311,808 Works

Supplementary material from "Revisiting metazoan phylogeny with genomic sampling of all phyla"

Christopher E. Laumer, Rosa Fernández, Sarah Lemer, David Combosch, Kevin Kocot, Ana Riesgo, Sonia C. S. Andrade, Wolfgang Sterrer, Martin V. Sørensen & Gonzalo Giribet
Proper biological interpretation of a phylogeny can sometimes hinge on the placement of key taxa—or fail when such key taxa are not sampled. In this light, we here present the first attempt to investigate (though not conclusively resolve) animal relationships using genome-scale data from all phyla. Results from the site-heterogeneous CAT + GTR model recapitulate many established major clades, and strongly confirm some recent discoveries, such as a monophyletic Lophophorata, and a sister group relationship between Gnathifera...

Supplementary material from "Revisiting metazoan phylogeny with genomic sampling of all phyla"

Christopher E. Laumer, Rosa Fernández, Sarah Lemer, David Combosch, Kevin Kocot, Ana Riesgo, Sonia C. S. Andrade, Wolfgang Sterrer, Martin V. Sørensen & Gonzalo Giribet
Proper biological interpretation of a phylogeny can sometimes hinge on the placement of key taxa—or fail when such key taxa are not sampled. In this light, we here present the first attempt to investigate (though not conclusively resolve) animal relationships using genome-scale data from all phyla. Results from the site-heterogeneous CAT + GTR model recapitulate many established major clades, and strongly confirm some recent discoveries, such as a monophyletic Lophophorata, and a sister group relationship between Gnathifera...

Supplementary material from "Revisiting metazoan phylogeny with genomic sampling of all phyla"

Christopher E. Laumer, Rosa Fernández, Sarah Lemer, David Combosch, Kevin Kocot, Ana Riesgo, Sonia C. S. Andrade, Wolfgang Sterrer, Martin V. Sørensen & Gonzalo Giribet
Proper biological interpretation of a phylogeny can sometimes hinge on the placement of key taxa—or fail when such key taxa are not sampled. In this light, we here present the first attempt to investigate (though not conclusively resolve) animal relationships using genome-scale data from all phyla. Results from the site-heterogeneous CAT + GTR model recapitulate many established major clades, and strongly confirm some recent discoveries, such as a monophyletic Lophophorata, and a sister group relationship between Gnathifera...

Supplementary material from "Hierarchical social modularity in gorillas"

Robin E. Morrison, Milou Groenenberg, Thomas Breuer, Marie L. Manguette & Peter D. Walsh
Modern human societies show hierarchical social modularity (HSM) in which lower-order social units like nuclear families are nested inside increasingly larger units. It has been argued that this HSM evolved independently and after the chimpanzee–human split due to greater recognition of, and bonding between, dispersed kin. We used network modularity analysis and hierarchical clustering to quantify community structure within two western lowland gorilla populations. In both communities, we detected two hierarchically nested tiers of social...

Supplementary material from "Hierarchical social modularity in gorillas"

Robin E. Morrison, Milou Groenenberg, Thomas Breuer, Marie L. Manguette & Peter D. Walsh
Modern human societies show hierarchical social modularity (HSM) in which lower-order social units like nuclear families are nested inside increasingly larger units. It has been argued that this HSM evolved independently and after the chimpanzee–human split due to greater recognition of, and bonding between, dispersed kin. We used network modularity analysis and hierarchical clustering to quantify community structure within two western lowland gorilla populations. In both communities, we detected two hierarchically nested tiers of social...

Serious kidney disease in pregnancy: an Australian national cohort study protocol

Nadom Safi, Elizabeth Sullivan, Zhuoyang Li, Mark Brown, William Hague, Stephen McDonald, Michael Peek, Angela Makris, Angela O’Brien & Shilpanjali Jesudason
Abstract Background Maternal kidney disease (acute kidney injury (AKI), advanced chronic kidney disease (CKD), dependence on dialysis or a kidney transplant) has a substantial impact on pregnancy, with risks of significant perinatal morbidity. These pregnancies require integrated multidisciplinary care to manage a complex and often challenging clinical situation. The ability to deliver optimal care is currently hindered by a lack of understanding around prevalence, management and outcomes in Australia. This study aims to expand an...

Serious kidney disease in pregnancy: an Australian national cohort study protocol

Nadom Safi, Elizabeth Sullivan, Zhuoyang Li, Mark Brown, William Hague, Stephen McDonald, Michael Peek, Angela Makris, Angela O’Brien & Shilpanjali Jesudason
Abstract Background Maternal kidney disease (acute kidney injury (AKI), advanced chronic kidney disease (CKD), dependence on dialysis or a kidney transplant) has a substantial impact on pregnancy, with risks of significant perinatal morbidity. These pregnancies require integrated multidisciplinary care to manage a complex and often challenging clinical situation. The ability to deliver optimal care is currently hindered by a lack of understanding around prevalence, management and outcomes in Australia. This study aims to expand an...

Mucosal delivery of Lactococcus lactis carrying an anti-TNF scFv expression vector ameliorates experimental colitis in mice

Maria Chiabai, Juliana Almeida, Mariana Azevedo, Suelen Fernandes, Vanessa Pereira, Raffael Castro, Márcio Jerônimo, Isabel Sousa, Leonora Souza Vianna, Anderson Miyoshi, Anamelia Bocca, Andrea Maranhão & Marcelo Brigido
Abstract Background Anti-Tumor Necrosis Factor-alpha therapy has become clinically important for treating inflammatory bowel disease. However, the use of conventional immunotherapy requires a systemic exposure of patients and collateral side effects. Lactic acid bacteria have been shown to be effective as mucosal delivering system for cytokine and single domain antibodies, and it is amenable to clinical purposes. Therefore, lactic acid bacteria may function as vehicles for delivery of therapeutic antibodies molecules to the gastrointestinal tract...

Mucosal delivery of Lactococcus lactis carrying an anti-TNF scFv expression vector ameliorates experimental colitis in mice

Maria Chiabai, Juliana Almeida, Mariana Azevedo, Suelen Fernandes, Vanessa Pereira, Raffael Castro, Márcio Jerônimo, Isabel Sousa, Leonora Souza Vianna, Anderson Miyoshi, Anamelia Bocca, Andrea Maranhão & Marcelo Brigido
Abstract Background Anti-Tumor Necrosis Factor-alpha therapy has become clinically important for treating inflammatory bowel disease. However, the use of conventional immunotherapy requires a systemic exposure of patients and collateral side effects. Lactic acid bacteria have been shown to be effective as mucosal delivering system for cytokine and single domain antibodies, and it is amenable to clinical purposes. Therefore, lactic acid bacteria may function as vehicles for delivery of therapeutic antibodies molecules to the gastrointestinal tract...

Health service utilization among African American women living with systemic lupus erythematosus: perceived impacts of a self-management intervention

Abena Twumasi, Anna Shao, Charmayne Dunlop-Thomas, Cristina Drenkard & Hannah Cooper
Abstract Background Healthcare access, utilization, and quality play critical roles in shaping mortality and morbidity among patients diagnosed with systemic lupus erythematosus (SLE), and yet healthcare access, utilization, and quality can be suboptimal for many people living with SLE. The aim of this qualitative study was to explore the perceived impact of a peer-led, group-based educational intervention (the Chronic Disease Self-Management Program [CDSMP]) on healthcare engagement behaviors among African American women with SLE. Methods Participants...

Health service utilization among African American women living with systemic lupus erythematosus: perceived impacts of a self-management intervention

Abena Twumasi, Anna Shao, Charmayne Dunlop-Thomas, Cristina Drenkard & Hannah Cooper
Abstract Background Healthcare access, utilization, and quality play critical roles in shaping mortality and morbidity among patients diagnosed with systemic lupus erythematosus (SLE), and yet healthcare access, utilization, and quality can be suboptimal for many people living with SLE. The aim of this qualitative study was to explore the perceived impact of a peer-led, group-based educational intervention (the Chronic Disease Self-Management Program [CDSMP]) on healthcare engagement behaviors among African American women with SLE. Methods Participants...

Clinical features and genetic spectrum in Chinese patients with recessive hereditary spastic paraplegia

Qiao Wei, Hai-Lin Dong, Li-Ying Pan, Cong-Xin Chen, Yang-Tian Yan, Rou-Min Wang, Hong-Fu Li, Zhi-Jun Liu, Qing-Qing Tao & Zhi-Ying Wu
Abstract Background Although many causative genes of hereditary spastic paraplegia (HSP) have been uncovered in recent years, there are still approximately 50% of HSP patients without genetically diagnosis, especially in autosomal recessive (AR) HSP patients. Rare studies have been performed to determine the genetic spectrum and clinical profiles of recessive HSP patients in the Chinese population. Methods In this study, we investigated 24 Chinese index AR/sporadic patients by targeted next-generation sequencing (NGS), Sanger sequencing and...

Cost of dialysis therapies in rural and remote Australia â a micro-costing analysis

G. Gorham, K. Howard, Y. Zhao, A. Ahmed, P. Lawton, C. Sajiv, S. Majoni, P. Wood, T. Conlon, S. Signal, S. Robinson, S. Brown & A. Cass
Abstract Background Maintenance dialysis is a costly and resource intense activity. In Australia, inadequate health infrastructure and poor access to technically skilled staff can limit service provision in remote areas where many Aboriginal dialysis patients live. With most studies based on urban service provision, there is little evidence to guide service development. However permanent relocation to an urban area for treatment can have significant social and financial impacts that are poorly quantified. This study is...

Cost of dialysis therapies in rural and remote Australia â a micro-costing analysis

G. Gorham, K. Howard, Y. Zhao, A. Ahmed, P. Lawton, C. Sajiv, S. Majoni, P. Wood, T. Conlon, S. Signal, S. Robinson, S. Brown & A. Cass
Abstract Background Maintenance dialysis is a costly and resource intense activity. In Australia, inadequate health infrastructure and poor access to technically skilled staff can limit service provision in remote areas where many Aboriginal dialysis patients live. With most studies based on urban service provision, there is little evidence to guide service development. However permanent relocation to an urban area for treatment can have significant social and financial impacts that are poorly quantified. This study is...

Clinical features and genetic spectrum in Chinese patients with recessive hereditary spastic paraplegia

Qiao Wei, Hai-Lin Dong, Li-Ying Pan, Cong-Xin Chen, Yang-Tian Yan, Rou-Min Wang, Hong-Fu Li, Zhi-Jun Liu, Qing-Qing Tao & Zhi-Ying Wu
Abstract Background Although many causative genes of hereditary spastic paraplegia (HSP) have been uncovered in recent years, there are still approximately 50% of HSP patients without genetically diagnosis, especially in autosomal recessive (AR) HSP patients. Rare studies have been performed to determine the genetic spectrum and clinical profiles of recessive HSP patients in the Chinese population. Methods In this study, we investigated 24 Chinese index AR/sporadic patients by targeted next-generation sequencing (NGS), Sanger sequencing and...

3D CoMoSe4 Nanosheet Arrays Converted Directly from Hydrothermally Processed CoMoO4 Nanosheet Arrays by Plasma-Assisted Selenization Process Toward Excellent Anode Material in Sodium-Ion Battery

Shan Zhang, Yuanfei Ai, Shu-Chi Wu, Hsiang-Ju Liao, Teng-Yu Su, Jyun-Hong Chen, Chuan-Hsun Wang, Ling Lee, Yu-Ze Chen, Binbin Xu, Shin-Yi Tang, Ding Wu, Shao-Shin Lee, Jun Yin, Jing Li, Junyong Kang & Yu-Lun Chueh
Abstract In this work, three-dimensional (3D) CoMoSe4 nanosheet arrays on network fibers of a carbon cloth denoted as CoMoSe4@C converted directly from CoMoO4 nanosheet arrays prepared by a hydrothermal process followed by the plasma-assisted selenization at a low temperature of 450 °C as an anode for sodium-ion battery (SIB) were demonstrated for the first time. With the plasma-assisted treatment on the selenization process, oxygen (O) atoms can be replaced by selenium (Se) atoms without the degradation...

HPV vaccination has not increased sexual activity or accelerated sexual debut in a college-aged cohort of men and women

Andrew Brouwer, Rachel Delinger, Marisa Eisenberg, Lora Campredon, Heather Walline, Thomas Carey & Rafael Meza
Abstract Background The human papillomavirus (HPV) is the most common sexually transmitted infection and is linked to several types of cancer. HPV vaccination uptake in the U.S. is relatively low, despite the vaccine’s high efficacy. Some parents of adolescents have concerns that vaccination will encourage sexual behavior and therefore choose not to vaccinate. Previous studies investigating vaccination and sexual behavior have included only young women and girls. Methods The objective of this study is to...

3D CoMoSe4 Nanosheet Arrays Converted Directly from Hydrothermally Processed CoMoO4 Nanosheet Arrays by Plasma-Assisted Selenization Process Toward Excellent Anode Material in Sodium-Ion Battery

Shan Zhang, Yuanfei Ai, Shu-Chi Wu, Hsiang-Ju Liao, Teng-Yu Su, Jyun-Hong Chen, Chuan-Hsun Wang, Ling Lee, Yu-Ze Chen, Binbin Xu, Shin-Yi Tang, Ding Wu, Shao-Shin Lee, Jun Yin, Jing Li, Junyong Kang & Yu-Lun Chueh
Abstract In this work, three-dimensional (3D) CoMoSe4 nanosheet arrays on network fibers of a carbon cloth denoted as CoMoSe4@C converted directly from CoMoO4 nanosheet arrays prepared by a hydrothermal process followed by the plasma-assisted selenization at a low temperature of 450 °C as an anode for sodium-ion battery (SIB) were demonstrated for the first time. With the plasma-assisted treatment on the selenization process, oxygen (O) atoms can be replaced by selenium (Se) atoms without the degradation...

HPV vaccination has not increased sexual activity or accelerated sexual debut in a college-aged cohort of men and women

Andrew Brouwer, Rachel Delinger, Marisa Eisenberg, Lora Campredon, Heather Walline, Thomas Carey & Rafael Meza
Abstract Background The human papillomavirus (HPV) is the most common sexually transmitted infection and is linked to several types of cancer. HPV vaccination uptake in the U.S. is relatively low, despite the vaccine’s high efficacy. Some parents of adolescents have concerns that vaccination will encourage sexual behavior and therefore choose not to vaccinate. Previous studies investigating vaccination and sexual behavior have included only young women and girls. Methods The objective of this study is to...

Towards seeing the visual impairments in Parkinson’s disease: protocol for a multicentre observational, cross-sectional study

Carlijn Borm, Mario Werkmann, Femke Visser, Marina Peball, Diana Putz, Klaus Seppi, Werner Poewe, Irene Notting, Annemarie Vlaar, Thomas Theelen, Carel Hoyng, Bastiaan Bloem & Nienke Vries
Abstract Background Visual disorders are common in Parkinson’s disease (PD) but their exact frequency and severity are unknown. Good visual functioning is crucial for patients with PD, because of their need to compensate for loss of automated motor control and their postural instability, forcing patients to guide their movements visually. Here, we describe the study design of a cross-sectional, multi-centre study aiming to: (1) validate the Visual Impairment screening questionnaire (VIPD-Q, which aims to identify...

Towards seeing the visual impairments in Parkinson’s disease: protocol for a multicentre observational, cross-sectional study

Carlijn Borm, Mario Werkmann, Femke Visser, Marina Peball, Diana Putz, Klaus Seppi, Werner Poewe, Irene Notting, Annemarie Vlaar, Thomas Theelen, Carel Hoyng, Bastiaan Bloem & Nienke Vries
Abstract Background Visual disorders are common in Parkinson’s disease (PD) but their exact frequency and severity are unknown. Good visual functioning is crucial for patients with PD, because of their need to compensate for loss of automated motor control and their postural instability, forcing patients to guide their movements visually. Here, we describe the study design of a cross-sectional, multi-centre study aiming to: (1) validate the Visual Impairment screening questionnaire (VIPD-Q, which aims to identify...

Small RNA profiling of Cavendish banana roots inoculated with Fusarium oxysporum f. sp. cubense race 1 and tropical race 4

Shulang Fei, Elizabeth Czislowski, Stephen Fletcher, Jonathan Peters, Jacqueline Batley, Elizabeth Aitken & Neena Mitter
Abstract Fusarium wilt, caused by the soil-borne fungal pathogen, Fusarium oxysporum f. sp. cubense (Foc), is considered as one of the most threatening diseases of banana. The Cavendish variety, resistant to Foc race 1 (R1), is susceptible to tropical race 4 (TR4), an aggressive race of the pathogen which is of increasing concern worldwide. Previous studies have revealed that plant small RNAs (sRNAs) play crucial roles in the host response to pathogen infection. To investigate...

Small RNA profiling of Cavendish banana roots inoculated with Fusarium oxysporum f. sp. cubense race 1 and tropical race 4

Shulang Fei, Elizabeth Czislowski, Stephen Fletcher, Jonathan Peters, Jacqueline Batley, Elizabeth Aitken & Neena Mitter
Abstract Fusarium wilt, caused by the soil-borne fungal pathogen, Fusarium oxysporum f. sp. cubense (Foc), is considered as one of the most threatening diseases of banana. The Cavendish variety, resistant to Foc race 1 (R1), is susceptible to tropical race 4 (TR4), an aggressive race of the pathogen which is of increasing concern worldwide. Previous studies have revealed that plant small RNAs (sRNAs) play crucial roles in the host response to pathogen infection. To investigate...

Characterization of an iron-inducible Haemaphysalis longicornis tick-derived promoter in an Ixodes scapularis-derived tick cell line (ISE6)

Emmanuel Hernandez, Kodai Kusakisako, Takeshi Hatta & Tetsuya Tanaka
Abstract Background Ticks are important vectors of disease-causing pathogens. With the rise of resistance to chemical acaricides, alternative methods in tick control are warranted. Gene manipulation has been successful in controlling mosquitoes and mosquito-borne diseases and is now looked upon as a candidate method to control ticks and tick-borne pathogens. Our previous study has identified the actin and ferritin promoter regions in the Haemaphysalis longicornis tick. Results Here, the ferritin-derived promoter from the H. longicornis...

The magnitude and correlates of common mental disorder among outpatient medical patients in Ethiopia: an institution based cross-sectional study

Mehbub Denur, Getachew Tesfaw & Zegeye Yohannis
Abstract Objective Common mental disorder has a high prevalence in the general population worldwide. One in four patients visiting any health services has at least one mental disorders and negatively impacts quality of life, physical wellbeing, poor level of functioning, and poor medication adherence. However, research into common mental illness and associated factors among people with outpatient medical patients in low and meddle-income countries is limited. Therefore, this study aimed to explore common mental disorder...

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