningful latent representations, but which has limited explicit control of batch effects. Rather than prioritizing batch effect...

An emergency department nurse led intervention to facilitate serious illness conversations among seriously ill older adults: A feasibility study

Kei Ouchi, Rachel S. Lee, Susan D. Block, Emily L. Aaronson, Mohammad A. Hasdianda, Wei Wang, Sarah Rossmassler, Ruth Palan Lopez, Donna Berry, Rebecca Sudore, Mara A. Schonberg & James A. Tulsky
Background:Serious illness conversations may lead to care consistent with patients’ goals near the end of life. The emergency department could serve as an important time and location for these conversations.Aim:To determine the feasibility of an emergency department-based, brief motivational interview to stimulate serious illness conversations among seriously ill older adults by trained nurses.Design:A pre-/post-intervention studySettings/participants:In an urban, tertiary care, academic medical center and a community hospital from January 2021 to January 2022, we prospectively enrolled...

Self-assembly of DNA nanostructure containing cell-specific aptamer as a precise drug delivery system for cancer therapy in non-small cell lung cancer

Ning Wang, Chang Yu, Tingting Xu, Dan Yao, Lingye Zhu, Zhifa Shen & Xiaoying Huang
Abstract Background As the most common subtype in lung cancer, the precise and efficient treatment for non-small cell lung cancer (NSCLC) remains an outstanding challenge owing to early metastasis and poor prognosis. Chemotherapy, the most commonly used treatment modality, is a difficult choice for many cancer patients due to insufficient drug accumulation in tumor sites and severe systemic side-effects. In this study, we constructed a cell-specific aptamer-modified DNA nanostructure (Apt-NS) as a targeting drug delivery...

STEAP3 can predict the prognosis and shape the tumor microenvironment of clear cell renal cell carcinoma

Jiyue Wu, Qing Bi, Xiang Zheng, Huawei Cao, Changzhen Hao, Zejia Sun & Wei Wang
Abstract Clear cell renal cell carcinoma (ccRCC) is a common malignant tumor of the urinary system characterized by poor prognosis and difficult treatment. It has been reported that iron metabolism dysregulation is a common phenomenon in ccRCC and is closely related to the process of ccRCC. But still now, the exact function and underlying mechanisms of iron metabolism dysregulation in ccRCC have not been fully elucidated. In this study, we comprehensively investigated the prognostic value...

Genomic Architecture of Yield Performance of an Elite Rice Hybrid Revealed by its Derived Recombinant Inbred Line and Their Backcross Hybrid Populations

Fan Zhang, Conghe Zhang, Xiuqin Zhao, Shuangbing Zhu, Kai Chen, Guixiang Zhou, Zhichao Wu, Min Li, Tianqing Zheng, Wensheng Wang, Zhi Yan, Qinyong Fei, Zhikang Li, Jinjie Chen & Jianlong Xu
Abstract Background Since its development and wide adoption in China, hybrid rice has reached the yield plateau for more than three decades. To understand the genetic basis of heterosis in rice and accelerate hybrid rice breeding, the yield performances of the elite rice hybrid, Quan-you-si-miao (QYSM) were genetically dissected by whole-genome sequencing, large-scale phenotyping of 1061 recombined inbred lines (RILs) and 1061 backcross F1 (BCF1) hybrids derived from QYSM’s parents across three environments and gene-based...

Aberrant methylation of Serpine1 mediates lung injury in neonatal mice prenatally exposed to intrauterine inflammation

Dongting Yao, Jiuru Zhao, Qianqian Zhang, Tao Wang, Meng Ni, Sudong Qi, Qianwen Shen, Wei Li, Baihe Li, Xiya Ding & Zhiwei Liu
Abstract Background Intrauterine inflammation (IUI) alters epigenetic modifications in offspring, leading to lung injury. However, the epigenetic mechanism underlying IUI-induced lung injury remains uncertain. In the present study, we aim to investigate the effect of IUI on lung development, and to identify the key molecule involved in this process and its epigenetic regulatory mechanism. Results Serpine1 was upregulated in the lung tissue of neonatal mice with IUI. Intranasal delivery of Serpine1 siRNA markedly reversed IUI-induced...

Chinese Industrial Emissions Database (CIED)

Ling Tang, Min Jia, Junai Yang, Ling Li, Xin Bo & Zhifu Mi
The Chinese Industrial Emissions Database (CIED) provides inventory of particulate matter (PM), SO2 and NOX from Chinese industries from 2015 to 2018, based on direct measurements from China’s continuous emission monitoring systems (CEMS) network.

Integrated physiological and transcriptional dissection reveals the core genes involving nutrient transport and osmoregulatory substance biosynthesis in allohexaploid wheat seedlings under salt stress

Jun-fan Chen, Ying Liu, Tian-yu Zhang, Zheng-fu Zhou, Jin-yong Huang, Ting Zhou & Ying-peng Hua
Abstract Background Soil salinization has become a global problem restricting the seed yield and quality of crops, including wheat (Triticum aestivum L.). Salinity significantly alters plant morphology and severely disrupts physiological homeostasis. Salt tolerance of wheat has been widely studied whereas core ion transporters responsive to salt stress remain elusive. Results In this study, the wheat seedlings were subjected to salinity toxicity for morpho-physiological and transcriptomic analysis of wheat salt tolerance. There was a inversely...

P800SO3-PEG: a renal clearable bone-targeted fluorophore for theranostic imaging

Haoran Wang, Homan Kang, Jason Dinh, Shinya Yokomizo, Wesley R. Stiles, Molly Tully, Kevin Cardenas, Surbhi Srinivas, Jason Ingerick, Sung Ahn, Kai Bao & Hak Soo Choi
Abstract Background Due to the deep tissue penetration and reduced scattering, NIR-II fluorescence imaging is advantageous over conventional visible and NIR-I fluorescence imaging for the detection of bone growth, metabolism, metastasis, and other bone-related diseases. Methods Bone-targeted heptamethine cyanine fluorophores were synthesized by substituting the meso-carbon with a sulfur atom, resulting in a bathochromic shift and increased fluorescence intensity. The physicochemical, optical, and thermal stability of newly synthesized bone-targeted NIR fluorophores was performed in aqueous...

Circular RNA circPVT1 promotes nasopharyngeal carcinoma metastasis via the β-TrCP/c-Myc/SRSF1 positive feedback loop

Yongzhen Mo, Yumin Wang, Yian Wang, Xiangying Deng, Qijia Yan, Chunmei Fan, Shuai Zhang, Shanshan Zhang, Zhaojian Gong, Lei Shi, Qianjin Liao, Can Guo, Yong Li, Guiyuan Li, Zhaoyang Zeng, Weihong Jiang, Wei Xiong & Bo Xiang
Abstract Background Circular RNAs (circRNAs) act as gene expression regulators and are involved in cancer progression. However, their functions have not been sufficiently investigated in nasopharyngeal carcinoma (NPC). Methods The expression profiles of circRNAs in NPC cells within different metastatic potential were reanalyzed. Quantitative reverse transcription PCR and in situ hybridization were used to detect the expression level of circPVT1 in NPC cells and tissue samples. The association of expression level of circPVT1 with clinical...

Registration Year

  • 2022

Resource Types

  • Collection


  • Institute of Botany
  • Shanghai Jiao Tong University
  • Chinese Academy of Medical Sciences & Peking Union Medical College
  • Zhejiang University
  • University of Chinese Academy of Sciences
  • Fudan University
  • Huazhong University of Science and Technology
  • Jilin University
  • Tongji University
  • First Affiliated Hospital of Xi'an Jiaotong University