Dataset produced as part of a study to investigate asthma control and management among schoolchildren in urban Uganda. Each row represents one child with asthma. Variables include data on asthma symptoms and management approaches.
Codelists for: \"Understanding thresholds of blood pressure and predicted cardiovascular disease risk in guiding blood pressure treatment: a cohort study in English primary care\"Emily Herrett
A set of codelists that cover cardiovascular disease and target organ damage, including heart failure, chronic kidney disease and haemorrhagic stroke.
Data for: \"Vaccine Confidence and Hesitancy at the start of COVID-19 vaccine deployment in the UK: An embedded mixed-methods study\"Chrissy Roberts, Hannah Brindle, Nina Rogers, Rosalind M. Eggo, Luisa Enria & Shelley Lees
The study used a mixed-methods approach based upon an online survey and an embedded quantitative/qualitative design to explore perceptions and attitudes associated with intention to either accept or refuse offers of vaccination in different demographic groups during the early stages of the UK’s mass COVID-19 vaccination programme (December 2020). Key outputs include: a tabular dataset containing survey responses, a data dictionary that explains survey data variables, an R scripts that enable reproduction of analyses (Analysis_Script.R),...
Data collected as part of two cross-sectional surveys to investigate metabolic outcomes and markers of inflammation in urban and rural locations in Uganda. It contains information obtained from 313 participants (one row represents one participant). 48 variables are recorded, including data on inflammatory markers (cytokines and chemokines), location of residence (urban versus rural), metabolic parameters (including HOMA-IR, blood pressure, blood glucose) and socio-demographic characteristics.
Data associated with a pilot and feasibility study of the maintenance of serum potassium levels ≥ 3.6 mEq/L vs ≥ 4.5 mEq/L after isolated elective coronary artery bypass grafting, and the incidence of new-onset atrial fibrillation. Data was collected from patients scheduled to undergo a heart operation called Coronary Artery Bypass Graft Surgery (CABG) at two NHS hospitals in London.
A dataset produced as part of the SUMUT study, investigating plasmodium falciparum drug resistant genotypes. It consists of two tables: (1) a "full data" table that contains individual-level information on 404 individuals who were found to be positive, either by pfmdr1 nested PCR or 18S rDNA nested PCR; and (2) a "cohort data" table that contains information on 195 individuals positive by microscopy and randomised to receive either dihydroartemisinin-piperaquine (DP) or artemether-lumefantrine (AL). Data was...
Morbidity code lists for: \"The effects of antenatal care, ethnicity and social deprivation on the risk of stillbirth in the UK: A cohort study using routinely collected data\"Amanda Clery, Caroline Minassian, Liam Smeeth & Rohini Mathur
A list of Read codes to identify pre-pregnancy diagnoses of: diabetes, cardiovascular diseases (including hypertension and pre-eclampsia), anxiety and depression, cancer, epilepsy, smoking status and alcohol consumption for women in the study cohort from the Clinical Practice Research Datalink.
Read v2 codes for diagnoses of diabetes mellitus, or codes indicating that diabetes mellitus had resolved. For this project, patients were considered to have diabetes if they had a diabetes diagnosis ever recorded and the latest diabetes code prior to the index date did not have a 'resolved' flag.
A quantitative dataset collected as part of the ARGUS study that presents the clinical and bacteriological outcomes of 168 participants who had a positive urine culture at baseline and underwent a follow-up visit. Adult participants were recruited from primary healthcare facilities in Harare, Zimbabwe. Data was collected from participant interviews using electronic Case Report Forms (CRFs). Laboratory results were recorded using specifically designed Case Report Forms (CRFs).
Blood pressure levels among children in rural Uganda: results from 1,913 children in a general population surveySheila Kansiime
A tabular dataset collected as part of a cross-sectional study in south-western Uganda. It contains information on demographic, anthropometric and blood pressure measurements from children aged 6-12 years. Children with elevated blood pressure (systolic and/or diastolic blood pressure greater or equal to the 95th percentile for age, height and sex) were invited for two further assessments 6-18 months later.
Data for: \"Flavivirus integrations in Aedes aegypti are limited and highly conserved across samples from different geographic regions unlike integrations in Aedes albopictus\"Anton Spadar, Jody Phelan, Ernest Diez-Benavente, Monica Campos, Lara Ferrero Gomez, Fady Mohareb, Taane G. Clark & Susana Campino
Supplementary material published to support a paper titled "Flavivirus integrations in Aedes aegypti are limited and highly conserved across samples from different geographic regions unlike integrations in Aedes albopictus". It includes: (1) descriptive statistics of excluded and retained sequences; (2) BLASTN results processing flow diagram; (3) an Excel spreadsheet containing BLASTN hits from AaegL5 assembly; (4) an Excel spreadsheet containing accession IDs of all used flavivirus genomes; (5) an Excel spreadsheet listing BLASTN hits from...
Data from: Examining the human infectious reservoir for Plasmodium falciparum malaria in areas of differing transmission intensityBronner P. Gonçalves, Melissa C. Kapulu, Patrick Sawa, Wamdaogo M. Guelbéogo, Alfred B. Tiono, Lynn Grignard, Will Stone, Joel Hellewell, Kjerstin Lanke, Guido J. H. Bastiaens, John Bradley, Issa Nébié, Joyce M. Ngoi, Robin Oriango, Dora Mkabili, Maureen Nyaurah, Janet Midega, Dyann F. Wirth, Kevin Marsh, Thomas S. Churcher, Philip Bejon, Sodiomon B. Sirima, Chris Drakeley & Teun Bousema
A detailed understanding of the human infectious reservoir is essential for improving malaria transmission-reducing interventions. Here we report a multi-regional assessment of population-wide malaria transmission potential based on 1209 mosquito feeding assays in endemic areas of Burkina Faso and Kenya. Across both sites, we identified 39 infectious individuals. In high endemicity settings, infectious individuals were identifiable by research-grade microscopy (92.6%; 25/27), whilst one of three infectious individuals in the lowest endemicity setting was detected by...
Data from: Prescription of antibiotics at drug shops and strategies to improve quality of care and patient safety: a cross-sectional survey in the private sector in UgandaAnthony K. Mbonye, Esther Buregyeya, Elizeus Rutebemberwa, Sian E. Clarke, Sham Lal, Kristian S. Hansen, Pascal Magnussen & Philip LaRussa
Objectives: The main objective of this study was to assess antibiotic prescription practices at registered drug shops with a focus on upper respiratory tract infections among children in order to provide data for policy discussions aimed at improving quality of care and patient safety in the private health sector in Uganda. Methods: A survey was conducted within 57 parishes from August to October 2014 in Mukono district, Uganda. Data was captured on the following variables:...
Data from: Seasonal influenza vaccination delivery through community pharmacists in England: evaluation of the London pilotKatherine Atkins, Albert Jan Van Hoek, Conall Watson, Marc Baguelin, Lethiwe Choga, Anika Patel, Thara Raj, Mark Jit & Ulla Griffiths
Objective: To evaluate the effectiveness and cost of the pan-London pharmacy initiative, a programme that allows administration of seasonal influenza vaccination to eligible patients at pharmacies. Design: We analysed 2013–15 data on vaccination uptake in pharmacies via the Sonar reporting system, and the total vaccination uptake via 2011–15 ImmForm GP reporting system data. We conducted an online survey of London pharmacists who participate in the programme to assess time use data, vaccine choice, investment costs,...
Data from: Safety of single low-dose primaquine in glucose-6-phosphate dehydrogenase deficient falciparum-infected African males: two open-label, randomized, safety trialsGuido Bastiaens, Alfred B. Tiono, Joseph Okebe, Helmi Pett, Sam A. Coulibaly, Bronner P. Gonçalves, Muna Affara, Alphonse Ouédraogo, Edith C. Bougouma, Guillaume S. Sanou, Issa Nébié, John Bradley, Kjerstin H. W. Lanke, Mikko Niemi, Sodiomon B. Sirima, Umberto D'Alessandro, Teun Bousema, Chris Drakeley, Guido J. H. Bastiaens, Helmi E. Pett & Umberto D’Alessandro
Background: Primaquine (PQ) actively clears mature Plasmodium falciparum gametocytes but in glucose-6-phosphate dehydrogenase deficient (G6PDd) individuals can cause hemolysis. We assessed the safety of low-dose PQ in combination with artemether-lumefantrine (AL) or dihydroartemisinin-piperaquine (DP) in G6PDd African males with asymptomatic P. falciparum malaria. Methods and findings: In Burkina Faso, G6PDd adult males were randomized to treatment with AL alone (n = 10) or with PQ at 0.25 (n = 20) or 0.40 mg/kg (n =...
Malaria vectors in sub-Saharan Africa have proven themselves very difficult adversaries in the global struggle against malaria. Decades of anti-vector interventions have yielded mixed results – with successful reductions in transmission in some areas, and limited impacts in others. These varying successes can be ascribed to a lack of universally effective vector control tools, as well as the development of insecticide resistance in mosquito populations. Understanding the impact of vector control on mosquito populations is...
Data from: Women's experiences of mistreatment during childbirth: a comparative view of home- and facility-based births in PakistanWaqas Hameed & Bilal Iqbal Avan
Introduction: Respectful and dignified healthcare is a fundamental right for every woman. However, many women seeking childbirth services, especially those in low-income countries such as Pakistan, are mistreated by their birth attendants. The aim of this epidemiological study was to estimate the prevalence of mistreatment and types of mistreatment among women giving birth in facility- and home-based settings in Pakistan in order to address the lack of empirical evidence on this topic. The study also...
Data from: Human cytomegalovirus epidemiology and relationship to tuberculosis and cardiovascular disease risk factors in a rural Ugandan cohortLisa Stockdale, Stephen Nash, Angela Nalwoga, Hannah Painter, Gershim Asiki, Helen Fletcher & Robert Newton
Human cytomegalovirus (HCMV) infection has been associated with increased mortality, specifically cardiovascular disease (CVD), in high-income countries (HICs). There is a paucity of data in low- and middle-income countries (LMICs) where HCMV seropositivity is higher. Serum samples from 2,174 Ugandan individuals were investigated for HCMV antibodies and data linked to demographic information, co-infections and a variety of CVD measurements. HCMV seropositivity was 83% by one year of age, increasing to 95% by five years. Female...
Data from: Association between probable postnatal depression and increased infant mortality and morbidity: findings from the DON population-based cohort study in rural GhanaBenedict Weobong, Augustinus H. A. Ten Asbroek, Seyi Soremekun, Lu Gram, Seeba Amenga-Etego, Samuel Danso, Seth Owusu-Agyei, Martin Prince & Betty R. Kirkwood
Objectives: To assess the impact of probable depression in the immediate postnatal period on subsequent infant mortality and morbidity. Design: Cohort study nested within 4 weekly surveillance of all women of reproductive age to identify pregnancies and collect data on births and deaths. Setting: Rural/periurban communities within the Kintampo Health Research Centre study area of the Brong-Ahafo Region of Ghana. Participants: 16 560 mothers who had a live singleton birth reported between 24 March 2008...
Data from: The temporal dynamics and infectiousness of subpatent Plasmodium falciparum infections in relation to parasite densityHannah C. Slater, Amanda Ross, Ingrid Felger, Natalie E. Hofmann, Leanne Robinson, Jackie Cook, Bronner P. Gonçalves, Anders Björkman, Andre Lin Ouedraogo, Ulrika Morris, Mwinyi Msellem, Cristian Koepfli, Ivo Mueller, Fitsum Tadesse, Endalamaw Gadisa, Smita Das, Gonzalo Domingo, Melissa Kapulu, Janet Midega, Seth Owusu-Agyei, Cécile Nabet, Renaud Piarroux, Ogobara Doumbo, Safiatou Niare Doumbo, Kwadwo Koram … & Lucy C. Okell
Malaria infections occurring below the limit of detection of standard diagnostics are common in all endemic settings. However, key questions remain surrounding their contribution to sustaining transmission and whether they need to be detected and targeted to achieve malaria elimination. In this study we analyse a range of malaria datasets to quantify the density, detectability, course of infection and infectiousness of subpatent infections. Asymptomatically infected individuals have lower parasite densities on average in low transmission...
Introduction: We analyse a large sample of the Twitter activity that developed around the social movement 'Occupy Wall Street', to study the complex interactions between the human communication activity and the semantic content of a debate. Methods: We use a network approach based on the analysis of the bipartite graph @Users-#Hashtags and of its projections: the 'semantic network', whose nodes are hashtags, and the 'users interest network', whose nodes are users. In the first instance,...
Knowledge, attitudes and practices relating to antibiotic use and resistance among prescribers from public primary healthcare facilities in Harare, ZimbabweIoana Olaru
Overuse of antibiotics is one of the main drivers for antimicrobial resistance (AMR). Globally, most antibiotics are prescribed in the outpatient setting. This survey aimed to explore attitudes and practices with regards to microbiology tests, AMR and antibiotic prescribing among healthcare providers at public primary health clinics in Harare, Zimbabwe. Methods: This cross-sectional survey was conducted in nine primary health clinics located in low-income suburbs of Harare between October and December 2020. In Zimbabwe, primary...
London School of Hygiene & Tropical Medicine78
Radboud University Nijmegen6
Medical Research Council6
Centre National de Recherche et de Formation sur le Paludisme5
Imperial College London4
University College London3
Radboud University Nijmegen Medical Centre3
Biomedical Research and Training Institute2
Erasmus University Medical Center2
University of Edinburgh2