Data from: Functional advantages of conserved intrinsic disorder in RNA-binding proteins

Mihaly Varadi, Fruzsina Zsolyomi, Mainak Guharoy & Peter Tompa
Proteins form large macromolecular assemblies with RNA that govern essential molecular processes. RNA-binding proteins have often been associated with conformational flexibility, yet the extent and functional implications of their intrinsic disorder have never been fully assessed. Here, through large-scale analysis of comprehensive protein sequence and structure datasets we demonstrate the prevalence of intrinsic structural disorder in RNA-binding proteins and domains. We addressed their functionality through a quantitative description of the evolutionary conservation of disordered segments...

Registration Year

  • 2015

Resource Types

  • Dataset


  • Vrije Universiteit Brussel
  • Institute of Enzymology