The chicken pan-genome reveals gene content variation and a promoter region deletion in IGF2BP1 affecting body size

Kejun Wang, Haifei Hu, Yadong Tian, Jingyi Li, Armin Scheben, Chenxi Zhang, Yiyi Li, Junfeng Wu, Lan Yang, Xuewei Fan, Guirong Sun, Donghua Li, Yanhua Zhang, Ruili Han, Ruirui Jiang, Hetian Huang, Fengbin Yan, Yanbin Wang, Zhuanjian Li, Guoxi Li, Xiaojun Liu, Wenting Li, David Edwards & Xiangtao Kang
Domestication and breeding have reshaped the genomic architecture of chicken, but the retention and loss of genomic elements during these evolutionary processes remain unclear. We present the first chicken pan-genome constructed using 664 individuals, which identified an additional ∼66.5 Mb sequences that are absent from the reference genome (GRCg6a). The constructed pan-genome encoded 20,491 predicated protein-coding genes, of which higher expression level are observed in conserved genes relative to dispensable genes. Presence/absence variation (PAV) analyses...

Registration Year

  • 2021
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  • Dataset
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Affiliations

  • Central Sericultural Germplasm Resources Centre
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  • Cold Spring Harbor Laboratory
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  • University of Western Australia
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  • Henan Agricultural University
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  • Brazilian College of Animal Reproduction
    1
  • Henan University of Science and Technology
    1