Objective: To determine whether non-pharmaceutical retail outlets are aboding to the current Medicines and Healthcare products Regulatory Agency (MHRA) national guidelines for over-the-counter (OTC) sales of aspirin and paracetamol. Methods: Stages 1 and 2 of the study deployed eight and four medical students, respectively, to undertake a mystery shopper style investigation. Stage 1: eight medical students attempted to buy ≥96 tablets/capsules aspirin or paracetamol in one transaction in 62 shops. Stage 2: four medical students...

To assess whether people with an existing musculoskeletal painful condition (pain in the joints and the muscles around them) have worse outcomes following a diagnosis of another illness. These illnesses were heart attack, stroke, cancer, dementia, and pneumonia.

Mechanosensory transduction by vertebrate hair cells depends on a protein complex at the tips of shorter stereocilia associated with mechanoelectrical transduction channels activated by tip links in the hair bundle. In mammalian hair cells, this complex includes transmembrane channel-like protein subunit 1 (TMC1), lipoma HMGIC fusion partner-like 5 protein (LHFPL5) and protocadherin 15 (PCDH15), a lower-end component of the tip link. TMC1 interacts with LHFPL5 and PCDH15 but how the complex develops to maturity, and...

The dataset contains measurements of fluorescein, dopachrome and nitrous oxide production from incubation experiments of streambed sediments. The sediments were collected in five pseudo-replicates from 0 to 10cm depth using a 5cm-diameter AMS slide hammer and trowel at two locations within the Wood Brook, Staffordshire, in June 2015. Samples were collected from two reaches within the stream, a mid-stream sandy reach and a downstream gravel reach. The sediment was used in laboratory incubation experiments to...

Additional file 1: Supplementary Tables 1-6.

These files contain the lists of CPRD medical and product codes used to define all variables in the paper “Trends in gabapentinoid prescribing in UK primary care using the Clinical Practice Research Datalink: an observational study“ by Ashworth et al published in Lancet Regional Health Europe 2023. Code lists are different for the two CPRD datasets GOLD and Aurum and the correct code list must be used in each.

Raw diffraction data relating to ∝GlcNAc-1-P bound conglutinin structure ID: 6RYN. Zipped archive consisting of image files.

These data were produced by the PRELIM project, funded by Arthritis Research UK/Versus Arthritis. The dataset comprises individual patient data, de-identified, from respondents to a cross-sectional survey of health and care undertaken in 11 general practices in 2017 and sampling two overlapping groups: (i) patients aged 35+ years who consulted for a selected common musculoskeletal condition in the previous 12 months, (ii) a random sample of the registered population (irrespective of consultation) aged 35+ years.

Journal of Conflict Archaeology

These files contain the lists of CPRD medical and product codes and ICD-10 codes (used in HES APC data) used to define all variables in the paper “Safety of colchicine and NSAID prophylaxis when initiating urate-lowering therapy for gout: propensity score-matched cohort studies in the UK Clinical Practice Research Datalink“ by Roddy et al, in press as of 2 March 2023. Code lists are different for the two CPRD datasets GOLD and Aurum and the...

Supplementary files: Search Strategy List of Excluded studies.csv PRISMA checklist

Supplementary files: Search Strategy List of Excluded studies.csv PRISMA checklist

Objectives. Health systems with strong primary care tend to have better population outcomes, but in many countries demand for care is growing. We sought to identify mechanisms of primary care that influence premature mortality. Design. We developed a conceptual model of the mechanisms by which primary care influences premature mortality, and undertook a cross-sectional study in which population and primary care variables reflecting the model were used to explain variations in mortality under aged 75...

Additional file 1: Supplementary Tables 1-6.