Poststroke depression (PSD) is a common complication that seriously affects the functional recovery and prognosis of an individual. As some patients with PSD fail to respond to drug therapy, it is urgent to find a viable alternative treatment. An active exercise program known as foraging exercise (FE), using food as bait, was designed. First, focal ischemia and chronic unpredictable mild stress (CUMS) were used to establish a PSD model in rats. FE was then performed...

The remnant Comei igneous province in SE Tibet has been recognized as a product of early Kerguelen mantle plume activity. In this paper, we investigate mafic dykes and sills intruded into Lakang Formation in the southeastern Tethyan Himalaya. Based on new whole-rock geochemical, Sr-Nd-Pb isotopic and SHRIMP zircon U-Pb geochronological data, these rocks can be divided into three groups. Group 1 is composed of OIB-like mafic dykes and sills with lower εNd(t) (+1.78-+2.55) and dated...

Liver injury from any number of causes (e.g. chemical material, drugs and diet, viral infection) is a global health problem, and its mechanism is not clearly understood. MicroRNAs (miRNAs) expression profiling is gaining popularity because miRNAs, as key regulators in gene expression networks, can influence many biological processes and have also shown promise as biomarkers for disease. Previous studies reported the regulation effects of miRNAs in liver injury, whereas function and molecular mechanisms of miR-322-5p...

High-grade serous ovarian cancer (HGSOC) is the most common and malignant type of ovarian cancer, accounting for 70%–80% of mortality. However, the treatment of HGSOC has improved little in the past few decades. Metformin is the first-line medication for the treatment of type 2 diabetes and has now gained more attention in cancer treatment. In this study, we sought to identify potential hub genes that metformin could target in the treatment of HGSOC. We downloaded...

Additional file 1. Table S1: 811 genes of a genetic skeletal disease panel; Table S2: Primer sequence in this study; Table S3: Summary of clinical information and molecular results for 55 cases with skeletal abnormalities.

Additional file 13: Table S10: Two-way ANOVA test F-value of genes expression levels related to salicylic acid biosynthesis and signaling transduction for three C. sinensis cultivars (BY1, HJY and SCZ) affected by development stage (S) and cultivar (C).

Additional file 8: Table S5: Two-way ANOVA test F-value of expression levels of the genes related to flowering time and flower development for three C. sinensis cultivars (BY1, HJY and SCZ) affected by development stage (S) and cultivar (C).

Additional file 9: Table S6: Two-way ANOVA test F-value of genes expression levels related to auxin biosynthesis and signaling transduction for three C. sinensis cultivars (BY1, HJY and SCZ) affected by development stage (S) and cultivar (C).

Additional file 1.

Additional file 4.

Additional file 1: Table S1. Clinicopathological information of 53 pGI-DLBCL patients.

Additional file 1: Table S1. Clinicopathological information of 53 pGI-DLBCL patients.

Additional file 5: Table S5. Summary of IGLL5 and LRP1B mutations in pGI-DLBCL.

Additional file 1: Table S1. Gene lis for heatmap.

Gut microbiota composition in patients with advanced malignancies with anti-PD-1 therapy by 16s rDNA sequencing

Supplementary Material 12

This document describes the basic drawing data of Figure 3 (a)

This document describes the data of each point in the A1B3C3D2E1 structure irradiance distribution map

The data include volcanic aerosol forcing over different ocean and land regions, and monthly precipitation, sea surface temperature, sea surface height, and 850hPa zonal wind.

Plastic take-out food containers may release microplastics (MPs) into food and pose a potential risk to food safety and human health. Here, after being subjected to hot water treatment, MPs released from three types of plastic food containers (polypropylene, PP; polyethylene, PE; expanded polystyrene, EPS) were identified by micro-Raman spectroscopy. The results showed that the size of released MPs ranged from 0.8–38 μm and over 96% MPs were smaller than 10 μm. Various MPs concentrations...

Additional file 10: Table S7. Mutation site information screened by whole genome sequencing.

Additional file 6: Table S3. Primers for authenticity verification of mutant individuals.

Additional file 7: Table S4. Grain type datas.

Additional file 4. Table S4: ID and protein sequences of 60 CNXs family members in cotton.

Additional file 4. Table S4: ID and protein sequences of 60 CNXs family members in cotton.