Additional file 3 of SIRPα antibody combined with oncolytic virus OH2 protects against tumours by activating innate immunity and reprogramming the tumour immune microenvironmentDefeng Kong, Zhenrong Yang, Guoliang Li, Quanyou Wu, Zhaoru Gu, Duo Wan, Qi Zhang, Xiaoli Zhang, Shujun Cheng, Binlei Liu, Kaitai Zhang & Wen Zhang
Additional file 3: Figure S1. Cell proliferation assay results. Cell proliferation assay results of Raw264.7 cell lines treated with OH2 MOI=1 (red), OH2 MOI=0.5 (blue) and untreated (black) group by CCK8 assay in 72 hours. Figure S2. OH2 lysates induce RAW264.7 polarization and phagocytosis in vitro. A. Demonstration of the analysis of the phagocytosis by flow cytometry. B. Cell proliferation assay results of CT26, MC38 and 4T-1 cell lines treated with lysate (red), CFS (blue),...
Change trend of side length of lighting area with impact factorsKe Xu
This document describes the basic drawing data of Figure 6
Repair mechanism of Wuwei Fuzheng Yijing formula in di-2-ethylhexyl phthalate-induced sperm DNA fragmentation in miceChenming Zhang, Shiqi Wang, Zulong Wang, Qi Zhang, Rubing Chen, Hao Zhang, Zhong Hua & Sicheng Ma
Di-2-ethylhexyl phthalate (DEHP), a known persistent organic pollutant, can increase the sperm DNA fragmentation index (DFI). To investigate the mechanism underlying the repair of DEHP-induced sperm DNA damage in mice by Wuwei Fuzheng Yijing (WFY) formula. The potential targets of WFY and sperm DNA fragment (SDF) were obtained from the TCMSP, BATMAN-TCM, OMIM and GeneCards. The protein–protein interaction (PPI) network, GO and KEGG pathway analyses of WFY-SDF were constructed. An animal model of DEHP-induced sperm...
The role of Populus MYB94 transcription factor in seed germination requires the expression of ABA-responsive genesHaiyang Wang, Hui Huang & Qing Fang
Plant seed germination is easily influenced by endogenous gene expression, hormones and environmental conditions. Here, we investigated a Populus R2R3-MYB transcription factor (referred to as MYB94) that plays a role in seed germination in close relation to the hormone abscisic acid (ABA). Two independent Arabidopsis transgenic lines overexpressing MYB94 (Oe-lines) and wild-type (Wt) were no clear differences in the seed germination rates under normal conditions, but the germination rates of the two Oe-lines were both...
ATG7-mediated autophagy facilitates embryonic stem cell exit from naive pluripotency and marks commitment to differentiationJilong Zhou, Hainan He, Jing-Jing Zhang, Xin Liu, Wang Yao, Chengyu Li, Tian Xu, Shu-Yuan Yin, Dan-Ya Wu, Cheng-Li Dou, Qiao Li, Jiani Xiang, Wen-Jing Xiong, Li-Yan Wang, Jun-Ming Tang, Zhouyiyuan Xue, Xia Zhang & Yi-Liang Miao
Macroautophagy/autophagy is a conserved cellular mechanism to degrade unneeded cytoplasmic proteins and organelles to recycle their components, and it is critical for embryonic stem cell (ESC) self-renewal and somatic cell reprogramming. Whereas autophagy is essential for early development of embryos, no information exists regarding its functions during the transition from naive-to-primed pluripotency. Here, by using an in vitro transition model of ESCs to epiblast-like cells (EpiLCs), we find that dynamic changes in ATG7-dependent autophagy are...
Early activity of the Kerguelen Mantle plume: geochronology, geochemistry and Sr-Nd-Pb isotopes of mafic dykes and sills from the Tethyan HimalayaZhen Wang, Yuruo Shi, Tianshui Yang, J. Lawford Anderson, Jianxin Zhao, Wenxiao Peng, Chenyang Hou, Huiyi Sun, Weiwei Bian & Yiming Ma
The remnant Comei igneous province in SE Tibet has been recognized as a product of early Kerguelen mantle plume activity. In this paper, we investigate mafic dykes and sills intruded into Lakang Formation in the southeastern Tethyan Himalaya. Based on new whole-rock geochemical, Sr-Nd-Pb isotopic and SHRIMP zircon U-Pb geochronological data, these rocks can be divided into three groups. Group 1 is composed of OIB-like mafic dykes and sills with lower εNd(t) (+1.78-+2.55) and dated...
How does the selection of National Development Zones affect urban green innovation?Xiaolin Yu & Kai Wan
The launch of the selection process for National Development Zones (NDZs) marked a fundamental change in the construction of development zones, making it an essential position for local authorities to implement high-quality development. Based on the data of prefecture-level cities in China from 2000 to 2018, this paper examines the impact and mechanism of selecting NDZs on urban green innovation through a double-difference spatial durbin model using the selection of NDZs as a “quasi-natural experiment”....
Additional file 5 of Oxidative stress genes in patients with esophageal squamous cell carcinoma: construction of a novel prognostic signature and characterization of tumor microenvironment infiltrationWei Liu, Hao-Shuai Yang, Shao-Yi Zheng, Hong-He Luo, Yan-Fen Feng & Yi-Yan Lei
Additional file 5: Table S4. The results of univariate Cox proportional hazards regression analyses between clinical features and risk score in the training, testing, and entire sets.
Additional file 4 of Combining QTL mapping and RNA-Seq Unravels candidate genes for Alfalfa (Medicago sativa L.) leaf developmentXueqian Jiang, Xijiang Yang, Fan Zhang, Tianhui Yang, Changfu Yang, Fei He, Ting Gao, Chuan Wang, Qingchuan Yang, Zhen Wang & Junmei Kang
Additional file 4: Table S2. List of 2,443 leaf-specific genes.
Additional file 5 of Combining QTL mapping and RNA-Seq Unravels candidate genes for Alfalfa (Medicago sativa L.) leaf developmentXueqian Jiang, Xijiang Yang, Fan Zhang, Tianhui Yang, Changfu Yang, Fei He, Ting Gao, Chuan Wang, Qingchuan Yang, Zhen Wang & Junmei Kang
Additional file 5: Table S3. List of 2,061 up-regulated genes (‘sativa’ Vs ‘falcata’).
Additional file 3 of Comprehensive analysis of alternative polyadenylation regulators concerning CD276 and immune infiltration in bladder cancerMing Xiong, Wencheng Li, Longwang Wang, Liang Chen, Zhaohui Chen, Chengcheng Wei, Futian Zhang, Jiawei Chen, Gallina Kazobinka, Jun Zhao & Teng Hou
Additional file 3: Supplementary Table 2. Correlation statistics between CPSF3 and immune checkpoint-related genes.
Additional file 1 of Gray matter reduction in bilateral insula mediating adverse psychiatric effects of body mass index in schizophreniaHui Wu, Guochao Dai, Muyeseer Aizezi, Juan Tang, Ke Zou, Yuhua Wu & Xiaoli Wu
Additional file 1: Fig. S1. Partial correlation analysis between BMI and bilateral insula in SZ group, controlling for sex, age and education. Fig. S2. Partial correction analysis between negative symptom and bilateral insula in SZ group, controlling for sex, age and education. Fig. S3. Results of bilateral insula in the whole-brain VBM analyses. Red indicates the bilateral insula in the main effects of diagnosis (SZ
Additional file 1 of SIRPα antibody combined with oncolytic virus OH2 protects against tumours by activating innate immunity and reprogramming the tumour immune microenvironmentDefeng Kong, Zhenrong Yang, Guoliang Li, Quanyou Wu, Zhaoru Gu, Duo Wan, Qi Zhang, Xiaoli Zhang, Shujun Cheng, Binlei Liu, Kaitai Zhang & Wen Zhang
Additional file 1: Table S1. Gene lis for heatmap.
S/N value of illuminance uniformityKe Xu
This document describes the basic drawing data of Figure 3 (a)
illuminance distribution map to the A1B3C3D2E1 structureKe Xu
This document describes the data of each point in the A1B3C3D2E1 structure irradiance distribution map
Novel mycoplasma nucleomodulin MbovP475 decreased cell viability by regulating expression of CRYAB and MCF2L2Gang Zhao, Doukun Lu, Shujuan Wang, Hui Zhang, Xifang Zhu, Zhiyu Hao, Ali Dawood, Yingyu Chen, Elise Schieck, Changmin Hu, Xi Chen, Liguo Yang & Aizhen Guo
Nucleomodulins are secreted bacterial proteins whose molecular targets are located in host cell nuclei. They are gaining attention as critical virulence factors that either modify the epigenetics of host cells or directly regulate host gene expression. Mycoplasma bovis is a major veterinary pathogen that secretes several potential virulence factors. The aim of this study was to determine whether any of their secreted proteins might function as nucleomodulins. After an initial in silico screening, the nuclear...
Additional file 7 of Evolution patterns of NBS genes in the genus Dendrobium and NBS-LRR gene expression in D. officinale by salicylic acid treatmentJiapeng Yang, Caijun Xiong, Siyuan Li, Cheng Zhou, Lingli Li, Qingyun Xue, Wei Liu, Zhitao Niu & Xiaoyu Ding
Additional file 7.
Additional file 8 of Evolution patterns of NBS genes in the genus Dendrobium and NBS-LRR gene expression in D. officinale by salicylic acid treatmentJiapeng Yang, Caijun Xiong, Siyuan Li, Cheng Zhou, Lingli Li, Qingyun Xue, Wei Liu, Zhitao Niu & Xiaoyu Ding
Additional file 8.
Additional file 1 of Analysis of risk factors related to extremely and very preterm birth: a retrospective studyXiaohong Ji, Chengqian Wu, Min Chen, Lili Wu, Ting Li, Zhijing Miao, Yan Lv & Hongjuan Ding
Supplementary Material 1
Additional file 1 of Hydrogen gas alleviates lipopolysaccharide-induced acute lung injury and inflammatory response in miceHongling Yin, Yajing Feng, Yi Duan, Shaolin Ma, Zhongliang Guo & Youzhen Wei
Additional file 1.
Additional file 11 of Evolution patterns of NBS genes in the genus Dendrobium and NBS-LRR gene expression in D. officinale by salicylic acid treatmentJiapeng Yang, Caijun Xiong, Siyuan Li, Cheng Zhou, Lingli Li, Qingyun Xue, Wei Liu, Zhitao Niu & Xiaoyu Ding
Additional file 11.
Additional file 4 of Evolution patterns of NBS genes in the genus Dendrobium and NBS-LRR gene expression in D. officinale by salicylic acid treatmentJiapeng Yang, Caijun Xiong, Siyuan Li, Cheng Zhou, Lingli Li, Qingyun Xue, Wei Liu, Zhitao Niu & Xiaoyu Ding
Additional file 4.
Additional file 1 of Prognostic risk assessment model and drug sensitivity analysis of colon adenocarcinoma (COAD) based on immune-related lncRNA pairsZezhou Hao, Pengchen Liang, Changyu He, Shuang Sha, Ziyuan Yang, Yixin Liu, Junfeng Shi, Zhenggang Zhu & Qing Chang
Additional file 1. 1229 lncRNAs screens associated with immune genes.
Epidemiological characteristics and molecular features of carbapenem-resistant Enterobacter strains in China: a multicenter genomic studyZhichen Zhu, Xiaofang Xie, Hua Yu, Wei Jia, Bin Shan, Bin Huang, Fen Qu, Siqiang Niu, Jinnan Lv, Qizhao Gao, Feinan Qian, Xiangxiang Tian, Yaxuan Zhai, Yicheng Wen, Chengcheng Yang, Jie Zhu, Yiwei Tang, Liang Chen & Hong Du
Epidemiological characteristics and molecular features of carbapenem-resistant Enterobacter (CR-Ent) species remain unclear in China. In this study, we performed a genomic study on 92 isolates from Enterobacter-caused infections from a multicenter study in China. Whole genome sequencing (WGS) was used to determine the genome sequence of 92 non-duplicated CR-Ent strains collected from multiple tertiary health centres. The precise species of Enterobacter strains were identified by average nucleotide identity (ANI) and in silico DNA–DNA hybridization (isDDH)....
Genome-wide identification of genes critical for in vivo fitness of multi-drug resistant porcine extraintestinal pathogenic Escherichia coli by transposon-directed insertion site sequencing using a mouse infection modelFan Yin, Yan Hu, Zixuan Bu, Yuying Liu, Hui Zhang, Yawen Hu, Ying Xue, Shaowen Li, Chen Tan, Xiabing Chen, Lu Li, Rui Zhou & Qi Huang
Extraintestinal pathogenic Escherichia coli (ExPEC) is an important zoonotic pathogen. Recently, ExPEC has been reported to be an emerging problem in pig farming. However, the mechanism of pathogenicity of porcine ExPEC remains to be revealed. In this study, we constructed a transposon (Tn) mutagenesis library covering Tn insertion in over 72% of the chromosome-encoded genes of a virulent and multi-drug resistant porcine ExPEC strain PCN033. By using a mouse infection model, a transposon-directed insertion site...
Chinese Academy of Medical Sciences & Peking Union Medical College111
Peking University First Hospital82
Shanghai University of Traditional Chinese Medicine80
Capital Medical University76
University of Chinese Academy of Sciences76
Shanghai Jiao Tong University73