Osteosarcoma (OS), the most prevalent bone malignancy, mainly affects children and adolescents. Despite recent advances in multimodal therapy, the overall survival rate for OS patients remains poor. Chinese herb medicine (CHM) is an alternative therapeutic option for multifaceted diseases such as malignant tumors. For centuries in China, polygonum cuspidatum, a classic CHM, has been used to treat several diseases, nevertheless, the mechanisms underlying its therapeutic effects have not been fully elucidated. Through network pharmacology and...

Building detection from very high resolution (VHR) optical remote sensing images, which is an essential but challenging task in remote sensing, has attracted increased attention in recent years. However, despite the many methods that have been developed, an in-depth review of the recent literature on building extraction from VHR optical images is still lacking. In this article, we present a comprehensive review of the recent advances (since 2000) in this field. In total, we survey...

Off-label drug use embodies a thorough clinical diagnosis and evaluation of treatment needs and should not be confused with unreasonable drug use, but it also faces potential risks with drug safety and legal issues. We first established a guideline working group. Following the guideline development process recommended by the World Health Organization Handbook and the Chinese Medical Association, the key questions were determined through literature searches of PubMed, CNKI (Chinese National Knowledge Infrastructure) and other...

Off-label drug use embodies a thorough clinical diagnosis and evaluation of treatment needs and should not be confused with unreasonable drug use, but it also faces potential risks with drug safety and legal issues. We first established a guideline working group. Following the guideline development process recommended by the World Health Organization Handbook and the Chinese Medical Association, the key questions were determined through literature searches of PubMed, CNKI (Chinese National Knowledge Infrastructure) and other...

Lung cancer has been recognized as the most common malignant neoplasm of the respiratory system with extremely high morbidity, among which non-small cell lung cancer (NSCLC) accounts for the majority. Many published literatures have revealed the roles of GSG2 in the progression of ovarian cancer, bladder cancer and breast cancer. However, there were no reports on the relationship between GSG2 and NSCLC. Herein, GSG2 was identified as a potential tumor promoter in NSCLC development, whose...

Additional file 1. Tabel S1. Proxies for SNPs not found in the outcome dataset (Forward MR); Tabel S2. Characteristics of the genetic variants associated with body mass index; Tabel S3. Characteristics of the genetic variants associated with waist-to-hip ratio; Tabel S4. Characteristics of the genetic variants associated with body mass index in replication analyses; Tabel S5. Characteristics of the genetic variants associated with waist-to-hip ratio in replication analyses; Tabel S6. Proxies for SNPs not found...

Additional file 1: Table S1. Physical characteristics of the major enzyme-encoding genes of flavonoid metabolic pathway in C. sativa.

Additional file 4:Table S3. Secondary structure predication of the CsFLS proteins in C. sativa.

Additional file 2. Supplementary Table S1. Tissue gradient dehydration procedure before paraffin section.

Additional file 3. Supplementary Table S2. Hematoxylin-Eosin (HE) staining procedure.

Additional file 4. Supplementary Table S3. Information of 165 apoptosis pathway related genes in GSEA analysis.

Additional file 6. Supplementary Table S5. Gene information of KEGG analysis.

Experimental infections with different pathogen strains give insight into pathogen life history traits. The purpose of our study was to compare variation in tissue infection prevalence and spirochete abundance among strains of B. burgdorferi in a rodent host (Mus musculus, C3H/HeJ). Male and female mice were experimentally infected via tick bite with one of 12 strains. Ear tissue biopsies were taken at days 29, 59, and 89 post-infection (PI), and 7 tissues were collected at...

Additional file 1: Table S1. Baseline characteristics on death and MACE risks. Table S2. Baseline characteristics on LVEF and LVMI. Table S3. Relationship between metabolites and death risk. Table S4. Relationship between metabolites and MACE risk. Table S5. Multivariate Cox proportional hazards model for clinical outcomes. Table S6. Spearman correlation analysis between clinical factors and those metabolites associated with death risk. Table S7. Spearman correlation analysis between clinical factors and those metabolites associated with death...

Additional file 1: Table S1. Clinical data of patients with primary CRC.

Accurate estimation of the change in crime over time is a critical first step toward better understanding of public safety in large urban environments. Bayesian hierarchical modeling is a natural way to study spatial variation in urban crime dynamics at the neighborhood level, since it facilitates principled “sharing of information” between spatially adjacent neighborhoods. Typically, however, cities contain many physical and social boundaries that may manifest as spatial discontinuities in crime patterns. In this situation,...

Additional file 2: Supplementary Table 1. The results of the GSEA.

Additional file 2: Supplementary Table 1. The results of the GSEA.

Additional file 5.

Additional file 1. The “raw datasets” file includes raw clinical data of all patients included in this study. As shown in the raw datasets, each patient has the detailed clinical data including age, body mass index (BMI), number of previous early miscarriage, number of previous late miscarriage, number of previous still birth, number of previous spontaneous abortions, history of preterm birth, history of fetal congenital anomalies, nulliparas, twin birth and etc. Also, the low dose...

Additional file 1. The “raw datasets” file includes raw clinical data of all patients included in this study. As shown in the raw datasets, each patient has the detailed clinical data including age, body mass index (BMI), number of previous early miscarriage, number of previous late miscarriage, number of previous still birth, number of previous spontaneous abortions, history of preterm birth, history of fetal congenital anomalies, nulliparas, twin birth and etc. Also, the low dose...

Additional file 3. Digital raw data.

Abstract Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the intestine, demonstrating an increasing incidence every year. TongXieYaoFang (TXYF) has been used widely in China as a complementary therapy to relieve the symptoms of IBD for hundreds of years. In the present research, a network pharmacology-based approach was used to systematically explore the intrinsic mechanisms of TXYF in IBD at the molecular level. Network pharmacology-based methods, which mainly included database mining, screening of...

Additional file 1. Datasheet.

Additional file 1. Supplementary Data 1. ERRα target genes in CCLE AML cell lines.