6 Works

Large-scale neural recordings with single neuron resolution using Neuropixels probes in human cortex

Angelique C Paulk, Yoav Kfir, Arjun R Khanna, Martina L Mustroph, Eric M Trautmann, Dan J Soper, Sergey D Stavisky, Marleen Welkenhuysen, Barundeb Dutta, Krisha V Shenoy, Leigh R Hochberg, R. Mark Richardson, Ziv M Williams & Sydney S Cash
Recent advances in multi-electrode array technology have made it possible to monitor large neuronal ensembles at cellular resolution in animal models. In humans, however, current approaches restrict recordings to few neurons per penetrating electrode or combine the signals of thousands of neurons in local field potential (LFP) recordings. Here, we describe a new probe variant and set of techniques which enable simultaneous recording from over 200 well-isolated cortical single units in human participants during intraoperative...

Generalizable EHR-R-REDCap pipeline for a national multi-institutional rare tumor patient registry

Sophia Shalhout, Farees Saqlain, Kayla Wright, Oladayo Akinyemi & David Miller
Objective: To develop a clinical informatics pipeline designed to capture large-scale structured EHR data for a national patient registry. Materials and Methods: The EHR-R-REDCap pipeline is implemented using R-statistical software to remap and import structured EHR data into the REDCap-based multi-institutional Merkel Cell Carcinoma (MCC) Patient Registry using an adaptable data dictionary. Results: Clinical laboratory data were extracted from EPIC Clarity across several participating institutions. Labs were transformed, remapped and imported into the MCC registry...

Facemasks: Perceptions and use in an ED population during COVID-19

Vidya Eswaran, Anna Marie Chang, R Gentry Wilkerson, Kelli O'Laughlin, Brian Chinnock, Stephanie Eucker, Brigitte Baumann, Nancy Anaya, Daniel Miller, Adrianne Haggins, Jesus Torres, Erik Anderson, Stephen Lim, Martina Caldwell, Ali Raja & Robert Rodriguez
Study Objective: Facemask use is associated with reduced transmission of SARS-CoV-2. Most surveys assessing perceptions and practices of mask use miss the most vulnerable racial, ethnic, and socio-economic populations. These same populations have suffered disproportionate impacts from the pandemic. The purpose of this study was to assess beliefs, access, and practices of mask wearing across 15 urban emergency department (ED) populations. Methods: This was a secondary analysis of a cross-sectional study of ED patients from...

Continuous glucose monitoring in cystic fibrosis: glycemic relationships, clinical correlations, and implications for CFRD diagnosis

Melissa Putman & Scully Kevin
Context: The clinical utility and implications of continuous glucose monitoring (CGM) in cystic fibrosis (CF) are unclear. Objective: We examined the correlation between CGM measures and clinical outcomes in adults with CF, investigated the relationship between hemoglobin A1c (HbA1c) and CGM-derived average glucose (AG), and explored CGM measures that distinguish cystic fibrosis–related diabetes (CFRD) from normal and abnormal glucose tolerance. Methods: This prospective observational study included 77 adults with CF who had CGM and HbA1c...

Telerobotic neurovascular interventions with magnetic manipulation

Yoonho Kim, Emily Genevriere, Pablo Harker, Jaehun Choe, Marcin Balicki, Robert W. Regenhardt, Justin E. Vranic, Adam A. Dmytriw, Aman B. Patel & Xuanhe Zhao
Advances in robotic technology have been adopted in various subspecialties of both open and minimally invasive surgery, offering benefits such as enhanced surgical precision and accuracy with reduced fatigue of the surgeon. Despite the advantages, robotic applications to endovascular neurosurgery have remained largely unexplored because of technical challenges such as the miniaturization of robotic devices that can reach the complex and tortuous vasculature of the brain. Although some commercial systems enable robotic manipulation of conventional...

Genetic modifiers of Huntington’s disease differentially influence motor and cognitive domains

Jong-Min Lee
Genome-wide association studies (GWAS) of Huntington’s disease (HD) have identified six DNA maintenance gene loci (among others) as modifiers and implicated a two step-mechanism of pathogenesis: somatic instability of the causative HTT CAG repeat with subsequent triggering of neuronal damage. The largest studies have been limited to HD individuals with a rater-estimated age at motor onset. To capitalize on the wealth of phenotypic data in several large HD natural history studies, we have performed algorithmic...

Registration Year

  • 2022
    6

Resource Types

  • Dataset
    6

Affiliations

  • Massachusetts General Hospital
    6
  • University of Washington
    1
  • Boston Children's Hospital
    1
  • Stanford University
    1
  • University of Michigan–Ann Arbor
    1
  • Duke University
    1
  • Thomas Jefferson University
    1
  • Henry Ford Hospital
    1
  • Columbia University Medical Center
    1
  • Louisiana State University Health Sciences Center New Orleans
    1