The MAISHA study (component A) is a mixed-methods evaluation, including a cluster randomised trial (CRT), of a small group based social empowerment intervention to prevent intimate partner violence (IPV) against women in Mwanza city, Tanzania. The trial was conducted among women already participating in a group-based microfinance scheme, with the microfinance group being the unit of randomisation and (in the intervention arm) the unit of intervention delivery. The CRT involved two surveys of trial participants...
Read codes for depression.
Data from: Substantial contribution of submicroscopical Plasmodium falciparum gametocyte carriage to the infectious reservoir in an area of seasonal transmission.André Lin Ouédraogo, Teun Bousema, Petra Schneider, Sake J. De Vlas, Edith Ilboudo-Sanogo, Nadine Cuzin-Ouattara, Issa Nébié, Will Roeffen, Jan Peter Verhave, Adrian J.F. Luty & Robert Sauerwein
Background: Man to mosquito transmission of malaria depends on the presence of the sexual stage parasites, gametocytes, that often circulate at low densities. Gametocyte densities below the microscopical threshold of detection may be sufficient to infect mosquitoes but the importance of submicroscopical gametocyte carriage in different transmission settings is unknown. Methodology/Principal Findings: Membrane feeding experiments were carried out on 80 children below 14 years of age at the end of the wet season in an...
Quality of care in a differentiated HIV service delivery intervention in Tanzania: A mixed methods studyNwanneka Okere, Judith Meta, Werner Maokola, Giulia Martelli, Eric Van Praag, Denise Naniche, Gabriela Gomez, Anton Pozniak, Tobias Rinke De Wit, Josien De Klerk & Sabine Hermans
Background: Differentiated service delivery (DSD) offers benefits to people living with HIV (improved access, peer support), and the health system (clinic decongestion, efficient service delivery). ART clubs, 15-30 clients who usually meet within the community, are one of the most common DSD options. However, evidence about the quality of care (QoC) delivered in DSD is still limited. Materials and Methods: We conducted a concurrent triangulation mixed methods study as part of the Test & Treat...
Background: Universal access to Primary Eye Care (PEC) is a key global initiative to reduce and prevent avoidable causes of visual impairment (VI). PEC can address minor eye conditions, simple forms of uncorrected refractive error (URE) and create a referral pathway for specialist eye care, thus offering a potential solution to a lack of eye health specialists in low-income countries. However, there is little information on the population need for PEC, including prevalence of URE...
Data from: Weekend admission as an independent predictor of mortality: an analysis of Scottish hospital admissionsAdam E. Handel, Sunil V. Patel, Andrew Skingsley, Katrina Bramley, Roma Sobieski & Sreeram V. Ramagopalan
OBJECTIVES: Weekend admissions have been shown to be associated with an increased risk of mortality compared with weekday admissions for many diagnoses. We analysed emergency department admissions within the Scottish National Health Service to investigate whether mortality is increased in case of weekend emergency department admissions. DESIGN: A cohort study. SETTING: Scotland National Health Service (NHS) emergency departments. PARTICIPANTS: 5 271 327 emergency department admissions between 1999 and 2009. We included all patients admitted via...
Data from: Temperature and population density determine reservoir regions of spatial persistence in highland malariaAmir S. Siraj, Menno J. Bouma, Mauricio Santos-Vega, Asnakew K. Yeshiwondim, Dale S. Rothman, Damtew Yadeta, Paul C. Sutton & Mercedes Pascual
A better understanding of malaria persistence in highly seasonal environments such as highlands and desert fringes requires identifying the factors behind the spatial reservoir of the pathogen in the low season. In these ‘unstable’ malaria regions, such reservoirs play a critical role by allowing persistence during the low transmission season and therefore, between seasonal outbreaks. In the highlands of East Africa, the most populated epidemic regions in Africa, temperature is expected to be intimately connected...
Antenatal code list for: \"The effects of antenatal care, ethnicity and social deprivation on the risk of stillbirth in the UK: A cohort study using routinely collected data\"Amanda Clery, Caroline Minnasian, Liam Smeeth & Rohini Mathur
A list of Read codes and entity types used to identify events in the Clinical Practice Research Datalink that identify the antenatal appointments women in the Pregnancy Register had. These were used to quantify the frequency and timing of antenatal care, the exposure variable for the study.
Data from: A randomized feasibility trial comparing four antimalarial drug regimens to induce Plasmodium falciparum gametocytemia in the controlled human malaria infection modelIsaie J. Reuling, Lisanne A Van De Schans, Luc E Coffeng, Kjerstin Lanke, Lisette Meerstein-Kessel, Wouter Graumans, Geert-Jan Van Gemert, Karina Teelen, Rianne Siebelink-Stoter, Marga Van De Vegte-Bolmer, Quirijn De Mast, André J Van Der Ven, Karen Ivinson, Cornelus C Hermsen, Sake De Vlas, John Bradley, Katharine A Collins, Christian F Ockenhouse, James McCarthy, Robert W. Sauerwein & Teun Bousema
Background: Malaria elimination strategies require a thorough understanding of parasite transmission from human to mosquito. A clinical model to induce gametocytes to understand their dynamics and evaluate transmission-blocking interventions (TBI) is currently unavailable. Here, we explore the use of the well-established Controlled Human Malaria Infection model (CHMI) to induce gametocyte carriage with different antimalarial drug regimens. Methods: In a single centre, open-label randomised trial, healthy malaria-naive participants (aged 18–35 years) were infected with Plasmodium falciparum...
Objective: To clarify whether deaths associated with hot and cold days are among the frail who would have died anyway in the next few weeks or months. Design: Time series regression analysis of annual deaths in relation to annual summaries of cold and heat. Setting: London, UK. Participants: 3 530 280 deaths from all natural causes among London residents between October 1949 and September 2006. Main outcome measures: Change in annual risk of death (all...
Data from: Understanding willingness to use oral pre-exposure prophylaxis for HIV prevention among men who have sex with men in ChinaXia Wang, Adam Bourne, Pulin Liu, Jiangli Sun, Thomas Cai, Gitau Mburu, Matteo Cassolato, Bangyuan Wang & Wang Zhou
Background: Oral pre-exposure prophylaxis (PrEP) is recommended as an additional prevention choice for men who have sex with men (MSM) at substantial risk of HIV. The aim of this study was to evaluate the extent, and reasons, for MSM’s willingness to use oral PrEP in Wuhan and Shanghai, China. Methods: Between May and December 2015, a cross-sectional survey was conducted among 487 MSM recruited through snowball sampling in physical locations frequented by MSM and through...
Data from: Safety and immunogenicity of H1/IC31®, an adjuvanted TB subunit vaccine, in HIV-infected adults with CD4+ Lymphocyte counts greater than 350 cells/mm3: a phase II, multi-centre, double-blind, randomized, placebo-controlled trialKlaus Reither, Lynn Katsoulis, Trevor Beattie, Nicolene Gardiner, Nicole Lenz, Khadija Said, Elirehema Mfinanga, Christian Pohl, Katherine L. Fielding, Hannah Jeffery, Benjamin M. Kagina, Elisabeth J. Hughes, Thomas J. Scriba, Willem A. Hanekom, Søren T. Hoff, Peter Bang, Ingrid Kromann, Claudia Daubenberger, Peter Andersen & Gavin J. Churchyard
Background: Novel tuberculosis vaccines should be safe, immunogenic, and effective in various population groups, including HIV-infected individuals. In this phase II multi-centre, double-blind, placebo-controlled trial, the safety and immunogenicity of the novel H1/IC31 vaccine, a fusion protein of Ag85B-ESAT-6 (H1) formulated with the adjuvant IC31, was evaluated in HIV-infected adults. Methods: HIV-infected adults with CD4+ T cell counts >350/mm3 and without evidence of active tuberculosis were enrolled and followed until day 182. H1/IC31 vaccine or...
Behavioural change towards reduced intensity physical activity is disproportionately prevalent among adults with serious health issues or self-perception of high risk during the UK COVID-19 lockdown.Chrissy Roberts, Nina Rogers, Naomi Waterlow, Hannah Brindle, Luisa Enria & Shelley Lees
Quantitative data on physical activity and health behaviours during the UK COVID-19 lockdown. The anonymous web-based survey was performed between 6th April and 22 April 2020, approximately mapping to weeks 3-5 of the lockdown in the UK. The main survey included 49 questions which covered a broad range of topics including (1) Demographics, (2) Health and Health Behaviours, (3) Adherence to COVID-19 Control measures, (4) Information sources used to learn about COVID-19, (5) Trust in...
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Data from: The impact of long-term azithromycin on antibiotic resistance in HIV-associated chronic lung diseaseRegina Esinam Abotsi, Mark P. Nicol, Grace McHugh, Victoria Simms, Andrea M. Rehman, Charmaine Barthus, Lucky G. Ngwira, Brenda Kwambana-Adams, Robert S Heyderman, Jon Ø Odland, Rashida A Ferrand & Felix S. Dube
Background: Selection for resistance to azithromycin (AZM) and other antibiotics such as tetracyclines and lincosamides remains a concern with long-term AZM use for treatment of chronic lung diseases (CLD). We investigated the impact of 48 weeks of AZM on the carriage and antibiotic resistance of common respiratory bacteria among children with HIV-associated CLD. Methods: Nasopharyngeal (NP) swabs and sputa were collected at baseline, 48 and 72 weeks from participants with HIV-associated CLD randomised to receive...
Read v2 codes for diagnoses of asthma, or recording that a previous diagnosis of asthma had resolved (resolved=1). For this project, the definition was designed to follow national guidance on indications for influenza vaccination, namely: Asthma that requires continuous or repeated use of inhaled or systemic steroids or with previous exacerbations requiring hospital admission. Individuals were defined as having asthma if there was a code for asthma at any time before the index date AND...
Ethnicity code list For: \"The effects of antenatal care, ethnicity and social deprivation on the risk of stillbirth in the UK: A cohort study using routinely collected data\"Amanda Clery, Caroline Minassian, Liam Smeeth & Rohini Mathur
A list of Read codes and entity types used to identify the ethnicity of women in the study cohort from the Clinical Practice Research Datalink.
Data supporting \"A Snapshot of the Practicality of, and Barriers to, Implementation of COVID-19 Interventions: Public Health and Healthcare Workers' Perceptions\"Rosanna Glazik
Data collected as part of a cross-sectional study of Public Health Workers (PHWs) and Healthcare Workers (HCWs) perceptions of the implementation, practicality of, and barriers to implementation of COVID-19 non-pharmaceutical interventions (NPIs) and pharmaceutical interventions (PIs). It consists of two tabular datasets, one that contain survey responses collected from Public Health Workers, and a second that contains survey responses of Healthcare workers. Variables include data on socio-demographic characteristics and key COVID-19 NPIs and PIs. Each...
An anonymised dataset of 424 individuals across 272 clusters (compounds) who gave written informed consent to participate in a study of sanitation-related quality of life in the Nhlamankulu district of Maputo, Mozambique in May 2019. The dataset contains variables on compound code, socio-demographic information, sanitation infrastructure, SanQoL outcomes, ranking of SanQoL attributes, mental wellbeing outcomes, and asset ownership.
Follow up data from a prospective study of Rhematic Heart Disease prevalence in rural Ethiopia to support article in PLOS Neglected Tropical Diseases
Patterns of non-communicable comorbidities at start of tuberculosis treatment in three regions of the Philippines: St-ATT cohort baseline dataSharon Cox & Benjamin Faguer
Data collected as part of a facility-based prospective cohort study conducted in public (government) Tuberculosis (TB) Directly Observed Treatment (DOT) clinics in the Philippine. This dataset contains individual-level information that used in a cross-sectional analysis of selected data collected from the St-ATT cohort of Filipino adults at baseline who were enrolled within 5 days of initiating a new tuberculosis treatment regimen. Study information is available in the ISRCTN Registry ID: 16347615.
Infection with Plasmodium can elicit antibodies that inhibit parasite survival in the mosquito, when they are ingested in an infectious blood meal. Here, we determine the transmission-reducing activity (TRA) of naturally acquired antibodies from 648 malaria-exposed individuals using lab-based mosquito-feeding assays. Transmission inhibition is significantly associated with antibody responses to Pfs48/45, Pfs230, and to 43 novel gametocyte proteins assessed by protein microarray. In field-based mosquito-feeding assays the likelihood and rate of mosquito infection are significantly...
London School of Hygiene & Tropical Medicine67
Radboud University Nijmegen6
Medical Research Council6
Centre National de Recherche et de Formation sur le Paludisme5
Imperial College London4
University College London3
Radboud University Nijmegen Medical Centre3
Erasmus University Medical Center2
University of Edinburgh2
University of Southampton2