147 Works

Knockdown of circ_0001679 alleviates lipopolysaccharide-induced MLE-12 lung cell injury by regulating the miR-338-3p/ mitogen-activated protein kinase 1 axis

Shenggui Lu, Xinmiao Wu, Shuai Xin, Jing Zhang, Hanying Lin, Yu Miao & Yixin Li
The upregulation of circ_0001679 was reported in lipopolysaccharide (LPS)-induced lung injury mouse model, but its functional roles and mechanisms in LPS-induced lung injury remain to be investigated. In this study, we aimed to explore the potential role of circ_0001679 in septic acute lung injury. We initially established an in vitro lung cell injury model using LPS-treated MLE-12 cells. siRNAs targeting circRNA_0001679 were employed to stably knock down circRNA_0001679, followed by functional assays to investigate the...

Establishment of a subcutaneous adipogenesis model and distinct roles of LKB1 regulation on adipocyte lipid accumulation in high-altitude Bos grunniens

Yongqi Yue, Yonglin Hua, Jing Zhang, Yu Guo, Dan Zhao, Wentao Huo, Yan Xiong, Fenfen Chen, Yaqiu Lin, Xianrong Xiong & Jian Li
The domestic yak was regarded as a valuable model to explore the molecular mechanism of high-altitude animal adaptation, including the extreme tolerance of starvation and cold stress, which is closely associated with specifically seasonal deposition and metabolism of subcutaneous adipose tissue. However, the key regulators for these processes remain largely unknown. Here, the yak adipogenesis model in vitro was established and liver kinase b1 (LKB1) was regarded as a key negative regulator involved in yak...

Assessing pre-pandemic carbon footprint of diet transitions in UK nations and regions

Mustafa Ali, S. C. Lenny Koh, Lingxuan Liu, Jing Zhang, William Roberts, Dawn Robins & Dave Cooper
Food supply chains hold significant embodied carbon emissions that need to be mitigated and neutralized. This study aimed to explore the historical Greenhouse Gas (GHG) emissions associated with household food consumption at a local scale i.e. across the eight English regions and the four nations that comprise the United Kingdom (UK). UK EatWell guidelines were used to explore the potential change in emissions and food costs in a scenario of transitions to healthier diets across...

DARS-AS1 recruits METTL3/METTL14 to bind and enhance DARS mRNA m6A modification and translation for cytoprotective autophagy in cervical cancer

Miaohua Zhu, Weiwei Shen, Qiming Wang, Xiaoming Zhou, Jiaying Wang, Tingting Wang & Jing Zhang
Cervical cancer (CC) is one of the most prevalent malignancies among females. Cytoprotective autophagy could confer cancer cell tolerance to hypoxic stress, promoting cell survival and adaptation. Aspartyl-tRNA synthetase 1 antisense 1 (DARS-AS1) is an oncogenic long non-coding RNA (lncRNA) in various cancers, but how DARS-AS1 regulates cytoprotective autophagy in hypoxic environment in CC remains unclear. Chromatin immunoprecipitation (ChIP) and luciferase reporter assays were conducted to explore the interaction between hypoxia-inducible factor 1 subunit alpha...

Epg5 deficiency leads to primary ovarian insufficiency due to WT1 accumulation in mouse granulosa cells

Wenwen Liu, Min Chen, Chao Liu, Liying Wang, Huafang Wei, Ruidan Zhang, Zhengxing Ren, Yinghong Chen, Mengcheng Luo, Jianguo Zhao, Hongwei Jiang, Fei Gao & Wei Li
Primary ovarian insufficiency (POI), also known as premature ovarian failure, is an ovarian defect in humans characterized by the premature depletion of ovarian follicles before the age of 40. However, the mechanisms underlying POI remain largely unknown. Here, we show that knockout of Epg5 (ectopic P-granules autophagy protein 5 homolog (C. elegans)) results in subfertility in female mice, which exhibit a POI-like phenotype. Single-cell RNA sequencing analysis revealed that the knockout of Epg5 affected the...

Additional file 2 of Circulating tumor DNA integrating tissue clonality detects minimal residual disease in resectable non-small-cell lung cancer

Siwei Wang, Ming Li, Jingyuan Zhang, Peng Xing, Min Wu, Fancheng Meng, Feng Jiang, Jie Wang, Hua Bao, Jianfeng Huang, Binhui Ren, Mingfeng Yu, Ninglei Qiu, Houhuai Li, Fangliang Yuan, Zhi Zhang, Hui Jia, Xinxin Lu, Shuai Zhang, Xiaojun Wang, Youtao Xu, Wenjia Xia, Tongyan Liu, Weizhang Xu, Xinyu Xu … & Rong Yin
Additional file 2. Table S2: Adjuvant treatment information.

Additional file 3 of Genetic diversity in the transmission-blocking vaccine candidate Plasmodium vivax gametocyte protein Pvs230 from the China–Myanmar border area and central Myanmar

Xin Zhao, Yubing Hu, Yan Zhao, Lin Wang, Zifang Wu, Myat Thu Soe, Myat Phone Kyaw, Liwang Cui, Xiaotong Zhu & Yaming Cao
Additional file 3: Table S3. Codon-based tests for selection on Pvs230 in China–Myanmar border and Myanmar isolates.

Decreased echinocandin susceptibility in Candida parapsilosis causing candidemia and emergence of a pan-echinocandin resistant case in China

Yating Ning, Meng Xiao, David S. Perlin, Yanan Zhao, Minya Lu, Yi Li, Zhengyu Luo, Rongchen Dai, Shengjie Li, Jiajun Xu, Lingli Liu, Hong He, Yun Liu, Fushun Li, Yuguang Guo, Zhongju Chen, Yingchun Xu, Tianshu Sun & Li Zhang
Candida parapsilosis is becoming a predominant non-albicans cause of invasive candidiasis (IC). Echinocandins are the preferred choice for IC treatment and prophylaxis. Resistance to echinocandins in C. parapsilosis has emerged in several countries, but little is known about the susceptibility profile in China or about mechanisms of resistance. Here, we investigated the echinocandin susceptibilities of 2523 C. parapsilosis isolates collected from China and further explored the resistance mechanism among echinocandin-resistant isolates. Anidulafungin exhibited the highest...

Additional file 1 of Modular networks and genomic variation during progression from stable angina pectoris through ischemic cardiomyopathy to chronic heart failure

Lin Chen, Ya-Nan Yu, Jun Liu, Yin-ying Chen, Bo Wang, Yi-Fei Qi, Shuang Guan, Xi Liu, Bing Li, Ying-Ying Zhang, Yuanhui Hu & Zhong Wang
Additional file 1: Table S1. Targets for ICM, SAP and CHF.

Additional file 1 of Functional transcriptome analyses of Drosophila suzukii midgut reveal mating-dependent reproductive plasticity in females

Shisi Xing, Dan Deng, Wen wen & Wei Peng
Additional file 1: Supplementary Table S1. Alignment statistics of the virginand mated D. suzukii female midgut RNA-Seq analysis. Supplementary Table S2. All genes description and FPKM value in D.suzukii virgin and mated female midguttranscriptomes. Supplementary Table S3. Differentially expressed genes in pairwise comparison in D. suzukii virgin and mated female midguttranscriptomes. Supplementary Table S4. GO classification of the differentially expressed genes in pairwise comparisonin D. suzukii virgin and mated femalemidguttranscriptomes. Three main categories, namely biological...

Additional file 1 of Functional transcriptome analyses of Drosophila suzukii midgut reveal mating-dependent reproductive plasticity in females

Shisi Xing, Dan Deng, Wen wen & Wei Peng
Additional file 1: Supplementary Table S1. Alignment statistics of the virginand mated D. suzukii female midgut RNA-Seq analysis. Supplementary Table S2. All genes description and FPKM value in D.suzukii virgin and mated female midguttranscriptomes. Supplementary Table S3. Differentially expressed genes in pairwise comparison in D. suzukii virgin and mated female midguttranscriptomes. Supplementary Table S4. GO classification of the differentially expressed genes in pairwise comparisonin D. suzukii virgin and mated femalemidguttranscriptomes. Three main categories, namely biological...

Additional file 1 of Identification of quantitative trait loci for related traits of stalk lodging resistance using genome-wide association studies in maize (Zea mays L.)

Lifen Wu, Yunxiao Zheng, Fuchao Jiao, Ming Wang, Jing Zhang, Zhongqin Zhang, Yaqun Huang, Xiaoyan Jia, Liying Zhu, Yongfeng Zhao, Jinjie Guo & Jingtang Chen
Additional file 1: Supplementary Table S1. List of genes within the 120 kb upstream and downstream extension of significant SNPs identified via GWAS. Supplementary Table S2. SNPs detected for lodging resistance-related traits using BLUP value in the association mapping panel. Supplementary Table S3. List of genes within the 120 kb upstream and downstream extension of significant SNPs identified via GWAS.

Table S8.xlsx from Transcriptome analysis and mining of genes related to shade tolerance in foxtail millet (Setaria italica (L.) P. Beauv.)

Dan Liu, Yanjiao Cui, Zilong Zhao, Jing Zhang, Suying Li & Zhengli Liu
A stereo interplanting system with foxtail millet beneath chestnut trees is an effective planting method to raise the utilization of land in chestnut orchards, increase yields and improve quality of chestnut nuts. Consequently, exploration of genes involved in shade tolerance response in foxtail millet and breeding shade-tolerant varieties have become urgent issues. In this study, RNA-seq of leaf samples from two shade-tolerant varieties and three shade-intolerant varieties of foxtail millet at the booting stage was...

Table S6.xlsx from Transcriptome analysis and mining of genes related to shade tolerance in foxtail millet (Setaria italica (L.) P. Beauv.)

Dan Liu, Yanjiao Cui, Zilong Zhao, Jing Zhang, Suying Li & Zhengli Liu
A stereo interplanting system with foxtail millet beneath chestnut trees is an effective planting method to raise the utilization of land in chestnut orchards, increase yields and improve quality of chestnut nuts. Consequently, exploration of genes involved in shade tolerance response in foxtail millet and breeding shade-tolerant varieties have become urgent issues. In this study, RNA-seq of leaf samples from two shade-tolerant varieties and three shade-intolerant varieties of foxtail millet at the booting stage was...

Additional file 14 of Methylome and transcriptome data integration reveals potential roles of DNA methylation and candidate biomarkers of cow Streptococcus uberis subclinical mastitis

Mengqi Wang, Nathalie Bissonnette, Mario Laterrière, Pier-Luc Dudemaine, David Gagné, Jean-Philippe Roy, Xin Zhao, Marc-André Sirard & Eveline M. Ibeagha-Awemu
Additional file 14: Table S9. The list of differentially expressed (DE) genes and their functional enrichment.

Additional file 7 of Methylome and transcriptome data integration reveals potential roles of DNA methylation and candidate biomarkers of cow Streptococcus uberis subclinical mastitis

Mengqi Wang, Nathalie Bissonnette, Mario Laterrière, Pier-Luc Dudemaine, David Gagné, Jean-Philippe Roy, Xin Zhao, Marc-André Sirard & Eveline M. Ibeagha-Awemu
Additional file 7: Table S2. Read mapping statistics of whole-genome bisulfite sequencing data and RNA sequencing data of six cows.

Additional file 11 of Profiling ATM regulated genes in Drosophila at physiological condition and after ionizing radiation

Jun Liu, Tianyu Jin, Lanxi Ran, Ze Zhao, Rui Zhu, Gangcai Xie & Xiaolin Bi
Additional file 11: Table S8. lncRNA counts.

Additional file 5 of Profiling ATM regulated genes in Drosophila at physiological condition and after ionizing radiation

Jun Liu, Tianyu Jin, Lanxi Ran, Ze Zhao, Rui Zhu, Gangcai Xie & Xiaolin Bi
Additional file 5: Table S2. Protein-coding genes sequenced.

Additional file 7 of Profiling ATM regulated genes in Drosophila at physiological condition and after ionizing radiation

Jun Liu, Tianyu Jin, Lanxi Ran, Ze Zhao, Rui Zhu, Gangcai Xie & Xiaolin Bi
Additional file 7: Table S4. Differentially expressed protein-coding genes in atm mutated flies after X-ray irradiation.

Additional file 8 of Profiling ATM regulated genes in Drosophila at physiological condition and after ionizing radiation

Jun Liu, Tianyu Jin, Lanxi Ran, Ze Zhao, Rui Zhu, Gangcai Xie & Xiaolin Bi
Additional file 8: Table S5. miRNA counts.

Additional file 13 of Methylome and transcriptome data integration reveals potential roles of DNA methylation and candidate biomarkers of cow Streptococcus uberis subclinical mastitis

Mengqi Wang, Nathalie Bissonnette, Mario Laterrière, Pier-Luc Dudemaine, David Gagné, Jean-Philippe Roy, Xin Zhao, Marc-André Sirard & Eveline M. Ibeagha-Awemu
Additional file 13: Table S8. The list of differentially methylated haplotype blocks (dMHBs) and functional enrichment for hyper dMHBs.

Additional file 2 of Whole-transcriptome profiles of Chrysanthemum seticuspe improve genome annotation and shed new light on mRNA–miRNA–lncRNA networks in ray florets and disc florets

Daojin Sun, Jing Zhang, Jun He, Zhiqiang Geng, Song Li, Jiali Zhang, Peiling Li, Lingling Zhang, Zhenxing Wang, Likai Wang, Fadi Chen & Aiping Song
Additional file 2.

Epidemiology, evolution, and biological characteristics of H6 avian influenza viruses in China

Xiaohao Xu, Qi Chen, Min Tan, Jia Liu, Xiyan Li, Lei Yang, Yuelong Shu, Dayan Wang & Wenfei Zhu
H6 avian influenza virus (AIV) is one of the most prevalent AIV subtypes in birds globally. To investigate the current situation and characteristics of H6 AIVs circulating in China, we analysed the epidemiology, genetic evolution and pathogenic features of this subtype. During 2000-2021, H6 subtype AIVs spread widely through Southern China and presented high host diversity. On analysing 171 H6 viruses isolated during 2009-2021, dynamic reassortments were observed among H6 and other co-circulating AIV subtypes,...

Analysis of microplastics released from plastic take-out food containers based on thermal properties and morphology study

Jia-Ling Hu, Yipin Duan, Huai-Ning Zhong, Qin-Bao Lin, Tianlong Zhang, Chuang-Chuang Zhao, Sheng Chen, Ben Dong, Dan Li, Jing Wang, Ming-Zhen Mo, Jie Chen & Jian-Guo Zheng
Plastic take-out food containers may release microplastics (MPs) into food and pose a potential risk to food safety and human health. Here, after being subjected to hot water treatment, MPs released from three types of plastic food containers (polypropylene, PP; polyethylene, PE; expanded polystyrene, EPS) were identified by micro-Raman spectroscopy. The results showed that the size of released MPs ranged from 0.8–38 μm and over 96% MPs were smaller than 10 μm. Various MPs concentrations...

Protection of intestinal immune barrier against ischemia/reperfusion injury in a swine model using anisodamine hydrobromide

Guijuan Dong, Jun Yang, Xin Zhao & Shubin Guo
Abstract Intestinal ischemia/reperfusion (I/R) causes barrier impairment and bacterial influx. This study explored the protective effects of anisodamine hydrobromide (AH) on intestinal I/R injury caused by cardiopulmonary resuscitation (CPR) after cardiac arrest (CA). After successful CPR, minipigs were randomly divided into two groups (n = 8): saline and AH (4 mg/kg), and then treated with saline or AH via central venous injection, respectively. The same procedures without ventricular fibrillation initiation were conducted in the Sham...

Registration Year

  • 2022
    147

Resource Types

  • Dataset
    147

Affiliations

  • Zunyi Medical University
    147
  • Zhejiang University
    125
  • University of Chinese Academy of Sciences
    108
  • Shandong University
    102
  • Capital Medical University
    92
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    91
  • Fujian Medical University
    91
  • Soochow University
    89
  • Chinese Academy of Sciences
    80
  • Sun Yat-sen University
    76