4 Works

Intravital quantification reveals dynamic calcium concentration changes across B cell differentiation stages

Carolin Ulbricht, Ruth Leben, Asylkhan Rakhymzhan, Frank Kirchhoff, Lars Nitschke, Helena Radbruch, Raluca Niesner & Anja Hauser
Calcium is a universal second messenger present in all eukaryotic cells. The mobilization and storage of Ca2+ ions drives a number of signaling-related processes, stress-responses or metabolic changes, all of which are relevant for the development of immune cells and their adaption to pathogens. Here, we introduce the FRET-reporter mouse YellowCaB expressing the genetically encoded calcium indicator TN-XXL in B lymphocytes. Calcium-induced conformation change of TN-XXL results in FRET-donor quenching measurable by two-photon fluorescence lifetime...

Auxin signaling and vascular cambium formation enables storage metabolism in cassava tuberous roots

David Rüscher, José María Corral, Anna Vittoria Carluccio, Patrick A.W. Klemens, Andreas Gisel, Livia Stavolone, Ekkehard Neuhaus, Frank Ludewig, Uwe Sonnewald & Wolfgang Zierer
Cassava storage roots are among the most important root crops worldwide and represent one of the most consumed staple foods in Sub-Saharan Africa. The vegetatively propagated tropical shrub can form many starchy tuberous roots from its stem. These storage roots are formed through the activation of secondary root growth processes. However, the underlying genetic regulation of storage root development is largely unknown. Here we report on distinct structural and transcriptional changes occurring during the early...

Online Appendix and Cetacean Datasets for: The Occurrence Birth-Death Process for combined-evidence analysis in macroevolution and epidemiology

Jérémy Andréoletti, Antoine Zwaans, Rachel Warnock, Gabriel Aguirre-Fernández, Joëlle Barido-Sottani, Ankit Gupta, Tanja Stadler & Marc Manceau
Phylodynamic models generally aim at jointly inferring phylogenetic relationships, model parameters, and more recently, the number of lineages through time, based on molecular sequence data. In the fields of epidemiology and macroevolution these models can be used to estimate, respectively, the past number of infected individuals (prevalence) or the past number of species (paleodiversity) through time. Recent years have seen the development of “total-evidence” analyses, which combine molecular and morphological data from extant and past...

Adaptive Behavior of Dynamic Orthoester Cryptands

Oleksandr Shyshov, René‐Chris Brachvogel, Tobias Bachmann, Rubitha Srikantharajah, Doris Segets, Frank Hampel, Ralph Puchta & Max von Delius
A lid for every pot: Cryptands based on orthoester bridgeheads offer an elegant entry to experiments in which a metal ion selects its preferred host from a dynamic mixture of competing subcomponents....

Registration Year

  • 2021

Resource Types

  • Dataset


  • University of Erlangen-Nuremberg
  • Charité
  • German Rheumatism Research Centre
  • Saarland University
  • University of Zurich
  • University of Ulm
  • International Institute of Tropical Agriculture
  • Freie Universität Berlin
  • Iowa State University
  • University of Kaiserslautern