90,364 Works

Impact of E-vapor aerosols on the cardiovascular and respiratory systems in ApoE−/− mice

Justyna Szostak, Ee Wong, Bjoern Titz, Tom Lee, Sin Wong, Tiffany Low, Kyonghee Lee, Jingjie Zhang, Ashutosh Kumar, Walter Schlage, Emmanuel Guedj, Blaine Phillips, Patrice Leroy, Ansgar Buettner, Florian Martin, Alain Sewer, Arkadiusz Kuczaj, Nikolai Ivanov, Karsta Luettich, Patrick Vanscheeuwijck, Manuel Peitsch, Julia Hoeng & Yang Xiang
This study aims to investigate the impact of exposure to e-vapor aerosols on the cardiovascular and respiratory systems. The assessment was performed over a 6-month period on ApoE−/− female mice. Three different E-vapor formulations (carrier (propylene glycol and vegetable glycerol), base (carrier and nicotine) and test (base and flavor)) were tested and compared with the impact of exposure to the mainstream smoke of cigarettes. Classical endpoints were first explored: biomarkers of exposure, hematological and lipidic...

Cyclophilin a signaling induces pericyte-associated blood-brain barrier disruption after subarachnoid hemorrhage

, , Xuan Zhang, Qiang Li, Jie Qu, , Fan Yang, , John Zhang, Xin Liu, , Hua Feng &
Abstract Objective The potential roles and mechanisms of pericytes in maintaining blood–brain barrier (BBB) integrity, which would be helpful for the development of therapeutic strategies for subarachnoid hemorrhage (SAH), remain unclear. We sought to provide evidence on the potential role of pericytes in BBB disruption and possible involvement and mechanism of CypA signaling in both cultured pericytes and SAH models. Methods Three hundred fifty-three adult male C57B6J mice weighing 22 to 30 g, 29 CypA−/−...

Proteomic analysis reflects an environmental alkalinization-coupled pH-dependent mechanism of regulating lignocellulases in Trichoderma guizhouense NJAU4742

, Xing Chen, Tuo Li, Han Zhu, , &
Abstract Background Filamentous fungi have the ability to efficiently decompose plant biomass, and thus are widely used in the biofuel and bioprocess industries. In process, ambient pH has been reported to strongly affect the performance of the applied functional filamentous fungi. In this study, Trichoderma guizhouense NJAU4742 was investigated under the fermentation of rice straw at different initial pH values for a detailed study. Results The results showed that NJAU4742 strain could tolerate ambient pH...

Transcriptome analysis of the hippocampus in environmental noise-exposed SAMP8 mice reveals regulatory pathways associated with Alzheimer’s disease neuropathology

, , , , , Kun Wang, , , Ming Zhang & Bo Cui
Abstract Background Chronic noise exposure is one environmental hazard that is associated with genetic susceptibility factors that increase Alzheimer’s disease (AD) pathogenesis. However, the comprehensive understanding of the link between chronic noise stress and AD is limited. Herein, we investigated the effects of chronic noise exposure on AD-like changes in senescence-accelerated mouse prone 8 (SAMP8). Methods A total of 30 male SAMP8 mice were randomly divided into the noise-exposed group, the control group, and aging...

Introduction : Generation as an Open Question

Jens Späth

Enhanced Growth of ZDDP-Based Tribofilms on Laser-Interference Patterned Cylinder Roller Bearings

Chia-Jui Hsu, Andreas Stratmann, Andreas Rosenkranz & Carsten Gachot

SCHARR collection

Beverley Jones & Helen Foster
For collecting SCHARR items together

Highly Sensitive and Selective VOC Sensor Systems Based on Semiconductor Gas Sensors: How to?

Andreas Schütze, Tobias Baur, Martin Leidinger, Wolfhard Reimringer, Ralf Jung, Thorsten Conrad & Tilman Sauerwald

Calcium in Red Blood Cells—A Perilous Balance

Anna Bogdanova, Asya Makhro, Jue Wang, Peter Lipp & Lars Kaestner

Interaction and UV-Stability of Various Organic Capping Agents on the Surface of Anatase Nanoparticles

Mohsin Raza, Angelika Bachinger, Nina Zahn & Guido Kickelbick

Recent Progress in Pharmaceutical Therapies for Castration-Resistant Prostate Cancer

Lina Yin, Qingzhong Hu & Rolf W. Hartmann

Tribo-Mechanisms of Carbon Nanotubes: Friction and Wear Behavior of CNT-Reinforced Nickel Matrix Composites and CNT-Coated Bulk Nickel

Leander Reinert, Sebastian Suárez & Andreas Rosenkranz

Homogeneous Biosensing Based on Magnetic Particle Labels

Stefan Schrittwieser, Beatriz Pelaz, Wolfgang J. Parak, Sergio Lentijo-Mozo, Katerina Soulantica, Jan Dieckhoff, Frank Ludwig, Annegret Guenther, Andreas Tschöpe & Joerg Schotter

The Reactive Sulfur Species Concept: 15 Years On

Gregory I. Giles, Muhammad Jawad Nasim, Wesam Ali & Claus Jacob

Inorganic Reactive Sulfur-Nitrogen Species: Intricate Release Mechanisms or Cacophony in Yellow, Blue and Red?

Marian Grman, Jawad Nasim, Roman Leontiev, Anton Misak, Veronika Jakusova, Karol Ondrias & Claus Jacob

Transcriptome analysis of Clinopodium gracile (Benth.) Matsum and identification of genes related to Triterpenoid Saponin biosynthesis

, , , , , &
Abstract Background Clinopodium gracile (Benth.) Matsum (C. gracile) is an annual herb with pharmacological properties effective in the treatment of various diseases, including hepatic carcinoma. Triterpenoid saponins are crucial bioactive compounds in C. gracile. However, the molecular understanding of the triterpenoid saponin biosynthesis pathway remains unclear. Results In this study, we performed RNA sequencing (RNA-Seq) analysis of the flowers, leaves, roots, and stems of C. gracile plants using the BGISEQ-500 platform. The assembly of transcripts...

Transcriptome analysis of Clinopodium gracile (Benth.) Matsum and identification of genes related to Triterpenoid Saponin biosynthesis

, , , , , &
Abstract Background Clinopodium gracile (Benth.) Matsum (C. gracile) is an annual herb with pharmacological properties effective in the treatment of various diseases, including hepatic carcinoma. Triterpenoid saponins are crucial bioactive compounds in C. gracile. However, the molecular understanding of the triterpenoid saponin biosynthesis pathway remains unclear. Results In this study, we performed RNA sequencing (RNA-Seq) analysis of the flowers, leaves, roots, and stems of C. gracile plants using the BGISEQ-500 platform. The assembly of transcripts...

Supplementary material from \"Functional differences in seasonally absorbed nitrogen in a winter-green perennial herb\"

Satomi Nishitani, Atsushi Ishida, Toshie Nakamura & Naoki Kachi
Nitrogen (N) uptake in response to its availability and effective N-use are important for determining plant fitness, as N is a major limiting resource and its availability changes both seasonally and annually. Storage organs such as bulbs are considered an adaptive trait with respect to plant N-use strategies. It is well known that N is remobilized from storage organs to satisfy the high demand for new growth that is not completely satisfied by external uptake...

APPLICATION OF MICROBIOLOGICAL METHODS TO IMPROVE TECHNOLOGIES OF STORAGE AND TRANSPORTATION OF LEAF VEGETABLE PRODUCTS

The paper presents study results of the microbial community associated with leaf vegetable products during its transportation and short-term storage. The authors have determined the number and composition of microorganisms that live on the surface (epiphytes) and inside (endophytes) of parsley and dill leaf tissue after three- and six-fold unloading of the product and its subsequent storage for 3 days at a temperature of + 4°C. It has been revealed that the number of microorganisms...

Structural revision and pharmacological activity of hemslecin C

Kun Yu, , Ying Li, Xue Cui, Bo Liu &
Hemslecin C, a compound with a novel skeleton, is synthesized by refluxing hemslecin A with KOH in alcohol. Hemslecin C was structurally characterized by specific optical rotation measurement, high-resolution mass spectroscopy, and nuclear magnetic resonance spectroscopic analysis. In addition, the molecular structure of hemslecin C was unambiguously determined by X-ray single-crystal determination. We found that its structure was different from that reported in the literature. The acetyl group of hemslecin A is transferred to the...

Correlating cognitive functions to symptom domains and insight in Egyptian patients with schizophrenia

Afaf Hamed Khalil, Marwa Abd El-Meguid, Mostafa Bastawy, Samah Rabei, Ramy Ali & Mohamed Hossam Eldin Abd Elmoneam
Introduction:Cognitive impairment is one of the fundamental features among patients with schizophrenia. The relationship between schizophrenia symptoms, insight and cognitive domains remains controversial. We aimed to study these relations in a sample of Egyptian patients with schizophrenia.Methods:A total of 109 patients with schizophrenia were assessed using Structured Clinical Interview for DSM-IV (Diagnostic and Statistical Manual of Mental Disorders (4th ed.)) Axis I diagnosis (SCID-I), Positive and Negative Syndrome Scale (PANSS) and Scale to Assess Unawareness...

Robustness of entanglement as an indicator of topological phases in quantum walks

Wang Qin-Qin, Xiao-Ye Xu, Wei-Wei Pan, , Zhe Chen, Yong-Tao Zhan, Kai Sun, Jin-Shi Xu, Geng Chen & Yong-Jian Han
How to reveal topological phases and their boundaries is an intriguing issue in various systems. Entanglement, which plays fundamental role in quantum information, has been found profoundly related to the topological phases. However, experimentally exploring this relation is precluded by the limited ability to obtain the entanglement in many-body systems. In this work, we propose and experimentally demonstrate that the robustness of entanglement, quantified by the von Neumann entropy, can be used to reveal the...

Damage mechanics-based modeling approaches for cyclic analysis of precast concrete structures: A comparative study

De-Cheng Feng, Zhun Wang, Xu-Yang Cao & Gang Wu
Precast concrete frame structures are widely adopted around the world due to their various advantages, so it is important to study their seismic performance. The development of damage mechanics has enabled us to accurately investigate the typical failure mechanisms of precast structures. This paper presents three of the most commonly used modeling approaches based on damage mechanics for analysis of precast reinforced concrete structures under cyclic loading and compares the performance of the three models....

Sentiment analysis of real-world migraine tweets for population research

Hao Deng, , Dana P Turner, Katherine E Sexton, Sara M Burns, Matthias Eikermann, , Dan Cheng & Timothy T Houle
Background:Migraine is a highly prevalent disorder that is typically episodic in nature. Social network data reflecting personal commentary on everyday life patterns, including those interrupted by migraine, represent a unique window into the real-life experience of those willing to share them. The experience of a migraine attack might be captured by twitter text data, and this information might be used to complement our current knowledge of activity in the general population and even lead to...

Transcriptomic profiling disclosed the role of DNA methylation and histone modifications in tumor-infiltrating myeloid-derived suppressor cell subsets in colorectal cancer

, Reem Saleh, Salman Toor, , Ayman Ahmed, Mohamed Kurer, Khaled Murshed, , Mohamed Abu Nada & Eyad Elkord
Abstract Background Increased numbers of myeloid-derived suppressor cells (MDSCs) are positively correlated with poor prognosis and reduced survivals of cancer patients. They play central roles in tumor immune evasion and tumor metastasis. However, limited data are available on phenotypic/transcriptomic characteristics of the different MDSCs subsets in cancer. These cells include immature (I-MDSCs), monocytic (M-MDSCs), and polymorphonuclear/granulocytic (PMN-MDSCs). Methods Phenotypic characterization of myeloid subsets from 27 colorectal cancer (CRC) patients was assessed by flow cytometric analyses....

Registration Year

  • 2020
    90,364

Resource Types

  • Collection
    90,364

Affiliations

  • Imperial College London
    52
  • Cardiff University
    35
  • Ca Foscari University of Venice
    14
  • Vanderbilt University
    12
  • London School of Hygiene & Tropical Medicine
    11
  • Delft University of Technology
    11
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    8
  • Polytechnic Institute of Viseu
    7
  • Escuela Internacional de Negocios y Desarrollo Empresarial de Colombia
    7
  • Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    6