90,362 Works

Understanding Work Teams From a Network Perspective: A Review and Future Research Directions

Semin Park, Travis J. Grosser, Adam A. Roebuck & John E. Mathieu
As social network theory and methodology advance, scholars in multiple fields have increasingly become interested in examining work teams using network perspectives. Social networks not only enabled work team researchers to theorize about interdependencies and the dynamic interplay of team components (i.e., individuals, dyads, and whole teams) but also provided a methodological tool kit with which to operationalize and test hypotheses about such interdependencies. To this end, the purpose of this article is to conduct...

BDNF Met allele Is Associated With Lower Cognitive Function in Poststroke Rehabilitation

, Lili Qi, , , Lei Cai, John Wong, , Xun Luo, , , & Qing Mei Wang
Background and purpose. The identification of a genetic role for cognitive outcome could influence the design of individualized treatment in poststroke rehabilitation. The aim of this study is to determine whether brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is independently associated with poststroke functional outcome. Methods. A total of 775 stroke patients with genomic data were identified from the Partners HealthCare Biobank, which contains a large number of genotypes from Biobank’s consented patients. Of 775 stroke...

Association between metabolic syndrome and prognosis of breast cancer: a meta-analysis of follow-up studies

, , Chen Zeng, Meng Yang, Gang Li, Jiang Han & Wei Wu
Abstract Background Metabolic syndrome (MetS) has been suggested to be a risk factor for many cancers, including breast cancer. However, it remains unclear whether MetS predicts poor prognosis in women with breast cancer. A meta-analysis was performed to summarize the association between MetS and clinical outcome in women with breast cancer. Methods Cohort studies were identified by search of PubMed and Embase databases. A random-effect model incorporating the potential heterogeneity was applied to pool the...

Replication crisis = trust crisis? The effect of successful vs failed replications on laypeople’s trust in researchers and research

Friederike Hendriks, Dorothe Kienhues & Rainer Bromme
In methodological and practical debates about replications in science, it is (often implicitly) assumed that replications will affect public trust in science. In this preregistered experiment (N = 484), we varied (a) whether a replication attempt was successful or not and (b) whether the replication was authored by the same, or another lab. Results showed that ratings of study credibility (e.g. evidence strength, ηP2 = .15) and researcher trustworthiness (e.g. expertise, ηP2 = .15) were...

Effect of Dexmedetomidine on duration of mechanical ventilation in septic patients: a systematic review and meta-analysis

, , , , , Mitchell Levy &
Abstract Background Because of its analgesic and light sedative properties, the highly selective alpha-2 adrenergic receptor agonist dexmedetomidine (DEX) has been suggested for the treatment of septic patients, but its effect on the duration of mechanical ventilation remains unclear. The present study was conducted to review the extant literature in DEX and determine its influence on ventilation time in adult septic patients. Methods Databases of PubMed, Cochrane, and EMBASE were applied till 20th January 2019...

Measurement invariance across gender and age groups, validity and reliability of the Chinese version of the short-form supportive care needs survey questionnaire (SCNS-SF34)

Edmond Choi, , Inda Soong, Karen Chan, Conrad Lee, Alice Ng, Wing Sze, Janice Tsang, Victor Lee & Wendy Lam
Abstract Background Despite the wide use of the Short-Form Supportive Care Needs Survey Questionnaire (SCNS-SF34), the measurement invariance of the SCNS-SF34 across the main groups—gender and age—which might be of interest in the application of the instrument has never been confirmed. To provide an accurate assessment tool to evaluate the unmet needs of Chinese cancer patients, the present study aimed to assess the measurement invariance of the SCNS-SF34 across gender and age groups and to...

TeamMate: a longitudinal study of New Zealand working farm dogs. I. Methods, population characteristics and health on enrolment

Katja Isaksen, Lori Linney, Helen Williamson, Nick Cave, , Elizabeth Norman & Naomi Cogger
Abstract Background Working farm dogs are invaluable on New Zealand sheep and beef farms. To date no study describing farm dog population and health has included information about incidence of illness and injury, or risk factors affecting health and career duration. This paper describes the methodology and initial results from TeamMate, a longitudinal study that was designed to address this gap. We describe the study population, husbandry practices, and prevalence of clinical abnormalities on enrolment....

High-resolution organic geochemical bulk parameter and biomarker records off eastern North Greenland

Nicole Syring
A high-resolution biomarker record was carried out on Polarstern Cruise PS93.1 (2015) to reconstruct past sea-ice variability off the continental eastern North Greenland shelf. This area is strongly influenced by cold surface waters and drift ice transported via East Greenland Current, meltwater pulses from the outlet glaciers of the Northeast Greenland Ice Stream and the build-up of landfast ice. The AMS 14C-dated Holocene Kastenlot Core PS93/025 reflects high sedimentation rates ranging between 25-30 cm/kyr over...

Supplementary material from \"Functional traits of the gut microbiome correlated with host lipid content in a natural population of Drosophila melanogaster\"

David Kang & Angela E. Douglas
Most research on the nutritional significance of the gut microbiome is conducted on laboratory animals, and its relevance to wild animals is largely unknown. This study investigated the microbiome correlates of lipid content in individual wild fruit flies, Drosophila melanogaster. Lipid content varied 3.6-fold among the flies and was significantly correlated with the abundance of gut-derived bacterial DNA sequences that were assigned to genes contributing to 16 KEGG pathways. These included genes encoding sugar transporters...

Quantitative Analysis of Ellipsoid Zone in Acute Posterior Multifocal Placoid Pigment Epitheliopathy

Andrew W. Browne, Waseem Ansari, Ming Hu, Kimberly Baynes, , & Sunil K. Srivastava
Purpose:Quantitative end points for uveitis are needed. Here we quantify the rate of ellipsoid zone (EZ) recovery on optical coherence tomography (OCT) and correlate it with visual acuity (VA) improvement in patients with acute posterior multifocal placoid pigmented epitheliopathy (APMPPE). We use automated and manually graded EZ area analysis to assess EZ recovery in APMPPE.Methods:We performed a retrospective review of 9 APMPPE cases (18 eyes) that had characteristic clinical examination and fluorescein angiography findings, outer...

Circulating angiopoietin-2 and the risk of mortality in patients with acute respiratory distress syndrome: a systematic review and meta-analysis of 10 prospective cohort studies

, & Qiang Guo
Background:Angiopoietin-2 (Ang-2), as one of the ligands of endothelial receptor Tie2, is known to be significant for vessel maturation and stabilization after birth. Previous studies showed the relationship between Ang-2 level and the risk of mortality in patients with acute respiratory distress syndrome (ARDS). However, the link between circulating Ang-2 and the risk of mortality in patients with ARDS varied in different investigations.Results:We performed a systematic review and meta-analysis of all available cohort studies regarding...

Autologous internal limiting membrane transplant for recurrent idiopathic macular holes

Tommaso Rossi, & Guido Ripandelli
Purpose:To report a series of recurrent idiopathic macular holes treated by means of a free autologous internal limiting membrane flap and compare visual and anatomic results to a control group undergoing further internal limiting membrane peeling and novel gas tamponade.Methods:Retrospective surgical series of 15 consecutive patients receiving autologous internal limiting membrane flap compared to 14 patients operated on for internal limiting membrane peeling enlargement. Autologous internal limiting membrane flap was created after brilliant blue G...

Crosstalk in the darkness: bulb vernalization activates meristem transition via circadian rhythm and photoperiodic pathway

Tomer Ben Michael, Adi Faigenboim, Einat Shemesh-Mayer, Itzhak Forer, Chen Gershberg, , Haim Rabinowitch & Rina Kamenetsky-Goldstein
Abstract Background Geophytes possess specialized storage organs - bulbs, tubers, corms or rhizomes, which allow their survival during unfovarable periods and provide energy support for sprouting and sexual and vegetative reproduction. Bulbing and flowering of the geophyte depend on the combined effects of the internal and external factors, especially temperature and photoperiod. Many geophytes are extensively used in agriculture, but mechanisms of regulation of their flowering and bulbing are still unclear. Results Comparative morpho-physiological and...

Measuring resilience prospectively as the speed of affect recovery in daily life: a complex systems perspective on mental health

Anna Kuranova, Sanne Booij, Claudia Menne-Lothmann, Jeroen Decoster, Ruud Van Winkel, Philippe Delespaul, Marc De Hert, Catherine Derom, Evert Thiery, Bart Rutten, Nele Jacobs, Jim Van Os, Johanna Wigman & Marieke Wichers
Abstract Introduction There is growing evidence that mental disorders behave like complex dynamic systems. Complex dynamic systems theory states that a slower recovery from small perturbations indicates a loss of resilience of a system. This study is the first to test whether the speed of recovery of affect states from small daily life perturbations predicts changes in psychopathological symptoms over 1 year in a group of adolescents at increased risk for mental disorders. Methods We...

EGFR T790M relative mutation purity predicts osimertinib treatment efficacy in non-small cell lung cancer patients

, , Yan Huang, , , Xue Hou, , , Ting Zhou, , & Li Zhang
Abstract Background Despite the impressive anti-tumor activity of osimertinib in epidermal growth factor receptor (EGFR) T790M-positive non-small cell lung cancer (NSCLC) patients, 30–40% of patients still show limited response. There is therefore a need to identify biomarkers that accurately predict the response to osimertinib therapy. In this study, 54 patients with targeted next-generation sequencing of circulating tumor DNA before osimertinib treatment and known T790M positivity were included. We investigated the predictive value of baseline circulating...

Comparison of immune responses to Loa loa stage-specific antigen extracts in Loa loa-exposed BALB/c mice upon clearance of infection

, Manuel Ritter, , Narcisse Gandjui, Mathias Esum, Fanny Fombad, Abdel Njouendou, Patrick Ndongmo, Mark Taylor, Achim Hoerauf, Laura Layland, Joseph Turner & Samuel Wanji
Abstract Background Different immune mechanisms are capable of killing developmental stages of filarial nematodes and these mechanisms are also likely to vary between the primary and a challenge infection. However, the lack of a detailed analysis of cytokine, chemokine and immunoglobulin levels in human loiasis is still evident. Therefore, detailed analysis of immune responses induced by the different developmental stages of Loa loa in immune-competent BALB/c mice will aid in the characterization of distinct immune...

Clinical Epidemiology of Alcohol Use Disorders in Military Personnel versus the General Population in Canada

Tamara L. Taillieu, Tracie O. Afifi, Mark A. Zamorski, Sarah Turner, , Murray B. Stein &
Objectives:Research suggests a high prevalence of problematic alcohol use among military personnel relative to civilians. Our primary objectives were to compare the prevalence, correlates, help-seeking behaviors, perceived need for care, and barriers to care for alcohol use disorders (AUDs) in the Canadian Armed Forces (CAF) and the Canadian general population (CGP).Methods:Data were from 2 nationally representative surveys collected by Statistics Canada: (1) the Canadian Community Health Survey on Mental Health collected in 2012 (N =...

Association of low urine pH as a metabolic feature with abdominal obesity

, Hee Kyung Chang &
ObjectiveLow urine pH (LUP) is not only affected by environmental factors, but is also a feature of metabolic syndrome (MS), which is characterized by insulin resistance, abdominal obesity, dyslipidaemia and hypertension. However, it is unclear which factors contribute most to urine acidity. This study investigated factors influencing LUP and the link between LUP and metabolic traits in South Korea.MethodsParticipants were middle-aged subjects (age, 52.2 ± 8.9 years; average body mass index, 24.6 ± 3.2 kg/m2),...

Bridging the Gender Wage Gap: Gendered Cultural Sentiments, Sex Segregation, and Occupation-Level Wages.

Robert E. Freeland & Catherine E. Harnois
The extent to which cultural beliefs about gender shape occupation-level wages remains a central yet unresolved question in the study of gender inequality. Human capital theorists predict that gendered beliefs have no direct effect on occupation-level wages. Devaluation theorists argue that occupations associated with women and femininity are systematically devalued and thus underpaid. We test these explanations using data from the American Community Survey, the Occupational Information Network, and an affect control theory (ACT) data...

Acupuncture for postprandial distress syndrome: a randomized controlled pilot trial

Jian-Feng Tu, Jing-Wen Yang, Li-Qiong Wang, Yang Zheng, Li-Wen Zhang, Yong-Ting Li, Xin Zhang, Guang-Xia Shi, Jun Wang, , Yi Du, , Lu Cheng &
Background:Evidence for treating postprandial distress syndrome with acupuncture is limited.Aim:We aimed to evaluate the feasibility of verum acupuncture versus sham acupuncture in patients with postprandial distress syndrome.Methods:A total of 42 eligible patients were randomly allocated to either verum acupuncture or sham acupuncture groups in a 1:1 ratio. Each patient received 12 sessions over 4 weeks. The primary outcome was the response rate based on the overall treatment effect (OTE) 4 weeks after randomization. Secondary outcomes...

Timing of renal replacement therapy for patients with acute kidney injury: A systematic review and meta-analysis

Mark Andonovic, Richard Shemilt, Malcolm Sim, Jamie P Traynor, Martin Shaw, Patrick B Mark & Kathryn A Puxty
BackgroundAcute kidney injury is associated with high mortality, and the optimal time to start renal replacement therapy for acute kidney injury is unknown despite several randomised controlled trials on the subject. We performed a systematic review and meta-analysis to assess the effect of earlier initiation of renal replacement therapy for acute kidney injury on mortality and reported secondary outcomes.MethodsAll literature in databases EMBASE, MEDLINE and CENTRAL was searched from January 1970 to March 2019 using...

The Development of a Measure to Assess Social Reactions to Self-Injury Disclosure

Brooke A. Ammerman & Michael S. McCloskey
Only approximately half of individuals engaging in nonsuicidal self-injury (NSSI) ever disclose their behavior. Yet there is a dearth of research aimed at understanding NSSI disclosure and the outcomes of choosing to disclose, such as social reactions to NSSI disclosure. The current study aimed to develop and validate a measure of perceived social reactions to the disclosure of NSSI, the Self-Injury Social Reactions Questionnaire (SI-SRQ). Results supported a three-factor structure of the SI-SRQ assessing positive...

Identifying glycan motifs using a novel subtree mining approach

Lachlan Coff, Jeffrey Chan, Paul Ramsland & Andrew Guy
Abstract Background Glycans are complex sugar chains, crucial to many biological processes. By participating in binding interactions with proteins, glycans often play key roles in host–pathogen interactions. The specificities of glycan-binding proteins, such as lectins and antibodies, are governed by motifs within larger glycan structures, and improved characterisations of these determinants would aid research into human diseases. Identification of motifs has previously been approached as a frequent subtree mining problem, and we extend these approaches...

Tau-tubulin kinase 1 and amyloid-β peptide induce phosphorylation of collapsin response mediator protein-2 and enhance neurite degeneration in Alzheimer disease mouse models

Seiko Ikezu, Kaitlin Ingraham Dixie, , Takashi Watanabe, Kozo Kaibuchi &
Abstract The accumulation of phosphorylated tau protein (pTau) in the entorhinal cortex (EC) is the earliest tau pathology in Alzheimer’s disease (AD). Tau tubulin kinase-1 (TTBK1) is a neuron-specific tau kinase and expressed in the EC and hippocampal regions in both human and mouse brains. Here we report that collapsin response mediator protein-2 (CRMP2), a critical mediator of growth cone collapse, is a new downstream target of TTBK1 and is accumulated in the EC region...

Inflexibility of the plasma miRNA response following a high-carbohydrate meal in overweight insulin-resistant women

, , , , , , , &
Abstract Context Metabolic inflexibility is a characteristic of insulin resistance, limiting the ability to transiently regulate oxidative metabolism and gene expression in response to nutrient availability. Little is known of the flexibility of post-transcriptional regulation, including circulatory miRNAs (c-miRNAs). Design The abundances of targeted c-miRNAs, with reported functions in metabolic regulation, were analysed in response to a high-carbohydrate meal in healthy weight insulin-sensitive (IS) and overweight insulin-resistant (IR) women. Participants Age-matched healthy weight IS (n...

Registration Year

  • 2020

Resource Types

  • Collection


  • Imperial College London
  • Cardiff University
  • Ca Foscari University of Venice
  • Vanderbilt University
  • London School of Hygiene & Tropical Medicine
  • Delft University of Technology
  • Chinese Academy of Medical Sciences & Peking Union Medical College
  • Polytechnic Institute of Viseu
  • Escuela Internacional de Negocios y Desarrollo Empresarial de Colombia
  • Istituto Nazionale di Geofisica e Vulcanologia (INGV)