3 Works

Data from: The kinetochore prevents centromere-proximal crossover recombination during meiosis

Nadine Vincenten, Lisa-Marie Kuhl, Isabel Lam, Ashwini Oke, Alastair R. W. Kerr, Andreas Hochwagen, Jennifer C. Fung, Scott Keeney, Gerben Vader & Adèle L. Marston
During meiosis, crossover recombination is essential to link homologous chromosomes and drive 22 faithful chromosome segregation. Crossover recombination is non-random across the genome, 23 and centromere-proximal crossovers are associated with an increased risk of aneuploidy, 24 including Trisomy 21 in humans. Here, we identify the conserved Ctf19/CCAN kinetochore sub- 25 complex as a major factor that minimizes potentially deleterious centromere-proximal crossovers 26 in budding yeast. We uncover multi-layered suppression of pericentromeric recombination by the 27...

Data from: Genome-wide errant targeting by Hairy

Kurtulus Kok, Ahmet Ay, Li M. Li & David N. Arnosti
Metazoan transcriptional repressors regulate chromatin through diverse histone modifications. Contributions of individual factors to the chromatin landscape in development is difficult to establish, as global surveys reflect multiple changes in regulators. Therefore, we studied the conserved Hairy/Enhancer of Split family repressor Hairy, analyzing histone marks and gene expression in Drosophila embryos. This long-range repressor mediates histone acetylation and methylation in large blocks, with highly context-specific effects on target genes. Most strikingly, Hairy exhibits biochemical activity...

Data from: Genetic architecture and functional characterization of genes underlying the rapid diversification of male external genitalia between Drosophila simulans and Drosophila mauritiana

Kentaro M. Tanaka, Corinna Hopfen, Matthew R. Herbert, Christian Schlötterer, David L. Stern, John P. Masly, Alistair P. McGregor & Maria D. S. Nunes
Male sexual characters are often among the first traits to diverge between closely related species and identifying the genetic basis of such changes can contribute to our understanding of their evolutionary history. However, little is known about the genetic architecture or the specific genes underlying the evolution of male genitalia. The morphology of the claspers, posterior lobes and anal plates exhibit striking differences between Drosophila mauritiana and Drosophila simulans. Using QTL and introgression-based high-resolution mapping,...

Registration Year

  • 2015
    3

Resource Types

  • Dataset
    3

Affiliations

  • Howard Hughes Medical Institute
    3
  • New York University
    1
  • University of Edinburgh
    1
  • Wellcome Trust
    1
  • University of Oklahoma
    1
  • Max Planck Institute of Molecular Physiology
    1
  • Oxford Brookes University
    1
  • Colgate University
    1
  • Michigan State University
    1
  • Medical University of Vienna
    1