26 Works

Coevolutionary theory of hosts and parasites

Lydia Buckingham & Ben Ashby
Host and parasite evolution are closely intertwined, with selection for adaptations and counter-adaptations forming a coevolutionary feedback loop. Coevolutionary dynamics are often difficult to intuit due to these feedbacks and are hard to demonstrate empirically in most systems. Theoretical models have therefore played a crucial role in shaping our understanding of host-parasite coevolution. Theoretical models vary widely in their assumptions, approaches and aims, and such variety makes it difficult, especially for non-theoreticians and those new...

Remating opportunities and low costs underlie maternal desertion

Grant C. McDonald, Innes C. Cuthill, Tamás Székely & András Kosztolányi
Parental care can enhance offspring survival but may impose significant costs to parents. The costs and benefits of care are key to understanding patterns of parental care, where parents can benefit by having their partner increase investment in care, while reducing their own effort. However, investigating the costs and benefits of parental care in wild populations is challenging. Here we use highly detailed behavioural observations in families of a small shorebird, where one parent frequently...

Additional file 6 of Metabolic engineering of Escherichia coli BW25113 for the production of 5-Aminolevulinic Acid based on CRISPR/Cas9 mediated gene knockout and metabolic pathway modification

Changchuan Ye, Yuting Yang, Xi Chen, Lijie Yang, Xia Hua, Mengjie Yang, Xiangfang Zeng & Shiyan Qiao
Additional file 6: Fig S6. Standard Plot for ALA measurement. x: the absorbance at 554 nm; y: ALA concentration of sample after diluted (mg/L).

Inflammatory activation and immune cell infiltration are main biological characteristics of SARS-CoV-2 infected myocardium

Rui Zhang, Xi Chen, Wenjie Zuo, Zhenjun Ji, Yangyang Qu, Yamin Su, Mingming Yang, Pengfei Zuo, Genshan Ma & Yongjun Li
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) can target cardiomyocytes (CMs) to directly invade the heart resulting in high mortality. This study aims to explore the biological characteristics of SARS-CoV-2 infected myocardium based on omics by collecting transcriptome data and analyzing them with a series of bioinformatics tools. Totally, 86 differentially expressed genes (DEGs) were discovered in SARS-CoV-2 infected CMs, and 15 miRNAs were discovered to target 60 genes. Functional enrichment analysis indicated that these...

Inflammatory activation and immune cell infiltration are main biological characteristics of SARS-CoV-2 infected myocardium

Rui Zhang, Xi Chen, Wenjie Zuo, Zhenjun Ji, Yangyang Qu, Yamin Su, Mingming Yang, Pengfei Zuo, Genshan Ma & Yongjun Li
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) can target cardiomyocytes (CMs) to directly invade the heart resulting in high mortality. This study aims to explore the biological characteristics of SARS-CoV-2 infected myocardium based on omics by collecting transcriptome data and analyzing them with a series of bioinformatics tools. Totally, 86 differentially expressed genes (DEGs) were discovered in SARS-CoV-2 infected CMs, and 15 miRNAs were discovered to target 60 genes. Functional enrichment analysis indicated that these...

The impact of paleoclimatic changes on body size evolution in marine fishes

Emily Troyer, Ricardo Betancur-R, Lily Hughes, Mark Westneat, Giorgio Carnevale, William White, John Pogonoski, James Tyler, Carole Baldwin, Guillermo Ortí, Julien Clavel, Dahiana Arcila & Andrew Brinkworth
Body size is an important species trait, correlating with lifespan, fecundity, and other ecological factors. Over Earth’s geological history, climate shifts have occurred, potentially shaping body size evolution in many clades. General rules attempting to summarize body size evolution include Bergmann’s rule, which states that species grow to larger sizes in cooler environments and smaller sizes in warmer environments; and Cope’s rule, which poses that lineages tend to increase in size over evolutionary time. Tetraodontiform...

Additional file 6 of NLRP3 inflammasome regulates astrocyte transformation in brain injury induced by chronic intermittent hypoxia

Ningning She, Yewen Shi, Yani Feng, Lina Ma, Yuqi Yuan, Yitong Zhang, Zine Cao, Xi Chen, Bingjie Zhao, Haiqin Liu & Xiaoyong Ren
Additional file 6: Table S1. The primer sequences uesd in RT-qPCR.

Supplementary files for: Why should we compare morphological and molecular disparity?

Conrad Van Den Ende, Mark Puttick, Araxi Urrutia & Matthew Wills
1. Indices of morphological disparity seek to summarise the highly multivariate morphological variation across groups of species within clades, time bins or other groups. Morphological variation can be quantified using geometric morphometric, outline or surface-based methods. These are most effective when morphological differences are relatively modest and there are numerous ubiquitous landmarks and phase-aligned features of shape variation. The most disparate samples, such as those across classes and phyla, typically necessitate the use of discrete...

Additional file 5 of Multi-dimensional relationships among dementia, depression and prescribed drugs in England and Wales hospitals

Alok Joshi, Stephen Todd, David P. Finn, Paula L. McClean & KongFatt Wong-Lin
Additional file 5. Standardised features.

Numerical investigation of asymmetric weld fusion geometry in laser welding of aluminium alloy with beam oscillation

Xi Chen, Nan Jiang, Meng Jiang, Yang Du, Shengchong Ma, Yuan Chen, Caiwang Tan, Zhenglong Lei, Sicong Zhao & Yanbin Chen
In this work, the asymmetric weld fusion geometry in oscillating laser beam welding (OLBW) of aluminium alloy was reported and investigated using a numerical approach. A multi-physics heat transfer and fluid flow model of OLBW was developed and validated with the corresponding experimental results. The weld fusion geometry, temperature fields, and fluid flow behaviours for four commonly used oscillation modes, line, circle, eight, and infinity, were calculated to analyse the origin of the asymmetric weld...

Novel mycoplasma nucleomodulin MbovP475 decreased cell viability by regulating expression of CRYAB and MCF2L2

Gang Zhao, Doukun Lu, Shujuan Wang, Hui Zhang, Xifang Zhu, Zhiyu Hao, Ali Dawood, Yingyu Chen, Elise Schieck, Changmin Hu, Xi Chen, Liguo Yang & Aizhen Guo
Nucleomodulins are secreted bacterial proteins whose molecular targets are located in host cell nuclei. They are gaining attention as critical virulence factors that either modify the epigenetics of host cells or directly regulate host gene expression. Mycoplasma bovis is a major veterinary pathogen that secretes several potential virulence factors. The aim of this study was to determine whether any of their secreted proteins might function as nucleomodulins. After an initial in silico screening, the nuclear...

Additional file 2 of Multi-dimensional relationships among dementia, depression and prescribed drugs in England and Wales hospitals

Alok Joshi, Stephen Todd, David P. Finn, Paula L. McClean & KongFatt Wong-Lin
Additional file 2. Correlation values exceed the Pearson pairwise correlation coefficient threshold of 0.4.

Additional file 6 of NLRP3 inflammasome regulates astrocyte transformation in brain injury induced by chronic intermittent hypoxia

Ningning She, Yewen Shi, Yani Feng, Lina Ma, Yuqi Yuan, Yitong Zhang, Zine Cao, Xi Chen, Bingjie Zhao, Haiqin Liu & Xiaoyong Ren
Additional file 6: Table S1. The primer sequences uesd in RT-qPCR.

Novel mycoplasma nucleomodulin MbovP475 decreased cell viability by regulating expression of CRYAB and MCF2L2

Gang Zhao, Doukun Lu, Shujuan Wang, Hui Zhang, Xifang Zhu, Zhiyu Hao, Ali Dawood, Yingyu Chen, Elise Schieck, Changmin Hu, Xi Chen, Liguo Yang & Aizhen Guo
Nucleomodulins are secreted bacterial proteins whose molecular targets are located in host cell nuclei. They are gaining attention as critical virulence factors that either modify the epigenetics of host cells or directly regulate host gene expression. Mycoplasma bovis is a major veterinary pathogen that secretes several potential virulence factors. The aim of this study was to determine whether any of their secreted proteins might function as nucleomodulins. After an initial in silico screening, the nuclear...

Additional file 3 of Multi-dimensional relationships among dementia, depression and prescribed drugs in England and Wales hospitals

Alok Joshi, Stephen Todd, David P. Finn, Paula L. McClean & KongFatt Wong-Lin
Additional file 3. NAD dataset.

Additional file 1 of Multi-dimensional relationships among dementia, depression and prescribed drugs in England and Wales hospitals

Alok Joshi, Stephen Todd, David P. Finn, Paula L. McClean & KongFatt Wong-Lin
Additional file 1. Correlation among the features.

Additional file 3 of Multi-dimensional relationships among dementia, depression and prescribed drugs in England and Wales hospitals

Alok Joshi, Stephen Todd, David P. Finn, Paula L. McClean & KongFatt Wong-Lin
Additional file 3. NAD dataset.

DRAM: A three-dimensional analytical model for the mobilisation of root reinforcement in direct shear conditions – Data repository

Gerrit Meijer, Jonathan Knappett, Glyn Bengough, Daniel Bull, Teng Liang & David Muir Wood
This dataset contains data of experiments underlying the work presented in the linked Ecological Engineering journal publication (DOI: 10.1016/j.ecoleng.2022.106621). Source code for the DRAM model (written in R) can be found in a separate repository (DOI: 10.5281/zenodo.6375587).

Numerical investigation of asymmetric weld fusion geometry in laser welding of aluminium alloy with beam oscillation

Xi Chen, Nan Jiang, Meng Jiang, Yang Du, Shengchong Ma, Yuan Chen, Caiwang Tan, Zhenglong Lei, Sicong Zhao & Yanbin Chen
In this work, the asymmetric weld fusion geometry in oscillating laser beam welding (OLBW) of aluminium alloy was reported and investigated using a numerical approach. A multi-physics heat transfer and fluid flow model of OLBW was developed and validated with the corresponding experimental results. The weld fusion geometry, temperature fields, and fluid flow behaviours for four commonly used oscillation modes, line, circle, eight, and infinity, were calculated to analyse the origin of the asymmetric weld...

Additional file 6 of Metabolic engineering of Escherichia coli BW25113 for the production of 5-Aminolevulinic Acid based on CRISPR/Cas9 mediated gene knockout and metabolic pathway modification

Changchuan Ye, Yuting Yang, Xi Chen, Lijie Yang, Xia Hua, Mengjie Yang, Xiangfang Zeng & Shiyan Qiao
Additional file 6: Fig S6. Standard Plot for ALA measurement. x: the absorbance at 554 nm; y: ALA concentration of sample after diluted (mg/L).

Mapping material use and modelling the embodied carbon in UK construction

Michal Drewniok, Jose M. Cruz Azevedo, Cyrille Dunant & Will Hawkins
The dataset present assumptions and results for the papers "Mapping material use and embodied carbon in the UK construction'' and "Modelling the embodied carbon cost of UK domestic building construction: Today to 2050"

Additional file 2 of Multi-dimensional relationships among dementia, depression and prescribed drugs in England and Wales hospitals

Alok Joshi, Stephen Todd, David P. Finn, Paula L. McClean & KongFatt Wong-Lin
Additional file 2. Correlation values exceed the Pearson pairwise correlation coefficient threshold of 0.4.

Additional file 5 of Multi-dimensional relationships among dementia, depression and prescribed drugs in England and Wales hospitals

Alok Joshi, Stephen Todd, David P. Finn, Paula L. McClean & KongFatt Wong-Lin
Additional file 5. Standardised features.

Additional file 1 of Multi-dimensional relationships among dementia, depression and prescribed drugs in England and Wales hospitals

Alok Joshi, Stephen Todd, David P. Finn, Paula L. McClean & KongFatt Wong-Lin
Additional file 1. Correlation among the features.

Additional file 1 of Phosphodiesterase 10A (PDE10A) as a novel target to suppress β-catenin and RAS signaling in epithelial ovarian cancer

Rebecca M. Borneman, Elaine Gavin, Alla Musiyenko, Wito Richter, Kevin J. Lee, David K. Crossman, Joel F. Andrews, Annelise M. Wilhite, Steven McClellan, Ileana Aragon, Antonio B. Ward, Xi Chen, Adam B. Keeton, Kristy Berry, Gary A. Piazza, Jennifer M. Scalici & Luciana Madeira da Silva
Additional file 1.

Registration Year

  • 2022
    26

Resource Types

  • Dataset
    26

Affiliations

  • University of Bath
    26
  • Zhejiang University
    13
  • Affiliated Hospital of Southwest Medical University
    12
  • North West Agriculture and Forestry University
    12
  • Sun Yat-sen University
    12
  • Ghent University
    12
  • Third Affiliated Hospital of Guangzhou Medical University
    12
  • Huazhong University of Science and Technology
    12
  • Chinese University of Hong Kong
    12
  • Guangzhou Medical University
    12