The Village Herald was a weekly newspaper from Princess Anne, Maryland. The Herald featured local news, poetry, and limited national news.

The Village Herald was a weekly newspaper from Princess Anne, Maryland. The Herald featured local news, poetry, and limited national news.

The Village Herald was a weekly newspaper from Princess Anne, Maryland. The Herald featured local news, poetry, and limited national news.

Drawing from life-span psychology, we conducted two studies to test perceptions of time left in the future as an underlying mechanism for age differences in self-reported social risk taking. Study 1 included 120 younger (25–35 years) and 119 older (60–91 years) community-dwelling adults. Study 2 included 439 participants (18–85 years) mostly recruited from Amazon Mechanical Turk. In both studies, older age was associated with rating a lower likelihood of social risk taking (e.g., speaking about...

Equity crowdfunding (ECF) has potential benefits that might be attractive to high-quality entrepreneurs, including fast access to a large pool of investors and obtaining feedback from the market. However, there are potential costs associated with ECF due to early public disclosure of entrepreneurial activities, communication costs with large pools of investors, and equity dilution that could discourage future equity investors; these costs suggest that ECF attracts low-quality entrepreneurs. In this paper, we hypothesize that entrepreneurs...

BackgroundChronic pain is frequently comorbid with anxiety disorder, thereby complicating its treatment. Polydatin, a component from the root of Polygonum cuspidatum, has shown neuroprotection in the central nervous system. However, its effects on pain and anxiety processing have been rarely investigated. In this study, mice were injected with complete Freund’s adjuvant (CFA) at the hindpaw to induce pain- and anxiety-like behaviors.ResultsTreatment with polydatin (25 mg/kg) alleviated the anxiety-like behaviors but not pain perception in these...

Abstract Background It has been hypothesized that heteromers of adenosine A2A receptors (A2AR) and cannabinoid CB1 receptors (CB1R) localized in glutamatergic nerve terminals mediate the integration of adenosine and endocannabinoid signaling involved in the modulation of striatal excitatory neurotransmission. Previous studies have demonstrated the existence of A2AR-CB1R heteromers in artificial cell systems. A dependence of A2AR signaling for the Gi protein-mediated CB1R signaling was described as one of its main biochemical characteristics. However, recent studies...

raw data for version 2 "Dipeptidyl peptidase-IV inhibitors used in type-2 diabetes inhibit a phospholipase C: a case of promiscuous scaffolds in proteins"

Background:Dual diagnosis (DD), as the co-occurrence of a substance use disorder and a psychiatric disorder, is underestimated, under-diagnosed and often poorly treated throughout the world, although it is highly prevalent in people suffering from a mental disorder.Aims and methods:This review analyzed 48 studies from a PubMed and PsycINFO databases search, in order to verify the state of the art regarding the organization of community health services for DD treatment.Results:Four macro-themes have been identified: service organization,...

OpenLab ha lo scopo di coordinare i processi di divulgazione scientifica dell’ateneo di Firenze per costituire un punto d'incontro inclusivo e interdisciplinare tra studiosi, gruppi di ricerca, studenti e cittadini nell’orizzonte della ricerca dell’Unità del Sapere promuovendo il dialogo tra tutte le forme di cultura (dalla Letteratura alla Chimica, dalla Filosofia alla Danza, alla Musica, al Teatro etc.) OpenLab è la vetrina dei progetti di ricerca dell’università in grado di mettere immediatamente in contatto tra...

Under what conditions do rebel organizations control territory during civil war? How do civilians influence the distribution of territorial control? This article introduces a civilian agency theory, emphasizing community collective action capacity (CAC) defined by underlying social network structure, to complement existing explanations of territorial control. I argue communities with greater CAC mobilize information and resources more efficiently, increasing belligerents’ incentives to control territory. However, CAC also increases community bargaining power to demand costly investments...

Children who are dual language learners (DLLs) often have more difficulty acquiring English early literacy skills than their English monolingual peers. Much remains to be learned about efficacious early literacy instructional interventions and their effects on English early literacy skills of DLLs. The purposes of this systematic review were to describe key features of English early literacy interventions provided to children who were DLLs and their effects on English early literacy skills. We conducted an...

Objectives:Examine the relationships among structural disadvantage, friendship network age composition, and violent offending by investigating the contextual and individual etiology of affiliating with older friends and exploring the mechanisms that link friendship network age composition to violent offending.Method:Hierarchical linear models analyze 8,481 respondents distributed across 1,485 census tracts from the National Longitudinal Study of Adolescent to Adult Health. Social network data are used to construct a measure of the proportion of a respondent’s friendship network...

X-Porous TTA is a variant of the conventional tibial tuberosity advancement for the treatment of the cruciate-deficient stifle in the dog. Although the basic principles are the same, the technique presents some peculiarities. The most important specific feature is represented by the use of a single screw on the tibial side of the plate. The tibial screw will function as a hinge, allowing the tibial crest to exert cyclic compression on the tibial metaphysis during...

The Village Herald was a weekly newspaper from Princess Anne, Maryland. The Herald featured local news, poetry, and limited national news.

Abstract Background Cymbidium faberi is one of the oldest cultivars of oriental orchids, with an elegant flower fragrance. In order to investigate the molecular mechanism and the functions of related proteins in the methyl jasmonate (MeJA) signaling pathway, one of the main components of flower fragrance in C. faberi, yeast one- and two-hybrid three-frame cDNA libraries were constructed. Results In this study, a modified cDNA library used for yeast one- and two-hybrid screening was successfully...

Abstract Background Plant receptors with lysin motifs (LsyM) recognize microbial signals such as fungal chitin and lipo-chitooligosaccharidic Nod factors of nitrogen-fixing rhizobia. It is generally assumed that ligand-induced dimerization of LysM receptors is an essential step in activation of intracellular kinase domains and downstream signaling. Consequently, genes required for plant defense and establishment of symbiosis are expressed. We recently found that three LysM receptor proteins (namely LYK1, LYK4 and LYK5) of Arabidopsis thaliana form a...

Abstract Background Plant receptors with lysin motifs (LsyM) recognize microbial signals such as fungal chitin and lipo-chitooligosaccharidic Nod factors of nitrogen-fixing rhizobia. It is generally assumed that ligand-induced dimerization of LysM receptors is an essential step in activation of intracellular kinase domains and downstream signaling. Consequently, genes required for plant defense and establishment of symbiosis are expressed. We recently found that three LysM receptor proteins (namely LYK1, LYK4 and LYK5) of Arabidopsis thaliana form a...

Abstract Retention approaches in forest management are today common in several North European countries, integrated into the clearcutting practice as a way to promote biodiversity and maintain ecosystem functions. Individual green trees and retention patches (tree groups) are retained at final harvest, and deadwood is left at site or created. Here, we review research on retention in Sweden, Finland, Norway, the Baltic States, and NW Russia, with special focus on biodiversity. Following the first publication...

Abstract Background This study was conducted to understand the molecular epidemiology of circulating Chlamydia trachomatis (Ct) strains in Sapporo, Japan. Methods A total of 713 endocervical samples collected from April 2016 to March 2019 were screened for Ct. The obtained Ct positive samples were analyzed by ompA genotyping and multilocus sequence analysis (MLSA). Results Eighty-three (11.6%) samples were positive for Ct plasmid DNA. Sequence analysis of the ompA gene from the 61 positive cases revealed...

Abstract Background Uncontrolled hypertension is the most important risk factor and leading cause of cardiovascular diseases. It is predicted that the number of people with hypertension will increase, and a large proportion of this increase will occur in developing countries. The highest prevalence of uncontrolled hypertension is reported in sub-Saharan Africa, and treatment for hypertension is unacceptably low. Hypertension commonly co-exists with comorbidities and this is associated with poorer health outcomes for patients. This review...

Abstract Background Wet direct-seeded rice is a possible alternative to conventional puddled transplanted rice; the former uses less water and reduces labor requirements. Improving seed reserve utilization efficiency (SRUE) is a key factor in facilitating the application of this technology. However, the QTLs controlling this trait are poorly investigated. In this study, a genome-wide association study (GWAS) was conducted using a natural population composed of 542 accessions of rice (Oryza sativa L.) which were genotyped...