Data from: Diet- and genetically-induced obesity differentially affect the fecal microbiome and metabolome in Apc1638N mice

Anna C. Pfalzer, Paula-Dene C. Nesbeth, Laurence D. Parnell, Lakshmanan K. Iyer, Zhenhua Liu, Anne V. Kane, C-Y. Oliver Chen, Albert K. Tai, Thomas A. Bowman, Martin S. Obin, Joel B. Mason, Andrew S. Greenberg, Sang-Woon Choi, Jacob Selhub, Ligi Paul & Jimmy W. Crott
Obesity is a risk factor for colorectal cancer (CRC), and alterations in the colonic microbiome and metabolome may be mechanistically involved in this relationship. The relative contribution of diet and obesity per se are unclear. We compared the effect of diet- and genetically-induced obesity on the intestinal microbiome and metabolome in a mouse model of CRC. Apc1638N mice were made obese by either high fat (HF) feeding or the presence of the Leprdb/db (DbDb) mutation....

Registration Year

  • 2015
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Resource Types

  • Dataset
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Affiliations

  • Tufts Medical Center
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  • University of Massachusetts Amherst
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  • CHA University
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  • Tufts University
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