782 Works

Data from: Rainfall pulse response of carbon fluxes in a temperate grass ecosystem in the semiarid Loess Plateau

Yakun Tang, Jun Jiang, Chen Chen, Yunming Chen & Xu Wu
Rainfall pulses can significantly influence carbon cycling in water limited ecosystems. The magnitude of carbon flux component responses to precipitation may vary depending on precipitation amount and antecedent soil moisture, associated with nonlinear responses of plants and soil microbes. The present study was carried out in a temperate grass ecosystem during 2013–2015 in the semiarid Loess Plateau of China, to examine the response of carbon fluxes to precipitation using the “threshold-delay” model. The unique contribution...

Dominant factors of the phosphorus regulatory network differ under various dietary phosphate loads in healthy individuals

Guoxin Ye, Jiaying Zhang, Zhaori Bi, Weichen Zhang, Minmin Zhang, Qian Zhang, Mengjing Wang & Jing Chen
The purpose of this study was to explore the contribution of each factor of the phosphorus metabolism network following phosphorus diet intervention via Granger causality analysis. In this study, a total of six healthy male volunteers were enrolled. All participants sequentially received regular, low-, and high-phosphorus diets. Consumption of each diet lasted for five days, with a 5-day washout period between different diets. Blood and urinary samples were collected on the fifth day of consumption...

Predictive factors associated with disease recurrence in patients with severe intrahepatic cholestasis of pregnancy: a retrospective study of 118 cases

Ting Wang, Weixiao Zhou, Ruoan Jiang, Jianbo Lai, Peiyue Jiang, Xinning Chen & Baohua Li
To compare the clinical characteristics of pregnant women and perinatal outcomes with or without recurrent severe intrahepatic cholestasis of pregnancy (sICP), and identify possible factors associated with disease recurrence. A retrospective study of 164,603 deliveries was performed to identify pregnant women diagnosed with sICP in the previous pregnancy from January 2012 to December 2020. Eligible patients were divided into two subgroups according to the status of disease recurrence in the second pregnancy: recurrent severe ICP...

In vitro study on the effect of peucedanol on the activity of cytochrome P450 enzymes

Cun Zhang, Yongwei Li, Changlong Yin, Jie Zheng & Guozhi Liu
Peucedanol is a major extract of Peucedanum japonicum Thunb. (Apiaceae) roots, which is a commonly used herb in paediatrics. Its interaction with cytochrome P450 enzymes (CYP450s) would lead to adverse effects or even failure of therapy. The interaction between peucedanol and CYP450s was investigated. Peucedanol (0, 2.5, 5, 10, 25, 50, and 100 μM) was incubated with eight human liver CYP isoforms (CYP1A2, 2A6, 3A4, 2C8, 2C9, 2C19, 2D6, and 2E1), in pooled human liver...

Genome-wide comparison of the GRAS protein family in eight Rosaceae species and GRAS gene expression analysis in Chinese white pear (Pyrus bretschneideri Rehder)

Wenjing Chang, Manyi Sun, Mingyue Zhang, Zikai Tang, Jiawen Sheng, Yueyuan Liu, Bobo Song, Jiaming Li, Kejiao Zhao & Jun Wu
The GRAS protein family encodes a family of plant-specific transcription factors that have diverse and significant functions in regulating plant development and anthocyanin biosynthesis. Our study represents the comprehensive identification and comparison of GRAS protein family genes in the Rosaceae. Here, 535 GRAS genes were screened from eight Rosaceae species. Phylogenetic analysis revealed that whole-genome duplication (WGD) events and dispersed duplication events were the major mechanisms promoting the expansion of the GRAS protein family in...

Identification of biomarkers related to Tumor-Infiltrating Lymphocytes (TILs) infiltration with gene co-expression network in colorectal cancer

Rong Liao, Qi-Zhi Ma, Cong-Ya Zhou, Jun-Jun Li, Ning-Na Weng, Yang Yang & Qing Zhu
Colorectal cancer (CRC) is one of the most common tumors, ranking second in the global cause of death from cancer. The prognosis of advanced patients is still very poor. In this study, hub modules with the highest association with tumor-infiltrating immune cells were identified by weighted gene co-expression network analysis based on CRC expression data from the Gene Expression Omnibus database. Next, three hub genes (ADAM8, IL-1A, VAV3) related to infiltrating immune cells were identified...

Paeoniflorin reduce luxS/AI-2 system-controlled biofilm formation and virulence in Streptococcus suis

Jinpeng Li, Qingying Fan, Manyu Jin, Chenlong Mao, Hui Zhang, Xiaoling Zhang, Liyun Sun, Daniel Grenier, Li Yi, Xiaogai Hou & Yang Wang
Streptococcus suis (S. suis), more specifically serotype 2, is a bacterial pathogen that threatens the lives of pigs and humans. Like many other pathogens, S. suis exhibits quorum sensing (QS) system-controlled virulence factors, such as biofilm formation that complicates treatment. Therefore, impairing the QS involving LuxS/AI-2 cycle in S. suis, may be a promising alternative strategy for overcoming S. suis infections. In this study, we investigated paeoniflorin (PF), a monoterpenoid glycoside compound extracted from peony,...

Statistical Optimization and Bulk Scale Validation of the Effects of Cationic Pre-treatment of Cotton Fabric for Digital Printing with Reactive Dyes

Saira Faisal, Muhammad Ali, Shenela Naqvi & Long Lin
Digital printing has the potential of enabling cleaner printing or even dyeing of cotton fabrics. However, whilst effluent-free digital printing and dyeing of synthetic textile fabrics have seen some success, the same remain elusive for cotton fabrics. The study reported in this paper aimed to optimize the process parameters of cationic pre-treatment with a view to creating a cleaner cotton fabric digital printing process that could be sustainably implemented at bulk-scale production. Thus, process variables...

Z-score of some pulsed-wave Doppler indices of right pulmonary artery segments of normal fetuses in the second and third trimestries

Weida Liu, Xianchen Wang, Na Li, Mei Pan, Bei Wang, Xiaohui Peng, Ran Chen & Bowen Zhao
To establish the Z-score equation of right pulmonary artery (RPA) segments for some valuable pulse-wave Doppler parameters (PWD) and estimate their reference ranges in normal fetuses. Two hundred and seventy-three normal singleton fetuses at 18–38 weeks were enrolled in this fetal echocardiography of a prospective cross-sectional study. The proximal, middle, and distal segments of RPA of pulsed-wave Doppler parameters, such as peak systolic velocity (PSV) and pulsation index (PI) were obtained by using fetal Doppler...

Identification of a 3-gene signature based on differentially expressed invasion genes related to cancer molecular subtypes to predict the prognosis of osteosarcoma patients

Yue Wan, Ning Qu, Yang Yang, Jing Ma, Zhe Li & Zhenyu Zhang
Invasion is a critical pathway leading to tumor metastasis. This study constructed an invasion-related polygenic signature to predict osteosarcoma prognosis. We initially determined two molecular subtypes of osteosarcoma, Cluster1 (C1) and Cluster2 (C2).. A 3 invasive-gene signature was established by univariate Cox analysis and least absolute shrinkage and selection operator (LASSO) Cox regression analysis of the differentially expressed genes (DEGs) between the two subtypes, and was validated in internal and two external data sets (GSE21257...

Anti-neoplastic characteristics and potential targets of calycosin against bisphenol A-related osteosarcoma: bioinformatics analysis

Qijin Pan, Ka Wu, Jiachang Tan, Yu Li, Xiao Liang & Min Su
Environmentally, bisphenol A (BPA) is a well-known pollutant caused human health risk, including osteosarcoma (OS). OS, a deadly bone neoplasia, may occur in children and adults. However, the anti-OS pharmacotherapy prescribes limitedly in clinical practice. Interestingly, previous experimental evidences indicate calycosin-exerting potential anti-OS actions. Thus, in this report, we aimed to further characterize and detail the therapeutic targets and molecular mechanisms of calycosin-anti-BPA-related OS by using network pharmacology and molecular docking analyses. In results, the...

Metabolomics research on the effect of dexamethasone‐induced chronic stress in serum of rabbits

Hongli Liu, Bin Zhang, Lei Liu & Fuchang Li
Stress is a common factor that reduces production performance. However, the physiology of stress is not fully understood. In this study, 40-day-old rabbits were injected 1.0 mg/kg BW Dexamethasone to induce stress. A metabolomic study on serum of stress-induced rabbits was performed to research the metabolism mechanism of stress by using ultra-performance liquid chromatography coupled to mass spectrometry (UPLC–MS). Clear separations between stress rabbits and control rabbits were observed by principal component analysis (PCA) based...

Metabolomics research on the effect of dexamethasone‐induced chronic stress in serum of rabbits

Hongli Liu, Bin Zhang, Lei Liu & Fuchang Li
Stress is a common factor that reduces production performance. However, the physiology of stress is not fully understood. In this study, 40-day-old rabbits were injected 1.0 mg/kg BW Dexamethasone to induce stress. A metabolomic study on serum of stress-induced rabbits was performed to research the metabolism mechanism of stress by using ultra-performance liquid chromatography coupled to mass spectrometry (UPLC–MS). Clear separations between stress rabbits and control rabbits were observed by principal component analysis (PCA) based...

Nutritional components and protein quality analysis of genetically modified phytase maize

Yichun Hu, Liqin Linghu, Min Li, Deqian Mao, Yu Zhang, Xiaoguang Yang & Lichen Yang
The nutritional components and protein quality of genetically modified maize expressing phytase gene (GM) were analyzed and evaluated in this study. The nutritional components were analyzed by Chinese national standard methods. The ileostomy Bama miniature pigs were utilized to analyze the true digestibility of protein and amino acids. The digestible indispensable amino acid score (DIAAS) was adopted to evaluate the protein quality of GM, its parental maize (PM) and commercial available maize Zhengdan 958 (ZD)....

MeCP2-induced heterochromatin organization is driven by oligomerization-based liquid–liquid phase separation and restricted by DNA methylation

Hui Zhang, Hector Romero, Annika Schmidt, Katalina Gagova, Weihua Qin, Bianca Bertulat, Anne Lehmkuhl, Manuela Milden, Malte Eck, Tobias Meckel, Heinrich Leonhardt & M. Cristina Cardoso
Heterochromatin is the highly compacted form of chromatin with various condensation levels hallmarked by high DNA methylation. MeCP2 is mostly known as a DNA methylation reader but has also been reported as a heterochromatin organizer. Here, we combine liquid–liquid phase separation (LLPS) analysis and single-molecule tracking with quantification of local MeCP2 concentrations in vitro and in vivo to explore the mechanism of MeCP2-driven heterochromatin organization and dynamics. We show that MeCP2 alone forms liquid-like spherical...

Identification of fibronectin 1 (FN1) and complement component 3 (C3) as immune infiltration-related biomarkers for diabetic nephropathy using integrated bioinformatic analysis

Yuejun Wang, Mingming Zhao & Yu Zhang
Immune cell infiltration (ICI) plays a pivotal role in the development of diabetic nephropathy (DN). Evidence suggests that immune-related genes play an important role in the initiation of inflammation and the recruitment of immune cells. However, the underlying mechanisms and immune-related biomarkers in DN have not been elucidated. Therefore, this study aimed to explore immune-related biomarkers in DN and the underlying mechanisms using bioinformatic approaches. In this study, four DN glomerular datasets were downloaded, merged,...

Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients

Yong Xiong, Yuan Liu, Liu Cao, Dehe Wang, Ming Guo, Ao Jiang, Dong Guo, Wenjia Hu, Jiayi Yang, Zhidong Tang, Honglong Wu, Yongquan Lin, Meiyuan Zhang, Qi Zhang, Mang Shi, Yingle Liu, Yu Zhou, Ke Lan & Yu Chen
Circulating in China and 158 other countries and areas, the ongoing COVID-19 outbreak has caused devastating mortality and posed a great threat to public health. However, efforts to identify effectively supportive therapeutic drugs and treatments has been hampered by our limited understanding of host immune response for this fatal disease. To characterize the transcriptional signatures of host inflammatory response to SARS-CoV-2 (HCoV-19) infection, we carried out transcriptome sequencing of the RNAs isolated from the bronchoalveolar...

Molecular investigation of infection sources and transmission chains of brucellosis in Zhejiang, China

Heng Wang, Wei-min Xu, Kuang-ji Zhu, Su-juan Zhu, Hong-fang Zhang, Jia Wang, Yang Yang, Feng-yao Shao, Neng-ming Jiang, Zhen-yang Tao, Hang-yi Jin, Yi Tang, Liang-liang Huo, Fang Dong, Zhen-jun Li, Hua Ding & Zhi-guo Liu
In the present study, a total of 7793 samples from 5 different types of hosts were collected and tested, with a seroprevalence of 2.4% (184/7793). Although the seroprevalence of human and animal brucellosis is relatively low, numbers of human brucellosis cases reported have increased continuously from 2004 to 2018. A total of 118 Brucella strains containing 4 biotypes were obtained, including Brucella melitensis bv.1 (n = 8) and bv.3 (n = 106), Brucella abortus bv.3...

Transcriptome analysis of adipocytokines and their-related LncRNAs in lung adenocarcinoma revealing the association with prognosis, immune infiltration, and metabolic characteristics

Jie Ren, Hui Zhang, Jinna Wang, Yingsong Xu, Lei Zhao & Qihang Yuan
Lung adenocarcinoma (LUAD) is amongst the major contributors to cancer-related deaths on a global scale. Adipocytokines and long non-coding RNAs (lncRNAs) are indispensable participants in cancer. We performed a pan-cancer analysis of the mRNA expression, single nucleotide variation, copy number variation, and prognostic value of adipocytokines. LUAD samples were obtained from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) databases. Simultaneously, train, internal and external cohorts were grouped. After a stepwise screening...

Decreasing species richness and positive Rapoport effects of Crambidae (Lepidoptera) on Mount Taibai

Yufeng Zheng, Zhaofu Yang, Bolan Yang & Jinyu Zhan
The vertical gradient pattern of species richness has been studied intensively over the past decades. Among these, Rapoport's rule is one of the important hypotheses of the patterns of species richness and macroecology, asserting the latitude or altitude distributional width of animal and plant species gradually narrows from a high latitude or high altitude area to low latitude or low altitude areas. However, altitudinal distributions and Rapoport’s rule have rarely been tested for Asian Lepidopterans....

Enhancing integrated denitrifying anaerobic methane oxidation and Anammox processes for nitrogen and methane removal: A review

Yan Chen, Guangming Jiang, Muttucumaru Sivakumar & Jiangping Wu
The integration of denitrifying anaerobic methane oxidation (DAMO) and anaerobic ammonium oxidation (Anammox) simultaneously converts ammonium, methane, and oxidized nitrogen species (nitrite and nitrate) to harmless N2 and CO2. This integrated and complementary process achieves the nitrogen and carbon cycles in wastewater with the potential to be applied widely at full scale to realize energy-positive wastewater treatment plants (WWTPs). In this review, we summarize the collaborative and competitive interactions of DAMO–Anammox microorganisms and systematically evaluate...

Binary mixing of lithospheric mantle and asthenosphere beneath Tengchong volcano, SE Tibet: evidence from noble gas isotopic signatures

Kefei Chen, Huaiyu He, Finlay Stuart, Shaolin Liu, Xiwei Xu, Zhihui Cheng, Dinghui Yang, Jiyong Li, Fei Su & Wenshuai Wang
The Miocene–Quaternary Tengchong volcanic field in SE Tibet was generated after the main stage of continental collision between India and Eurasia. Consensus on the origin of Tengchong volcanism has not yet been achieved. In this study, we analysed the He-Ar isotopic compositions of olivine and pyroxene phenocrysts, whole-rock major and trace elements and Sr-Nd-Pb isotopic compositions. The 3He/4He ratios range from 4.1 to 8.2 Ra (Ra = 1.4 × 10−6), overlapping the values of mid-ocean...

Binary mixing of lithospheric mantle and asthenosphere beneath Tengchong volcano, SE Tibet: evidence from noble gas isotopic signatures

Kefei Chen, Huaiyu He, Finlay Stuart, Shaolin Liu, Xiwei Xu, Zhihui Cheng, Dinghui Yang, Jiyong Li, Fei Su & Wenshuai Wang
The Miocene–Quaternary Tengchong volcanic field in SE Tibet was generated after the main stage of continental collision between India and Eurasia. Consensus on the origin of Tengchong volcanism has not yet been achieved. In this study, we analysed the He-Ar isotopic compositions of olivine and pyroxene phenocrysts, whole-rock major and trace elements and Sr-Nd-Pb isotopic compositions. The 3He/4He ratios range from 4.1 to 8.2 Ra (Ra = 1.4 × 10−6), overlapping the values of mid-ocean...

Data from: Mycorrhizal symbiosis pathway and edaphic fertility frame root economics space among tree species

Han Yan, Grégoire T. Freschet, Huimin Wang, J. Aaron Hogan, Shenggong Li, Oscar J. Valverde-Barrantes, Xiaoli Fu, Ruili Wang, Xiaoqin Dai, Lei Jiang, Shengwang Meng, Fengting Yang, Miaomiao Zhang & Liang Kou
The root economics space (RES) is multidimensional and largely shaped by belowground biotic and abiotic influences. However, how root-fungal symbioses and edaphic fertility drive this complexity remains unclear. Here, we measured absorptive root traits of 112 tree species in temperate and subtropical forests of China, including traits linked to functional differences between arbuscular mycorrhizal (AM) and ectomycorrhizal (ECM) hosts. Our data, from known mycorrhizal tree species, revealed a ‘fungal-symbiosis’ dimension distinguishing AM from ECM species....

Long non-coding RNA PCAT1 drives clear cell renal cell carcinoma by upregulating YAP via sponging miR-656 and miR-539

Rui Wang, Bin Zheng, Hongyan Liu & Xiuxian Wan
Clear cell renal cell carcinoma (ccRCC) is the most common RCC subtype with high metastasis, poor prognosis and conventional chemotherapy resistance. Prostate cancer associated transcript 1 (PCAT1) is an important lncRNA that was reported to be involved in cell proliferation, migration and invasion of several types of cancer cells. However, its role in ccRCC is still undetermined. This study found that PCAT1 levels were elevated in ccRCC tumors as well as several ccRCC cells, and...

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