62 Works

Failure pattern and suggestions for target volume delineation of carcinoma showing thymus-like differentiation treated with intensity-modulated radiotherapy

Fang-Fang Kong, Guang-Sen Pan, Rui-Ping Zhai, Cheng-Run Du, Xia-Yun He, Chun-Ying Shen, Xue-Guan Lu, Tuan-Qi Sun, Yu Wang, Qing-Hai Ji, Chao-Su Hu & Hong-Mei Ying
Abstract Background To review our long-term clinical experience, analyze the failure patterns, and give suggestions for target volume delineation of carcinoma showing thymus-like differentiation (CASTLE) treated with intensity-modulated radiotherapy (IMRT). Methods From April 2008 to May 2019, 30 patients with CASTLE treated by postoperative or radical IMRT in our center were retrospectively reviewed. A total dose of 56-60 Gy in 28–30 fractions was prescribed to patients without residual disease and 66 Gy in 33 fractions...

Repetitive mild TBI causes pTau aggregation in nigra without altering preexisting fibril induced Parkinson’s-like pathology burden

Vedad Delic, Joshua H. Karp, Maynard Guzman, Gabriel R. Arismendi, Katherine J. Stalnaker, Julia A. Burton, Kathleen E. Murray, Joshua P. Stamos, Kevin D. Beck, Arpine Sokratian, Andrew B. West & Bruce A. Citron
Abstract Population studies have shown that traumatic brain injury (TBI) is associated with an increased risk for Parkinson’s disease (PD) and among U.S. Veterans with a history of TBI this risk is 56% higher. The most common type of TBI is mild (mTBI) and often occurs repeatedly among athletes, military personnel, and victims of domestic violence. PD is classically characterized by deficits in fine motor movement control resulting from progressive neurodegeneration of dopaminergic neurons in...

Spinal microglia contribute to sustained inflammatory pain via amplifying neuronal activity

Nan Gu, Min-Hee Yi, Madhuvika Murugan, Manling Xie, Sebastian Parusel, Jiyun Peng, Ukpong B. Eyo, Christine L. Hunt, Hailong Dong & Long-Jun Wu
Abstract Microglia are highly dynamic immune cells of the central nervous system (CNS). Microglial processes interact with neuronal elements constantly on the order of minutes. The functional significance of this acute microglia-neuron interaction and its potential role in the context of pain is still largely unknown. Here, we found that spinal microglia increased their process motility and electrophysiological reactivity within an hour after the insult in a mouse model of formalin-induced acute, sustained, inflammatory pain....

Comparative analysis of three common imaging modalities for nasolabial cysts

Shengyang Liu, Dingqian Hao, Liang Yu, Hui Ma, Hui Zhao, Shujuan Sun, Peng Yu, Hongzhi Ji, Li Shi, Yuzhu Wan & Aiping Chen
ObjectiveTo compare the clinical diagnostic value of ultrasonography (USG), computed tomography (CT), and magnetic resonance imaging (MRI) for nasolabial cysts.MethodsThe clinical and imaging data of 20 patients with 21 nasolabial cysts confirmed surgically and histopathologically were retrospectively analyzed.ResultsThe largest cyst was 3.4 × 2.7 × 2.3 cm, and the smallest cyst was 1.1 × 0.7 × 0.5 cm. All cysts were located in the soft tissue between the nasolabial fold and maxillary bone. USG showed...

Activation of arcuate nucleus glucagon-like peptide-1 receptor-expressing neurons suppresses food intake

Ishnoor Singh, Le Wang, Baijuan Xia, Ji Liu, Azeddine Tahiri, Abdelfattah El Ouaamari, Michael B. Wheeler & Zhiping P. Pang
Abstract Background Central nervous system (CNS) control of metabolism plays a pivotal role in maintaining energy balance. In the brain, Glucagon-like peptide 1 (GLP-1), encoded by the proglucagon ‘Gcg’ gene, produced in a distinct population of neurons in the nucleus tractus solitarius (NTS), has been shown to regulate feeding behavior leading to the suppression of appetite. However, neuronal networks that mediate endogenous GLP-1 action in the CNS on feeding and energy balance are not well...

Activation of arcuate nucleus glucagon-like peptide-1 receptor-expressing neurons suppresses food intake

Ishnoor Singh, Le Wang, Baijuan Xia, Ji Liu, Azeddine Tahiri, Abdelfattah El Ouaamari, Michael B. Wheeler & Zhiping P. Pang
Abstract Background Central nervous system (CNS) control of metabolism plays a pivotal role in maintaining energy balance. In the brain, Glucagon-like peptide 1 (GLP-1), encoded by the proglucagon ‘Gcg’ gene, produced in a distinct population of neurons in the nucleus tractus solitarius (NTS), has been shown to regulate feeding behavior leading to the suppression of appetite. However, neuronal networks that mediate endogenous GLP-1 action in the CNS on feeding and energy balance are not well...

A general modeling framework for exploring the impact of individual concern and personal protection on vector-borne disease dynamics

Kimberlyn Roosa & Nina H. Fefferman
Abstract Background As climate variability and extreme weather events associated with climate change become more prevalent, public health authorities can expect to face an expanding spectrum of vector-borne diseases with increasing incidence and geographical spread. Common interventions include the use of larvicides and adulticides, as well as targeted communications to increase public awareness regarding the need for personal protective measures, such as mosquito repellant, protective clothing, and mosquito nets. Here, we propose a simplified compartmental...

A review on the application of the exposome paradigm to unveil the environmental determinants of age-related diseases

Enmin Ding, Yu Wang, Juan Liu, Song Tang & Xiaoming Shi
Abstract Age-related diseases account for almost half of all diseases among adults worldwide, and their incidence is substantially affected by the exposome, which is the sum of all exogenous and endogenous environmental exposures and the human body’s response to these exposures throughout the entire lifespan. Herein, we perform a comprehensive review of the epidemiological literature to determine the key elements of the exposome that affect the development of age-related diseases and the roles of aging...

MICALL2 as a substrate of ubiquitinase TRIM21 regulates tumorigenesis of colorectal cancer

Pushuai Wen, Huade Wang, Yi Li, Xinyao Sui, Zhijuan Hou, Xiaoyan Guo, Wanying Xue, Dahua Liu, Yu Wang & Jing Gao
Abstract Background Molecule interacting with CasL-like protein 2 (MICALL2) is believed to regulate cytoskeleton dynamics, tight junction formation, and neurite outgrowth. However, its biological role and the underlying mechanism in colorectal cancer (CRC) remain largely elusive. Methods qRT-PCR, Western blotting and immunohistochemistry assays were used to detect the expression levels of different genes. Next, mass spectrometry, co-immunoprecipitation and immunofluorescence staining were used to detect the interactions of proteins. Furthermore, MTT assay, colony formation assay, wound-healing...

Preliminary validation of the pica, ARFID and rumination disorder interview ARFID questionnaire (PARDI-AR-Q)

Rachel Bryant-Waugh, Casey M. Stern, Melissa J. Dreier, Nadia Micali, Lucy J. Cooke, Megan C. Kuhnle, Helen Burton Murray, Shirley B. Wang, Lauren Breithaupt, Kendra R. Becker, Madhusmita Misra, Elizabeth A. Lawson, Kamryn T. Eddy & Jennifer J. Thomas
Abstract Background The Pica, ARFID, and Rumination Disorder Interview (PARDI) is a structured interview that can be used to determine diagnosis, presenting characteristics, and severity across three disorders, including avoidant/restrictive food intake disorder (ARFID). The purpose of this study was to evaluate the psychometric properties of a questionnaire focused specifically on ARFID (PARDI-AR-Q), which has the potential to provide related information with less participant burden. Methods Adolescents and adults (n = 71, ages 14–40 years)...

Bifacial-metasurface-enabled pancake metalens with polarized space-folding

Chen Chen, Xin Ye, Jiacheng Sun, Yuxin Chen, Chunyu Huang, Xingjian Xiao, Wange Song, Shining Zhu & Tao Li
Replacing traditional refractive lenses with metalenses that have ultrathin and flat architecture could make imaging systems more compact. However, the space between the lens and image is usually the dominating factor in determining the bulkiness, and it cannot be shortened just by using thinner lenses. Here, we propose a pancake metalens that folds the optical path at will using a metacavity consisting of a spin-dependent bifacial metasurface and a mirror. We first verify the asymmetric...

Accurate Determination of Trace Cadmium in Soil Samples with Graphite Furnace Atomic Absorption Spectrometry Using Metal–Organic Frameworks as Matrix Modifiers

Hanyi Liu, Hao Cui, Yu Wang, Zhenmao Jiang, Lidan Lei & Shiqiang Wei
Cadmium (Cd) is a highly toxic heavy metal that is widely distributed in soils at low concentrations. Its volatilization loss occurs at an ashing temperature higher than 350 °C. Accordingly, the accurate determination of its concentration in soils often requires the addition of chemical modifiers by graphite furnace atomic absorption spectrometry (GFAAS) to improve the thermal stability of Cd. In this work, a metal–organic framework (MOF, UIO-66-NH2) was utilized as a matrix modifier to improve...

Characterization of diazotrophic root endophytes in Chinese silvergrass (Miscanthus sinensis)

Yongbin Li, Rui Yang, Max M. Häggblom, Mengyan Li, Lifang Guo, Baoqin Li, Max Kolton, Zhiguo Cao, Mohsen Solemani, Zheng Chen, Zhimin Xu, Wenlong Gao, Bei Yan & Weimin Sun
Abstract Background Phytoremediation is a potentially cost-effective way to remediate highly contaminated mine tailing sites. However, nutrient limitations, especially the deficiency of nitrogen (N), can hinder the growth of plants and impair the phytoremediation of mine tailings. Nevertheless, pioneer plants can successfully colonize mine tailings and exhibit potential for tailing phytoremediation. Diazotrophs, especially diazotrophic endophytes, can promote the growth of their host plants. This was tested in a mine-tailing habitat by a combination of field...

Bifacial-metasurface-enabled pancake metalens with polarized space-folding

Chen Chen, Xin Ye, Jiacheng Sun, Yuxin Chen, Chunyu Huang, Xingjian Xiao, Wange Song, Shining Zhu & Tao Li
Replacing traditional refractive lenses with metalenses that have ultrathin and flat architecture could make imaging systems more compact. However, the space between the lens and image is usually the dominating factor in determining the bulkiness, and it cannot be shortened just by using thinner lenses. Here, we propose a pancake metalens that folds the optical path at will using a metacavity consisting of a spin-dependent bifacial metasurface and a mirror. We first verify the asymmetric...

A genetic map of the chromatin regulators to drug response in cancer cells

Bo Chen, Pengfei Li, Mingyue Liu, Kaidong Liu, Min Zou, Yiding Geng, Shuping Zhuang, Huanhuan Xu, Linzhu Wang, Tingting Chen, Yawei Li, Zhangxiang Zhao, Lishuang Qi & Yunyan Gu
Abstract Background Diverse drug vulnerabilities owing to the Chromatin regulators (CRs) genetic interaction across various cancers, but the identification of CRs genetic interaction remains challenging. Methods In order to provide a global view of the CRs genetic interaction in cancer cells, we developed a method to identify potential drug response-related CRs genetic interactions for specific cancer types by integrating the screen of CRISPR-Cas9 and pharmacogenomic response datasets. Results Totally, 625 drug response-related CRs synthetic lethality...

Metabolic profiling and pharmacokinetic studies of Baihu-Guizhi decoction in rats by UFLC-Q-TOF–MS/MS and UHPLC-Q-TRAP-MS/MS

Yan He, Zhenkun Zhou, Weijie Li, Yanqiong Zhang, Ruoyao Shi, Tao Li, Linlin Jin, Hongliang Yao, Na Lin & Hao Wu
Abstract Background Baihu-Guizhi decoction (BHGZD) is a well-documented traditional Chinese Medicine (TCM) prescription that has been extensively applied to treating rheumatoid arthritis. Despite of its beneficial outcomes, the chemical constituents of BHGZD have not been fully portrayed and the in vivo absorption, distribution, metabolism, and excretion (ADME) patterns of absorbed components have never been described. Methods Characterization of absorbed components and in vivo biotransformation profiling of these feature compounds were based on the ultra-fast liquid...

A general modeling framework for exploring the impact of individual concern and personal protection on vector-borne disease dynamics

Kimberlyn Roosa & Nina H. Fefferman
Abstract Background As climate variability and extreme weather events associated with climate change become more prevalent, public health authorities can expect to face an expanding spectrum of vector-borne diseases with increasing incidence and geographical spread. Common interventions include the use of larvicides and adulticides, as well as targeted communications to increase public awareness regarding the need for personal protective measures, such as mosquito repellant, protective clothing, and mosquito nets. Here, we propose a simplified compartmental...

The important role of NLRP6 inflammasome in Pasteurella multocida infection

Xingping Wu, Zheng Zeng, Hongliang Tian, Lianci Peng, Dongyi Xu, Yu Wang, Chao Ye, Yuanyi Peng & Rendong Fang
Abstract Pasteurella multocida (P. multocida) can cause severe respiratory disease in cattle, resulting in high mortality and morbidity. Inflammasomes are multiprotein complexes in the cytoplasm that recognize pathogens and play an important role in the host defense against microbial infection. In this study, the mechanism of P. multocida-induced NLRP6 inflammasome activation was investigated in vitro and in vivo. Firstly, P. multocida induced severe inflammation with a large number of inflammatory cells infiltrating the lungs of...

A comprehensive update on CIDO: the community-based coronavirus infectious disease ontology

Yongqun He, Hong Yu, Anthony Huffman, Asiyah Yu Lin, Darren A. Natale, John Beverley, Ling Zheng, Yehoshua Perl, Zhigang Wang, Yingtong Liu, Edison Ong, Yang Wang, Philip Huang, Long Tran, Jinyang Du, Zalan Shah, Easheta Shah, Roshan Desai, Hsin-hui Huang, Yujia Tian, Eric Merrell, William D. Duncan, Sivaram Arabandi, Lynn M. Schriml, Jie Zheng … & Barry Smith
Abstract Background The current COVID-19 pandemic and the previous SARS/MERS outbreaks of 2003 and 2012 have resulted in a series of major global public health crises. We argue that in the interest of developing effective and safe vaccines and drugs and to better understand coronaviruses and associated disease mechenisms it is necessary to integrate the large and exponentially growing body of heterogeneous coronavirus data. Ontologies play an important role in standard-based knowledge and data representation,...

Risk factors for in-stent restenosis in maintenance hemodialysis patients with central venous occlusive disease and biomechanical assessment of stents

Yang Yu, Yuqin Xiong, Tao Li, Jingyuan Zhou, Weijie Yan, Yan Xiong, Yu Chen & Ping Fu
Objectives:To investigate the risk factors and biomechanical mechanisms of in-stent restenosis (ISR) in central venous occlusive disease (CVOD).Patients and methods:This retrospective study consecutively included 77 maintenance hemodialysis (MHD) patients with CVOD who received the first percutaneous transluminal angioplasty with stenting (PTS) due to symptomatic CVOD in a tertiary hospital. The mean age was 59.7 ± 14.0 years, and 51.9% of patients were male. The clinical characteristics, occurrence of ISR and patency rates were recorded. Finite...

Risk factors for in-stent restenosis in maintenance hemodialysis patients with central venous occlusive disease and biomechanical assessment of stents

Yang Yu, Yuqin Xiong, Tao Li, Jingyuan Zhou, Weijie Yan, Yan Xiong, Yu Chen & Ping Fu
Objectives:To investigate the risk factors and biomechanical mechanisms of in-stent restenosis (ISR) in central venous occlusive disease (CVOD).Patients and methods:This retrospective study consecutively included 77 maintenance hemodialysis (MHD) patients with CVOD who received the first percutaneous transluminal angioplasty with stenting (PTS) due to symptomatic CVOD in a tertiary hospital. The mean age was 59.7 ± 14.0 years, and 51.9% of patients were male. The clinical characteristics, occurrence of ISR and patency rates were recorded. Finite...

Categorical perception of Mandarin lexical tones in language-delayed autistic children

Yicheng Rong, Yi Weng, Fei Chen & Gang Peng
Enhanced pitch perception has been identified in autistic individuals, but it remains understudied whether such enhancement can be observed in the lexical tone perception of language-delayed autistic children. This study examined the categorical perception of Mandarin lexical tones in 23 language-delayed autistic children and two groups of non-autistic children, with one matched on chronological age (n = 23) and the other on developmental age in language ability (n = 23). The participants were required to...

Self-registration of constant-step rotating Mueller matrix polarimeters

Tao Xuan, Haoyu Zhai, Honghui He, Chao He, Liu Shaoxiong & Hui Ma
Time-division framework is commonly used in Mueller matrix polarimeters (MPs), which takes extra numbers of images at the same position in an acquisition sequence. In this Letter, we utilize measurement redundancy to raise a unique loss function which can reflect and evaluate the degree of mis-registration of Mueller matrix (MM) polarimetric images. Further, we demonstrate that the constant-step rotating MPs have a self-registration loss function free from systematic errors. Based on this property, we propose...

Spinal microglia contribute to sustained inflammatory pain via amplifying neuronal activity

Nan Gu, Min-Hee Yi, Madhuvika Murugan, Manling Xie, Sebastian Parusel, Jiyun Peng, Ukpong B. Eyo, Christine L. Hunt, Hailong Dong & Long-Jun Wu
Abstract Microglia are highly dynamic immune cells of the central nervous system (CNS). Microglial processes interact with neuronal elements constantly on the order of minutes. The functional significance of this acute microglia-neuron interaction and its potential role in the context of pain is still largely unknown. Here, we found that spinal microglia increased their process motility and electrophysiological reactivity within an hour after the insult in a mouse model of formalin-induced acute, sustained, inflammatory pain....

Survival comparison of different histological subtypes of oropharyngeal squamous cell carcinoma: A propensity-matched score analysis based on SEER database

Tao Li, Yi Wang, Xianwang Xiang & Chuanjun Chen
ObjectiveThe purpose of this study was to analyze the difference of survival rates in paitents with oropharyngeal keratinizing squamous cell carcinoma (KSCC), nonkeratinizing squamous cell carcinoma (NKSCC), basaloid squamous cell carcinoma (BSCC), and papillary squamous cell carcinoma (PSCC).Materials and methodsPatients diagnosed with oropharyngeal squamous cell carcinoma between 2004 and 2015 were collected from the SEER database. Cox proportional hazards models and Kaplan–Meier curves were used for survival analysis. Propensity score matching (PSM) was performed to...

Registration Year

  • 2023
    7
  • 2022
    53
  • 2021
    2

Resource Types

  • Collection
    62

Affiliations

  • Rutgers, The State University of New Jersey
    62
  • Zhejiang University
    41
  • Shanghai Jiao Tong University
    41
  • West China Hospital of Sichuan University
    39
  • Chinese Center For Disease Control and Prevention
    32
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    30
  • Peking University
    28
  • Fudan University
    25
  • Southern Medical University
    25
  • Wuhan University
    21