Supplemental tables from: Antifibrogenic activities of CYP11A1-derived vitamin D3-hydroxyderivatives are dependent on RORγ

Zorica Janjetovic, Arnold Postlethwaite Postlethwaite, Hong Soon Kang, Tae Kang Kim, Robert Tuckey, David Crossman, Anton Jetten & Andrzej Alominski
Previous studies showed that non-calcemic 20(OH)D3, a product of CYP11A1 action on vitamin D3, has antifibrotic activity in human dermal fibroblasts and in a bleomycin mouse model of scleroderma. In this study we tested the role of RORγ, which is expressed in skin, in the action of CYP11A1-derived secosteroids using murine fibroblasts isolated from the skin of wild type (RORg+/+), knock out (RORg-/-) and heterozygote (RORg+/-) mice. CYP11A1-derived 20(OH)D3, 20,23(OH)2D3, 1,20(OH)2D3, and 1,20,23(OH)3D3 inhibited proliferation...

Registration Year

  • 2020
    1

Resource Types

  • Dataset
    1

Affiliations

  • University of Tennessee Health Science Center
    1
  • University of Alabama at Birmingham
    1
  • National Institutes of Health
    1
  • University of Western Australia
    1