Quick Urban Analysis Kit (qua-kit) is a web platform for simple urban design editing, sharing and discussion. Qua-kit is integrated into a series of massive open online courses (MOOCs) called Future Cities, which is developed by the chair of Information Architecture (iA) at ETH Zürich. This dataset contains student submissions (design geometry), discussions, and related data in the form of an SQL dump. In addition, the archive contains example data analysis scripts.

Bichromatic photonic crystal structures are based on the coexistence of two different periodicities in the dielectric constant profile. They are realized starting from a photonic crystal waveguide and modifying the lattice constant only in the waveguide region. In this work, we numerically investigate the spectral and topological properties of bichromatic structures. Our calculations demonstrate that they provide a photonic analog of the integer quantum Hall state, a well known example of a topological insulator. The...

Bichromatic photonic crystal structures are based on the coexistence of two different periodicities in the dielectric constant profile. They are realized starting from a photonic crystal waveguide and modifying the lattice constant only in the waveguide region. In this work, we numerically investigate the spectral and topological properties of bichromatic structures. Our calculations demonstrate that they provide a photonic analog of the integer quantum Hall state, a well known example of a topological insulator. The...

Abstract Objectives The aim of the study is to explore the relationship between CCDC69 expression and resistance of ovarian cancer cells to cisplatin and reveal the underlying mechanism. Methods One hundred thirty five ovarian cancer patients with intact chemo-response information from The Cancer Genome Atlas (TCGA) database were included and analyzed. Stable CCDC69 overexpressing 293 and ovarian cancer A2780 cell lines were established and subjected to examine cell apoptosis and cell cycle distribution using CCK-8...

Abstract Background Despite their importance as vectors of zoonotic parasites that can impact human and animal health, Culicoides species distribution across different habitat types is largely unknown. Here we document the community composition of Culicoides found in an urban environment including developed and natural sites in east central Texas, a region of high vector diversity due to subtropical climates, and report their infection status with haemoparasites. Results A total of 251 individual Culicoides were collected...

Abstract Background Synthetic indolyl- pyridinyl- propenones (IPPs) induce methuosis, a form of non-apoptotic cell death, in glioblastoma and other cancer cell lines. Methuosis is characterized by accumulation of cytoplasmic vacuoles derived from macropinosomes and late endosomes, followed by metabolic failure and rupture of the plasma membrane. However, not all IPPs that cause vacuolization are cytotoxic. The main goals of the present study were to identify key signaling pathways that contribute to methuosis induced by cytotoxic...

In this thesis, I study some aspects of how students learn to use math to make sense of physical phenomena. Solving physics problems usually requires dealing with algebraic expressions. That can take the form of reading equations you’re given, manipulating them, or creating them. It’s possible to use equations simply according to formal rules of algebra, but most students also learn to interpret the equations and use the equations as ways to bolster their physical...

Ristova et al., (2018): Natural Genetic Variation Shapes Root System Responses to Phytohormones in Arabidopsis. Plant Journal. DOI: 10.1111/tpj.14034.

Tidal disruption events (TDEs) refer to the scenario where a star passes within the tidal disruption sphere of a supermassive black hole (SMBH) and becomes torn apart by tidal stresses. In the classical picture, a thermal flare is expected once the bound stellar debris circularize to form an accretion disk that feeds onto the black hole. This flare of radiation provides a unique window to study the demographics of black holes within distant and quiescent...

Self-assembling materials have become ubiquitous in modern society. Thus, a great challenge exists in developing nonpolar building blocks for self-assembling materials in a simple, efficient, and scalable manner. It is also important to find new ways in which to utilize such building blocks in a versatile manner. In this work, precision polyolefins and end-group functionalized poly(-olefinates) (x-PAOs) were successfully used as simple, easily accessible nonpolar building blocks for the development of new nanostructured materials. Specifically,...

Virtual reality (VR) is poised to become the new medium through which we engage, view, and consume content. In contrast to traditional 2D desktop displays, which restrict our interaction space onto an arbitrary 2D-plane with unnatural interaction mechanisms, VR expands the visualization and interaction space into our 3D domain, enabling natural observations and interactions with information. With the rise of Big Data, processing and visualizing such enormous datasets is of utmost importance and remains a...

To what extent do peacekeeper fatalities affect states’ contributions to UN operations? While the deaths of peacekeepers are thought to be a factor in states’ decisions to reduce the magnitude of their participation in a mission, not all states respond similarly to peacekeeper fatalities. I hypothesize that democracies and wealthy countries are likely to be more sensitive to peacekeeper deaths than their non-democratic and poorer counterparts. Analyses of UN peacekeeping operations between 1990 and 2011...

The purpose of this research was to identify the various types of employment held by music alumni at one university. We also compare the perceptions of alumni who currently work primarily in music with those of alumni who work outside the field. A mixed-methods research design that relied on surveys and interviews was used to gather data. Alumni employed primarily outside the field held a wide variety of roles and many reported incorporating their musical...

Background. Reference life expectancies inform frequently used health metrics, which play an integral role in determining resource allocation and health policy decision making. Existing reference life expectancies are not able to account for variation in geographies, populations, and disease states. Using a computer simulation, we developed a reference life expectancy estimation that considers competing causes of mortality, and is tailored to population characteristics. Methods. We developed a Monte Carlo microsimulation model that explicitly represented the...

Background. Reference life expectancies inform frequently used health metrics, which play an integral role in determining resource allocation and health policy decision making. Existing reference life expectancies are not able to account for variation in geographies, populations, and disease states. Using a computer simulation, we developed a reference life expectancy estimation that considers competing causes of mortality, and is tailored to population characteristics. Methods. We developed a Monte Carlo microsimulation model that explicitly represented the...

Five experiments (N = 2,251) and a meta-analysis examine how group labels shape Americans’ levels of prejudice, behavioral intentions, and policy preferences toward immigrants living in the US without authorization. These studies extend research documenting how the perceived negativity of group labels (e.g., those describing gay people) affects people’s downstream attitudes. To this end, Study 1 examines the perceived negativity of the five most commonly used labels to describe unauthorized immigrants. Study 2 found that...

Abstract Background Children with developmental coordination disorder (DCD) experience a range of difficulties that can potentially limit their academic, social and physical ability. Recent research has developed interventions that aim to improve motor outcomes in a variety of paediatric cohorts using video gaming equipment. Therefore, we aimed to systematically review the literature on virtual reality or video game interventions that aim to improve motor outcomes in children with DCD. Methods Seven databases were searched for...

Abstract Background Developing new antibabesial drugs with a low toxic effect to the animal and with no resistance from Babesia parasites is in urgent demand. In this concern, the antimalarial, anticancer and antioxidant effect of thymoquinone (TQ), a phytochemical compound found in the plant Nigella sativa, has been reported. Therefore, in the present study, the antibabesial effect of this compound was evaluated on the growth of piroplasm parasites. Results Significant inhibition (P < 0.05) of...

Abstract Background Insights into the genetic capacities of species to adapt to future climate change can be gained by using comparative genomic and transcriptomic data to reconstruct the genetic changes associated with such adaptations in the past. Here we investigate the genetic changes associated with adaptation to arid environments, specifically climatic extremes and new cactus hosts, through such an analysis of five repleta group Drosophila species. Results We find disproportionately high rates of gene gains...

Abstract Background Defects in the type and degree of cellular glycosylation impact oncogenesis on multiple levels. Although the type of glycosylation is determined by protein sequence encoded by the genome, the extent and modifications of glycosylation depends on the activity of biosynthetic enzymes and recent data suggests that the glycome is also subject to epigenetic regulation. This study focuses on the ability of HDAC inhibition to alter glycosylation and to lead to pro-oncogenic alterations in...

Abstract Background Aging is accompanied with loss of tissue homeostasis and accumulation of cellular damages. As one of the important metabolic centers, liver shows age-related dysregulation of lipid metabolism, impaired detoxification pathway, increased inflammation and oxidative stress response. However, the mechanisms for these age-related changes still remain unclear. In the fruit fly, Drosophila melanogaster, liver-like functions are controlled by two distinct tissues, fat body and oenocytes. Compared to fat body, little is known about how...

Abstract Background Efficient treatments against metastatic melanoma dissemination are still lacking. Here, we report that low-cytotoxic concentrations of 5-aza-2′-deoxycytidine, a DNA demethylating agent, prevent in vitro 3D invasiveness of metastatic melanoma cells and reduce lung metastasis formation in vivo. Results We unravelled that this beneficial effect is in part due to MIR-199A2 re-expression by promoter demethylation. Alone, this miR showed an anti-invasive and anti-metastatic effect. Throughout integration of micro-RNA target prediction databases with transcriptomic analysis...

Abstract Russian sturgeon (Acipenser gueldenstaedtii) is commercially important in Korea because its caviar is highly prized. Although the early ontogeny of the species has been described, behavioral modifications in response to various light intensities or diel photoperiodicity patterns have not been studied extensively. The objective of the present study was to examine the behavioral characteristics of hatchery-produced A. gueldenstaedtii prelarvae over a diel photoperiodic cycle. During a diel light cycle comprising 16 h of daylight (450 lx),...