18,102 Works

Equinus Correction During Multilevel Surgery in Adults With Cerebral Palsy

Cornelia Putz, Eva Maria Mertens, Sebastian I. Wolf, Andreas Geisbüsch, Mirjam Niklasch, Simone Gantz, Leonhard Döderlein, Thomas Dreher & Matthias C. Klotz
Background:Equinus foot deformity constitutes a common gait disorder in ambulatory adults with bilateral spastic cerebral palsy (BSCP). The outcome after intramuscular aponeurotic lengthening in the context of single-event multilevel surgery (SEMLS) in adulthood has not been investigated.Methods:We followed a group of 31 ambulatory adults with BSCP and equinus who underwent SEMLS including gastrocnemius-soleus intramuscular aponeurotic recession or Achilles tendon lengthening. All patients were analyzed preoperatively and at least 1 year (mean follow-up period: 1.6 years)...

Outcomes of ADHD Symptoms in Late Adolescence: Are Developmental Subtypes Important?

Aja Louise Murray, Tom Booth, Bonnie Auyeung, Manuel Eisner, Denis Ribeaud & Ingrid Obsuth
Objective: Substantial individual variation exists in the age of onset and course of ADHD symptoms over development. We evaluated whether, within this variation, meaningful developmental subtypes can be defined. Method: Using growth mixture modeling in a community-based sample (N = 1,571), we analyzed ADHD symptom trajectories based on measures taken at ages 7, 8, 9, 10, 11, 13, and 15 years. We evaluated whether those showing developmental trajectories characterized by later onsets versus early onsets...

The Evolution of Earned, Transparent, and Quantifiable Faculty Salary Compensation: The Johns Hopkins Pathology Experience

Kathleen H. Burns, Michael J. Borowitz, Karen C. Carroll, Christopher D. Gocke, Jody E. Hooper, Timothy Amukele, Aaron A. R. Tobian, Allen Valentine, Rob Kahl, Vanessa Rodas-Eral, John K. Boitnott, J. Brooks Jackson, Fred Sanfilippo & Ralph H. Hruban
Faculty value equitable and transparent policies for determining salaries and expect their compensation to compare favorably to the marketplace. Academic institutions use compensation to recruit and retain talented faculty as well as to reward accomplishment. Institutions are therefore working to decrease salary disparities that appear arbitrary or reflect long-standing biases and to identify metrics for merit-based remuneration. Ours is a large academic pathology department with 97 tenure-track faculty. Faculty salaries are comprised of 3 parts...

The Global Increase in the Socioeconomic Achievement Gap, 1964 to 2015

Anna K. Chmielewski
The “socioeconomic achievement gap”—the disparity in academic achievement between students from high- and low-socioeconomic status (SES) backgrounds—is well-known in the sociology of education. The SES achievement gap has been documented across a wide range of countries. Yet in most countries, we do not know whether the SES achievement gap has been changing over time. This study combines 30 international large-scale assessments over 50 years, representing 100 countries and about 5.8 million students. SES achievement gaps...

The Global Increase in the Socioeconomic Achievement Gap, 1964 to 2015

Anna K. Chmielewski
The “socioeconomic achievement gap”—the disparity in academic achievement between students from high- and low-socioeconomic status (SES) backgrounds—is well-known in the sociology of education. The SES achievement gap has been documented across a wide range of countries. Yet in most countries, we do not know whether the SES achievement gap has been changing over time. This study combines 30 international large-scale assessments over 50 years, representing 100 countries and about 5.8 million students. SES achievement gaps...

Assessing the Feasibility of Measuring Variation in Facility Design Among American Childbirth Facilities

Avery Plough, Deb Polzin-Rosenberg, Grace Galvin, Amie Shao, Brendan Sullivan, Natalie Henrich & Neel T. Shah
Objective:To assess the feasibility of quantifying variation in childbirth facility design and explore the implications for childbirth service delivery across the United States.Background:Design has been shown to impact quality of care in childbirth. However, most prior studies use qualitative data to examine associations between the design of patient rooms and patient experience. There has been limited exploration of measures of unit design and its impact on care provision.Method:We recruited 12 childbirth facilities that were diverse...

Biomechanical study of optimum anchorage in dome-shaped high tibial osteotomy

Toshiaki Takahashi, Manabu Takahashi, Haruyasu Yamamoto & Hiromasa Miura
Purpose:There has been no report to date on any biomechanical study regarding the strength of fixation at the osteotomy site in dome-shaped high tibial osteotomy (HTO). In this study, we evaluated the biomechanical strength of a spacer that we improved and determined the medial site of HTO.Methods:HTO correction angles of 15° and 20° were used in all experiments, which were performed on lower leg specimens from pigs (n = 12). The osteotomy site was fixed...

Assessing professional competence: a critical review of the Annual Review of Competence Progression

Katherine Woolf, Michael Page & Rowena Viney
The Annual Review of Competence Progression is used to determine whether trainee doctors in the United Kingdom are safe and competent to progress to the next training stage.In this article we provide evidence to inform recommendations to enhance the validity of the summative and formative elements of the Annual Review of Competency Progression. The work was commissioned as part of a Health Education England review.We systematic searched the peer reviewed and grey literature, synthesising findings...

Assessing professional competence: a critical review of the Annual Review of Competence Progression

Katherine Woolf, Michael Page & Rowena Viney
The Annual Review of Competence Progression is used to determine whether trainee doctors in the United Kingdom are safe and competent to progress to the next training stage.In this article we provide evidence to inform recommendations to enhance the validity of the summative and formative elements of the Annual Review of Competency Progression. The work was commissioned as part of a Health Education England review.We systematic searched the peer reviewed and grey literature, synthesising findings...

Kinematics uncertainty analysis of mine bolter manipulator based on Chebyshev interval algorithms

Jun Zhang, Qing-Xue Huang, Wenjun Meng, Xiangdong Yu, Guoying Meng & Lifeng Ma
A mine bolter is a fast, safe and economical support equipment, in which the manipulator is the key component for its parallel operation. In this study, the kinematics of mine bolter manipulator is selected as the research object. Aiming at the problem of the dynamic system response estimation of positive solution matrix with uncertain parameters, an interval estimation analysis method based on Chebyshev polynomial is proposed. The response envelope interval of the forward kinematics solution...

Kinematics uncertainty analysis of mine bolter manipulator based on Chebyshev interval algorithms

Jun Zhang, Qing-Xue Huang, Wenjun Meng, Xiangdong Yu, Guoying Meng & Lifeng Ma
A mine bolter is a fast, safe and economical support equipment, in which the manipulator is the key component for its parallel operation. In this study, the kinematics of mine bolter manipulator is selected as the research object. Aiming at the problem of the dynamic system response estimation of positive solution matrix with uncertain parameters, an interval estimation analysis method based on Chebyshev polynomial is proposed. The response envelope interval of the forward kinematics solution...

Magnetorheological suspension with capillary network

Jianjian Yang, Zhide Hu, Hua Yan & Fanghao Niu
The capillary force has been employed to facilitate an effective pathway for the preparation and design of magnetorheological suspensions. The network formation from pendular particle structure-driven assembly can potentially be used to stabilize particle suspension. Furthermore, the magnetic liquid bridge proposed can give rise to a dramatic enhancement in magnetorheological effect (20%–100% increment in storage modulus), suggesting the possibility of tuning field dependent rheological properties of magnetorheological suspensions by addition of minute amounts of ferrofluid.

Magnetorheological suspension with capillary network

Jianjian Yang, Zhide Hu, Hua Yan & Fanghao Niu
The capillary force has been employed to facilitate an effective pathway for the preparation and design of magnetorheological suspensions. The network formation from pendular particle structure-driven assembly can potentially be used to stabilize particle suspension. Furthermore, the magnetic liquid bridge proposed can give rise to a dramatic enhancement in magnetorheological effect (20%–100% increment in storage modulus), suggesting the possibility of tuning field dependent rheological properties of magnetorheological suspensions by addition of minute amounts of ferrofluid.

Properties and Function of the Medial Patellofemoral Ligament: A Systematic Review

Christian Huber, Qiang Zhang, William R. Taylor, Andrew A. Amis, Colin Smith & Seyyed Hamed Hosseini Nasab
Background:As the main passive structure preventing patellar lateral subluxation, accurate knowledge of the anatomy, material properties, and functional behavior of the medial patellofemoral ligament (MPFL) is critical for improving its reconstruction.Purpose:To provide a state-of-the-art understanding of the properties and function of the MPFL by undertaking a systematic review and statistical analysis of the literature.Study Design:Systematic review.Methods:On June 26, 2018, data for this systematic review were obtained by searching PubMed and Scopus. Articles containing numerical information...

Properties and Function of the Medial Patellofemoral Ligament: A Systematic Review

Christian Huber, Qiang Zhang, William R. Taylor, Andrew A. Amis, Colin Smith & Seyyed Hamed Hosseini Nasab
Background:As the main passive structure preventing patellar lateral subluxation, accurate knowledge of the anatomy, material properties, and functional behavior of the medial patellofemoral ligament (MPFL) is critical for improving its reconstruction.Purpose:To provide a state-of-the-art understanding of the properties and function of the MPFL by undertaking a systematic review and statistical analysis of the literature.Study Design:Systematic review.Methods:On June 26, 2018, data for this systematic review were obtained by searching PubMed and Scopus. Articles containing numerical information...

Single-Cell Profiles and Clinically Useful Properties of Human Mesenchymal Stem Cells of Adipose and Bone Marrow Origin

Wenyan Zhou, Junxin Lin, Kun Zhao, Kaixiu Jin, Qiulin He, Yejun Hu, Gang Feng, Youzhi Cai, Chen Xia, Hua Liu, Weiliang Shen, Xueqing Hu & Hongwei Ouyang
Background:Mesenchymal stem cells (MSCs) can be isolated from various tissues and can present themselves as a promising cell source for cell-based therapies. Although adipose- and bone marrow–derived mesenchymal stem cells have already been used in a considerable number of clinical trials for osteoarthritis treatment, systematic analyses from single- to bulk-cell resolution as well as clinical outcomes of these 2 MSCs are still insufficient.Purpose:To explore the characteristics and differences of adipose-derived stem cells (ADSCs) and bone...

Single-Cell Profiles and Clinically Useful Properties of Human Mesenchymal Stem Cells of Adipose and Bone Marrow Origin

Wenyan Zhou, Junxin Lin, Kun Zhao, Kaixiu Jin, Qiulin He, Yejun Hu, Gang Feng, Youzhi Cai, Chen Xia, Hua Liu, Weiliang Shen, Xueqing Hu & Hongwei Ouyang
Background:Mesenchymal stem cells (MSCs) can be isolated from various tissues and can present themselves as a promising cell source for cell-based therapies. Although adipose- and bone marrow–derived mesenchymal stem cells have already been used in a considerable number of clinical trials for osteoarthritis treatment, systematic analyses from single- to bulk-cell resolution as well as clinical outcomes of these 2 MSCs are still insufficient.Purpose:To explore the characteristics and differences of adipose-derived stem cells (ADSCs) and bone...

Activity Modification and Load Management of Adolescents With Patellofemoral Pain: A Prospective Intervention Study Including 151 Adolescents

Michael Skovdal Rathleff, Thomas Graven-Nielsen, Per Hölmich, Lukasz Winiarski, Kasper Krommes, Sinéad Holden & Kristian Thorborg
Background:Patellofemoral pain (PFP) affects 7% of adolescents, especially those who are highly active. Exercise-focused treatments show limited effect and overlook activity modification and load management. As many adolescents continue at high levels of sports despite pain, a new strategy addressing this problem is warranted.Purpose:To investigate the effects of a treatment strategy for adolescents that focuses on activity modification and load management.Study Design:Cohort study; Level of evidence, 2.Methods:Adolescents aged 10 to 14 years with PFP were...

Activity Modification and Load Management of Adolescents With Patellofemoral Pain: A Prospective Intervention Study Including 151 Adolescents

Michael Skovdal Rathleff, Thomas Graven-Nielsen, Per Hölmich, Lukasz Winiarski, Kasper Krommes, Sinéad Holden & Kristian Thorborg
Background:Patellofemoral pain (PFP) affects 7% of adolescents, especially those who are highly active. Exercise-focused treatments show limited effect and overlook activity modification and load management. As many adolescents continue at high levels of sports despite pain, a new strategy addressing this problem is warranted.Purpose:To investigate the effects of a treatment strategy for adolescents that focuses on activity modification and load management.Study Design:Cohort study; Level of evidence, 2.Methods:Adolescents aged 10 to 14 years with PFP were...

Augmented Ligament Reconstruction Partially Restores Hindfoot and Midfoot Kinematics After Lateral Ligament Ruptures

Hannelore Boey, Stefaan Verfaillie, Tassos Natsakis, Jos Vander Sloten & Ilse Jonkers
Background:Altered kinematics and persisting ankle instability have been associated with degenerative changes and osteochondral lesions.Purpose:To study the effect of ligament reconstruction surgery with suture tape augmentation (isolated anterior talofibular ligament [ATFL] vs combined ATFL and calcaneofibular ligament [CFL]) after lateral ligament ruptures (combined ATFL and CFL) on foot-ankle kinematics during simulated gait.Study Design:Controlled laboratory study.Methods:Five fresh-frozen cadaveric specimens were tested in a custom-built gait simulator in 5 different conditions: intact, ATFL rupture, ATFL-CFL rupture, ATFL-CFL...

Augmented Ligament Reconstruction Partially Restores Hindfoot and Midfoot Kinematics After Lateral Ligament Ruptures

Hannelore Boey, Stefaan Verfaillie, Tassos Natsakis, Jos Vander Sloten & Ilse Jonkers
Background:Altered kinematics and persisting ankle instability have been associated with degenerative changes and osteochondral lesions.Purpose:To study the effect of ligament reconstruction surgery with suture tape augmentation (isolated anterior talofibular ligament [ATFL] vs combined ATFL and calcaneofibular ligament [CFL]) after lateral ligament ruptures (combined ATFL and CFL) on foot-ankle kinematics during simulated gait.Study Design:Controlled laboratory study.Methods:Five fresh-frozen cadaveric specimens were tested in a custom-built gait simulator in 5 different conditions: intact, ATFL rupture, ATFL-CFL rupture, ATFL-CFL...

Performance and Return to Sport After Open Reduction and Internal Fixation of the Olecranon in Professional Baseball Players

Brandon J. Erickson, Peter N. Chalmers, John D’Angelo, Kevin Ma, Christopher S. Ahmad & Anthony A. Romeo
Background:The results of open reduction and internal fixation (ORIF) of stress reactions and fractures of the olecranon among professional baseball players with regard to return to sport (RTS) are unknown.Hypothesis/Purpose:To determine the RTS rate and performance of professional baseball players after ORIF of acute, displaced olecranon fractures and olecranon stress fractures and to compare the RTS rate and performance with that of matched controls. The authors hypothesized that there is a high rate of RTS...

Performance and Return to Sport After Open Reduction and Internal Fixation of the Olecranon in Professional Baseball Players

Brandon J. Erickson, Peter N. Chalmers, John D’Angelo, Kevin Ma, Christopher S. Ahmad & Anthony A. Romeo
Background:The results of open reduction and internal fixation (ORIF) of stress reactions and fractures of the olecranon among professional baseball players with regard to return to sport (RTS) are unknown.Hypothesis/Purpose:To determine the RTS rate and performance of professional baseball players after ORIF of acute, displaced olecranon fractures and olecranon stress fractures and to compare the RTS rate and performance with that of matched controls. The authors hypothesized that there is a high rate of RTS...

Long-term Clinical Outcomes of One-Stage Cartilage Repair in the Knee With Hyaluronic Acid–Based Scaffold Embedded With Mesenchymal Stem Cells Sourced From Bone Marrow Aspirate Concentrate

Alberto Gobbi & Graeme P. Whyte
Background:Cell-based cartilage repair performed as a single-stage procedure is an important advancement in the treatment of full-thickness cartilage injury and has potential for widespread clinical use.Purpose:To investigate the long-term clinical outcomes of cartilage repair in the knee with a hyaluronic acid–based scaffold embedded with bone marrow aspirate concentrate (HA-BMAC) for the treatment of full-thickness cartilage injury.Study Design:Case series; Level of evidence, 4.Methods:Patients underwent treatment of full-thickness chondral injury in the knee with HA-BMAC and were...

Long-term Clinical Outcomes of One-Stage Cartilage Repair in the Knee With Hyaluronic Acid–Based Scaffold Embedded With Mesenchymal Stem Cells Sourced From Bone Marrow Aspirate Concentrate

Alberto Gobbi & Graeme P. Whyte
Background:Cell-based cartilage repair performed as a single-stage procedure is an important advancement in the treatment of full-thickness cartilage injury and has potential for widespread clinical use.Purpose:To investigate the long-term clinical outcomes of cartilage repair in the knee with a hyaluronic acid–based scaffold embedded with bone marrow aspirate concentrate (HA-BMAC) for the treatment of full-thickness cartilage injury.Study Design:Case series; Level of evidence, 4.Methods:Patients underwent treatment of full-thickness chondral injury in the knee with HA-BMAC and were...

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