5 Works

Data from: A genetic signature of the evolution of loss of flight in the Galapagos cormorant

Alejandro Burga, Wang Weiguang, Eyal Ben-David, Paul C. Wolf, Andrew M. Ramey, Claudio Verdugo, Karen Lyons, Patricia G. Parker & Leonid Kruglyak
We have a limited understanding of the genetic and molecular basis of evolutionary changes in the size and proportion of limbs. We studied wing and pectoral skeleton reduction leading to flightlessness in the Galapagos cormorant (Phalacrocorax harrisi). We sequenced and de novo assembled the genomes of four cormorant species and applied a predictive and comparative genomics approach to find candidate variants that may have contributed to the evolution of flightlessness. These analyses and cross-species experiments...

Data from: Nuclear microenvironments modulate transcription from low-affinity enhancers

Albert Tsai, Anand K. Muthusamy, Mariana R. P. Alves, Luke D. Lavis, Robert H. Singer, David L. Stern, Justin Crocker & Mariana RP Alves
Transcription factors bind low-affinity DNA sequences for only short durations. It is not clear how brief, low-affinity interactions can drive efficient transcription. Here we report that the transcription factor Ultrabithorax (Ubx) utilizes low-affinity binding sites in the Drosophila melanogaster shavenbaby (svb) locus and related enhancers in nuclear microenvironments of high Ubx concentrations. Related enhancers colocalize to the same microenvironments independently of their chromosomal location, suggesting that microenvironments are highly differentiated transcription domains. Manipulating the affinity...

Data from: Synchronized excitability in a network enables generation of internal neuronal sequences

Yingxue Wang, Zachary Roth & Eva Pastalkova
Hippocampal place field sequences are supported by sensory cues and network internal mechanisms. In contrast, sharp-wave (SPW) sequences, theta sequences, and episode field sequences are internally generated. The relationship of these sequences to memory is unclear. SPW sequences have been shown to support learning and have been assumed to also support episodic memory. Conversely, we demonstrate these SPW sequences were present in trained rats even after episodic memory was impaired and after other internal sequences...

Data from: Pioneer cells established by the [SWI+] prion can promote dispersal and out-crossing in yeast

Gregory A. Newby & Susan Lindquist
To thrive in an ever-changing environment, microbes must widely distribute their progeny to colonize new territory. Simultaneously, they must evolve and adapt to the stresses of unpredictable surroundings. In both of these regards, diversity is key—if an entire population moved together or responded to the environment in the same way, it could easily go extinct. Here, we show that the epigenetic prion switch [SWI+] establishes a specialized subpopulation with a “pioneer” phenotypic program in Saccharomyces...

Data from: Experimental and statistical reevaluation provides no evidence for Drosophila courtship song rhythms

David L. Stern, Jan Clemens, Philip Coen, Adam J. Calhoun, John B. Hogenesch, Ben J. Arthur & Mala Murthy
From 1980 to 1992, a series of influential papers reported on the discovery, genetics, and evolution of a periodic cycling of the interval between Drosophila male courtship song pulses. The molecular mechanisms underlying this periodicity were never described. To reinitiate investigation of this phenomenon, we previously performed automated segmentation of songs but failed to detect the proposed rhythm [Arthur BJ, et al. (2013) BMC Biol 11:11; Stern DL (2014) BMC Biol 12:38]. Kyriacou et al....

Registration Year

  • 2017
    5

Resource Types

  • Dataset
    5

Affiliations

  • Howard Hughes Medical Institute
    5
  • Princeton University
    1
  • European Molecular Biology Laboratory
    1
  • Cincinnati Children's Hospital Medical Center
    1
  • University Austral de Chile
    1
  • University College London
    1
  • United States Geological Survey
    1
  • University of Missouri–St. Louis
    1
  • Orthopaedic Institute for Children
    1
  • Massachusetts Institute of Technology
    1