166 Works

Data from: The REporting of studies Conducted using Observational Routinely-collected health Data (RECORD) statement: methods for arriving at consensus and developing reporting guidelines

Stuart G. Nicholls, Pauline Quach, Erik Von Elm, Astrid Guttmann, David Moher, Irene Petersen, Henrik T. Sørensen, Liam Smeeth, Sinéad M. Langan & Eric I. Benchimol
Objective: Routinely collected health data, collected for administrative and clinical purposes, without specific a priori research questions, are increasingly used for observational, comparative effectiveness, health services research, and clinical trials. The rapid evolution and availability of routinely collected data for research has brought to light specific issues not addressed by existing reporting guidelines. The aim of the present project was to determine the priorities of stakeholders in order to guide the development of the REporting...

Data from: Distinguishing between reservoir exposure and human-to-human transmission for emerging pathogens using case onset data

Adam Kucharski, Harriet L. Mills, Amy Pinsent, Christophe Fraser, Maria Van Kerkhove, Christl A. Donnelly, Steven Riley & Harriet Mills
Pathogens such as MERS-CoV, influenza A/H5N1 and influenza A/H7N9 are currently generating sporadic clusters of spillover human cases from animal reservoirs. The lack of a clear human epidemic suggests that the basic reproductive number R0 is below or very close to one for all three infections. However, robust cluster-based estimates for low R0 values are still desirable so as to help prioritise scarce resources between different emerging infections and to detect significant changes between clusters...

Data from: How do patients and health workers interact around malaria rapid diagnostic testing, and how are the tests experienced by patients in practice? A qualitative study in western Uganda

Robin Altaras, Anthony Nuwa, Bosco Agaba, Elizabeth Streat, James K. Tibenderana, Sandrine Martin & Clare E. Strachan
Background: Successful scale-up in the use of malaria rapid diagnostic tests (RDTs) requires that patients accept testing and treatment based on RDT results and that healthcare providers treat according to test results. Patient-provider communication is a key component of quality care, and leads to improved patient satisfaction, higher adherence to treatment and better health outcomes. Voiced or perceived patient expectations are also known to influence treatment decision-making among healthcare providers. While there has been a...

Data from: The impact of hotspot-targeted interventions on malaria transmission in Rachuonyo south district in the western Kenyan highlands: a cluster-randomized controlled trial

Teun Bousema, Gillian Stresman, Amrish Y. Baidjoe, John Bradley, Philip Knight, William Stone, Victor Osoti, Euniah Makori, Chrispin Owaga, Wycliffe Odongo, Pauline China, Shehu Shagari, Ogobara K. Doumbo, Robert W. Sauerwein, Simon Kariuki, Chris Drakeley, Jennifer Stevenson & Jonathan Cox
Background: Malaria transmission is highly heterogeneous, generating malaria hotspots that can fuel malaria transmission across a wider area. Targeting hotspots may represent an efficacious strategy for reducing malaria transmission. We determined the impact of interventions targeted to serologically defined malaria hotspots on malaria transmission both inside hotspots and in surrounding communities. Methods and Findings: Twenty-seven serologically defined malaria hotspots were detected in a survey conducted from 24 June to 31 July 2011 that included 17,503...

The Plasmodium falciparum artemisinin susceptibility-associated AP-2 adaptin mu subunit is clathrin-independent and essential for schizont-maturation

Colin J. Sutherland
Proteomics datasets, presented as a set of tables, produced as part of Dr Ryan Henrici's PhD project (completed 2018).

Estimation of Controlled Direct Effects in Longitudinal Mediation Analyses with Latent Variables in Randomized Studies

Wen Wei Loh, Beatrijs Moerkerke, Tom Loeys, Louise Poppe, Geert Crombez & Stijn Vansteelandt
In a randomized study with longitudinal data on a mediator and outcome, estimating the direct effect of treatment on the outcome at a particular time requires adjusting for confounding of the association between the outcome and all preceding instances of the mediator. When the confounders are themselves affected by treatment, standard regression adjustment is prone to severe bias. In contrast, G-estimation requires less stringent assumptions than path analysis using SEM to unbiasedly estimate the direct...

Combined Protocol for Acute Malnutrition Study (ComPAS) dataset

Jeanette Bailey, Charles Opondo, Natasha Lelijveld, Bethany Marron, Pamela Onyoo, Eunice Musyoki, Susan Adongo, Andre Briend, Mark Manary & Marko Kerac

SONA project - Asthma management data

Emily Webb & Harriet Mpairwe
Dataset produced as part of a study to investigate asthma control and management among schoolchildren in urban Uganda. Each row represents one child with asthma. Variables include data on asthma symptoms and management approaches.

Data from: Changing patterns of cataract services in North-West Nigeria: 2005–2016

Nasiru Muhammad, Muhammad D. Adamu, Mpyet Caleb, Nuhu Mohammed Maishanu, Aliyu M. Jabo, Muhammad M. Rabiu, Covadonga Bascaran, Sunday Isiyaku & Allen Foster
Purpose This study was conducted to assess the impact of the eye care programme on cataract blindness and cataract surgical services in Sokoto, Nigeria over a 12 year period 2005-2016. Methods Data from the 2005 population based cross-sectional study of blindness in Sokoto state was re-analysed to obtain baseline estimates of the prevalence of cataract blindness and cataract surgical coverage for persons 50 years and over in Wurno health zone. A population based survey of...

Data from: Monogamy promotes altruistic sterility in insect societies

Nicholas G. Davies & Andy Gardner
Monogamy is associated with sibling-directed altruism in multiple animal taxa, including insects, birds, and mammals. Inclusive-fitness theory readily explains this pattern by identifying high relatedness as a promoter of altruism. In keeping with this prediction, monogamy should promote the evolution of voluntary sterility in insect societies if sterile workers make for better helpers. However, a recent mathematical population-genetics analysis failed to identify a consistent effect of monogamy on voluntary worker sterility. Here, we revisit that...

Anopheles stephensi mosquitoes as vectors of Plasmodium vivax and falciparum, Horn of Africa, 2019

Fitsum G. Tadesse, Temesgen Ashine, Hiwot Teka, Endashaw Esayas, Louisa A. Messenger, Wakweya Chali, Lisette Meerstein-Kessel, Thomas Walker, Sinknesh Wolde Behaksra, Kjerstin Lanke, Roel Heutink, Claire L. Jeffries, Daniel Abebe Mekonnen, Elifaged Hailemeskel, Surafel K. Tebeje, Temesgen Tafesse, Abrham Gashaw, Tizita Tsegaye, Tadele Emiru, Kigozi Simon, Eyuel Asemahegn Bogale, Gedeon Yohannes, Soriya Kedir, Girma Shumie, Senya Asfer Sabir … & Teun Bousema
An. stephensi, an efficient malaria vector in parts of Asia and Africa, was observed in 75.3% of water sources surveyed, and contributed to 80.9% of wild-caught Anopheles mosquitoes in Awash Sebat Kilo, Ethiopia. High susceptibility of these mosquitoes to Plasmodium falciparum and vivax infection presents a challenge for malaria control in the Horn of Africa. This study was conducted in Awash Sebat Kilo, Ethiopia, an area of perennial malaria transmission, from April to September 2019....

Data from: Process evaluation of a national primary eye care programme in Rwanda

Jennifer L. Y. Yip, Tess Bright, Sebastian Ford, Wanjiku Mathenge & Hannah Faal
Background: Visual impairment is a global public health problem, with an estimated 285 million affected globally, of which 43% are due to refractive error. A lack of specialist eye care in low and middle-income countries indicates a new model of care would support a task-shifting model and address this urgent need. We describe the features and results of the process evaluation of a national primary eye care (PEC) programme in Rwanda. Methods: We used the...

Plasmodium falciparum gametocyte density and infectivity in peripheral blood and skin tissue of naturally infected parasite carriers in Burkina Faso

Teun Bousema, Elamaran Meibalan, Aissata Barry, Matthew Gibbins, Shehu Awandu, Lisette Meerstein-Kessel, Fiona Achar, Selina Bopp, Christopher Moxon, Amidou Diarra, Siaka Debe, Nicolas Ouedraogo, Ines Barry-Some, Emilie Badoum, Traore Fagnima, Kjerstin Lanke, Bronner Goncalves, John Bradley, Dyann Wirth, Chris Drakeley, Wamdaogo Guelbeogo, Alfred Tiono, Matthias Marti, Matthew P Gibbins, Fiona Achcar … & Alfred B Tiono
Background Plasmodium falciparum transmission depends on mature gametocytes that can be ingested by mosquitoes taking a blood meal on human skin. Although gametocyte skin sequestration has long been hypothesized as important contributor to efficient malaria transmission, this has never been formally tested. Methods In naturally infected gametocyte carriers from Burkina Faso, we assessed infectivity to mosquitoes by direct skin feeding and membrane feeding. We directly quantified male and female gametocytes and asexual parasites in finger-prick...

Data from: Functional antibodies against Plasmodium falciparum sporozoites are associated with a longer time to qPCR-detected infection among schoolchildren in Burkina Faso

Aissata Barry, Marije C. Behet, Issa Nébié, Kjerstin Lanke, Lynn Grignard, Alphonse Ouedraogo, Issiaka Soulama, Chris Drakeley, Robert Sauerwein, Judith M. Bolscher, Koen J. Dechering, Teun Bousema, Alfred B. Tiono & Bronner P. Gonçalves
Background: Individuals living in malaria-endemic regions develop naturally acquired immunity against severe malarial disease, but it is unclear whether immunity that affects the establishment of infections develops following continuous natural exposure. Methods: We cleared schoolchildren in Burkina Faso of possible sub-patent infections and examined them weekly for incident infections by PCR. Plasma samples collected at enrolment were used to quantify antibodies to the pre-eryhrocytic-stage antigens circumsporozoite protein (CSP) and liver stage antigen. Sporozoite gliding inhibition...

ARGUS study - clinical and bacteriological outcomes dataset

Ioana Olaru
Background: Treatment for urinary tract infections (UTIs) is usually empiric and is based on local antimicrobial resistance data. These data, however, are scarce in low-resource settings. The aim of this study is to determine the impact of antibiotic treatment on clinical and bacteriological outcomes in patients presenting with UTI symptoms to primary care in Harare. Methods: This cohort study enrolled participants presenting with UTI symptoms to 10 primary healthcare clinics in Harare between July 2019...

Data for: \"Vaccine Confidence and Hesitancy at the start of COVID-19 vaccine deployment in the UK: An embedded mixed-methods study\"

Chrissy Roberts, Hannah Brindle, Nina Rogers, Rosalind M. Eggo, Luisa Enria & Shelley Lees
The study used a mixed-methods approach based upon an online survey and an embedded quantitative/qualitative design to explore perceptions and attitudes associated with intention to either accept or refuse offers of vaccination in different demographic groups during the early stages of the UK’s mass COVID-19 vaccination programme (December 2020). Key outputs include: a tabular dataset containing survey responses, a data dictionary that explains survey data variables, an R scripts that enable reproduction of analyses (Analysis_Script.R),...

Tight K Pilot Study Dataset

Joanna Sturgess & Matthew Dodd
Data associated with a pilot and feasibility study of the maintenance of serum potassium levels ≥ 3.6 mEq/L vs ≥ 4.5 mEq/L after isolated elective coronary artery bypass grafting, and the incidence of new-onset atrial fibrillation. Data was collected from patients scheduled to undergo a heart operation called Coronary Artery Bypass Graft Surgery (CABG) at two NHS hospitals in London.

Codelists for: \"Understanding thresholds of blood pressure and predicted cardiovascular disease risk in guiding blood pressure treatment: a cohort study in English primary care\"

Emily Herrett
A set of codelists that cover cardiovascular disease and target organ damage, including heart failure, chronic kidney disease and haemorrhagic stroke.

Identifying optimal capsid duplication length for the stability of reporter flaviviruses

Coleman Baker, Yang Liu, Jing Zou, Antonio Muruato, Xuping Xie & Pei-Yong Shi
Mosquito-transmitted flaviviruses cause widespread disease across the world. To provide better molecular tools for drug screens and pathogenesis studies, we report a new approach to produce stable NanoLuc-tagged flaviviruses, including dengue virus serotypes 1-4, Japanese encephalitis virus, yellow fever virus, West Nile virus, and Zika virus. Since the reporter gene is often engineered at the capsid gene region, the capsid sequence must be duplicated to flank the reporter gene; such capsid duplication is essential for...

Data supporting \"Profiles of inflammation in rural and urban Uganda\"

Richard Sanya & Emily Webb
Data collected as part of two cross-sectional surveys to investigate metabolic outcomes and markers of inflammation in urban and rural locations in Uganda. It contains information obtained from 313 participants (one row represents one participant). 48 variables are recorded, including data on inflammatory markers (cytokines and chemokines), location of residence (urban versus rural), metabolic parameters (including HOMA-IR, blood pressure, blood glucose) and socio-demographic characteristics.

Plant derived active compounds as potential anti SARS-CoV-2 agents: an in-silico study

Dharmendra Kashyap, Shweta Jakhmola, Deeksha Tiwari, Rajesh Kumar, N. S. Hari Narayana Moorthy, Manivannan Elangovan, Natércia F. Brás & Hem Chandra Jha
Plants are a valued potential source of drugs for a variety of diseases and are often considered less toxic to humans. We investigated antiviral compounds that may potentially target SARS-CoV-2 antigenic spike (S) and host proteins; angiotensin-converting enzyme2 (ACE2), and transmembrane serine protease2 (TMPRSS2). We scrutinized 36 phytochemicals from 15 Indian medicinal plants known to be effective against RNA viruses via molecular docking. Besides, the TMPRSS2 structure was modeled and validated using the SWISS-MODEL. Docking...

Plasmodium falciparum drug resistant genotypes - SUMUT study, North Sumatera, 2015

Colin Sutherland & Inke Nadia Lubis
A dataset produced as part of the SUMUT study, investigating plasmodium falciparum drug resistant genotypes. It consists of two tables: (1) a "full data" table that contains individual-level information on 404 individuals who were found to be positive, either by pfmdr1 nested PCR or 18S rDNA nested PCR; and (2) a "cohort data" table that contains information on 195 individuals positive by microscopy and randomised to receive either dihydroartemisinin-piperaquine (DP) or artemether-lumefantrine (AL). Data was...

Support files for: The acceptability of the AMBITION-cm treatment regimen for HIV-associated cryptococcal meningitis: findings from a qualitative methods study of participants and researchers in Botswana and Uganda

David Lawrence, Agnes Ssali, Neo Moshashane, Georgina Nabaggala, Lebogang Maphane, Thomas Harrison, David Meya, Joseph Jarvis & Janet Seeley
The AMBITION-cm trial for HIV-associated cryptococcal meningitis had a qualitative methods study embedded within the AMBITION-cm sites in Botswana and Uganda. Eligible trial participants, surrogate decision makers, and researchers at both sites were contacted to participate in a set of in-depth interviews (IDIs). This fileset contains a set of collection tools produced and used for the in-depth interviews, as well as the participation information sheets, consent forms and interview schedules for each group.

Additional file 2 of Development and validation of an extended Cox prognostic model for patients with ER/PR+ and HER2− breast cancer: a retrospective cohort study

Yiqun Xie, Xizhou Li, Ying Wu, Wenting Cui & Yang Liu
Additional file 2: Appendix 2. Hazard ratios and their 95% confidence limits of Ki67, PR, ER, and age. Figure 1. Hazard ratios and their 95% confidence limits for a series of binary variables of Ki67. Figure 2. Hazard ratios and their 95% confidence limits for a series of binary variables of ER. Figure 3. Hazard ratios and their 95% confidence limits for a series of binary variables of PR. Figure 4. Hazard ratios and their...

How do foundation year and internship experience shape doctors’ career intentions and decisions? A meta-ethnography

Yingxi Zhao, Daniel Mbuthia, Claire Blacklock, David Gathara, Catia Nicodemo, Sassy Molyneux & Mike English
Foundation years or internships are an important period for junior doctors to apply their knowledge and gain clinical competency. Experiences gained during the foundation years or internships are likely to inform newly qualified doctors’ opinions about how they want to continue their career. We aimed to understand how medical doctors’ internship experiences influence their career intention/decision. We conducted qualitative evidence synthesis using meta-ethnography. We searched six electronic bibliographic databases for papers published between 2000–2020 and...

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Affiliations

  • London School of Hygiene & Tropical Medicine
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