116 Works

The type I-E CRISPR-Cas system influences the acquisition of blaKPC-IncF plasmid in Klebsiella pneumonia

Ying Zhou, Yu Tang, Pan Fu, Dongxing Tian, Lianhua Yu, Yunkun Huang, Gang Li, Meng Li, Yong Wang, Zehua Yang, Xiaogang Xu, Zhe Yin, Dongsheng Zhou, Laurent Poirel & Xiaofei Jiang
Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae (KPC-KP) have disseminated worldwide and emerged as major threats to public health. Of epidemiological significance, the international pandemic of KPC-KP is primarily associated with CG258 isolates and blaKPC-IncF plasmids. CRISPR-Cas system is an adaptive immune system that can hinder gene expansion driven by horizontal gene transfer. Because of blaKPC-IncF plasmids are favored by CG258 K. pneumoniae, it was of interest to examine the co-distribution of CRISPR and blaKPC-IncF plasmids...

β-Sitosterol-loaded solid lipid nanoparticles ameliorate complete Freund’s adjuvant-induced arthritis in rats: involvement of NF-кB and HO-1/Nrf-2 pathway

Feng Zhang, Zhiyu Liu, Xijing He, Zhanqi Li, Bin Shi & Fengmei Cai
Rheumatoid arthritis (RA), autoimmune disease that is categorized via chronic inflammation manifestation, obesity, cardiovascular risk and even enhanced the mortality and affect the 0.3 and 1% of population worldwide. The current experimental study was scrutinize the anti-arthritic effect of β-sitosterol loaded solid lipid nanoparticles (SLN) against complete Fruend adjuvant (CFA)-induced arthritis via dual pathway. Double emulsion solvent displacement method was used for the preparation of β-sitosterol solid lipid nanoparticles (SLN). CFA was used to induce...

Vegetation Carbon Accumulation Driven by Stand Characteristics and Climatic Factors in Subtropical Forests of Southeastern China

Zhipeng Ge, Weisong Wen, Lin Xu, Guangsheng Chen, Guomo Zhou, Biyong Ji, Yufeng Zhou, Guoliang Zhu & Yongjun Shi
Subtropical forests act as a carbon sink and play an important role in mitigating global warming. However, the understanding of the effects of stand characteristics and climatic factors on forest carbon sequestration capacity remains limited. Based on multiple regression analyses using structural equation modeling and plot-level data of coniferous and broadleaf forests from the national forest resource inventories, our study quantified vegetation carbon accumulation rate (VCAR) and the underlying influence pattern in Zhejiang Province, Southeastern...

Fat mass and obesity-associated protein (FTO) mediates signal transducer and activator of transcription 3 (STAT3)-drived resistance of breast cancer to doxorubicin

Yan Wang, Zhiqiang Cheng, Jing Xu, Meina Lai, Liming Liu, Min Zuo & Lin Dang
Excessive activation of signal transducer and activator of transcription 3 (STAT3) is implicated in breast cancer (BC) chemoresistance, but its underlying mechanism is not fully understood. There are STAT3 binding sites in fat mass and obesity-associated protein (FTO) promoter region, thus STAT3 may regulate the transcription of FTO. This study aimed to investigate the correlation between FTO and STAT3 in BC chemoresistance. Herein, FTO and STAT3 were highly expressed in doxorubicin-resistant BC (BC-DoxR) cells. CHIP...

Contribution of plant–bacteria interactions to horizontal gene transfer in plants

Hongsheng Cai, Yingying Liu & Changhong Guo
Horizontal gene transfer (HGT) is recognized as a major driver of adaptive evolution in prokaryotes. However, HGT seems impossible in eukaryotes, particularly as recipients; therefore, debate rages regarding whether HGT takes place in eukaryotes, in addition to its potential mechanism or frequency. Bacterial symbionts, whether mutualistic, commensalistic or parasitic, have been considered potential donors for eukaryotes. In this study, we used a bacterial–plant interaction system to systematically investigate HGT in plants. In total, 373 HGT...

Genomic population structure of Helicobacter pylori Shanghai isolates and identification of genomic features uniquely linked with pathogenicity

Feng Yang, Jinghao Zhang, Su Wang, Zhaoyang Sun, Jun Zhou, Feng Li, Yue Liu, Li Ding, Yixin Liu, Wenjing Chi, Tao Liu, Yongqun He, Ping Xiang, Zhijun Bao, Michal A. Olszewski, Hu Zhao & Yanmei Zhang
Severe Helicobacter pylori-linked gastric disorders are especially prevalent in the East Asia region. The ability of H. pylori to cause different clinical outcomes is thought to be associated with unique sets of its genetic features. However, only few genetic features have been definitively linked to specific gastrointestinal pathologies. Genome heterogeneity of clinical H. pylori strains from patients with four different gastric disorders was studied to explore the population structure and molecular genomic features and their...

Identification of a novel circular RNA circZNF652/miR-486-5p/SERPINE1 signaling cascade that regulates cancer aggressiveness in glioblastoma (GBM)

Liang Liu, Shan Xiao, Yan Wang, Zifeng Zhu, Yiyao Cao, Sen Yang, Rongkang Mai & Yong Zheng
Circular RNAs (circRNAs) are closely associated with cancer development in glioblastoma (GBM), and this study aims to explore the molecular mechanisms of a novel circular RNA circZNF652 in regulating GBM aggressiveness. The present study found that CircZNF652 and SERPINE1 were upregulated, while miR-486-5p was downregulated in GBM tissues and cell lines, and GBM patients with high expression of CircZNF652 and SERPINE1, and patients with low expression of miR-486-5p tended to have a worse prognosis. Further...

Downregulation of Smad4 expression confers chemoresistance against imatinib mesylate to chronic myeloid leukemia K562 cells

Jiangzhao Zhang, Min Zhang, Yan Liang, Min Liu & Zhiping Huang
Objective: Imatinib mesylate (IM), a tyrosine kinase inhibitor, exhibits clinically prominent effects against chronic myeloid leukemia (CML); however, a few patients have shown resistance to IM treatment, resulting in disease progression. Smad4 is a tumor inhibitor that transduces TGF-β signaling and modulates genomic stability. Previous studies have indicated that decreased Smad4 expression played a bidirectional role in chemosensitivity in many types of cancers. Therefore, this study aims to evaluate the association between IM sensitivity and...

Acetylshikonin suppresses diffuse large B-Cell Lymphoma cell growth by targeting the T-lymphokine-activated killer cell-originated protein kinase signalling pathway

Jieke Cui, Rong Guo, Yingjun Wang, Yue Song, Xuewen Song, Hongwen Li, Xiaoqin Song & Jiwei Li
Diffuse large B-cell lymphoma (DLBCL) is one of the most common causes of cancer death worldwide, and responds poorly to the existing treatments. Thus, identifying novel therapeutic targets of DLBCL is urgently needed. In this study, we found that T-lymphokine-activated killer cell-originated protein kinase (TOPK) was highly expressed in DLBCL cells and tissues. Data from the GEPIA database also indicated that TOPK was highly expressed in DLBCL tissues. The high expression levels of proteins were...

Additional file 1 of Cancer-associated fibroblast-specific lncRNA LINC01614 enhances glutamine uptake in lung adenocarcinoma

Tongyan Liu, Chencheng Han, Panqi Fang, Zhifei Ma, Xiaoxiao Wang, Hao Chen, Siwei Wang, Fanchen Meng, Cheng Wang, Erbao Zhang, Guozhang Dong, Hongyu Zhu, Wenda Yin, Jie Wang, Xianglin Zuo, Mantang Qiu, Jinke Wang, Xu Qian, Hongbing Shen, Lin Xu, Zhibin Hu & Rong Yin
Additional file 1. Supplementary Tables.

Ultra-High Dimensional Quantile Regression for Longitudinal Data: An Application to Blood Pressure Analysis

Tianhai Zu, Heng Lian, Brittany Green & Yan Yu
Despite major advances in research and treatment, identifying important genotype risk factors for high blood pressure remains challenging. Traditional genome-wide association studies (GWAS) focus on one single nucleotide polymorphism (SNP) at a time. We aim to select among over half a million SNPs along with time-varying phenotype variables via simultaneous modeling and variable selection, focusing on the most dangerous blood pressure levels at high quantiles. Taking advantage of rich data from a large-scale public health...

Additional file 2 of Sex differences exist in adult heart group 2 innate lymphoid cells

Hongyan Peng, Shuting Wu, Shanshan Wang, Qinglan Yang, Lili Wang, Shuju Zhang, Minghui Huang, Yana Li, Peiwen Xiong, Zhaohui Zhang, Yue Cai, Liping Li, Youcai Deng & Yafei Deng
Additional file 2. DEGs of ILC2 and its clusters between female and male mice.

Additional file 1 of Tim-3 downregulation by Toxoplasma gondii infection contributes to decidual dendritic cell dysfunction

Hongbing Xie, Zhidan Li, Guangmei Zheng, Chunyan Yang, Xianbing Liu, Xiaoyan Xu, Yushan Ren, Chao Wang & Xuemei Hu
Additional file 1: Table S1. Antibodies (catalogue no., vendor, clone, fluorochrome, concentration) used in this study.

Additional file 1 of Circular RNA circLOC101928570 suppresses systemic lupus erythematosus progression by targeting the miR-150-5p/c-myb axis

Xingwang Zhao, Rui Dong, Zhongwei Tang, Juan Wang, Chunyou Wang, Zhiqiang Song, Bing Ni, Longlong Zhang, Xiaochong He & Yi You
Additional file 1: Table S1. Detailed information on the SLE patients.

Additional file 1 of Characteristics of oral microbiome of healthcare workers in different clinical scenarios: a cross-sectional analysis

Zhixia Zhang, Wenyi Yu, Guangyao Li, Yukun He, Zhiming Shi, Jing Wu, Xinqian Ma, Yu Zhu, Lili Zhao, Siqin Liu, Yue Wei, Jianbo Xue, Shuming Guo & Zhancheng Gao
Additional File 1: Supplementary Table S1

Additional file 5 of Integrative analyses of maternal plasma cell-free DNA nucleosome footprint differences reveal chromosomal aneuploidy fetuses gene expression profile

Min Zhang, Kun Li, Shoufang Qu, Zhiwei Guo, Yuanli Wang, Xu Yang, Junhua Zhou, Guojun Ouyang, Rongtao Weng, Fenxia Li, Yingsong Wu & Xuexi Yang
Additional file 5: Table S5. Immunity genes with differential promoter coverage in all trisomic pregnant women.

Additional file 1 of Integrative analyses of maternal plasma cell-free DNA nucleosome footprint differences reveal chromosomal aneuploidy fetuses gene expression profile

Min Zhang, Kun Li, Shoufang Qu, Zhiwei Guo, Yuanli Wang, Xu Yang, Junhua Zhou, Guojun Ouyang, Rongtao Weng, Fenxia Li, Yingsong Wu & Xuexi Yang
Additional file 1: Table S1. Differential promoter coverage genes and GO, KEGG enrichment analysis results of differential genes for all pregnant women with trisomy.

Additional file 2 of Integrative analyses of maternal plasma cell-free DNA nucleosome footprint differences reveal chromosomal aneuploidy fetuses gene expression profile

Min Zhang, Kun Li, Shoufang Qu, Zhiwei Guo, Yuanli Wang, Xu Yang, Junhua Zhou, Guojun Ouyang, Rongtao Weng, Fenxia Li, Yingsong Wu & Xuexi Yang
Additional file 2: Table S2. Differential promoter coverage genes and GO, KEGG enrichment analysis results of differential genes for pregnant women with trisomy 21.

Additional file 2 of mTORC1-c-Myc pathway rewires methionine metabolism for HCC progression through suppressing SIRT4 mediated ADP ribosylation of MAT2A

Liang Zhao, Huizhao Su, Xiaomeng Liu, Hongquan Wang, Yukuan Feng, Yan Wang, Haiqiang Chen, Luo Dai, Shihui Lai, Siqi Xu, Chong Li, Jihui Hao & Bo Tang
Additional file 2: Table S1. Detected gene levels upon methionine restriction in livers of HCC mouce models.

Systematically analyzed molecular characteristics of lung adenocarcinoma using metabolism-related genes classification

Xiaoming Huang, Feng Zhang, Junqi Lin, Shaoming Lin, Guanle Shen, Xiaozhu Chen & Wenbiao Chen
Abstract High heterogeneity of lung adenocarcinoma (LUAD) is a major clinical challenge. This study aims to characterize the molecular features of LUAD through classification based on metabolism-related genes. A total of 500 LUAD samples from The Cancer Genome Atlas (TCGA) and 612 from Gene Expression Omnibus (GEO) were integrated with 2,753 metabolism-related genes to determine the molecular classification. Systematic bioinformatics analysis was used to conduct correlation analysis between metabolism-related classification and molecular characteristics of LUAD....

Plant community responses to alterations in soil abiotic and biotic conditions are decoupled for above- and belowground traits

Chenguang Gao, T. Martijn Bezemer, Peter M. Van Bodegom, Hans C. Cornelissen, Richard van Logtestijn, Xiangyu Liu, Riccardo Mancinelli, Harrie van der Hagen, Meng Zhou & Nadejda A. Soudzilovskaia
File containing plant functional traits data and plant composition data used for analyzing the responses of plant functional traits to soil inoculation treatments.

Identification of Escherichia coli β-glucuronidase inhibitors from Polygonum cuspidatum Siebold & Zucc.

Jing-Xin Li, Yu Wang, Ying Hao, Xiao-Kui Huo, Cheng-Peng Sun, Xiao-Xia Zhao, Jin-Cheng Wang, Jian-Bin Zhang, Jing Ning, Xiang-Ge Tian, Chao Wang, Wen-Yu Zhao, Xia Lv, Ya-Chen Li & Xiao-Chi Ma
Abstract Gut bacterial β-glucuronidase (GUS) can reactivate xenobiotics that exert enterohepatic circulation- triggered gastrointestinal tract toxicity. GUS inhibitors can alleviate drug-induced enteropathy and improve treatment outcomes. We evaluated the inhibitory effect of Polygonum cuspidatum Siebold & Zucc. and its major constituents against Escherichia coli GUS (EcGUS), and characterized the inhibitory mechanism of each of the components. Trans-resveratrol 4’-O-β-D-glucopyranoside (HZ-1) and (-)-epicatechin gallate (HZ-2) isolated from P. cuspidatum were identified as the key components and potent...

Vegetation Carbon Accumulation Driven by Stand Characteristics and Climatic Factors in Subtropical Forests of Southeastern China

Zhipeng Ge, Weisong Wen, Lin Xu, Guangsheng Chen, Guomo Zhou, Biyong Ji, Yufeng Zhou, Guoliang Zhu & Yongjun Shi
Subtropical forests act as a carbon sink and play an important role in mitigating global warming. However, the understanding of the effects of stand characteristics and climatic factors on forest carbon sequestration capacity remains limited. Based on multiple regression analyses using structural equation modeling and plot-level data of coniferous and broadleaf forests from the national forest resource inventories, our study quantified vegetation carbon accumulation rate (VCAR) and the underlying influence pattern in Zhejiang Province, Southeastern...

Genome-wide screening for the G-protein-coupled receptor (GPCR) pathway-related therapeutic gene RGS19 (regulator of G protein signaling 19) in bladder cancer

Yue Liu, Weiming Lou, Guang Chen, Bing Ding, Jin Kuang, Yize Zhang, Cong Wang, Sainan Duan, Ying Deng & Xiongbing Lu
Bladder cancer is one of the most severe genitourinary cancers, causing high morbidity worldwide. However, the underlying molecular mechanism is not clear, and it is urgent to find target genes for treatment. G-protein-coupled receptors are currently a target of high interest for drug design. Thus, we aimed to identify a target gene-related to G-protein-coupled receptors for therapy. We used The Cancer Genome Atlas (TCGA) and DepMap databases to obtain the expression and clinical data of...

The role of CCR2 in prognosis of patients with endometrial cancer and tumor microenvironment remodeling

Lin Xu, Qin Fang, Youqing Miao, Mengting Xu, Yichun Wang, Lizhou Sun & Xuemei Jia
Tumor microenvironment (TME) plays a core role in the genesis and progress of endometrial carcinoma (EC). The immune system, a crucial element of TME, functions in various immune cells. In this paper, we have tried to evaluate the prognosis in EC patients by the status of TME. The ESTIMATE algorithm was implemented to computer the number of immune and stromal components in EC tissues from the Cancer Genome Atlas dataset. The CIBERSORT algorithm was employed...

Registration Year

  • 2023
    13
  • 2022
    76
  • 2021
    21
  • 2020
    3
  • 2019
    3

Resource Types

  • Dataset
    116

Affiliations

  • Binzhou Medical University
    116
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    82
  • Capital Medical University
    76
  • Sun Yat-sen University
    70
  • Shanghai Jiao Tong University
    66
  • Sichuan University
    62
  • Nankai University
    62
  • Fudan University
    60
  • Chinese PLA General Hospital
    58
  • Anhui Medical University
    57