33 Works

Data from: Revisiting protein aggregation as pathogenic in sporadic Parkinson’s and Alzheimer’s diseases

Alberto J. Espay, Joaquin A. Vizcarra, Luca Marsili, Anthony E. Lang, David K. Simon, Aristide Merola, Keith A. Josephs, Alfonso Fasano, Francesca Morgante, Rodolfo Savica, J. Timothy Greenamyre, Franca Cambi, Tritia R. Yamasaki, Caroline M. Tanner, Ziv Gan-Or, Irene Litvan, Ignacio F. Mata, Cyrus P. Zabetian, Patrik Brundin, Hubert H. Fernandez, David G. Standaert, Marcelo A. Kauffman, Michael A. Schwarzschild, S. Pablo Sardi, Todd Sherer … & James B. Leverenz
The gold standard for a definitive diagnosis of Parkinson’s disease (PD) is the pathologic finding of aggregated alpha-synuclein into Lewy bodies and for Alzheimer’s disease (AD) aggregated amyloid into plaques and hyperphosphorylated tau into tangles. Implicit in this clinico-pathologic-based nosology is the assumption that pathological protein aggregation at autopsy reflect pathogenesis at disease onset. While these aggregates may in exceptional cases be on a causal pathway in humans (e.g., aggregated alpha-synuclein in SNCA gene multiplication...

Data from: Implications of dimeric activation of PDE6 for rod phototransduction

Trevor D. Lamb, Martin Heck & Timothy W. Kraft
We examine the implications of a recent report providing evidence that two transducins must bind to the rod phosphodiesterase to elicit significant hydrolytic activity. To predict the rod photoreceptor's electrical response, we use numerical simulation of the two-dimensional diffusional contact of interacting molecules at the surface of the disc membrane, and then we use the simulated PDE activity as the driving function for the downstream reaction cascade. The results account for a number of aspects...

Data from: Female investment in offspring size and number shifts seasonally in a lizard with single-egg clutches

Timothy S. Mitchell, Joshua M. Hall & Daniel A. Warner
The timing of reproduction strongly influences reproductive success in many organisms. For species with extended reproductive seasons, the quality of the environment may change throughout the season in ways that impact offspring survival, and, accordingly, aspects of reproductive strategies may shift to maximize fitness. Life-history theory predicts that if offspring environments deteriorate through the season, females should shift from producing more, smaller offspring early in the season to fewer, higher quality offspring later in the...

Data from: Dietary patterns during adulthood and cognitive performance in midlife: the CARDIA study

Claire T. McEvoy, Tina Hoang, Stephen Sidney, Lyn M. Steffen, David R. Jacobs, James M. Shikany, John T. Wilkins & Kristine Yaffe
Objective: To investigate whether dietary patterns (Mediterranean diet (MedDiet), Dietary Approaches to Stop Hypertension (DASH) and A Priori Diet Quality Score (APDQS)) during adulthood are associated with better midlife cognitive performance. Methods: We studied 2,621 CARDIA participants: 45% black, 57% female, and age 25±3.5 years at baseline (1985-6). Diet scores were calculated from repeated diet history up to year 20. Linear models were used to examine association between tertiles of diet score and year 25...

Data from: A survey of risk tolerance to multiple sclerosis therapies

Robert J. Fox, Carol Cosenza, Lauren Cripps, Paul Ford, MaryBeth Mercer, Sneha Natarajan, Amber Salter, Tuula Tyry & Stacey S. Cofield
Objective: To determine tolerance to various risk scenarios associated with current MS therapies. Methods: People with MS from the North American Research Committee on Multiple Sclerosis (NARCOMS) Registry’s online cohort and the National Multiple Sclerosis Society were invited to complete a questionnaire on tolerance to real-world risks associated with a hypothetical therapy. Multiple risks levels were presented including, skin rash, infection, kidney injury, thyroid injury, liver injury, and PML. Results: Both progressive multifocal leukoencephalopathy (PML)...

Discovery proteomics by mass spectrometry comparing secreted proteins from young and old mouse lung mesenchymal stromal cells

Diptiman Chanda, Victor Thannickal & James Mobley
Lung mesenchymal stromal cells (L-MSCs) were isolated from the young ( 3 months) and old (22-24 months) mice (N = 4 each) following collagenase digestion of the lungs and anchorage-dependent growth. Culture media was collected from young and old L-MSCs (10^6 cells) grown in culture for 24 hrs in serum-free condition. Culture media was then centrifuged to remove any cellular debris. Five (5) ml of supernatants were concentrated using 3kDa Molecular weight cut-off filters, and...

Genetic diversity of a marine foundation species, Laminaria hyperborea (Phaeophyceae Laminariales), along the coast of Ireland

Stacy Krueger-Hadfield, Kathryn Schoenrock, Aisha O' Connor, Stephane Mauger, Myriam Valero, Joao Neiva & Ester Serrao
Worldwide, kelp populations are stressed by warming, increased storms and other man-driven disturbances. Marine population distributions are projected to retreat poleward with climate change if they cannot adapt to changing conditions, which would potentially lead to a regime shift in subtidal habitats. In Northern Europe, Laminaria hyperboreais a subtidal ecosystem engineer whose distribution has shifted over millennia, leaving predicted areas of high genetic diversity from the last glacial maximum (LGM) near its southern distribution limit...

Data from: Evolutionary history of chimpanzees inferred from complete mitochondrial genomes

Adam Bjork, Weimin Liu, Joel O Wertheim, Beatrice H Hahn & Michael Worobey
Investigations into the evolutionary history of the common chimpanzee, Pan troglodytes, have produced inconsistent results, due to differences in the types of molecular data considered, the model assumptions employed, and the quantity and geographical range of samples used. We amplified and sequenced 24 complete P. troglodytes mitochondrial genomes from fecal samples collected at multiple study sites throughout sub-Saharan Africa. Using a ‘relaxed molecular clock,’ fossil calibrations, and 12 additional complete primate mitochondrial genomes, we analyzed...

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