4 Works

Supplement to: Global impact of the COVID-19 pandemic on stroke care and intravenous thrombolysis

Raul Nogueira, Muhammed Qureshi, Mohamad Abdalkader, Sheila Martins, Hiroshi Yamagami, Zhongming Qiu, Ossama Mansour, Anvitha Sathya, Anna Czlonkowska, Georgios Tsivgoulis, Diana Aguiar De Sousa, Jelle Demeestere, Robert Mikulik, Peter Vanacker, James Siegler, Janika Korv, Jose Biller, Conrad Liang, Navdeep Sangha, Alicia Zha, Alexandra Czap, Christine Holmstedt, Tanya Turan, George Ntaios, Konark Malhotra … & Thanh Nguyen
Objective: The objectives of this study were to measure the global impact of the pandemic on the volumes for intravenous thrombolysis (IVT), IVT transfers, and stroke hospitalizations over 4 months at the height of the pandemic (March 1 to June 30, 2020) compared with two control 4-month periods. Methods: We conducted a cross-sectional, observational, retrospective study across 6 continents, 70 countries, and 457 stroke centers. Diagnoses were identified by their ICD-10 codes and/or classifications in...

Quantitative analysis of subcellular distributions with an open-source, object-based tool

Pearl Ryder & Dorothy Lerit
The subcellular localization of objects, such as organelles, proteins, or other molecules, instructs cellular form and function. Understanding the underlying spatial relationships between objects through colocalization analysis of microscopy images is a fundamental approach used to inform biological mechanisms. We generated an automated and customizable computational tool, the SubcellularDistribution pipeline, to facilitate object-based image analysis from 3D fluorescence microcopy images. To test the utility of the SubcellularDistribution pipeline, we examined the subcellular distribution of mRNA...

Data from: Krabbe disease variant classification using parental blood-based diagnostic RNA-seq

Samya Chakravorty
Krabbe disease (KD) is a rare autosomal recessive lysosomal storage disorder (LSD) associated with severe neurodegeneration and high mortality and is one of most prevalent LSDs at a recent estimate of 1 in 12,080 live births. The disease pathogenesis is related to low/undetectable galactocerebrosidase (GALC) activity resulting in an accumulation of a cytotoxic GALC substrate, psychosine (Psy), that leads to diffuse demyelination, psychomotor delays, and high morbidity/mortality across the disease spectrum. Although phenotypic prediction in...

Large mitochondrial DNA deletions in HIV sensory neuropathy

Ricardo Roda, David Bargiela, Weiran Chen, Ken Perry, Ronald J. Ellis, David B. Clifford, Ajay Bharti, Asha Kallianpur, Michelli F Oliveira, Monica M. Diaz, Leah H. Rubin, Christina Gavegnano, Justin C. McArthur, Ahmet Hoke & Michael Polydefkis
Objective: The primary objective of this study was to evaluate the correlation of large mitochondrial DNA deletions in skin samples of people with HIV with measure of neuropathy and prior exposure to therapy. We hypothesized that deletions would be associated with the presence of neuropathy. As secondary objectives we determined the correlation of deletion burden with demographic data and neuropathy measures. Methods: In this retrospective cohort study we measured the accumulation of large mtDNA deletions...

Registration Year

  • 2021

Resource Types

  • Dataset


  • Emory University School of Medicine
  • New York University Langone Medical Center
  • Kwame Nkrumah University of Science and Technology
  • Ain Shams University
  • Ain Shams University Hospital
  • Kaiser Permanente
  • Allegheny Health Network
  • Medical University of South Carolina
  • University of North Carolina
  • University of California, San Diego