166 Works

Data from: Reasons for low uptake of referrals to ear and hearing services for children in Malawi

Tess Bright, Wakisa Mulwafu, Richard Thindwa, Maria Zuurmond & Sarah Polack
Background: Early detection and appropriate intervention for children with hearing impairment is important for maximizing functioning and quality of life. The lack of ear and hearing services in low income countries is a significant challenge, however, evidence suggests that even where such services are available, and children are referred to them, uptake is low. The aim of this study was to assess uptake of and barriers to referrals to ear and hearing services for children...

Data from: Evolution and epidemic spread of SARS-CoV-2 in Brazil

Darlan S. Candido, Ingra M. Claro, Jaqueline G. De Jesus, William M. Souza, Filipe R. R. Moreira, Simon Dellicour, Thomas A. Mellan, Louis Du Plessis, Rafael H. M. Pereira, Flavia C. S. Sales, Erika R. Manuli, Julien Thézé, Luiz Almeida, Mariane T. Menezes, Carolina M. Voloch, Marcilio J. Fumagalli, Thaís M. Coletti, Camila A. M. Da Silva, Mariana S. Ramundo, Mariene R. Amorim, Henrique H. Hoeltgebaum, Swapnil Mishra, Mandev S. Gill, Luiz M. Carvalho, Lewis F. Buss … & Nuno R. Faria
Brazil currently has one of the fastest growing SARS-CoV-2 epidemics in the world. Owing to limited available data, assessments of the impact of non-pharmaceutical interventions (NPIs) on virus spread remain challenging. Using a mobility-driven transmission model, we show that NPIs reduced the reproduction number from >3 to 1–1.6 in São Paulo and Rio de Janeiro. Sequencing of 427 new genomes and analysis of a geographically representative genomic dataset identified >100 international virus introductions in Brazil....

Data from: Unravelling the immune signature of Plasmodium falciparum transmission-reducing immunity

Will J. R. Stone, Joseph J. Campo, André Lin Ouédraogo, Lisette Meerstein-Kessel, Isabelle Morlais, Dari Da, Anna Cohuet, Sandrine Nsango, Colin J. Sutherland, Marga Van De Vegte-Bolmer, Rianne Siebelink-Stoter, Geert-Jan Van Gemert, Wouter Graumans, Kjerstin Lanke, Adam D. Shandling, Jozelyn V. Pablo, Andy A. Teng, Sophie Jones, Roos M. De Jong, Amanda Fabra-García, John Bradley, Will Roeffen, Edwin Lasonder, Giuliana Gremo, Evelin Schwarzer … & Matthijs M. Jore
Infection with Plasmodium can elicit antibodies that inhibit parasite survival in the mosquito, when they are ingested in an infectious blood meal. Here, we determine the transmission-reducing activity (TRA) of naturally acquired antibodies from 648 malaria-exposed individuals using lab-based mosquito-feeding assays. Transmission inhibition is significantly associated with antibody responses to Pfs48/45, Pfs230, and to 43 novel gametocyte proteins assessed by protein microarray. In field-based mosquito-feeding assays the likelihood and rate of mosquito infection are significantly...

BILHIV Genital Self-Sampling Dataset

Sturt Amy, Emily Webb & Amaya Bustinduy

Influenza clinical risk groups 2017 version - Asthma

Sara Thomas
Read v2 codes for diagnoses of asthma, or recording that a previous diagnosis of asthma had resolved (resolved=1). For this project, the definition was designed to follow national guidance on indications for influenza vaccination, namely: Asthma that requires continuous or repeated use of inhaled or systemic steroids or with previous exacerbations requiring hospital admission. Individuals were defined as having asthma if there was a code for asthma at any time before the index date AND...

Influenza clinical risk groups 2017 version - Chronic cardiac conditions

Sara Thomas
Read v2 codes for diagnoses of chronic cardiac conditions as an indication for influenza vaccination, including congenital heart disease, hypertension with cardiac complications, chronic heart failure, history of myocardial infarction, and other cardiac conditions likely to require regular medication and/or follow-up. Definition designed to follow national guidance in indications for influenza vaccination https://www.gov.uk/government/publications/influenza-the-green-book-chapter-19

Quasispecies of SARS-CoV-2 revealed by single nucleotide polymorphisms (SNPs) analysis

Rongsui Gao, Wenhong Zu, Yang Liu, Junhua Li, Zeyao Li, Yanling Wen, Haiyan Wang, Jing Yuan, Lin Cheng, Shengyuan Zhang, Yu Zhang, Shuye Zhang, Weilong Liu, Xun Lan, Lei Liu, Feng Li & Zheng Zhang
New SARS-CoV-2 mutants have been continuously indentified with enhanced transmission ever since its outbreak in early 2020. As an RNA virus, SARS-CoV-2 has a high mutation rate due to the low fidelity of RNA polymerase. To study the single nucleotide polymorphisms (SNPs) dynamics of SARS-CoV-2, 158 SNPs with high confidence were identified by deep meta-transcriptomic sequencing, and the most common SNP type was C > T. Analyses of intra-host population diversity revealed that intra-host quasispecies’...

Data supporting \"A Snapshot of the Practicality of, and Barriers to, Implementation of COVID-19 Interventions: Public Health and Healthcare Workers' Perceptions\"

Rosanna Glazik
Data collected as part of a cross-sectional study of Public Health Workers (PHWs) and Healthcare Workers (HCWs) perceptions of the implementation, practicality of, and barriers to implementation of COVID-19 non-pharmaceutical interventions (NPIs) and pharmaceutical interventions (PIs). It consists of two tabular datasets, one that contain survey responses collected from Public Health Workers, and a second that contains survey responses of Healthcare workers. Variables include data on socio-demographic characteristics and key COVID-19 NPIs and PIs. Each...

Patterns of non-communicable comorbidities at start of tuberculosis treatment in three regions of the Philippines: St-ATT cohort baseline data

Sharon Cox & Benjamin Faguer
Data collected as part of a facility-based prospective cohort study conducted in public (government) Tuberculosis (TB) Directly Observed Treatment (DOT) clinics in the Philippine. This dataset contains individual-level information that used in a cross-sectional analysis of selected data collected from the St-ATT cohort of Filipino adults at baseline who were enrolled within 5 days of initiating a new tuberculosis treatment regimen. Study information is available in the ISRCTN Registry ID: 16347615.

Community-based prevalence of Rheumatic Heart Disease in rural Ethiopia: five-year follow-up.

David Phillips, Tadesse Gemechu, Eldryd Parry, Magdi Yacoub & Susy Kotit
Follow up data from a prospective study of Rhematic Heart Disease prevalence in rural Ethiopia to support article in PLOS Neglected Tropical Diseases

Data for: \"Sanitation-related Quality of Life (SanQoL) in Maputo, Mozambique\"

Ian Ross
An anonymised dataset of 424 individuals across 272 clusters (compounds) who gave written informed consent to participate in a study of sanitation-related quality of life in the Nhlamankulu district of Maputo, Mozambique in May 2019. The dataset contains variables on compound code, socio-demographic information, sanitation infrastructure, SanQoL outcomes, ranking of SanQoL attributes, mental wellbeing outcomes, and asset ownership.

The importance of fine-scale predictors of wild boar habitat use in an isolated population

Sonny Bacigalupo, Yu-Mei Ruby Chang, Linda Dixon, Simon Gubbins, Adam Kucharski & Julian Drewe
Predicting the likelihood of wildlife presence at potential wildlife-livestock interfaces is challenging. These interfaces are usually relatively small geographical areas where landscapes show large variation over small distances. Models of wildlife distribution based on coarse data over wide geographical ranges may not be representative of these interfaces. High-resolution data can help identify fine scale predictors of wildlife habitat use at a local scale and provide more accurate predictions of species habitat use. These data may...

From Black Box to Shining Spotlight

Andrew J. Sage, Yang Liu & Joe Sato
We introduce a pair of Shiny web applications that allow users to visualize random forest prediction intervals alongside those produced by linear regression models. The apps are designed to help undergraduate students deepen their understanding of the role that assumptions play in statistical modeling by comparing and contrasting intervals produced by regression models with those produced by more flexible algorithmic techniques. We describe the mechanics of each approach, illustrate the features of the apps, provide...

From Black Box to Shining Spotlight: Using Random Forest Prediction Intervals to Illuminate the Impact of Assumptions in Linear Regression

Andrew J. Sage, Yang Liu & Joe Sato
We introduce a pair of Shiny web applications that allow users to visualize random forest prediction intervals alongside those produced by linear regression models. The apps are designed to help undergraduate students deepen their understanding of the role that assumptions play in statistical modeling by comparing and contrasting intervals produced by regression models with those produced by more flexible algorithmic techniques. We describe the mechanics of each approach, illustrate the features of the apps, provide...

Decision Modelling for Health Economic Evaluation - Exercises

Andrew Briggs

Additional file 1 of Inequalities in the impact of COVID-19-associated disruptions on tuberculosis diagnosis by age and sex in 45 high TB burden countries

C. Finn McQuaid, Marc Y. R. Henrion, Rachael M. Burke, Peter MacPherson, Rebecca Nzawa-Soko & Katherine C. Horton
Additional file 1: Model code and additional tables and Figs. Table S1. Country-specific tuberculosis notifications for 2013-2020 by age and sex. Table S2. Country-specific linear models for expected notifications. Fig. S1. Country-specific linear models for expected notifications. Table S3. Country-specific numbers of missed or delayed diagnoses. Table S4. Country-specific risk-ratios for disruption to tuberculosis notifications due to the pandemic for men compared to women (both aged ≥ 15 years). Table S5. Country-specific risk-ratios for disruption...

Additional file 23 of Proteogenomic insights into the biology and treatment of pancreatic ductal adenocarcinoma

Yexin Tong, Mingjun Sun, Lingli Chen, Yunzhi Wang, Yan Li, Lingling Li, Xuan Zhang, Yumeng Cai, Jingbo Qie, Yanrui Pang, Ziyan Xu, Jiangyan Zhao, Xiaolei Zhang, Yang Liu, Sha Tian, Zhaoyu Qin, Jinwen Feng, Fan Zhang, Jiajun Zhu, Yifan Xu, Wenhui Lou, Yuan Ji, Jianyuan Zhao, Fuchu He, Yingyong Hou … & Chen Ding
Additional file 23: Table S1. Clinicopathologic Information and Multi-omics Data in PDAC Cohort. Table S1A Multi-omics information of PDAC cohort. Table S1B Clinicopathologic information of the 229 PDAC.

Additional file 1 of Comparison of femoral mechanics before and after internal fixation removal and the effect of sclerosis on femoral stress: a finite element analysis

Yang Liu, Wenjie Song, Haoran Liang, Chaoxin Li, Wenjie Niu, Huifeng Shao, Yuze Wang, Ziquan Yang, Pengcui Li, Xiaogang Wu, Yong He, Xiaochun Wei & Wangping Duan
Additional file 1.

Additional file 2 of Comparison of femoral mechanics before and after internal fixation removal and the effect of sclerosis on femoral stress: a finite element analysis

Yang Liu, Wenjie Song, Haoran Liang, Chaoxin Li, Wenjie Niu, Huifeng Shao, Yuze Wang, Ziquan Yang, Pengcui Li, Xiaogang Wu, Yong He, Xiaochun Wei & Wangping Duan
Additional file 2.

The pre-surgical factors that determine the decision to proceed to resection in children diagnosed with high-risk neuroblastoma in a resource limited setting

Jaques van Heerden, Mariana Kruger, Tonya Marianne Esterhuizen, Anel van Zyl, Marc Hendricks, Sharon Cox, Hansraj Mangray, Janet Poole, Gita Naidu, Ané Büchner, Mariza de Villiers, Jan du Plessis, Barry van Emmenes, Elmarie Matthews, Yashoda Manickchund & Derek Stanley Harrison
Surgical control has prognostic value in neuroblastoma (NB). Advanced NB is common at diagnosis in South Africa. We investigated the pre-surgery factors that influenced decisions to perform surgical resections. We included 204 patients with high-risk NB from a national retrospective study, who completed induction chemotherapy between 2000 and 2016. The median age was 32.4 months (IQR 15.1 − 53.5 months). Primary tumor resection was achieved in 76.9% of patients between 0-18 months of age, 51.8%...

Additional file 2 of Development and validation of an extended Cox prognostic model for patients with ER/PR+ and HER2− breast cancer: a retrospective cohort study

Yiqun Xie, Xizhou Li, Ying Wu, Wenting Cui & Yang Liu
Additional file 2: Appendix 2. Hazard ratios and their 95% confidence limits of Ki67, PR, ER, and age. Figure 1. Hazard ratios and their 95% confidence limits for a series of binary variables of Ki67. Figure 2. Hazard ratios and their 95% confidence limits for a series of binary variables of ER. Figure 3. Hazard ratios and their 95% confidence limits for a series of binary variables of PR. Figure 4. Hazard ratios and their...

Additional file 4 of Do in-service training materials for midwifery care providers in sub-Saharan Africa meet international competency standards? A scoping review 2000–2020

Joanne Welsh, Hashim Hounkpatin, Mechthild M. Gross, Claudia Hanson & Ann-Beth Moller
Supplementary Material 4

Additional file 4 of Do in-service training materials for midwifery care providers in sub-Saharan Africa meet international competency standards? A scoping review 2000–2020

Joanne Welsh, Hashim Hounkpatin, Mechthild M. Gross, Claudia Hanson & Ann-Beth Moller
Supplementary Material 4

How do foundation year and internship experience shape doctors’ career intentions and decisions? A meta-ethnography

Yingxi Zhao, Daniel Mbuthia, Claire Blacklock, David Gathara, Catia Nicodemo, Sassy Molyneux & Mike English
Foundation years or internships are an important period for junior doctors to apply their knowledge and gain clinical competency. Experiences gained during the foundation years or internships are likely to inform newly qualified doctors’ opinions about how they want to continue their career. We aimed to understand how medical doctors’ internship experiences influence their career intention/decision. We conducted qualitative evidence synthesis using meta-ethnography. We searched six electronic bibliographic databases for papers published between 2000–2020 and...

Registration Year

  • 2023
    7
  • 2022
    83
  • 2021
    22
  • 2020
    12
  • 2019
    10
  • 2018
    8
  • 2017
    6
  • 2016
    5
  • 2015
    7
  • 2014
    3

Resource Types

  • Dataset
    166

Affiliations

  • London School of Hygiene & Tropical Medicine
    166
  • Chinese Academy of Tropical Agricultural Sciences
    44
  • Sun Yat-sen University
    44
  • Zhejiang University
    44
  • Central South University
    44
  • Fudan University Shanghai Cancer Center
    44
  • Fairy Lake Botanical Garden
    44
  • Tangshan Gongren Hospital
    44
  • Shanghai University of Traditional Chinese Medicine
    44
  • Lund University
    44