3 Works

Oxidative Stress and NF-κB signaling are involved in LPS induced pulmonary dysplasia in chick embryos

Yun Long, Guang Wang, Ke Li, Zong-yi Zhang, Ping Zhang, Jing Zhang, Xiao-tan Zhang, Yongping Bao, Xuesong Yang & Peng-cheng Wang
Inflammation or dysbacteriosis-derived lipopolysaccharides (LPS) adversely influence the embryonic development of respiratory system. However, the precise pathological mechanisms still remain to be elucidated. In this study, we demonstrated that LPS exposure caused lung maldevelopment in chick embryos, including higher embryo mortality, increased thickness of alveolar gas exchange zone, and accumulation of PAS+ immature pulmonary cells, accompanied with reduced expression of alveolar epithelial cell markers and lamellar body count. Upon LPS exposure, pulmonary cell proliferation was...

Oxidative stress and NF-κB signaling are involved in LPS induced pulmonary dysplasia in chick embryos

Yun Long, Guang Wang, Ke Li, Zongyi Zhang, Ping Zhang, Jing Zhang, Xiaotan Zhang, Yongping Bao, Xuesong Yang & Pengcheng Wang
Inflammation or dysbacteriosis-derived lipopolysaccharides (LPS) adversely influence the embryonic development of respiratory system. However, the precise pathological mechanisms still remain to be elucidated. In this study, we demonstrated that LPS exposure caused lung maldevelopment in chick embryos, including higher embryo mortality, increased thickness of alveolar gas exchange zone, and accumulation of PAS+ immature pulmonary cells, accompanied with reduced expression of alveolar epithelial cell markers and lamellar body count. Upon LPS exposure, pulmonary cell proliferation was...

Oxidative stress and NF-κB signaling are involved in LPS induced pulmonary dysplasia in chick embryos

Yun Long, Guang Wang, Ke Li, Zongyi Zhang, Ping Zhang, Jing Zhang, Xiaotan Zhang, Yongping Bao, Xuesong Yang & Pengcheng Wang
Inflammation or dysbacteriosis-derived lipopolysaccharides (LPS) adversely influence the embryonic development of respiratory system. However, the precise pathological mechanisms still remain to be elucidated. In this study, we demonstrated that LPS exposure caused lung maldevelopment in chick embryos, including higher embryo mortality, increased thickness of alveolar gas exchange zone, and accumulation of PAS+ immature pulmonary cells, accompanied with reduced expression of alveolar epithelial cell markers and lamellar body count. Upon LPS exposure, pulmonary cell proliferation was...

Registration Year

  • 2018
    3

Resource Types

  • Dataset
    3

Affiliations

  • Hong Kong Polytechnic University
    3
  • Beijing Tian Tan Hospital
    3
  • Third Hospital of Hebei Medical University
    3
  • Sixth Affiliated Hospital of Sun Yat-sen University
    3
  • Sun Yat-sen University
    3
  • Guangzhou Center for Disease Control and Prevention
    3
  • Agricultural University of Hebei
    3
  • Zhejiang University
    3
  • Lanzhou Veterinary Research Institute
    3
  • Zunyi Medical University
    3