Data from: Spatial clustering of receptors and signaling molecules regulates NK cell response to peptide repertoire changes

Berenice Mbiribindi, Sayak Mukherjee, Dannielle Wellington, Jayajit Das & Salim I. Khakoo
Natural Killer (NK) cell activation requires the integration of inhibitory and activating signaling. Inhibitory signals are determined by members of the killer cell immunoglobulin-like receptor (KIR) family, which have major histocompatibility complex (MHC) class I ligands. Loss of this inhibitory signal leads to NK cell activation. Thus, down-regulation of MHC I during viral infection or cancer induces NK cells activation. However, NK cell activation in the presence of MHC-I has been demonstrated for HLA-C*0102 through...

Registration Year

  • 2019
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  • Dataset
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Affiliations

  • Nationwide Children's Hospital
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  • University of Southampton
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  • Institute of Bioinformatics and Applied Biotechnology
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