Sex differences characterise inflammatory profiles of cerebellar mitochondria and are attenuated in Parkinson’s disease

Thomas L Ingram, Freya Shephard, , , &
Response to inflammation is a key determinant in many diseases and their outcomes. Diseases that commonly affect older people are frequently associated with altered inflammatory processes. Neuroinflammation has been described in Parkinson’s disease (PD) brain and presents a potential therapeutic target. PD is characterised by the loss of dopaminergic neurons in the substantia nigra pars compacta and at the sub-cellular level, mitochondrial dysfunction is a key feature. However, there is evidence that a different region...

Registration Year

  • 2020
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  • Data Paper
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Affiliations

  • University of Nottingham
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  • Versus Arthritis
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