90,370 Works

Former Hyde Laundry Site Programme of Works

70 pages A4, bound.

Retrospektive Analyse von Nierentumoren bei unter 40-jährigen Patienten

Julian Henkes

Herstellung von Vektoren zu Ko-Expression fluoreszierender Proteine und miRNAs in eukaryotischen Zellen

Tobias Schreiber

Extracellular Vesicles—Connecting Kingdoms

Eric Woith, Gregor Fuhrmann & Matthias F. Melzig

3D Printing of a Reactive Hydrogel Bio-Ink Using a Static Mixing Tool

María Puertas-Bartolomé, Małgorzata K Włodarczyk-Biegun, Aránzazu Del Campo, Blanca Vázquez-Lasa & Julio San Román

Resampling the transmission matrix in an aberration-corrected Bessel mode basis

Pritam Pai, Jeroen Bosch & Allard Mosk
The study of the optical transmission matrix (TM) of a sample reveals important statistics of light transport through it. The accuracy of the statistics depends strongly on the orthogonality and completeness of the basis in which the TM is measured. While conventional experimental methods suffer from sampling effects and optical aberrations, we use a basis of Bessel modes of the first kind to faithfully recover the singular values, eigenvalues and eigenmodes of light propagation through...

Patchwork Metasurface Quantum Well Infrared Photodetectors with Broadened Photoresponse

Mel Hainey, Takaaki Mano, Takeshi Kasaya, Yoji Jimba, , , Hirotaka Osato, Kazuhiro Watanabe, Yoshimasa Sugimoto & Takuya Kawazu
Complex lightwave manipulation such as broadband absorption has been realized with metasurfaces based on laterally arranged metal-dielectric-metal cavities with different geometries. However, application of these metasurfaces for optoelectronic devices by incorporating functional dielectrics remains challenging. Here, we integrate a quantum well infrared photodetector (QWIP) with a metasurface made of a patchwork of square cavities with different dimensions arranged in a subwavelength unit cell. Our detector realizes wideband photoresponse approaching the entire responsivity spectrum of the...

Characterization of an angular domain fluorescence optical projection tomography system for mesoscopic lymph node imaging

Veronica Torres, , Wei Zhou, Jovan Brankov & Kenneth Tichauer
Transmittance and fluorescence optical projection tomography can offer high resolution and high contrast visualization of whole biological specimens; however, applications are limited to samples exhibiting minimal light scattering. Our previous work demonstrated that angular-domain techniques permitted imaging of ~1 cm-diameter non-cleared lymph nodes because of their low scattering nature. Here, an angle-restricted transmittance/fluorescence system is presented and characterized in terms of geometric and fluorescence concentration reconstruction accuracy; as well as spatial resolution, depth of focus,...

Correlation analysis between disease severity and inflammation-related parameters in patients with COVID-19: a retrospective study

Jing Gong, Hui Dong, Qing-Song Xia, Zhao-Yi Huang, , Yan Zhao, Wen-Hua Liu, , , Qi Wang & Fu-Er Lu
Abstract Background COVID-19 is highly contagious, and the crude mortality rate could reach 49% in critical patients. Inflammation concerns on disease progression. This study analyzed blood inflammation indicators among mild, severe and critical patients, helping to identify severe or critical patients early. Methods In this cross-sectional study, 100 patients were included and divided into mild, severe or critical groups according to disease condition. Correlation of peripheral blood inflammation-related indicators with disease criticality was analyzed. Cut-off...

The impact of hypertension on chronic kidney disease and end-stage renal disease is greater in men than women: a systematic review and meta-analysis

Misghina Weldegiorgis & Mark Woodward
Abstract Background Hypertension (HTN) is an established risk factor for chronic kidney disease (CKD) and end-stage renal disease (ESRD). Whether sex differences in the effect of HTN on CKD and ESRD incidence exist remains unclear. This systematic review and meta-analysis was conducted to evaluate the relative impact of HTN on CKD and ESRD risk in women compared with men. Methods We systematically searched Embase and PubMed for cohort studies until 24 July 2020. Studies were...

The impact of hypertension on chronic kidney disease and end-stage renal disease is greater in men than women: a systematic review and meta-analysis

Misghina Weldegiorgis & Mark Woodward
Abstract Background Hypertension (HTN) is an established risk factor for chronic kidney disease (CKD) and end-stage renal disease (ESRD). Whether sex differences in the effect of HTN on CKD and ESRD incidence exist remains unclear. This systematic review and meta-analysis was conducted to evaluate the relative impact of HTN on CKD and ESRD risk in women compared with men. Methods We systematically searched Embase and PubMed for cohort studies until 24 July 2020. Studies were...

Silent cerebral infarcts in patients with sickle cell disease: a systematic review and meta-analysis

Maite E. Houwing, Rowena L. Grohssteiner, Marjolein H. G. Dremmen, , Wichor M. Bramer, Anne P. J. De Pagter, , Tonya J. H. White, Meike W. Vernooij & Marjon H. Cnossen
Abstract Background and purpose Silent cerebral infarcts (SCIs) are the most common neurological complication in children and adults with sickle cell disease (SCD). In this systematic review, we provide an overview of studies that have detected SCIs in patients with SCD by cerebral magnetic resonance imaging (MRI). We focus on the frequency of SCIs, the risk factors involved in their development and their clinical consequences. Methods The databases of Embase, MEDLINE ALL via Ovid, Web...

Evaluation of the diagnostic accuracy of a new point-of-care rapid test for SARS-CoV-2 virus detection

Leonardo Miscio, Antonio Olivieri, Francesco Labonia, Gianfranco De Feo, Paolo Chiodini, Giuseppe Portella, Luigi Atripaldi, Roberto Parrella, Rodolfo Conenna, Franco Maria Buonaguro, Ernesta Cavalcanti, Paolo Ascierto, Gerardo Botti & Attilio Bianchi
Abstract Background The easy access to a quick diagnosis of coronavirus disease 2019 (COVID-19) is a key point to improve the management of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and to contain its spread. Up to now, laboratory real-time PCR is the standard of care, but requires a fully equipped laboratory and significant infrastructure. Consequently, new diagnostic tools are required. Methods In the present work, the diagnostic accuracy of the point-of-care rapid test "bKIT...

Inferring directional relationships in microbial communities using signed Bayesian networks

, , Daniel Ruiz-Perez, Trevor Cickovski &
Abstract Background Microbe-microbe and host-microbe interactions in a microbiome play a vital role in both health and disease. However, the structure of the microbial community and the colonization patterns are highly complex to infer even under controlled wet laboratory conditions. In this study, we investigate what information, if any, can be provided by a Bayesian Network (BN) about a microbial community. Unlike the previously proposed Co-occurrence Networks (CoNs), BNs are based on conditional dependencies and...

11C-UCB-J synaptic PET and multimodal imaging in dementia with Lewy bodies

Nicolas Nicastro, , George Savulich, Stephen F. Carter, Elijah Mak, Young T. Hong, Selena Milicevic Sephton, Tim D. Fryer, Franklin I. Aigbirhio, James B. Rowe & John T. O’Brien
Abstract Objective Dementia with Lewy bodies (DLB) is a common cause of dementia, but atrophy is mild compared to Alzheimer’s disease. We propose that DLB is associated instead with severe synaptic loss, and we test this hypothesis in vivo using positron emission tomography (PET) imaging of 11C-UCB-J, a ligand for presynaptic vesicle protein 2A (SV2A), a vesicle membrane protein ubiquitously expressed in synapses. Methods We performed 11C-UCB-J PET in two DLB patients (an amyloid-negative male...

Development and validation of an artificial intelligence system for grading colposcopic impressions and guiding biopsies

Peng Xue, Chao Tang, Qing Li, , Yu Shen, , , , , Wei Wang, , , , , Xun Zhang, Kai Ma, , , Man Tat Alexander Ng, , Youlin Qiao, Yu Jiang & Fanghui Zhao
Abstract Background Colposcopy diagnosis and directed biopsy are the key components in cervical cancer screening programs. However, their performance is limited by the requirement for experienced colposcopists. This study aimed to develop and validate a Colposcopic Artificial Intelligence Auxiliary Diagnostic System (CAIADS) for grading colposcopic impressions and guiding biopsies. Methods Anonymized digital records of 19,435 patients were obtained from six hospitals across China. These records included colposcopic images, clinical information, and pathological results (gold standard)....

Inferring directional relationships in microbial communities using signed Bayesian networks

, , Daniel Ruiz-Perez, Trevor Cickovski &
Abstract Background Microbe-microbe and host-microbe interactions in a microbiome play a vital role in both health and disease. However, the structure of the microbial community and the colonization patterns are highly complex to infer even under controlled wet laboratory conditions. In this study, we investigate what information, if any, can be provided by a Bayesian Network (BN) about a microbial community. Unlike the previously proposed Co-occurrence Networks (CoNs), BNs are based on conditional dependencies and...

A ligand-based computational drug repurposing pipeline using KNIME and Programmatic Data Access: case studies for rare diseases and COVID-19

& Barbara Zdrazil
Abstract Biomedical information mining is increasingly recognized as a promising technique to accelerate drug discovery and development. Especially, integrative approaches which mine data from several (open) data sources have become more attractive with the increasing possibilities to programmatically access data through Application Programming Interfaces (APIs). The use of open data in conjunction with free, platform-independent analytic tools provides the additional advantage of flexibility, re-usability, and transparency. Here, we present a strategy for performing ligand-based in...

Deep-UV hexagonal boron nitride (hBN)/BAlN distributed Bragg reflectors fabricated by RF-sputtering

Qiang Li, , , , Peng Hu, & Feng Yun
The hexagonal boron nitride (hBN) and BAlN films were prepared by RF-sputtering, which were used as the low and high refractive index layers. A series of hBN/BAlN distributed Bragg reflectors (DBRs) were prepared on sapphire substrate. The reflectivity of 9-pair hBN/BAlN (39 nm/33 nm) DBR reached 90% at 300 nm with a bandwidth of 45 nm, and which of 6-pair hBN/BAlN (35 nm/29 nm) reached 52% at 280 nm. The hBN/BAlN DBRs can be used...

Quantitative measurement of mechanical properties in wound healing processes in a corneal stroma model by using vibrational optical coherence elastography (OCE)

, , Duo Zhang, , Chris Purslow, Ying Yang, &
Traumatic corneal injury is one of the leading causes of blindness worldwide. In the cornea, wound healing is an extremely complicated process. However, little is known about how the biomechanical property changes in wound healing response of cornea. Collagen-based hydrogel incorporating corneal stromal cells has been developed into a threedimension (3D) equivalent of corneal stroma tissue in-vitro. In this study, mechanical properties of wounded stromal models were monitored quantitatively in real-time by vibrational optical coherence...

Registration Year

  • 2020
    90,370

Resource Types

  • Collection
    90,370

Affiliations

  • Imperial College London
    50
  • Cardiff University
    34
  • Ca Foscari University of Venice
    16
  • Vanderbilt University
    13
  • Delft University of Technology
    12
  • London School of Hygiene & Tropical Medicine
    11
  • Escuela Internacional de Negocios y Desarrollo Empresarial de Colombia
    9
  • Polytechnic Institute of Viseu
    8
  • Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    6
  • University of Beira Interior
    4