Behavioural change towards reduced intensity physical activity is disproportionately prevalent among adults with serious health issues or self-perception of high risk during the UK COVID-19 lockdown.Chrissy Roberts, Nina Rogers, Naomi Waterlow, Hannah Brindle, Luisa Enria & Shelley Lees
Quantitative data on physical activity and health behaviours during the UK COVID-19 lockdown. The anonymous web-based survey was performed between 6th April and 22 April 2020, approximately mapping to weeks 3-5 of the lockdown in the UK. The main survey included 49 questions which covered a broad range of topics including (1) Demographics, (2) Health and Health Behaviours, (3) Adherence to COVID-19 Control measures, (4) Information sources used to learn about COVID-19, (5) Trust in...
Data from: The impact of long-term azithromycin on antibiotic resistance in HIV-associated chronic lung diseaseRegina Esinam Abotsi, Mark P. Nicol, Grace McHugh, Victoria Simms, Andrea M. Rehman, Charmaine Barthus, Lucky G. Ngwira, Brenda Kwambana-Adams, Robert S Heyderman, Jon Ø Odland, Rashida A Ferrand & Felix S. Dube
Background: Selection for resistance to azithromycin (AZM) and other antibiotics such as tetracyclines and lincosamides remains a concern with long-term AZM use for treatment of chronic lung diseases (CLD). We investigated the impact of 48 weeks of AZM on the carriage and antibiotic resistance of common respiratory bacteria among children with HIV-associated CLD. Methods: Nasopharyngeal (NP) swabs and sputa were collected at baseline, 48 and 72 weeks from participants with HIV-associated CLD randomised to receive...
Quality of care in a differentiated HIV service delivery intervention in Tanzania: A mixed methods studyNwanneka Okere, Judith Meta, Werner Maokola, Giulia Martelli, Eric Van Praag, Denise Naniche, Gabriela Gomez, Anton Pozniak, Tobias Rinke De Wit, Josien De Klerk & Sabine Hermans
Background: Differentiated service delivery (DSD) offers benefits to people living with HIV (improved access, peer support), and the health system (clinic decongestion, efficient service delivery). ART clubs, 15-30 clients who usually meet within the community, are one of the most common DSD options. However, evidence about the quality of care (QoC) delivered in DSD is still limited. Materials and Methods: We conducted a concurrent triangulation mixed methods study as part of the Test & Treat...
Data supporting \"A Snapshot of the Practicality of, and Barriers to, Implementation of COVID-19 Interventions: Public Health and Healthcare Workers' Perceptions\"Rosanna Glazik
Data collected as part of a cross-sectional study of Public Health Workers (PHWs) and Healthcare Workers (HCWs) perceptions of the implementation, practicality of, and barriers to implementation of COVID-19 non-pharmaceutical interventions (NPIs) and pharmaceutical interventions (PIs). It consists of two tabular datasets, one that contain survey responses collected from Public Health Workers, and a second that contains survey responses of Healthcare workers. Variables include data on socio-demographic characteristics and key COVID-19 NPIs and PIs. Each...
An anonymised dataset of 424 individuals across 272 clusters (compounds) who gave written informed consent to participate in a study of sanitation-related quality of life in the Nhlamankulu district of Maputo, Mozambique in May 2019. The dataset contains variables on compound code, socio-demographic information, sanitation infrastructure, SanQoL outcomes, ranking of SanQoL attributes, mental wellbeing outcomes, and asset ownership.
Follow up data from a prospective study of Rhematic Heart Disease prevalence in rural Ethiopia to support article in PLOS Neglected Tropical Diseases
Patterns of non-communicable comorbidities at start of tuberculosis treatment in three regions of the Philippines: St-ATT cohort baseline dataSharon Cox & Benjamin Faguer
Data collected as part of a facility-based prospective cohort study conducted in public (government) Tuberculosis (TB) Directly Observed Treatment (DOT) clinics in the Philippine. This dataset contains individual-level information that used in a cross-sectional analysis of selected data collected from the St-ATT cohort of Filipino adults at baseline who were enrolled within 5 days of initiating a new tuberculosis treatment regimen. Study information is available in the ISRCTN Registry ID: 16347615.
Background: Treatment for urinary tract infections (UTIs) is usually empiric and is based on local antimicrobial resistance data. These data, however, are scarce in low-resource settings. The aim of this study is to determine the impact of antibiotic treatment on clinical and bacteriological outcomes in patients presenting with UTI symptoms to primary care in Harare. Methods: This cohort study enrolled participants presenting with UTI symptoms to 10 primary healthcare clinics in Harare between July 2019...
Plasmodium falciparum gametocyte density and infectivity in peripheral blood and skin tissue of naturally infected parasite carriers in Burkina FasoTeun Bousema, Elamaran Meibalan, Aissata Barry, Matthew Gibbins, Shehu Awandu, Lisette Meerstein-Kessel, Fiona Achar, Selina Bopp, Christopher Moxon, Amidou Diarra, Siaka Debe, Nicolas Ouedraogo, Ines Barry-Some, Emilie Badoum, Traore Fagnima, Kjerstin Lanke, Bronner Goncalves, John Bradley, Dyann Wirth, Chris Drakeley, Wamdaogo Guelbeogo, Alfred Tiono, Matthias Marti, Matthew P Gibbins, Fiona Achcar … & Alfred B Tiono
Background Plasmodium falciparum transmission depends on mature gametocytes that can be ingested by mosquitoes taking a blood meal on human skin. Although gametocyte skin sequestration has long been hypothesized as important contributor to efficient malaria transmission, this has never been formally tested. Methods In naturally infected gametocyte carriers from Burkina Faso, we assessed infectivity to mosquitoes by direct skin feeding and membrane feeding. We directly quantified male and female gametocytes and asexual parasites in finger-prick...
Codelists for: \"Understanding thresholds of blood pressure and predicted cardiovascular disease risk in guiding blood pressure treatment: a cohort study in English primary care\"Emily Herrett
A set of codelists that cover cardiovascular disease and target organ damage, including heart failure, chronic kidney disease and haemorrhagic stroke.
Data for: \"Vaccine Confidence and Hesitancy at the start of COVID-19 vaccine deployment in the UK: An embedded mixed-methods study\"Chrissy Roberts, Hannah Brindle, Nina Rogers, Rosalind M. Eggo, Luisa Enria & Shelley Lees
The study used a mixed-methods approach based upon an online survey and an embedded quantitative/qualitative design to explore perceptions and attitudes associated with intention to either accept or refuse offers of vaccination in different demographic groups during the early stages of the UK’s mass COVID-19 vaccination programme (December 2020). Key outputs include: a tabular dataset containing survey responses, a data dictionary that explains survey data variables, an R scripts that enable reproduction of analyses (Analysis_Script.R),...
Data collected as part of two cross-sectional surveys to investigate metabolic outcomes and markers of inflammation in urban and rural locations in Uganda. It contains information obtained from 313 participants (one row represents one participant). 48 variables are recorded, including data on inflammatory markers (cytokines and chemokines), location of residence (urban versus rural), metabolic parameters (including HOMA-IR, blood pressure, blood glucose) and socio-demographic characteristics.
Data associated with a pilot and feasibility study of the maintenance of serum potassium levels ≥ 3.6 mEq/L vs ≥ 4.5 mEq/L after isolated elective coronary artery bypass grafting, and the incidence of new-onset atrial fibrillation. Data was collected from patients scheduled to undergo a heart operation called Coronary Artery Bypass Graft Surgery (CABG) at two NHS hospitals in London.
A quantitative dataset collected as part of the ARGUS study that presents the clinical and bacteriological outcomes of 168 participants who had a positive urine culture at baseline and underwent a follow-up visit. Adult participants were recruited from primary healthcare facilities in Harare, Zimbabwe. Data was collected from participant interviews using electronic Case Report Forms (CRFs). Laboratory results were recorded using specifically designed Case Report Forms (CRFs).
Blood pressure levels among children in rural Uganda: results from 1,913 children in a general population surveySheila Kansiime
A tabular dataset collected as part of a cross-sectional study in south-western Uganda. It contains information on demographic, anthropometric and blood pressure measurements from children aged 6-12 years. Children with elevated blood pressure (systolic and/or diastolic blood pressure greater or equal to the 95th percentile for age, height and sex) were invited for two further assessments 6-18 months later.
Data for: \"Flavivirus integrations in Aedes aegypti are limited and highly conserved across samples from different geographic regions unlike integrations in Aedes albopictus\"Anton Spadar, Jody Phelan, Ernest Diez-Benavente, Monica Campos, Lara Ferrero Gomez, Fady Mohareb, Taane G. Clark & Susana Campino
Supplementary material published to support a paper titled "Flavivirus integrations in Aedes aegypti are limited and highly conserved across samples from different geographic regions unlike integrations in Aedes albopictus". It includes: (1) descriptive statistics of excluded and retained sequences; (2) BLASTN results processing flow diagram; (3) an Excel spreadsheet containing BLASTN hits from AaegL5 assembly; (4) an Excel spreadsheet containing accession IDs of all used flavivirus genomes; (5) an Excel spreadsheet listing BLASTN hits from...
Knowledge, attitudes and practices relating to antibiotic use and resistance among prescribers from public primary healthcare facilities in Harare, ZimbabweIoana Olaru
Overuse of antibiotics is one of the main drivers for antimicrobial resistance (AMR). Globally, most antibiotics are prescribed in the outpatient setting. This survey aimed to explore attitudes and practices with regards to microbiology tests, AMR and antibiotic prescribing among healthcare providers at public primary health clinics in Harare, Zimbabwe. Methods: This cross-sectional survey was conducted in nine primary health clinics located in low-income suburbs of Harare between October and December 2020. In Zimbabwe, primary...
London School of Hygiene & Tropical Medicine17
University of Glasgow1
UiT The Arctic University of Norway1
Biomedical Research and Training Institute1
African Training and Research Centre in Administration for Development1
Institut de Cancérologie de l'Ouest1
University of Southampton1
Chelsea and Westminster Hospital NHS Foundation Trust1
Doctors with Africa Cuamm1
University College London1