A keloid is defined as an overgrowth of the dense fibrous tissues that form around a wound. Since they destroy the vascular network, keloid tissues often exhibit anoxic conditions. Hypoxia-inducible factor-1α (HIF-1α) is a core factor that mediates hypoxia stress responses and regulates the hypoxic cellular and biological behaviors. In this study, we found that the expression level of HIF-1α in keloid tissue was significantly higher than that in the normal skin tissue. Hypoxia-induced HIF-1α...

The elevational alpha biodiversity gradient in mountain regions is one of the well-known ecological patterns, but its beta diversity pattern remains poorly-known. Examining the beta diversity and its components could enhance the understanding of community assembly mechanism. We studied the beta diversity pattern of the soil enchytraeids along a distinct elevational gradient (705—2280 m) on the Changbai Mountain, the best-preserved mountain in northeastern China. The overall abundance-based community dissimilarity was relatively high (ca. 0.70), largely...

1.Understanding the relationship between biodiversity and ecosystem functioning (BEF) is a central topic in ecology. Multi‐traits based functional diversity has been proposed to improve mechanistic understanding of the BEF relationship; however, how trait‐based functional diversity affects ecosystem functioning and processes has rarely been addressed in aquatic ecosystems. 2.Here, we examined the causal relationships between three phytoplankton functional diversity indices (FAD2, FDc, FRic) and Shannon diversity index versus resource use efficiency for nitrogen (RUEN), phosphorus (RUEP),...

More and more circular RNAs (circRNAs) revealed to play a critical role in the initiation and progression of cancer, however, the effects of circRNAs on non-small cell lung cancer (NSCLC) remain largely undetermined. In the present study, we screened the dysregulated circRNAs in paired NSCLC and normal samples from GEO database and identified circ_0043278 was to be significantly up-regulated in NSCLC and demonstrated it promotes NSCLC progression in vitro and in vivo. Then, we revealed...

More and more circular RNAs (circRNAs) revealed to play a critical role in the initiation and progression of cancer, however, the effects of circRNAs on non-small cell lung cancer (NSCLC) remain largely undetermined. In the present study, we screened the dysregulated circRNAs in paired NSCLC and normal samples from GEO database and identified circ_0043278 was to be significantly up-regulated in NSCLC and demonstrated it promotes NSCLC progression in vitro and in vivo. Then, we revealed...