Abstract Background MicroRNAs (miRNAs) and Twist1-induced epithelial-mesenchymal transition (EMT) in cancer cell dissemination are well established, but the involvement of long noncoding RNAs (lncRNAs) in Twist1-mediated signaling remains largely unknown. Methods RT-qPCR and western blotting were conducted to detect the expression levels of lncRNA JPX and Twist1 in lung cancer cell lines and tissues. The impact of JPX on Twist1 expression, cell growth, invasion, apoptosis, and in vivo tumor growth were investigated in lung cancer...

Objective:Understanding whether medical students feel safe in mental health placements is important to delivering effective and engaging training experiences.Method:Second year students completed anonymous online surveys before (n = 37) and after (n = 41) mental health placements, to gather qualitative and quantitative data about their sense of physical and emotional safety, and factors that positively and negatively influenced their experiences. Data were analysed using chi square and content analysis.Results:There was a disparity between students’ expectations...

Background: About 84% of the agriculture, fishing, and forestry occupational sector is comprised of farmers. This sector is at high risk for suicide in the United States. Recent disasters and trade upheavals may make farmers and their families more vulnerable to depression and suicide. This review focused on the risk for depression and suicide among United States’ primary farm operators and their families. Methods: A systematic search of the literature published between January 2000 and...

This article focuses on nonmonetary peer-to-peer (P2P) accommodation networks, examining the way in which personality traits, emotional solidarity factors, and technology-related perceptions affect the inclination to participate in these networks. To test the theoretical framework, a structural equation model is validated, based on a representative online survey of German consumers (N=600). The findings confirm the explanatory power of the model components considered that directly or indirectly impact individual usage intention. A group analysis distinguishes between...

This article focuses on nonmonetary peer-to-peer (P2P) accommodation networks, examining the way in which personality traits, emotional solidarity factors, and technology-related perceptions affect the inclination to participate in these networks. To test the theoretical framework, a structural equation model is validated, based on a representative online survey of German consumers (N=600). The findings confirm the explanatory power of the model components considered that directly or indirectly impact individual usage intention. A group analysis distinguishes between...

Habitat fragmentation is expected to reduce dispersal movements among patches as a result of increased inter-patch distances. Furthermore, since habitat fragmentation is expected to raise the costs of moving among patches in the landscape, it should hamper the ability or tendency of organisms to perform informed dispersal decisions. Here, we used microcosms of the ciliate Tetrahymena thermophila to test experimentally whether habitat fragmentation, manipulated through the length of corridors connecting patches differing in temperature, affects...

Abstract Background Positive end-expiratory pressure (PEEP) at minimum respiratory elastance during mechanical ventilation (MV) in patients with acute respiratory distress syndrome (ARDS) may improve patient care and outcome. The Clinical utilisation of respiratory elastance (CURE) trial is a two-arm, randomised controlled trial (RCT) investigating the performance of PEEP selected at an objective, model-based minimal respiratory system elastance in patients with ARDS. Methods and design The CURE RCT compares two groups of patients requiring invasive MV...

Abstract Background Positive end-expiratory pressure (PEEP) at minimum respiratory elastance during mechanical ventilation (MV) in patients with acute respiratory distress syndrome (ARDS) may improve patient care and outcome. The Clinical utilisation of respiratory elastance (CURE) trial is a two-arm, randomised controlled trial (RCT) investigating the performance of PEEP selected at an objective, model-based minimal respiratory system elastance in patients with ARDS. Methods and design The CURE RCT compares two groups of patients requiring invasive MV...

Pedagogy; pedagogical technologies; pedagogical skills

Life-history theory predicts a trade-off between offspring size and number. However, the role of intra-litter phenotypic variation in shaping this trade-off is often disregarded. We compared the strength of the relationship between litter size and mass from the perspective of the lightest and the heaviest yearling offspring in 110 brown bear litters in Sweden. We showed that the mass of the lightest yearlings decreased with increasing litter size, but that the mass of the heaviest...

Madagascar occupied an important place in the amalgamation of Gondwana and preserves a record of several Neoproterozoic events that are linked to orogenesis of the East African Orogen. In this study, we integrate remote sensing, field data and thermochronology to unravel complex deformation in the Ikalamavony and Itremo domains of central Madagascar. The deformation sequence comprises a gneissic foliation (S1), followed by south to south-west directed, tight to isoclinal, recumbent folding (D2). These are overprinted...

Abstract Background Li-ion batteries (LIB) are used in most portable electronics. Among a wide variety of materials, LiCoO2 (LCO) is one of the most used for the cathode of LIB. LCO particles induce oxidative stress in mouse lungs due to their Co content, and have a strong inflammatory potential. In this study, we assessed the mutagenic potential of LCO particles in lung cells in comparison to another particulate material used in LIB, LTO (Li4Ti5O12), which...

All eukaryotic life engages in symbioses with a diverse community of bacteria that are essential for performing basic life functions. In many cases, eukaryotic organisms form additional symbioses with other macroscopic eukaryotes. The tightly linked physical interactions that characterize many macroscopic symbioses creates opportunities for microbial transfer, which likely affects the diversity and function of individual microbiomes, and may ultimately lead to microbiome convergence between distantly related taxa. Here, we sequence the microbiomes of five...

Abstract Background As a novel class of noncoding RNAs, circRNAs have been recently identified to regulate tumorigenesis and aggressiveness. However, the function of circRNAs in colorectal cancer (CRC) metastasis remains unclear. We aimed to identify circRNAs that are upregulated in CRC tissues from patients and study their function in CRC metastasis. Methods We compared six pairs of CRC tissues and their matched adjacent non-tumor tissues by using circRNA microarray. We first evaluated the expression of...

This is a collection of ethnobotany related studies, figures, datasets and programs

Abstract Dopamine acts as a neurotransmitter to regulate a variety of physiological functions of the central nervous system. Thus, the fabrication of electrochemical active nanomaterials for sensitive dopamine detection is extremely important for human health. Herein, we constructed a highly efficient dopamine nonenzymatic biosensor using eggshell membrane (ESM) as a 3D network-like carrier-loaded Au and CeO2 nanocomposites. This approach has led to the uniform distribution of CeO2 and Au nanoparticles on the surface of ESM....

Abstract Background Truffles are symbiotic fungi that develop underground in association with plant roots, forming ectomycorrhizae. They are primarily known for the organoleptic qualities of their hypogeous fruiting bodies. Primarily, Tuber magnatum Pico is a greatly appreciated truffle species mainly distributed in Italy and Balkans. Its price and features are mostly depending on its geographical origin. However, the genetic variation within T. magnatum has been only partially investigated as well as its adaptation to several...

Abstract Background In normal mammalian development a high percentage of implantations is lost by spontaneous resorption. This is a major problem in assisted reproduction and blastocyst transfer. Which embryo will be resorbed is unpredictable. Resorption is very fast, so that with conventional methods only final haemorrhagic stages are encountered. Here we describe the histology and immunohistochemistry of 23 spontaneous embryo resorptions between days 7 and 13 of murine development, which were identified by high-resolution ultrasound...

Abstract Background According to scientific recommendations, paratransgenesis is one of the solutions for improving the effectiveness of the Global Malaria Eradication Programme. In paratransgenesis, symbiont microorganisms are used for distorting or blocking the parasite life-cycle, affecting the fitness and longevity of vectors or reducing the vectorial competence. It has been revealed recently that bacteria could be used as potent tools for double stranded RNA production and delivery to insects. Moreover, findings showed that RNase III...

Abstract Background Apart from PRKAR1A mutations in a subset of cyclical Cushing’s syndrome due to primary pigmented nodular adrenocortical disease, the molecular basis of cyclical Cushing’s syndrome has not been investigated. We speculated that cyclical Cushing’s syndrome may be due to mutations in the clock genes that govern circadian rhythms, including the hypothalamic-pituitary-adrenal axis. Case presentation A 47-year-old man presented with mass effects from a sellar lesion. He was ultimately diagnosed with cyclical Cushing’s disease...

Abstract Background This study was performed to investigate the association between lumbar disc herniation (LDH) and facet joint osteoarthritis (FJOA) using magnetic resonance imaging (MRI). Methods Between March 2012 and September 2018, a total of 441 segments from 394 patients with LDH were included in the study. LDH was classified according to the Michigan State University (MSU) classification, in which the degree of LDH is divided into 3 levels (expressed as 1, 2, and 3)...

Abstract Background Descriptive studies examining publication rates and citation counts demonstrate a geographic skew toward high-income countries (HIC), and research from low- or middle-income countries (LMICs) is generally underrepresented. This has been suggested to be due in part to reviewers’ and editors’ preference toward HIC sources; however, in the absence of controlled studies, it is impossible to assert whether there is bias or whether variations in the quality or relevance of the articles being reviewed...

Abstract Background and purpose The National Institutes of Health Stroke Scale (NIHSS) has been found to be biased toward the left hemispheric and motoric functions providing minimal assessment to the right hemispheric language and cognitive functions. The need to complement the role of the NIHSS is necessary in accurate and rapid assessment of AIS patients and better management. We hypothesized that combining the NIHSS with a quantitative analysis of Spoken Picture Description scale of Comprehensive...

This paper explores the nonlinear dynamics of a multidegree of freedom (MDoF) structure impacting a rigid stop. The contact mechanics is simplified by continuous sigmoid function idealisation of a lossless spring. By introducing a smooth nonlinear formulation, we avoid the computational expense of event-driven, piecewise, nonsmooth dynamics. A large parametric study using high-performance computing is undertaken. The nondimensional equations of motion suggest one primary structural parameter, contact-to-storey stiffness ratio, and two excitation parameters, nondimensional ground...

The Village Herald was a weekly newspaper from Princess Anne, Maryland. The Herald featured local news, poetry, and limited national news.