121 Works

Data from: Unravelling the immune signature of Plasmodium falciparum transmission-reducing immunity

Will J. R. Stone, Joseph J. Campo, André Lin Ouédraogo, Lisette Meerstein-Kessel, Isabelle Morlais, Dari Da, Anna Cohuet, Sandrine Nsango, Colin J. Sutherland, Marga Van De Vegte-Bolmer, Rianne Siebelink-Stoter, Geert-Jan Van Gemert, Wouter Graumans, Kjerstin Lanke, Adam D. Shandling, Jozelyn V. Pablo, Andy A. Teng, Sophie Jones, Roos M. De Jong, Amanda Fabra-García, John Bradley, Will Roeffen, Edwin Lasonder, Giuliana Gremo, Evelin Schwarzer … & Matthijs M. Jore
Infection with Plasmodium can elicit antibodies that inhibit parasite survival in the mosquito, when they are ingested in an infectious blood meal. Here, we determine the transmission-reducing activity (TRA) of naturally acquired antibodies from 648 malaria-exposed individuals using lab-based mosquito-feeding assays. Transmission inhibition is significantly associated with antibody responses to Pfs48/45, Pfs230, and to 43 novel gametocyte proteins assessed by protein microarray. In field-based mosquito-feeding assays the likelihood and rate of mosquito infection are significantly...

Data from: Empirical and theoretical investigation into the potential impacts of insecticide resistance on the effectiveness of insecticide-treated bed nets

Katey D. Glunt, Maureen Coetzee, Silvie Huijben, A. Alphonsine Koffi, Penelope A. Lynch, Raphael N'Guessan, Welbeck A. Oumbouke, Eleanore D. Sternberg & Matthew B. Thomas
In spite of widespread insecticide resistance in vector mosquitoes throughout Africa, there is limited evidence that long lasting insecticidal bed nets (LLINs) are failing to protect against malaria. Here, we showed that LLIN contact in the course of host-seeking resulted in higher mortality of resistant Anopheles spp. mosquitoes than predicted from standard laboratory exposures with the same net. We also found that sub-lethal contact with an LLIN caused a reduction in blood feeding and subsequent...

Data from: Reasons for low uptake of referrals to ear and hearing services for children in Malawi

Tess Bright, Wakisa Mulwafu, Richard Thindwa, Maria Zuurmond & Sarah Polack
Background: Early detection and appropriate intervention for children with hearing impairment is important for maximizing functioning and quality of life. The lack of ear and hearing services in low income countries is a significant challenge, however, evidence suggests that even where such services are available, and children are referred to them, uptake is low. The aim of this study was to assess uptake of and barriers to referrals to ear and hearing services for children...

Data from: A systematic review and meta-analysis of seroprevalence surveys of ebolavirus infection

Hilary Bower & Judith Glynn
Asymptomatic ebolavirus infection could greatly influence transmission dynamics, but there is little consensus on how frequently it occurs or even if it exists. This paper summarises the available evidence on seroprevalence of Ebola, Sudan and Bundibugyo virus IgG in people without known ebolavirus disease. Through systematic review, we identified 51 studies with seroprevalence results in sera collected from 1961 to 2016. We tabulated findings by study population, contact, assay, antigen and positivity threshold used, and...

Data from: Socioeconomic determinants of antibiotic consumption in the state of São Paulo, Brazil: the effect of restricting over-the-counter sales

Breno S. Kliemann, Anna S. Levin, M. Luísa Moura, Icaro Boszczowski & J. J. Lewis
Background: Improper antibiotic use is one of the main drivers of bacterial resistance to antibiotics, increasing infectious diseases morbidity and mortality and raising costs of healthcare. The level of antibiotic consumption has been shown to vary according to socioeconomic determinants (SED) such as income and access to education. In many Latin American countries, antibiotics could be easily purchased without a medical prescription in private pharmacies before enforcement of restrictions on over-the-counter (OTC) sales in recent...

Influenza clinical risk groups 2017 version - Asthma

Sara Thomas
Read v2 codes for diagnoses of asthma, or recording that a previous diagnosis of asthma had resolved (resolved=1). For this project, the definition was designed to follow national guidance on indications for influenza vaccination, namely: Asthma that requires continuous or repeated use of inhaled or systemic steroids or with previous exacerbations requiring hospital admission. Individuals were defined as having asthma if there was a code for asthma at any time before the index date AND...

Influenza clinical risk groups 2017 version - Chronic cardiac conditions

Sara Thomas
Read v2 codes for diagnoses of chronic cardiac conditions as an indication for influenza vaccination, including congenital heart disease, hypertension with cardiac complications, chronic heart failure, history of myocardial infarction, and other cardiac conditions likely to require regular medication and/or follow-up. Definition designed to follow national guidance in indications for influenza vaccination https://www.gov.uk/government/publications/influenza-the-green-book-chapter-19

Data from: Evolution and epidemic spread of SARS-CoV-2 in Brazil

Darlan S. Candido, Ingra M. Claro, Jaqueline G. De Jesus, William M. Souza, Filipe R. R. Moreira, Simon Dellicour, Thomas A. Mellan, Louis Du Plessis, Rafael H. M. Pereira, Flavia C. S. Sales, Erika R. Manuli, Julien Thézé, Luiz Almeida, Mariane T. Menezes, Carolina M. Voloch, Marcilio J. Fumagalli, Thaís M. Coletti, Camila A. M. Da Silva, Mariana S. Ramundo, Mariene R. Amorim, Henrique H. Hoeltgebaum, Swapnil Mishra, Mandev S. Gill, Luiz M. Carvalho, Lewis F. Buss … & Nuno R. Faria
Brazil currently has one of the fastest growing SARS-CoV-2 epidemics in the world. Owing to limited available data, assessments of the impact of non-pharmaceutical interventions (NPIs) on virus spread remain challenging. Using a mobility-driven transmission model, we show that NPIs reduced the reproduction number from >3 to 1–1.6 in São Paulo and Rio de Janeiro. Sequencing of 427 new genomes and analysis of a geographically representative genomic dataset identified >100 international virus introductions in Brazil....

Ethnicity code list For: \"The effects of antenatal care, ethnicity and social deprivation on the risk of stillbirth in the UK: A cohort study using routinely collected data\"

Amanda Clery, Caroline Minassian, Liam Smeeth & Rohini Mathur
A list of Read codes and entity types used to identify the ethnicity of women in the study cohort from the Clinical Practice Research Datalink.

BILHIV Genital Self-Sampling Dataset

Sturt Amy, Emily Webb & Amaya Bustinduy

Data supporting \"A Snapshot of the Practicality of, and Barriers to, Implementation of COVID-19 Interventions: Public Health and Healthcare Workers' Perceptions\"

Rosanna Glazik
Data collected as part of a cross-sectional study of Public Health Workers (PHWs) and Healthcare Workers (HCWs) perceptions of the implementation, practicality of, and barriers to implementation of COVID-19 non-pharmaceutical interventions (NPIs) and pharmaceutical interventions (PIs). It consists of two tabular datasets, one that contain survey responses collected from Public Health Workers, and a second that contains survey responses of Healthcare workers. Variables include data on socio-demographic characteristics and key COVID-19 NPIs and PIs. Each...

Community-based prevalence of Rheumatic Heart Disease in rural Ethiopia: five-year follow-up.

David Phillips, Tadesse Gemechu, Eldryd Parry, Magdi Yacoub & Susy Kotit
Follow up data from a prospective study of Rhematic Heart Disease prevalence in rural Ethiopia to support article in PLOS Neglected Tropical Diseases

Patterns of non-communicable comorbidities at start of tuberculosis treatment in three regions of the Philippines: St-ATT cohort baseline data

Sharon Cox & Benjamin Faguer
Data collected as part of a facility-based prospective cohort study conducted in public (government) Tuberculosis (TB) Directly Observed Treatment (DOT) clinics in the Philippine. This dataset contains individual-level information that used in a cross-sectional analysis of selected data collected from the St-ATT cohort of Filipino adults at baseline who were enrolled within 5 days of initiating a new tuberculosis treatment regimen. Study information is available in the ISRCTN Registry ID: 16347615.

Combined HIV Adolescent Prevention Study (CHAPS): qualitative survey data

Emily Webb
This dataset contains survey responses collected from 1,330 young people from South Africa, Uganda and Zimbabwe who took part in the CHAPS social science quantitative survey. The primary purpose of the survey was to investigate demographics and socio-behavioural risk factors related to HIV pre-exposure prophylaxis (PrEP) preferences amongst young people.

The importance of fine-scale predictors of wild boar habitat use in an isolated population

Sonny Bacigalupo, Yu-Mei Ruby Chang, Linda Dixon, Simon Gubbins, Adam Kucharski & Julian Drewe
Predicting the likelihood of wildlife presence at potential wildlife-livestock interfaces is challenging. These interfaces are usually relatively small geographical areas where landscapes show large variation over small distances. Models of wildlife distribution based on coarse data over wide geographical ranges may not be representative of these interfaces. High-resolution data can help identify fine scale predictors of wildlife habitat use at a local scale and provide more accurate predictions of species habitat use. These data may...

Data for: \"Sanitation-related Quality of Life (SanQoL) in Maputo, Mozambique\"

Ian Ross
An anonymised dataset of 424 individuals across 272 clusters (compounds) who gave written informed consent to participate in a study of sanitation-related quality of life in the Nhlamankulu district of Maputo, Mozambique in May 2019. The dataset contains variables on compound code, socio-demographic information, sanitation infrastructure, SanQoL outcomes, ranking of SanQoL attributes, mental wellbeing outcomes, and asset ownership.

From Black Box to Shining Spotlight: Using Random Forest Prediction Intervals to Illuminate the Impact of Assumptions in Linear Regression

Andrew J. Sage, Yang Liu & Joe Sato
We introduce a pair of Shiny web applications that allow users to visualize random forest prediction intervals alongside those produced by linear regression models. The apps are designed to help undergraduate students deepen their understanding of the role that assumptions play in statistical modeling by comparing and contrasting intervals produced by regression models with those produced by more flexible algorithmic techniques. We describe the mechanics of each approach, illustrate the features of the apps, provide...

From Black Box to Shining Spotlight

Andrew J. Sage, Yang Liu & Joe Sato
We introduce a pair of Shiny web applications that allow users to visualize random forest prediction intervals alongside those produced by linear regression models. The apps are designed to help undergraduate students deepen their understanding of the role that assumptions play in statistical modeling by comparing and contrasting intervals produced by regression models with those produced by more flexible algorithmic techniques. We describe the mechanics of each approach, illustrate the features of the apps, provide...

The pre-surgical factors that determine the decision to proceed to resection in children diagnosed with high-risk neuroblastoma in a resource limited setting

Jaques van Heerden, Mariana Kruger, Tonya Marianne Esterhuizen, Anel van Zyl, Marc Hendricks, Sharon Cox, Hansraj Mangray, Janet Poole, Gita Naidu, Ané Büchner, Mariza de Villiers, Jan du Plessis, Barry van Emmenes, Elmarie Matthews, Yashoda Manickchund & Derek Stanley Harrison
Surgical control has prognostic value in neuroblastoma (NB). Advanced NB is common at diagnosis in South Africa. We investigated the pre-surgery factors that influenced decisions to perform surgical resections. We included 204 patients with high-risk NB from a national retrospective study, who completed induction chemotherapy between 2000 and 2016. The median age was 32.4 months (IQR 15.1 − 53.5 months). Primary tumor resection was achieved in 76.9% of patients between 0-18 months of age, 51.8%...

Additional file 4 of Do in-service training materials for midwifery care providers in sub-Saharan Africa meet international competency standards? A scoping review 2000–2020

Joanne Welsh, Hashim Hounkpatin, Mechthild M. Gross, Claudia Hanson & Ann-Beth Moller
Supplementary Material 4

Additional file 4 of Do in-service training materials for midwifery care providers in sub-Saharan Africa meet international competency standards? A scoping review 2000–2020

Joanne Welsh, Hashim Hounkpatin, Mechthild M. Gross, Claudia Hanson & Ann-Beth Moller
Supplementary Material 4

Additional file 2 of Development and validation of an extended Cox prognostic model for patients with ER/PR+ and HER2− breast cancer: a retrospective cohort study

Yiqun Xie, Xizhou Li, Ying Wu, Wenting Cui & Yang Liu
Additional file 2: Appendix 2. Hazard ratios and their 95% confidence limits of Ki67, PR, ER, and age. Figure 1. Hazard ratios and their 95% confidence limits for a series of binary variables of Ki67. Figure 2. Hazard ratios and their 95% confidence limits for a series of binary variables of ER. Figure 3. Hazard ratios and their 95% confidence limits for a series of binary variables of PR. Figure 4. Hazard ratios and their...

Additional file 1 of Comparison of femoral mechanics before and after internal fixation removal and the effect of sclerosis on femoral stress: a finite element analysis

Yang Liu, Wenjie Song, Haoran Liang, Chaoxin Li, Wenjie Niu, Huifeng Shao, Yuze Wang, Ziquan Yang, Pengcui Li, Xiaogang Wu, Yong He, Xiaochun Wei & Wangping Duan
Additional file 1.

Additional file 2 of Comparison of femoral mechanics before and after internal fixation removal and the effect of sclerosis on femoral stress: a finite element analysis

Yang Liu, Wenjie Song, Haoran Liang, Chaoxin Li, Wenjie Niu, Huifeng Shao, Yuze Wang, Ziquan Yang, Pengcui Li, Xiaogang Wu, Yong He, Xiaochun Wei & Wangping Duan
Additional file 2.

Registration Year

  • 2022
    56
  • 2021
    17
  • 2020
    7
  • 2019
    9
  • 2018
    8
  • 2017
    6
  • 2016
    5
  • 2015
    7
  • 2014
    3
  • 2013
    1

Resource Types

  • Dataset
    121

Affiliations

  • London School of Hygiene & Tropical Medicine
    121
  • Chinese Academy of Tropical Agricultural Sciences
    17
  • Sun Yat-sen University
    17
  • Zhejiang University
    17
  • Central South University
    17
  • Fudan University Shanghai Cancer Center
    17
  • Fairy Lake Botanical Garden
    17
  • Tangshan Gongren Hospital
    17
  • Shanghai University of Traditional Chinese Medicine
    17
  • Lund University
    17