153 Works

IL-27 overexpression alleviates inflammatory response in allergic asthma by inhibiting Th9 differentiation and regulating Th1/Th2 balance

Peng Xiong, Tonglin Liu, Hao Huang, Yi Yuan, Wendi Zhang, Lina Fu & Yu Chen
To investigate the effect of IL-27 on Th9 differentiation and Th1/Th2 balance. C57BL/6 (B6) mice were treated with ovalbumin to establish an allergic asthma (AA) model and subjected to IL-27 overexpression (OV) and empty vector (EV). Hematoxylin-eosin (HE) staining was performed to observe lung tissue inflammation. Flow cytometry was carried out to evaluate the percentage of Th9, Th1, and Th2 cells. The expression of IL-27, IL-27R, IL-9, T-bet, IFN-γ, and IgE was evaluated by quantitative...

IL-27 overexpression alleviates inflammatory response in allergic asthma by inhibiting Th9 differentiation and regulating Th1/Th2 balance

Peng Xiong, Tonglin Liu, Hao Huang, Yi Yuan, Wendi Zhang, Lina Fu & Yu Chen
To investigate the effect of IL-27 on Th9 differentiation and Th1/Th2 balance. C57BL/6 (B6) mice were treated with ovalbumin to establish an allergic asthma (AA) model and subjected to IL-27 overexpression (OV) and empty vector (EV). Hematoxylin-eosin (HE) staining was performed to observe lung tissue inflammation. Flow cytometry was carried out to evaluate the percentage of Th9, Th1, and Th2 cells. The expression of IL-27, IL-27R, IL-9, T-bet, IFN-γ, and IgE was evaluated by quantitative...

Pharmacological characterization of the α2A-adrenergic receptor inhibiting rat hippocampal CA3 epileptiform activity: comparison of ligand efficacy and potency

Joseph P. Biggane, Ke Xu, Brianna L. Goldenstein, Kylie L. Davis, Elizabeth J. Luger, Bethany A. Davis, Chris W.D. Jurgens, Dianne M. Perez, James E. Porter & Van A. Doze
The mechanism underlying the antiepileptic actions of norepinephrine (NE) is unclear with conflicting results. Our objectives are to conclusively delineate the specific adrenergic receptor (AR) involved in attenuating hippocampal CA3 epileptiform activity and assess compounds for lead drug development. We utilized the picrotoxin model of seizure generation in rat brain slices using electrophysiological recordings. Epinephrine (EPI) reduced epileptiform burst frequency in a concentration-dependent manner. To identify the specific receptor involved in this response, the equilibrium...

Comparative transcriptomic analysis of rabbit interscapular brown adipose tissue whitening under physiological conditions

Lei Li, Qian Wan, Qiaoyun Long, Tao Nie, Shiting Zhao, Liufeng Mao, Chuanli Cheng, Chao Zuo, Kerry Loomes, Aimin Xu, Liangxue Lai, Xin Liu, Ziyuan Duan, Xiaoyan Hui & Donghai Wu
Interscapular brown adipose tissue (iBAT) of both rabbits and humans exhibits a similar whitening phenomenon under physiological conditions. However, the detailed characterization of iBAT whitening in them is still lacking. Here, we chose rabbits as a model to gain a better understanding of the molecular signature changes during the whitening process of iBAT by transcriptomic analysis of rabbit iBAT at day 1, day 14, 1 month and 4 months after birth. We applied non-invasive MRI...

Additional file 4 of Oxidative stress genes in patients with esophageal squamous cell carcinoma: construction of a novel prognostic signature and characterization of tumor microenvironment infiltration

Wei Liu, Hao-Shuai Yang, Shao-Yi Zheng, Hong-He Luo, Yan-Fen Feng & Yi-Yan Lei
Additional file 4: Table S3. The results of univariate Cox proportional hazards regression analyses between clinical features and risk score in the training, testing, and entire sets.

Additional file 5 of Oxidative stress genes in patients with esophageal squamous cell carcinoma: construction of a novel prognostic signature and characterization of tumor microenvironment infiltration

Wei Liu, Hao-Shuai Yang, Shao-Yi Zheng, Hong-He Luo, Yan-Fen Feng & Yi-Yan Lei
Additional file 5: Table S4. The results of univariate Cox proportional hazards regression analyses between clinical features and risk score in the training, testing, and entire sets.

A new technique for Asian nasal tip shaping: \"twin tower\" folding ear cartilage transplantation

Long Zhang, Jiang-wen Wang, Jun Ding, Xi Zhang, Xi-mei Wang, Zhan-zhao Zhang & Run-ze Yu
Rhinoplasty focuses on the establishment of the structural support of nasal cartilage and the shaping of the nasal tip. The purpose of this study was to explore the application of "double tower" folding ear cartilage transplantation for nasal tip shaping in rhinoplasty.

Novel mycoplasma nucleomodulin MbovP475 decreased cell viability by regulating expression of CRYAB and MCF2L2

Gang Zhao, Doukun Lu, Shujuan Wang, Hui Zhang, Xifang Zhu, Zhiyu Hao, Ali Dawood, Yingyu Chen, Elise Schieck, Changmin Hu, Xi Chen, Liguo Yang & Aizhen Guo
Nucleomodulins are secreted bacterial proteins whose molecular targets are located in host cell nuclei. They are gaining attention as critical virulence factors that either modify the epigenetics of host cells or directly regulate host gene expression. Mycoplasma bovis is a major veterinary pathogen that secretes several potential virulence factors. The aim of this study was to determine whether any of their secreted proteins might function as nucleomodulins. After an initial in silico screening, the nuclear...

Additional file 1 of Identification of HMGB2 associated with proliferation, invasion and prognosis in lung adenocarcinoma via weighted gene co-expression network analysis

Xie Qiu, Wei Liu, Yifan Zheng, Kai Zeng, Hao Wang, Haijun Sun & Jianhua Dai
Additional file 1: Table S1. Clinical informations and IHC score of patients with LUAD.

Additional file 4 of The H2A.Z-KDM1A complex promotes tumorigenesis by localizing in the nucleus to promote SFRP1 promoter methylation in cholangiocarcinoma cells

Qi Wang, Yongqiang Qi, Fei Xiong, Da Wang, Bing Wang & Yongjun Chen
Additional file 4: Table S1. Detailed information of the microarray used in this study.

chroma distribution map to the A1B3C3D2 structure

Ke Xu
This document describes the chromaticity coordinates of each point in A1B3C3D2 structure chromaticity distribution diagram

Variation curves of illumination uniformityand color mixing uniformity with impact factor E

Ke Xu
This document describes the basic drawing data of Figure 5

Additional file 1 of Glycoproteomics revealed novel N-glycosylation biomarkers for early diagnosis of lung adenocarcinoma cancers

Kai Fang, Qin Long, Zhonghua Liao, Chaoyu Zhang & Zhiqiang Jiang
Additional file 1: Table S1. MS identified information in this study.

Additional file 2 of Analysis of risk factors related to extremely and very preterm birth: a retrospective study

Xiaohong Ji, Chengqian Wu, Min Chen, Lili Wu, Ting Li, Zhijing Miao, Yan Lv & Hongjuan Ding
Supplementary Material 2

Transfer learning of individualized treatment rules from experimental to real-world data

Lili Wu & Shu Yang
Individualized treatment effect lies at the heart of precision medicine. Interpretable individualized treatment rules (ITRs) are desirable for clinicians or policymakers due to their intuitive appeal and transparency. The gold-standard approach to estimating the ITRs is randomized experiments, where subjects are randomized to different treatment groups and the confounding bias is minimized to the extent possible. However, experimental studies are limited in external validity because of their selection restrictions, and therefore the underlying study population...

Additional file 1 of Strategies to enhance CAR-T persistence

Yue Liu, Lingna An, Ruihao Huang, Jingkang Xiong, Haoyu Yang, Xiaoqi Wang & Xi Zhang
Additional file 1: Table S1. CRISPR system-based screenings for CAR-T cell optimization.

Additional file 1 of Strategies to enhance CAR-T persistence

Yue Liu, Lingna An, Ruihao Huang, Jingkang Xiong, Haoyu Yang, Xiaoqi Wang & Xi Zhang
Additional file 1: Table S1. CRISPR system-based screenings for CAR-T cell optimization.

Additional file 1 of Gray matter reduction in bilateral insula mediating adverse psychiatric effects of body mass index in schizophrenia

Hui Wu, Guochao Dai, Muyeseer Aizezi, Juan Tang, Ke Zou, Yuhua Wu & Xiaoli Wu
Additional file 1: Fig. S1. Partial correlation analysis between BMI and bilateral insula in SZ group, controlling for sex, age and education. Fig. S2. Partial correction analysis between negative symptom and bilateral insula in SZ group, controlling for sex, age and education. Fig. S3. Results of bilateral insula in the whole-brain VBM analyses. Red indicates the bilateral insula in the main effects of diagnosis (SZ

Additional file 1 of Construction of an SNP fingerprinting database and population genetic analysis of 329 cauliflower cultivars

Yuyao Yang, Mingjie Lyu, Jun Liu, Jianjin Wu, Qian Wang, Tianyu Xie, Haichao Li, Rui Chen, Deling Sun, Yingxia Yang & Xingwei Yao
Additional file 1.

Additional file 1 of Construction of an SNP fingerprinting database and population genetic analysis of 329 cauliflower cultivars

Yuyao Yang, Mingjie Lyu, Jun Liu, Jianjin Wu, Qian Wang, Tianyu Xie, Haichao Li, Rui Chen, Deling Sun, Yingxia Yang & Xingwei Yao
Additional file 1.

Additional file 7 of Evolution patterns of NBS genes in the genus Dendrobium and NBS-LRR gene expression in D. officinale by salicylic acid treatment

Jiapeng Yang, Caijun Xiong, Siyuan Li, Cheng Zhou, Lingli Li, Qingyun Xue, Wei Liu, Zhitao Niu & Xiaoyu Ding
Additional file 7.

Transfer Learning of Individualized Treatment Rules from Experimental to Real-World Data

Lili Wu & Shu Yang
Individualized treatment effect lies at the heart of precision medicine. Interpretable individualized treatment rules (ITRs) are desirable for clinicians or policymakers due to their intuitive appeal and transparency. The gold-standard approach to estimating the ITRs is randomized experiments, where subjects are randomized to different treatment groups and the confounding bias is minimized to the extent possible. However, experimental studies are limited in external validity because of their selection restrictions, and therefore the underlying study population...

Additional file 4 of Combining QTL mapping and RNA-Seq Unravels candidate genes for Alfalfa (Medicago sativa L.) leaf development

Xueqian Jiang, Xijiang Yang, Fan Zhang, Tianhui Yang, Changfu Yang, Fei He, Ting Gao, Chuan Wang, Qingchuan Yang, Zhen Wang & Junmei Kang
Additional file 4: Table S2. List of 2,443 leaf-specific genes.

Additional file 3 of Combining QTL mapping and RNA-Seq Unravels candidate genes for Alfalfa (Medicago sativa L.) leaf development

Xueqian Jiang, Xijiang Yang, Fan Zhang, Tianhui Yang, Changfu Yang, Fei He, Ting Gao, Chuan Wang, Qingchuan Yang, Zhen Wang & Junmei Kang
Additional file 3: Table S1 Analysis of variance for LL, LW and LA in an F1 population using mixed model for two years in two locations (CP and LF)

Modeling and Regionalization of China’s PM2.5 Using Spatial-Functional Mixture Models

Decai Liang, Haozhe Zhang, Xiaohui Chang & Hui Huang
Abstract–Severe air pollution affects billions of people around the world, particularly in developing countries such as China. Effective emission control policies rely primarily on a proper assessment of air pollutants and accurate spatial clustering outcomes. Unfortunately, emission patterns are difficult to observe as they are highly confounded by many meteorological and geographical factors. In this study, we propose a novel approach for modeling and clustering PM2.5concentrations across China. We model observed concentrations from monitoring stations...

Registration Year

  • 2022
    153

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Affiliations

  • Shanghai University
    153
  • Chinese Academy of Medical Sciences & Peking Union Medical College
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  • Fudan University
    93
  • Peking University First Hospital
    80
  • Shanghai University of Traditional Chinese Medicine
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  • Sichuan University
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  • Capital Medical University
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  • University of Chinese Academy of Sciences
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  • Shanghai Jiao Tong University
    71
  • Wuhan University
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