3 Works

Data from: Quantitative cross-species extrapolation between humans and fish: the case of the anti-depressant fluoxetine

Luigi Margiotta-Casaluci, Stewart F. Owen, Rob I. Cumming, Anna De Polo, Matthew J. Winter, Grace H. Panter, Mariann Rand-Weaver & John P. Sumpter
Fish are an important model for the pharmacological and toxicological characterization of human pharmaceuticals in drug discovery, drug safety assessment and environmental toxicology. However, do fish respond to pharmaceuticals as humans do? To address this question, we provide a novel quantitative cross-species extrapolation approach (qCSE) based on the hypothesis that similar plasma concentrations of pharmaceuticals cause comparable target-mediated effects in both humans and fish at similar level of biological organization (Read-Across Hypothesis). To validate this...

Data from: A new role for carbonic anhydrase 2 in the response of fish to copper and osmotic stress: implications for multi-stressors studies

Anna De Polo, Luigi Margiotta-Casaluci, Anne E. Lockyer & Mark D. Scrimshaw
The majority of ecotoxicological studies are performed under stable and optimal conditions, whereas in reality the complexity of the natural environment faces organisms with multiple stressors of different type and origin, which can activate pathways of response often difficult to interpret. In particular, aquatic organisms living in estuarine zones already impacted by metal contamination can be exposed to more severe salinity variations under a forecasted scenario of global change. In this context, the present study...

Data from: Effectiveness of continence promotion for older women via community organisations: a cluster randomised trial

Cara Tannenbaum, Rona Agnew, Andrea Benedetti, Doneal Thomas & Eleanor Van Den Heuvel
Objectives: The primary objective of this cluster randomised controlled trial was to compare the effectiveness of the three experimental continence promotion interventions against a control intervention on urinary symptom improvement in older women with untreated incontinence recruited from community organisations. Setting: 71 community organisations across the United Kingdom Participants: 259 women aged 60 years and older with untreated incontinence entered the trial; 88% completed the 3-month follow-up. Interventions: The three active interventions consisted of a...

Registration Year

  • 2014

Resource Types

  • Dataset


  • Brunel University London
  • University of Montreal
  • McGill University
  • Glasgow Caledonian University