318,465 Works

Thrombophilia testing in the inpatient setting: impact of an educational intervention

Henry Kwang, Eric Mou, Ilana Richman, Andre Kumar, Caroline Berube, Rajani Kaimal, Neera Ahuja, Stephanie Harman, Tyler Johnson, Neil Shah, Ronald Witteles, Robert Harrington, Lisa Shieh & Jason Hom
Abstract Background Thrombophilia testing is frequently ordered in the inpatient setting despite its limited impact on clinical decision-making and unreliable results in the setting of acute thrombosis or ongoing anticoagulation. We sought to determine the effect of an educational intervention in reducing inappropriate thrombophilia testing for hospitalized patients. Methods During the 2014 academic year, we implemented an educational intervention with a phase implementation design for Internal Medicine interns at Stanford University Hospital. The educational session...

Effectiveness of Yi-Zhi-An-Shen granules on cognition and sleep quality in older adults with amnestic mild cognitive impairment: protocol for a randomized, double-blind, placebo-controlled trial

Shengnan Yue, Ting He, Baiyang Li, Yanqin Qu, Hongmei Peng, Jinxin Chen, Ming Lei, Chongli Chen & Wenbin Wu
Abstract Background Amnestic mild cognitive impairment (aMCI) is a syndrome characterized by significant forgetfulness that does not meet the criteria of dementia. Individuals with aMCI are at greater risk of progressing to dementia. Current studies suggest that good sleep quality is linked with preserved cognition in the elderly, and sleep complaints are common among the elderly with amnesia. Therefore, improving their sleep may be helpful for maintaining and improving their cognitive capacity. According to the...

Effectiveness of Yi-Zhi-An-Shen granules on cognition and sleep quality in older adults with amnestic mild cognitive impairment: protocol for a randomized, double-blind, placebo-controlled trial

Shengnan Yue, Ting He, Baiyang Li, Yanqin Qu, Hongmei Peng, Jinxin Chen, Ming Lei, Chongli Chen & Wenbin Wu
Abstract Background Amnestic mild cognitive impairment (aMCI) is a syndrome characterized by significant forgetfulness that does not meet the criteria of dementia. Individuals with aMCI are at greater risk of progressing to dementia. Current studies suggest that good sleep quality is linked with preserved cognition in the elderly, and sleep complaints are common among the elderly with amnesia. Therefore, improving their sleep may be helpful for maintaining and improving their cognitive capacity. According to the...

Use of estimated glomerular filtration rate to predict incident chronic kidney disease in patients at risk of cardiovascular disease: a retrospective study

Saif Al-Shamsi, Abderrahim Oulhaj, Dybesh Regmi & Romona Govender
Abstract Background Patients with cardiovascular disease are at an increased risk of chronic kidney disease (CKD). However, data on incident CKD in patients with multiple vascular comorbidities are insufficient. In this study, we identified the predictors of CKD stages 3–5 in patients at risk of cardiovascular disease and used their estimated glomerular filtration rate (eGFR) to construct a nomogram to predict the 5-year risk of incident CKD. Methods Ambulatory data on 622 adults with preserved...

Use of estimated glomerular filtration rate to predict incident chronic kidney disease in patients at risk of cardiovascular disease: a retrospective study

Saif Al-Shamsi, Abderrahim Oulhaj, Dybesh Regmi & Romona Govender
Abstract Background Patients with cardiovascular disease are at an increased risk of chronic kidney disease (CKD). However, data on incident CKD in patients with multiple vascular comorbidities are insufficient. In this study, we identified the predictors of CKD stages 3–5 in patients at risk of cardiovascular disease and used their estimated glomerular filtration rate (eGFR) to construct a nomogram to predict the 5-year risk of incident CKD. Methods Ambulatory data on 622 adults with preserved...

Lipid accumulation impairs natural killer cell cytotoxicity and tumor control in the postoperative period

Seyedeh Niavarani, Christine Lawson, Orneala Bakos, Marie Boudaud, Cory Batenchuk, Samuel Rouleau & Lee-Hwa Tai
Abstract Background Natural killer (NK) cell dysfunction following cancer surgery has been shown to promote metastases. Recent studies demonstrate an emerging role for lipids in the modulation of NK cell innate responses. However, the mechanisms involved in lipid modulation of NK cell postoperative anti-tumor function are unknown. This current study will determine whether the lipid accumulation via scavenger receptors on NK cells is responsible for the increase in postoperative metastasis. Methods Lipid content in mouse...

Lipid accumulation impairs natural killer cell cytotoxicity and tumor control in the postoperative period

Seyedeh Niavarani, Christine Lawson, Orneala Bakos, Marie Boudaud, Cory Batenchuk, Samuel Rouleau & Lee-Hwa Tai
Abstract Background Natural killer (NK) cell dysfunction following cancer surgery has been shown to promote metastases. Recent studies demonstrate an emerging role for lipids in the modulation of NK cell innate responses. However, the mechanisms involved in lipid modulation of NK cell postoperative anti-tumor function are unknown. This current study will determine whether the lipid accumulation via scavenger receptors on NK cells is responsible for the increase in postoperative metastasis. Methods Lipid content in mouse...

Adolescent sexual initiation and pregnancy: what more can be learned through further analysis of the demographic and health surveys in the Philippines?

Christine Habito, Cathy Vaughan & Alison Morgan
Abstract Background Adolescent pregnancy poses risks to the life of a young mother and her baby, and can affect their health, educational and future employment outcomes. In many low- and middle-income countries like the Philippines, the Demographic and Health Surveys (DHS) Program is among the most reliable and easily accessible sources of demographic and health data for researchers, development workers, and policymakers. Data on adolescent sexual and reproductive health (SRH) are often limited, but in...

Adolescent sexual initiation and pregnancy: what more can be learned through further analysis of the demographic and health surveys in the Philippines?

Christine Habito, Cathy Vaughan & Alison Morgan
Abstract Background Adolescent pregnancy poses risks to the life of a young mother and her baby, and can affect their health, educational and future employment outcomes. In many low- and middle-income countries like the Philippines, the Demographic and Health Surveys (DHS) Program is among the most reliable and easily accessible sources of demographic and health data for researchers, development workers, and policymakers. Data on adolescent sexual and reproductive health (SRH) are often limited, but in...

Quantitative margin assessment of radiofrequency ablation of a solitary colorectal hepatic metastasis using MIRADA RTx on CT scans: a feasibility study

B. Sibinga Mulder, P. Hendriks, T. Baetens, A. Erkel, C. Rijswijk, R. Meer, C. Velde, A. Vahrmeijer, J. Mieog & M. Burgmans
Abstract Background Compared to surgery, radiofrequency ablation(RFA) for colorectal liver metastasis(CRLM) is associated with higher local recurrence(LR) rates. A wide margin (at least 5 mm) is generally recommended to prevent LR, but the optimal method to assess ablation margins is yet to be established. The aim of our study was to evaluate the feasibility and reproducibility of CT-CT co-registration, using MIRADA software, in order to assess ablation margins of patients with CRLM. Methods In this...

Quantitative margin assessment of radiofrequency ablation of a solitary colorectal hepatic metastasis using MIRADA RTx on CT scans: a feasibility study

B. Sibinga Mulder, P. Hendriks, T. Baetens, A. Erkel, C. Rijswijk, R. Meer, C. Velde, A. Vahrmeijer, J. Mieog & M. Burgmans
Abstract Background Compared to surgery, radiofrequency ablation(RFA) for colorectal liver metastasis(CRLM) is associated with higher local recurrence(LR) rates. A wide margin (at least 5 mm) is generally recommended to prevent LR, but the optimal method to assess ablation margins is yet to be established. The aim of our study was to evaluate the feasibility and reproducibility of CT-CT co-registration, using MIRADA software, in order to assess ablation margins of patients with CRLM. Methods In this...

Refining the predictive variables in the “Surgical Risk Preoperative Assessment System” (SURPAS): a descriptive analysis

William Henderson, Michael Bronsert, Karl Hammermeister, Anne Lambert-Kerzner & Robert Meguid
Abstract Background The Surgical Risk Preoperative Assessment System (SURPAS) is a parsimonious set of models providing accurate preoperative prediction of common adverse outcomes for individual patients. However, focus groups with surgeons and patients have developed a list of questions about and recommendations for how to further improve SURPAS’s usability and usefulness. Eight issues were systematically evaluated to improve SURPAS. Methods The eight issues were divided into three groups: concerns to be addressed through further analysis...

Refining the predictive variables in the “Surgical Risk Preoperative Assessment System” (SURPAS): a descriptive analysis

William Henderson, Michael Bronsert, Karl Hammermeister, Anne Lambert-Kerzner & Robert Meguid
Abstract Background The Surgical Risk Preoperative Assessment System (SURPAS) is a parsimonious set of models providing accurate preoperative prediction of common adverse outcomes for individual patients. However, focus groups with surgeons and patients have developed a list of questions about and recommendations for how to further improve SURPAS’s usability and usefulness. Eight issues were systematically evaluated to improve SURPAS. Methods The eight issues were divided into three groups: concerns to be addressed through further analysis...

Health service security of patients with 8 certain rare diseases: evidence from China’s national system for health service utilization of patients with healthcare insurance

Rui Min, Xiaoyan Zhang, Pengqian Fang, Biyan Wang & He Wang
Abstract Background Rare diseases are one of the major challenges in the era of precision medicine and reflect the social security level of minority groups. This study aimed to investigate healthcare service utilization and health security of patients with rare diseases in China. Methods From 29 provinces of Mainland China, 7,747 visits with eight common rare diseases who were linked to the national insurance database between 2014 and 2016 were selected as the study population,...

Health service security of patients with 8 certain rare diseases: evidence from China’s national system for health service utilization of patients with healthcare insurance

Rui Min, Xiaoyan Zhang, Pengqian Fang, Biyan Wang & He Wang
Abstract Background Rare diseases are one of the major challenges in the era of precision medicine and reflect the social security level of minority groups. This study aimed to investigate healthcare service utilization and health security of patients with rare diseases in China. Methods From 29 provinces of Mainland China, 7,747 visits with eight common rare diseases who were linked to the national insurance database between 2014 and 2016 were selected as the study population,...

Parkin gene mutations are not common, but its epigenetic inactivation is a frequent event and predicts poor survival in advanced breast cancer patients

Khushnuma Wahabi, Ahmad Perwez, Shabeena Kamarudheen, Zafar Bhat, Anurag Mehta & M. Rizvi
Abstract Background Progression of breast cancer involves both genetic and epigenetic factors. Parkin gene has been identified as a tumor suppressor gene in the pathogenesis of various cancers. Nevertheless, the putative role of Parkin in breast cancer remains largely unknown. Therefore, we evaluated the regulation of Parkin through both genetic and epigenetic mechanisms in breast carcinoma. Method A total of 156 breast carcinoma and their normal adjacent tissue samples were included for mutational analysis through...

Parkin gene mutations are not common, but its epigenetic inactivation is a frequent event and predicts poor survival in advanced breast cancer patients

Khushnuma Wahabi, Ahmad Perwez, Shabeena Kamarudheen, Zafar Bhat, Anurag Mehta & M. Rizvi
Abstract Background Progression of breast cancer involves both genetic and epigenetic factors. Parkin gene has been identified as a tumor suppressor gene in the pathogenesis of various cancers. Nevertheless, the putative role of Parkin in breast cancer remains largely unknown. Therefore, we evaluated the regulation of Parkin through both genetic and epigenetic mechanisms in breast carcinoma. Method A total of 156 breast carcinoma and their normal adjacent tissue samples were included for mutational analysis through...

Tracking localization and secretion of cellulase spatiotemporally and directly in living Trichoderma reesei

Chengcheng Li, Ai-Ping Pang, Hang Yang, Roujing Lv, Zhihua Zhou, Fu-Gen Wu & Fengming Lin
Abstract Background Filamentous fungi secret hydrolytic enzymes like cellulase and hemicellulase outside the cells, serving as important scavengers of plant biomass in nature and workhorses in the enzyme industry. Unlike the extensive study on the mechanism of cellulase production in fungi, research on spatiotemporal distribution and secretion of cellulase in fungi is lacking, retarding the deeper understanding of the molecular mechanism behind the fungal cellulase production. Result Recombinant Trichoderma reesei strains RBGL, RCBH, and RCMC...

Tracking localization and secretion of cellulase spatiotemporally and directly in living Trichoderma reesei

Chengcheng Li, Ai-Ping Pang, Hang Yang, Roujing Lv, Zhihua Zhou, Fu-Gen Wu & Fengming Lin
Abstract Background Filamentous fungi secret hydrolytic enzymes like cellulase and hemicellulase outside the cells, serving as important scavengers of plant biomass in nature and workhorses in the enzyme industry. Unlike the extensive study on the mechanism of cellulase production in fungi, research on spatiotemporal distribution and secretion of cellulase in fungi is lacking, retarding the deeper understanding of the molecular mechanism behind the fungal cellulase production. Result Recombinant Trichoderma reesei strains RBGL, RCBH, and RCMC...

Cytolytic activity correlates with the mutational burden and deregulated expression of immune checkpoints in colorectal cancer

Apostolos Zaravinos, Constantinos Roufas, Majdi Nagara, Beatriz Lucas Moreno, Maria Oblovatskaya, Christodoulos Efstathiades, Christos Dimopoulos & Georgios Ayiomamitis
Abstract Background Microsatellite unstable colorectal cancers (MSI+ CRCs) expressing PD-L1, respond to anti-PD-1 or anti-PD-L1 checkpoint blockade, whereas microsatellite-stable tumors do not respond the same. Our aim was to examine how the immune landscape relates to different aspects of the CRCâ s biology, including neoepitope burden. Methods We used TCGA data to stratify patients based on a cytolytic T-cell activity expression index and correlated immune cytolytic activity (CYT) with mutational, structural, and neoepitope features of...

Cytolytic activity correlates with the mutational burden and deregulated expression of immune checkpoints in colorectal cancer

Apostolos Zaravinos, Constantinos Roufas, Majdi Nagara, Beatriz Lucas Moreno, Maria Oblovatskaya, Christodoulos Efstathiades, Christos Dimopoulos & Georgios Ayiomamitis
Abstract Background Microsatellite unstable colorectal cancers (MSI+ CRCs) expressing PD-L1, respond to anti-PD-1 or anti-PD-L1 checkpoint blockade, whereas microsatellite-stable tumors do not respond the same. Our aim was to examine how the immune landscape relates to different aspects of the CRCâ s biology, including neoepitope burden. Methods We used TCGA data to stratify patients based on a cytolytic T-cell activity expression index and correlated immune cytolytic activity (CYT) with mutational, structural, and neoepitope features of...

Correlates of gastroenterology health-services utilization among patients with gastroesophageal reflux disease: a large database analysis

Wasef Na’amnih, Racheli Katz, Sophy Goren, Amir Ben-Tov, Tomer Ziv-Baran, Gabriel Chodick & Khitam Muhsen
Abstract Background Gastroesophageal reflux disease (GERD) is associated with high utilization of health care services. Diagnostic tests usually are not required to establish GERD diagnosis, but endoscopy is recommended for patients with alarm symptoms such as dysphagia and unintentional weight loss, and those whose symptoms are not relieved by proton pump inhibitors (PPIs) therapy. Evidence on the correlates of utilization of gastroenterology health services among GERD patients is limited. The study aim was to examine...

Correlates of gastroenterology health-services utilization among patients with gastroesophageal reflux disease: a large database analysis

Wasef Na’amnih, Racheli Katz, Sophy Goren, Amir Ben-Tov, Tomer Ziv-Baran, Gabriel Chodick & Khitam Muhsen
Abstract Background Gastroesophageal reflux disease (GERD) is associated with high utilization of health care services. Diagnostic tests usually are not required to establish GERD diagnosis, but endoscopy is recommended for patients with alarm symptoms such as dysphagia and unintentional weight loss, and those whose symptoms are not relieved by proton pump inhibitors (PPIs) therapy. Evidence on the correlates of utilization of gastroenterology health services among GERD patients is limited. The study aim was to examine...

Enterococcus faecium NCIMB 10415 administration improves the intestinal health and immunity in neonatal piglets infected by enterotoxigenic Escherichia coli K88

Xie Peng, Ru Wang, Liang Hu, Qiang Zhou, Yang Liu, Min Yang, Zhengfeng Fang, Yan Lin, Shengyu Xu, Bin Feng, Jian Li, Xuemei Jiang, Yong Zhuo, Hua Li, De Wu & Lianqiang Che
Abstract Background This study aimed to investigate the effects of oral administration of Enterococcus faecium NCIMB 10415 (E. faecium) on intestinal development, immunological parameters and gut microbiota of neonatal piglets challenged with enterotoxigenic Escherichia coli K88 (ETEC). A total of 96 1-day-old sow-reared piglets were randomly assigned to 2 groups, with 48 piglets in each group. The piglets were from 16 litters (6 piglets each litter), and 3 piglets each litter were allocated to the...

Enterococcus faecium NCIMB 10415 administration improves the intestinal health and immunity in neonatal piglets infected by enterotoxigenic Escherichia coli K88

Xie Peng, Ru Wang, Liang Hu, Qiang Zhou, Yang Liu, Min Yang, Zhengfeng Fang, Yan Lin, Shengyu Xu, Bin Feng, Jian Li, Xuemei Jiang, Yong Zhuo, Hua Li, De Wu & Lianqiang Che
Abstract Background This study aimed to investigate the effects of oral administration of Enterococcus faecium NCIMB 10415 (E. faecium) on intestinal development, immunological parameters and gut microbiota of neonatal piglets challenged with enterotoxigenic Escherichia coli K88 (ETEC). A total of 96 1-day-old sow-reared piglets were randomly assigned to 2 groups, with 48 piglets in each group. The piglets were from 16 litters (6 piglets each litter), and 3 piglets each litter were allocated to the...

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