ICD-1/BTF3 antagonizes SKN-1-mediated endoderm specification in Caenorhabditis elegans

Chee Kiang Ewe, Yamila N Torres Cleuren & Joel H Rothman
The entire C. elegans intestine is derived from a single endodermal progenitor cell (E), the posterior daughter arising from the asymmetric division of the EMS blastomere. During early embryonic development, maternally provided SKN-1/Nrf2 activates the mesendoderm gene regulatory network (GRN) in both E and its sister, MS. A triply redundant Wnt/MAPK/Src signaling system from the neighboring P2 blastomere polarizes EMS, resulting in activation of E fate on the side contacting it. In MS, and in...

Registration Year

  • 2019

Resource Types

  • Data Paper


  • University of California, Santa Barbara
  • University of Auckland