3 Works

Data from: Attention-related modulation of caudate neurons depends on superior colliculus activity

James Herman, Fabrice Arcizet & Richard Krauzlis
Recent work has implicated the basal ganglia in visual perception and attention, in addition to their traditional role in motor control. The basal ganglia, especially the caudate nucleus “head” (CDh) of the striatum, receive indirect anatomical connections from the superior colliculus (SC), a midbrain structure that is known to play a crucial role in the control of visual attention. To test the possible functional relationship between these subcortical structures, we recorded CDh neuronal activity before...

Directed Evolution of AAV for Efficient Gene Delivery to Canine and Primate Retina - Raw counts of variants from deep sequencing

Leah Byrne, Timothy Day, Meike Visel, Deniz Dalkara, Valerie Dufour, Felipe Pompeo Marinho, William Merigan, Gustavo Aguirre, William Beltran, David Schaffer & John Flannery
Efficient AAV-mediated gene delivery remains a significant obstacle to effective retinal gene therapies. Here, we apply the process of directed evolution – guided by deep sequencing and followed by direct in vivo secondary selection of high-performing vectors with a GFP-barcoded library – to create AAV viral capsids with new capabilities to deliver genes to the outer retina in large animals. The resulting vectors resulted in efficient targeting of photoreceptors, bipolar cells, and RPE cells in...

Data from: Error-robust modes of the retinal population code

Adrianna R. Loback, Gašper Tkačik, Jason S. Prentice, Mark L. Ioffe, , Olivier Marre & Michael J. Berry
Across the nervous system, certain population spiking patterns are observed far more frequently than others. A hypothesis about this structure is that these collective activity patterns function as population codewords–collective modes–carrying information distinct from that of any single cell. We investigate this phenomenon in recordings of ∼150 retinal ganglion cells, the retina’s output. We develop a novel statistical model that decomposes the population response into modes; it predicts the distribution of spiking activity in the...

Registration Year

  • 2020
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  • 2018
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  • 2016
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Resource Types

  • Dataset
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Affiliations

  • Institut de la Vision
    3
  • University of Pennsylvania
    1
  • Princeton University
    1
  • University of California, Berkeley
    1
  • University of Rochester
    1
  • Institute of Science and Technology Austria
    1
  • National Eye Institute
    1