481 Works

Additional file 1 of A potential pathogenic hypoxia-related gene HK2 in necrotizing enterocolitis (NEC) of newborns

Yujie Han, Xianghong Liu, Lili Kang, Dong Chen, Yongqing Li, Huiping Zhang, Mingying Sun, Hui Gao, Zhongtao Gai & Xiaoying Li
Additional file 1. Detailed functional results of DEmRNAs.

Genome-wide comparison of the GRAS protein family in eight Rosaceae species and GRAS gene expression analysis in Chinese white pear (Pyrus bretschneideri Rehder)

Wenjing Chang, Manyi Sun, Mingyue Zhang, Zikai Tang, Jiawen Sheng, Yueyuan Liu, Bobo Song, Jiaming Li, Kejiao Zhao & Jun Wu
The GRAS protein family encodes a family of plant-specific transcription factors that have diverse and significant functions in regulating plant development and anthocyanin biosynthesis. Our study represents the comprehensive identification and comparison of GRAS protein family genes in the Rosaceae. Here, 535 GRAS genes were screened from eight Rosaceae species. Phylogenetic analysis revealed that whole-genome duplication (WGD) events and dispersed duplication events were the major mechanisms promoting the expansion of the GRAS protein family in...

Additional file 14 of A comprehensive pan-cancer analysis of necroptosis molecules in four gynecologic cancers

Jianfeng Zheng, Xintong Cai, Yu Zhang, Huihui Wang, Li Liu, Fengling Tang, Linying Liu & Yang Sun
Additional file 14: Supplementary Table 2. The results of expression differences for pan-cancer analysis.

Additional file 14 of A comprehensive pan-cancer analysis of necroptosis molecules in four gynecologic cancers

Jianfeng Zheng, Xintong Cai, Yu Zhang, Huihui Wang, Li Liu, Fengling Tang, Linying Liu & Yang Sun
Additional file 14: Supplementary Table 2. The results of expression differences for pan-cancer analysis.

Identification of a novel circular RNA circZNF652/miR-486-5p/SERPINE1 signaling cascade that regulates cancer aggressiveness in glioblastoma (GBM)

Liang Liu, Shan Xiao, Yan Wang, Zifeng Zhu, Yiyao Cao, Sen Yang, Rongkang Mai & Yong Zheng
Circular RNAs (circRNAs) are closely associated with cancer development in glioblastoma (GBM), and this study aims to explore the molecular mechanisms of a novel circular RNA circZNF652 in regulating GBM aggressiveness. The present study found that CircZNF652 and SERPINE1 were upregulated, while miR-486-5p was downregulated in GBM tissues and cell lines, and GBM patients with high expression of CircZNF652 and SERPINE1, and patients with low expression of miR-486-5p tended to have a worse prognosis. Further...

A potential novel inflammation biomarker for predicting the prognosis of decompensated liver cirrhosis

Yanan Xie, Chiyi He & Wei Wang
This study aimed to explore the prognostic value of the lymphocyte (LYM)-to-white blood cell (WBC) ratio (LWR) in patients with decompensated liver cirrhosis (DLC). This study was conducted by recruiting 214 patients with DLC with different aetiologies (development cohort). Receiver operating characteristic (ROC) curve analyses were used to assess the predictive accuracy of the LWR, and Youden’s index was used to determine the optimal cut-off values of the LWR based on the ROC curve. Next,...

Additional file 2 of mTORC1-c-Myc pathway rewires methionine metabolism for HCC progression through suppressing SIRT4 mediated ADP ribosylation of MAT2A

Liang Zhao, Huizhao Su, Xiaomeng Liu, Hongquan Wang, Yukuan Feng, Yan Wang, Haiqiang Chen, Luo Dai, Shihui Lai, Siqi Xu, Chong Li, Jihui Hao & Bo Tang
Additional file 2: Table S1. Detected gene levels upon methionine restriction in livers of HCC mouce models.

Additional file 1 of Multi-omics reveals the key and specific miRNA-mRNA modules underlying salt tolerance in wild emmer wheat (Triticum dicoccoides L.)

Guang Yang, Wenqiu Pan, Rui Cao, Qifan Guo, Yue Cheng, Qinlong Zhao, Licao Cui & Xiaojun Nie
Additional file 1: Table S1. Details of identified miRNAs (conserved/known and novel). Table S2. Differentially expressed miRNAs of two genotypes at each treatment time point. Table S3. Details of target genes of differentially expressed miRNAs. Table S4. Differentially expressed mRNAs of two genotypes at each treatment time point. Table S5. Coherent miRNA-mRNA pairs of two genotypes at each treatment time point. Table S6. Salt tolerance-related miRNA-mRNA pairs. Table S7. Summary of co-expression network. Table S8....

Additional file 1 of Multi-omics reveals the key and specific miRNA-mRNA modules underlying salt tolerance in wild emmer wheat (Triticum dicoccoides L.)

Guang Yang, Wenqiu Pan, Rui Cao, Qifan Guo, Yue Cheng, Qinlong Zhao, Licao Cui & Xiaojun Nie
Additional file 1: Table S1. Details of identified miRNAs (conserved/known and novel). Table S2. Differentially expressed miRNAs of two genotypes at each treatment time point. Table S3. Details of target genes of differentially expressed miRNAs. Table S4. Differentially expressed mRNAs of two genotypes at each treatment time point. Table S5. Coherent miRNA-mRNA pairs of two genotypes at each treatment time point. Table S6. Salt tolerance-related miRNA-mRNA pairs. Table S7. Summary of co-expression network. Table S8....

Additional file 2 of Transcriptome and Metabolome Analyses Reveals the Pathway and Metabolites of Grain Quality Under Phytochrome B in Rice (Oryza sativa L.)

Fei Li, Ye Liu, Xiaohua Zhang, Lingzhi Liu, Yun Yan, Xin Ji, Fanshu Kong, Yafan Zhao, Junzhou Li, Ting Peng, Hongzheng Sun, Yanxiu Du & Quanzhi Zhao
Additional file 2. Table S2. Gene names and numbers for differential pathways.

Additional file 3 of Transcriptome and Metabolome Analyses Reveals the Pathway and Metabolites of Grain Quality Under Phytochrome B in Rice (Oryza sativa L.)

Fei Li, Ye Liu, Xiaohua Zhang, Lingzhi Liu, Yun Yan, Xin Ji, Fanshu Kong, Yafan Zhao, Junzhou Li, Ting Peng, Hongzheng Sun, Yanxiu Du & Quanzhi Zhao
Additional file 3. Table S3. The name and number of metabolites.

INFLUENCE OF HIGH-INTENSITY INTERVAL TRAINING ON TABLE TENNIS PLAYERS

Jing Chen & Jianming Wang
ABSTRACT Introduction The development of the technical level of table tennis and the reform of the rules require players to have a proportionally comprehensive technical base, aiming to climb to the top of world table tennis. Objective Study the effect of high-intensity competition on the physical fitness of table tennis players. Methods By analyzing the questionnaires of coaches and athletes in colleges and universities in Zhejiang province, as well as the development status and situation...

A new biomarker for the early diagnosis of gastric cancer: gastric juice- and serum-derived SNCG Supplementary material

Yangyang Pan, Yi Zheng, JIE YANG, Yi Wei, Hanrui Wu, Shuo Liu, Aihua Yin, Jinfeng Hu & Yan Zeng
A new biomarker for the early diagnosis of gastric cancer: gastric juice- and serum-derived SNCG Supplementary materials

Additional file 8 of Systems biology approach reveals a common molecular basis for COVID-19 and non-alcoholic fatty liver disease (NAFLD)

Shi-Tao Jiang, Yao-Ge Liu, Lei Zhang, Xin-Ting Sang, Yi-Yao Xu & Xin Lu
Additional file 8: Table S7. PPI network parameters.

Additional file 2 of Systems biology approach reveals a common molecular basis for COVID-19 and non-alcoholic fatty liver disease (NAFLD)

Shi-Tao Jiang, Yao-Ge Liu, Lei Zhang, Xin-Ting Sang, Yi-Yao Xu & Xin Lu
Additional file 2: Table S1. Differentially expressed genes for COVID-19.

Additional file 6 of Systems biology approach reveals a common molecular basis for COVID-19 and non-alcoholic fatty liver disease (NAFLD)

Shi-Tao Jiang, Yao-Ge Liu, Lei Zhang, Xin-Ting Sang, Yi-Yao Xu & Xin Lu
Additional file 6: Table S5. Gene ontology analysis.

Additional file 6 of Systems biology approach reveals a common molecular basis for COVID-19 and non-alcoholic fatty liver disease (NAFLD)

Shi-Tao Jiang, Yao-Ge Liu, Lei Zhang, Xin-Ting Sang, Yi-Yao Xu & Xin Lu
Additional file 6: Table S5. Gene ontology analysis.

Additional file 9 of Systems biology approach reveals a common molecular basis for COVID-19 and non-alcoholic fatty liver disease (NAFLD)

Shi-Tao Jiang, Yao-Ge Liu, Lei Zhang, Xin-Ting Sang, Yi-Yao Xu & Xin Lu
Additional file 9: Table S8. TFs-DEGs interaction network parameters.

Additional file 9 of Systems biology approach reveals a common molecular basis for COVID-19 and non-alcoholic fatty liver disease (NAFLD)

Shi-Tao Jiang, Yao-Ge Liu, Lei Zhang, Xin-Ting Sang, Yi-Yao Xu & Xin Lu
Additional file 9: Table S8. TFs-DEGs interaction network parameters.

Additional file 10 of Systems biology approach reveals a common molecular basis for COVID-19 and non-alcoholic fatty liver disease (NAFLD)

Shi-Tao Jiang, Yao-Ge Liu, Lei Zhang, Xin-Ting Sang, Yi-Yao Xu & Xin Lu
Additional file 10: Table S9. Parameters of miRNAs-DEGs interaction network.

Sprouty4 is epigenetically upregulated in human colorectal cancer

Alexei J. Stuckel, Shuai Zeng, Zhen Lyu, Wei Zhang, Xu Zhang, Urszula Dougherty, Reba Mustafi, Tripti Khare, Qiong Zhang, Trupti Joshi, Marc Bissonnette & Sharad Khare
Sprouty4 (SPRY4) has been frequently reported as a tumor suppressor and is therefore downregulated in various cancers. For the first time, we report that SPRY4 is epigenetically upregulated in colorectal cancer (CRC). In this study, we explored DNA methylation and hydroxymethylation levels of SPRY4 in CRC cells and patient samples and correlated these findings with mRNA and protein expression levels. Three loci within the promoter region of SPRY4 were evaluated for 5mC levels in CRC...

Functional study and epigenetic targets analyses of SIRT1 in intramuscular preadipocytes via ChIP-seq and mRNA-seq

Hongbiao Ran, Qiuya He, Yuting Han, Jikun Wang, Haibo Wang, Binglin Yue, Ming Zhang, Zhixin Chai, Xin Cai, Hui Wang & Jincheng Zhong
The SIRT1 epigenetic regulator is involved in hepatic lipid homoeostasis. However, the role of SIRT1 in regulating intramuscular fat deposition as well as the pathways and potential epigenetic targets involved remain unknown. Herein, we investigate SIRT1 function, its genome-wide epigenetic target profile, and transcriptomic changes under SIRT1 overexpression during yak intramuscular preadipocytes differentiation. To this end, we analysed the relationship between SIRT1 and intramuscular fat content as well as lipid metabolism-related genes in longissimus dorsi...

Functional study and epigenetic targets analyses of SIRT1 in intramuscular preadipocytes via ChIP-seq and mRNA-seq

Hongbiao Ran, Qiuya He, Yuting Han, Jikun Wang, Haibo Wang, Binglin Yue, Ming Zhang, Zhixin Chai, Xin Cai, Jincheng Zhong & Hui Wang
The SIRT1 epigenetic regulator is involved in hepatic lipid homoeostasis. However, the role of SIRT1 in regulating intramuscular fat deposition as well as the pathways and potential epigenetic targets involved remain unknown. Herein, we investigate SIRT1 function, its genome-wide epigenetic target profile, and transcriptomic changes under SIRT1 overexpression during yak intramuscular preadipocytes differentiation. To this end, we analysed the relationship between SIRT1 and intramuscular fat content as well as lipid metabolism-related genes in longissimus dorsi...

Additional file 3 of Genome-wide identification and characterization of lncRNAs in sunflower endosperm

Shuai Yu, Zhichao Zhang, Jing Li, Yanbin Zhu, Yanzhe Yin, Xiaoyu Zhang, Yuxin Dai, Ao Zhang, Cong Li, Yanshu Zhu, Jinjuan Fan, Yanye Ruan & Xiaomei Dong
Additional file 3: Table S3. GO Gene Ontology analysis of co-expressed protein-coding genes with all candidate lncRNAs.

Additional file 15 of Genome-wide identification and characterization of lncRNAs in sunflower endosperm

Shuai Yu, Zhichao Zhang, Jing Li, Yanbin Zhu, Yanzhe Yin, Xiaoyu Zhang, Yuxin Dai, Ao Zhang, Cong Li, Yanshu Zhu, Jinjuan Fan, Yanye Ruan & Xiaomei Dong
Additional file 15. GTF File of candidate lncRNAs identified in sunflower endosperm.

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