31 Works

Additional file 5 of Comparative transcriptomics in human COPD reveals dysregulated genes uniquely expressed in ferrets

Shah S. Hussain, Yvonne J. K. Edwards, Emily Falk Libby, Denise Stanford, Stephen A. Byzek, Don D. Sin, Merry-Lynn McDonald, S. Vamsee Raju & Steven M. Rowe
Additional file 5: Table S4. Complete list (52) of DEGs in common between ferret, mice, and human transcriptome.

Additional file 4 of Comparative transcriptomics in human COPD reveals dysregulated genes uniquely expressed in ferrets

Shah S. Hussain, Yvonne J. K. Edwards, Emily Falk Libby, Denise Stanford, Stephen A. Byzek, Don D. Sin, Merry-Lynn McDonald, S. Vamsee Raju & Steven M. Rowe
Additional file 4: Table S3. Complete annotation GO TERMS in smoke exposed ferrets compared to controls.

Additional file 5 of Comparative transcriptomics in human COPD reveals dysregulated genes uniquely expressed in ferrets

Shah S. Hussain, Yvonne J. K. Edwards, Emily Falk Libby, Denise Stanford, Stephen A. Byzek, Don D. Sin, Merry-Lynn McDonald, S. Vamsee Raju & Steven M. Rowe
Additional file 5: Table S4. Complete list (52) of DEGs in common between ferret, mice, and human transcriptome.

IL-27 overexpression alleviates inflammatory response in allergic asthma by inhibiting Th9 differentiation and regulating Th1/Th2 balance

Peng Xiong, Tonglin Liu, Hao Huang, Yi Yuan, Wendi Zhang, Lina Fu & Yu Chen
To investigate the effect of IL-27 on Th9 differentiation and Th1/Th2 balance. C57BL/6 (B6) mice were treated with ovalbumin to establish an allergic asthma (AA) model and subjected to IL-27 overexpression (OV) and empty vector (EV). Hematoxylin-eosin (HE) staining was performed to observe lung tissue inflammation. Flow cytometry was carried out to evaluate the percentage of Th9, Th1, and Th2 cells. The expression of IL-27, IL-27R, IL-9, T-bet, IFN-γ, and IgE was evaluated by quantitative...

IL-27 overexpression alleviates inflammatory response in allergic asthma by inhibiting Th9 differentiation and regulating Th1/Th2 balance

Peng Xiong, Tonglin Liu, Hao Huang, Yi Yuan, Wendi Zhang, Lina Fu & Yu Chen
To investigate the effect of IL-27 on Th9 differentiation and Th1/Th2 balance. C57BL/6 (B6) mice were treated with ovalbumin to establish an allergic asthma (AA) model and subjected to IL-27 overexpression (OV) and empty vector (EV). Hematoxylin-eosin (HE) staining was performed to observe lung tissue inflammation. Flow cytometry was carried out to evaluate the percentage of Th9, Th1, and Th2 cells. The expression of IL-27, IL-27R, IL-9, T-bet, IFN-γ, and IgE was evaluated by quantitative...

Additional file 4 of RBCK1 is an endogenous inhibitor for triple negative breast cancer via hippo/YAP axis

Zhongbo Li, Peng Su, Yinlu Ding, Honglei Gao, Huijie Yang, Xin Li, Xiao Yang, Yan Xia, Chenmiao Zhang, Mingxi Fu, Dehai Wang, Ye Zhang, Shu Zhuo, Jian Zhu & Ting Zhuang
Additional file 3. Digital raw data.

A Network Pharmacological Approach to Explore the Mechanisms of TongXieYaoFang in Inflammatory Bowel Disease

Wenli You, Mingjuan Li, Aiting Di, Xin Li, Hairui Gao, Cuixia Qiao, Bin Yu & Gang Zhao
Abstract Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the intestine, demonstrating an increasing incidence every year. TongXieYaoFang (TXYF) has been used widely in China as a complementary therapy to relieve the symptoms of IBD for hundreds of years. In the present research, a network pharmacology-based approach was used to systematically explore the intrinsic mechanisms of TXYF in IBD at the molecular level. Network pharmacology-based methods, which mainly included database mining, screening of...

Naringin regulates mitochondrial dynamics to protect against acetaminophen-induced hepatotoxicity by activating the AMPK/Nrf2 signaling pathway in vitro

Qiao Wu, Pengfei Yu, Yanzhen Bi, Zhijie Li, Wei Guo, Yu Chen & Zhongping Duan
Naringin (Nar) has been reported to exert potential hepatoprotective effects against acetaminophen (APAP)-induced injury. Mitochondrial dysfunction plays an important role in APAP-induced liver injury. However, the protective mechanism of Nar against mitochondrial damage has not been elucidated. Therefore, the aim of this study was to investigate the hepatoprotective effects of Nar against APAP and the possible mechanisms of actions. Primary rat hepatocytes and HepG2 cells were utilized to establish an in vitro model of APAP-induced...

Naringin regulates mitochondrial dynamics to protect against acetaminophen-induced hepatotoxicity by activating the AMPK/Nrf2 signaling pathway in vitro

Qiao Wu, Pengfei Yu, Yanzhen Bi, Zhijie Li, Wei Guo, Yu Chen & Zhongping Duan
Naringin (Nar) has been reported to exert potential hepatoprotective effects against acetaminophen (APAP)-induced injury. Mitochondrial dysfunction plays an important role in APAP-induced liver injury. However, the protective mechanism of Nar against mitochondrial damage has not been elucidated. Therefore, the aim of this study was to investigate the hepatoprotective effects of Nar against APAP and the possible mechanisms of actions. Primary rat hepatocytes and HepG2 cells were utilized to establish an in vitro model of APAP-induced...

Additional file 1 of Return of non-ACMG recommended incidental genetic findings to pediatric patients: considerations and opportunities from experiences in genomic sequencing

Kevin M. Bowling, Michelle L. Thompson, Melissa A. Kelly, Sarah Scollon, Anne M. Slavotinek, Bradford C. Powell, Brian M. Kirmse, Laura G. Hendon, Kyle B. Brothers, Bruce R. Korf, Gregory M. Cooper, John M. Greally & Anna C. E. Hurst
Additional file 1: Table S1. Incidental genetic findings identified across four study sites conducting genomic testing for pediatric patients (expanded version of Table 1).

Additional file 1 of Return of non-ACMG recommended incidental genetic findings to pediatric patients: considerations and opportunities from experiences in genomic sequencing

Kevin M. Bowling, Michelle L. Thompson, Melissa A. Kelly, Sarah Scollon, Anne M. Slavotinek, Bradford C. Powell, Brian M. Kirmse, Laura G. Hendon, Kyle B. Brothers, Bruce R. Korf, Gregory M. Cooper, John M. Greally & Anna C. E. Hurst
Additional file 1: Table S1. Incidental genetic findings identified across four study sites conducting genomic testing for pediatric patients (expanded version of Table 1).

Additional file 4 of A comprehensive update on CIDO: the community-based coronavirus infectious disease ontology

Yongqun He, Hong Yu, Anthony Huffman, Asiyah Yu Lin, Darren A. Natale, John Beverley, Ling Zheng, Yehoshua Perl, Zhigang Wang, Yingtong Liu, Edison Ong, Yang Wang, Philip Huang, Long Tran, Jinyang Du, Zalan Shah, Easheta Shah, Roshan Desai, Hsin-hui Huang, Yujia Tian, Eric Merrell, William D. Duncan, Sivaram Arabandi, Lynn M. Schriml, Jie Zheng … & Barry Smith
Additional file 4: Supplemental Table 3. Protein Ontology representation of SARS-CoV-2 proteins. Comparative information in RefSeq and UniProtKB is also provided.

Additional file 1 of Comparative transcriptomics in human COPD reveals dysregulated genes uniquely expressed in ferrets

Shah S. Hussain, Yvonne J. K. Edwards, Emily Falk Libby, Denise Stanford, Stephen A. Byzek, Don D. Sin, Merry-Lynn McDonald, S. Vamsee Raju & Steven M. Rowe
Additional file 1: Table S1. RNA-seq data for 12 samples (six biological replicates each for air and smoke experimental conditions) sequenced using an Illumina NextSeq 500 System. [GEO Accession Number GSE193749].

Additional file 4 of Comparative transcriptomics in human COPD reveals dysregulated genes uniquely expressed in ferrets

Shah S. Hussain, Yvonne J. K. Edwards, Emily Falk Libby, Denise Stanford, Stephen A. Byzek, Don D. Sin, Merry-Lynn McDonald, S. Vamsee Raju & Steven M. Rowe
Additional file 4: Table S3. Complete annotation GO TERMS in smoke exposed ferrets compared to controls.

Additional file 3 of RBCK1 is an endogenous inhibitor for triple negative breast cancer via hippo/YAP axis

Zhongbo Li, Peng Su, Yinlu Ding, Honglei Gao, Huijie Yang, Xin Li, Xiao Yang, Yan Xia, Chenmiao Zhang, Mingxi Fu, Dehai Wang, Ye Zhang, Shu Zhuo, Jian Zhu & Ting Zhuang
Additional file 2. Clinicopathological Data for 40 TNBC.

Additional file 1 of Phosphodiesterase 10A (PDE10A) as a novel target to suppress β-catenin and RAS signaling in epithelial ovarian cancer

Rebecca M. Borneman, Elaine Gavin, Alla Musiyenko, Wito Richter, Kevin J. Lee, David K. Crossman, Joel F. Andrews, Annelise M. Wilhite, Steven McClellan, Ileana Aragon, Antonio B. Ward, Xi Chen, Adam B. Keeton, Kristy Berry, Gary A. Piazza, Jennifer M. Scalici & Luciana Madeira da Silva
Additional file 1.

Additional file 1 of Phosphodiesterase 10A (PDE10A) as a novel target to suppress β-catenin and RAS signaling in epithelial ovarian cancer

Rebecca M. Borneman, Elaine Gavin, Alla Musiyenko, Wito Richter, Kevin J. Lee, David K. Crossman, Joel F. Andrews, Annelise M. Wilhite, Steven McClellan, Ileana Aragon, Antonio B. Ward, Xi Chen, Adam B. Keeton, Kristy Berry, Gary A. Piazza, Jennifer M. Scalici & Luciana Madeira da Silva
Additional file 1.

Methyl-Sensitive Amplification Polymorphism (MSAP) Analysis Provides Insights into the DNA Methylation Underlying Heterosis in Kenaf (Hibiscus Cannabinus L.) Drought Tolerance

Dengjie Luo, Shan Cao, Zengqiang Li, Meiqiong Tang, Caijin Wang, Enerand Mackon, Zhen Huang, Jiao Pan, Xia Wu, Qijing Wu, Hui Zhang, Renxue Li, Xin Li, Ru Li & Peng Chen
Kenaf (Hibiscus cannabinus L.) is an industrial fiber crop with significant heterosis and tolerance to abiotic stresses. However, the mechanism underlying heterosis in kenaf under drought conditions is completely unknown. In this study, F1 hybrids were remarkably tolerant to drought stress. Through methylation-sensitive amplification polymorphism (MSAP) analysis, we highlighted that total DNA methylation level under drought decreased by 11.2% in F1 and increased by 29.7% and 13.1% in parents CP079 and CP071, respectively. Unlike parents,...

Additional file 1 of Comparative transcriptomics in human COPD reveals dysregulated genes uniquely expressed in ferrets

Shah S. Hussain, Yvonne J. K. Edwards, Emily Falk Libby, Denise Stanford, Stephen A. Byzek, Don D. Sin, Merry-Lynn McDonald, S. Vamsee Raju & Steven M. Rowe
Additional file 1: Table S1. RNA-seq data for 12 samples (six biological replicates each for air and smoke experimental conditions) sequenced using an Illumina NextSeq 500 System. [GEO Accession Number GSE193749].

Characteristics of immune cell infiltration in inflamed mucosa of ulcerative colitis patients, hub gene candidates and key pathways in intestinal macrophage.

Yiqiu Peng, Zilu Cui, Yingying Li, Yuxi Yang, Yingyi Luan & Chenghong Yin
Tissue RNA was isolated from fresh mouse colon sample by Trizol reagent. Total RNA (1 µg) was reverse-transcribed using a reverse transcriptase kit (TakaRa, cat. RR036A-1, Tokyo, Japan). Hieff® qPCR SYBR Green Master Mix (Yeasen Biotechnolog, cat. 11201ES03, Shanghai, China) was used for Real-time qPCR. The comparative cycle threshold (Ct) method (2−ΔΔCT) was used to calculate relative expression, β-actin was used as the internal reference. We evaluated immunostaining by multiplying the intensity score and proportion...

Methyl-Sensitive Amplification Polymorphism (MSAP) Analysis Provides Insights into the DNA Methylation Underlying Heterosis in Kenaf (Hibiscus Cannabinus L.) Drought Tolerance

Dengjie Luo, Shan Cao, Zengqiang Li, Meiqiong Tang, Caijin Wang, Enerand Mackon, Zhen Huang, Jiao Pan, Xia Wu, Qijing Wu, Hui Zhang, Renxue Li, Xin Li, Ru Li & Peng Chen
Kenaf (Hibiscus cannabinus L.) is an industrial fiber crop with significant heterosis and tolerance to abiotic stresses. However, the mechanism underlying heterosis in kenaf under drought conditions is completely unknown. In this study, F1 hybrids were remarkably tolerant to drought stress. Through methylation-sensitive amplification polymorphism (MSAP) analysis, we highlighted that total DNA methylation level under drought decreased by 11.2% in F1 and increased by 29.7% and 13.1% in parents CP079 and CP071, respectively. Unlike parents,...

A Network Pharmacological Approach to Explore the Mechanisms of TongXieYaoFang in Inflammatory Bowel Disease

Wenli You, Mingjuan Li, Aiting Di, Xin Li, Hairui Gao, Cuixia Qiao, Bin Yu & Gang Zhao
Abstract Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the intestine, demonstrating an increasing incidence every year. TongXieYaoFang (TXYF) has been used widely in China as a complementary therapy to relieve the symptoms of IBD for hundreds of years. In the present research, a network pharmacology-based approach was used to systematically explore the intrinsic mechanisms of TXYF in IBD at the molecular level. Network pharmacology-based methods, which mainly included database mining, screening of...

Statistical Learning for Individualized Asset Allocation

Yi Ding, Yingying Li & Rui Song
We establish a high-dimensional statistical learning framework for individualized asset allocation. Our proposed methodology addresses continuous-action decision-making with a large number of characteristics. We develop a discretization approach to model the effect of continuous actions and allow the discretization frequency to be large and diverge with the number of observations. We estimate the value function of continuous-action using penalized regression with our proposed generalized penalties that are imposed on linear transformations of the model coefficients....

Species-specific effects and the ecological role of Programmed cell Death in the microalgae Ankistrodesmus (Sphaeropleales, Selenastraceae)

Marcelo Barreto Filho, Helena H. Vieira, James J. Morris & Inessa L. Bagatini
Reports of programmed cell death (PCD) in phytoplankton raise questions about the ecological evolutionary role of cell death in these organisms. We induced PCD by nitrogen deprivation and unregulated cell death (non-PCD) in one strain of the green microalga Ankistrodesmus densus and investigated the effects of the cell death supernatants on phylogenetically related co-occurring organisms using growth rates and maximum biomass as proxies of fitness. PCD-released materials from A. densus CCMA-UFSCar-3 significantly increased growth rates...

Additional file 3 of RBCK1 is an endogenous inhibitor for triple negative breast cancer via hippo/YAP axis

Zhongbo Li, Peng Su, Yinlu Ding, Honglei Gao, Huijie Yang, Xin Li, Xiao Yang, Yan Xia, Chenmiao Zhang, Mingxi Fu, Dehai Wang, Ye Zhang, Shu Zhuo, Jian Zhu & Ting Zhuang
Additional file 2. Clinicopathological Data for 40 TNBC.

Registration Year

  • 2022
    31

Resource Types

  • Dataset
    31

Affiliations

  • University of Alabama at Birmingham
    31
  • Fudan University
    16
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    16
  • China Agricultural University
    12
  • Nanjing Medical University
    12
  • Sun Yat-sen University
    10
  • University of Pennsylvania
    10
  • Central South University
    10
  • Jilin University
    10
  • Southern Medical University
    10