41 Works

Survival benefits of group living in a fluctuating environment

Sarah Guindre-Parker & Dustin Rubenstein
Group living is only predicted to arise when the fitness benefits outweigh the costs of sociality. Group-living species—including cooperatively breeding and family-living birds and mammals—occur most frequently in environments where climatic conditions fluctuate unpredictably from year-to-year. The fitness consequences of group living are thus expected to vary with changing environmental conditions, though few studies have examined this possibility. We examined whether living in large social groups improves adult survivorship in cooperatively breeding superb starlings (Lamprotornis...

Data associated with 'Metformin rescues Parkinson’s disease phenotypes caused by hyperactive mitochondria'

Danielle Mor, Salman Sohrabi, Rachel Kaletsky, William Keyes, Alp Tartici, Vrinda Kalia, Gary Miller & Coleen Murphy
Metabolic dysfunction occurs in many age-related neurodegenerative diseases, yet its role in disease etiology remains poorly understood. We recently discovered a potential causal link between the branched-chain amino acid transferase, BCAT-1, and the neurodegenerative movement disorder, Parkinson’s disease (PD). RNAi-mediated knockdown of C. elegans bcat-1 recapitulates PD-like features, including progressive motor deficits and neurodegeneration with age, yet the underlying mechanisms have remained unknown. Using transcriptomic, metabolomic, and imaging approaches, we show here that bcat-1 knockdown...

Slave Movement -- Angola Slave Trade in the Eighteenth Century, 1723-1771

Herbert S. Klein

Slave Movement -- Slave Trade to Jamaica, 1782-1788, 1805-1808

Herbert S. Klein & Stanley L. Engerman

Source data for: Antagonistic effects of intraspecific cooperation and interspecific competition on thermal performance

Sheng-Feng Shen, Hsiang-Yu Tsai, Dustin Rubenstein, Bo-Fei Chen, Mark Liu, Shih-Fan Chan, De-Pei Chen, Syuan-Jyun Sun & Tzu-Neng Yuan
Understanding how climate-mediated biotic interactions shape thermal niche width is critical in an era of global change. Yet, most previous work on thermal niches has ignored detailed mechanistic information about the relationship between temperature and organismal performance, which can be described by a thermal performance curve. Here, we develop a model that predicts the width of thermal performance curves will be narrower in the presence of interspecific competitors, causing a species’ optimal breeding temperature to...

The effect of interactive ozone chemistry on weak and strong stratospheric polar vortex events

Gabriel Chiodo, Jessica Oehrlein & Lorenzo M. Polvani
Modeling and observational studies have reported effects of stratospheric ozone extremes on Northern Hemisphere spring climate. Recent work has further suggested that the coupling of ozone chemistry and dynamics amplifies the surface response to midwinter sudden stratospheric warmings (SSWs). Here we study the importance of interactive ozone chemistry in representing the stratospheric polar vortex and Northern Hemisphere winter surface climate variability. We contrast two simulations from the interactive and specified chemistry (and thus ozone) versions...

Data from: Anxiety and depressive symptoms are associated with poor sleep health during a period of COVID-19 induced nation-wide lockdown: a cross-sectional analysis of adults in the Middle East

Yazan Al-Ajlouni
Background: Jordan, a Middle Eastern country, declared a state of national emergency due to the novel coronavirus (COVID-19) and a strict nation-wide lockdown on March 17, 2020, banning all travel and movement around the country, potentially impacting mental health. This study sought to investigate the association between mental health (e.g., anxiety and depressive symptoms) and sleep health among a sample of Jordanians living through a state of COVID-19 induced nation-wide lockdown. Methods: Using Facebook, participants...

Amyloid PET imaging in self-identified non-Hispanic Blacks from the Anti-Amyloid in Asymptomatic Alzheimer’s Disease (A4) Study – Supplementary Data

Kacie Deters, Valerio Napolioni, Reisa Sperling, Gabriel Kennedy, Michael Greicius, Richard Mayeux, Timothy Hohman & Elizabeth Mormino
The goal of the manuscript was to examine whether amyloid PET in CN individuals that were screened for the Anti-Amyloid in Asymptomatic AD (A4) study differed across self-identified, non-Hispanic White and Black (NHW and NHB) groups. We examined 3685 NHW and 144 NHB that passed initial screening for the A4 study and underwent amyloid PET. The effect of race on amyloid PET was examined using logistic (dichotomous groups) and linear (continuous values) regression controlling for...

Slave Movement -- Nantes Slave Trade in the Eighteenth Century, 1711-1791

Herbert S. Klein

Slave Movement -- Slave Trade to Havana, Cuba, 1790-1820

Herbert S. Klein

Slave Movement -- English Slave Trade, 1791-1799 (House of Lords Survey)

Herbert S. Klein

Spatial predictors of genomic and phenotypic variation differ in a lowland Middle American bird (Icterus gularis)

Lucas Rocha Moreira, Blanca E. Hernandez-Baños & Brian T. Smith
Spatial patterns of intraspecific variation are shaped by factors such as geographic distance among populations, historical changes in gene flow and interactions with local environments. Although these factors are not mutually exclusive and operate on both genomic and phenotypic variation, it is unclear how they affect these two axes of variation. We address this question by exploring the predictors of genomic and phenotypic divergence in Icterus gularis, a broadly distributed Middle American bird that exhibits...

Slave Movement -- Virginia Slave Trade in the Eighteenth Century, 1727-1769

Herbert S. Klein

The HCN domain couples voltage gating and cAMP response in hyperpolarization-activated cyclic nucleotide-gated channels

Andrea Saponaro, Federica Gasparri, Daniel Bauer, Christine Gross, Matteo Pisoni, Gerardo Abbandonato, Kay Hamacher, Bina Santoro, Anna Moroni, Alessandro Porro & Gerhard Thiel
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels control spontaneous electrical activity in heart and brain. Binding of cAMP to the cyclic nucleotide-binding domain (CNBD) facilitates channel opening by relieving a tonic inhibition exerted by the CNBD. Despite high resolution structures of the HCN1 channel in the cAMP bound and unbound states, the structural mechanism coupling ligand binding to channel gating is unknown. Here we show that the recently identified helical HCN-domain (HCND) mechanically couples the CNBD and...

Paired human macrophage RNA sequencing data

Jiaxin Fan, Jian Hu, Chenyi Xue, Hanrui Zhang, Katalin Susztak, Muredach Reilly, Rui Xiao & Mingyao Li
Allele-specific expression (ASE) analysis, which quantifies the relative expression of two alleles in a diploid individual, is a powerful tool for identifying cis-regulated gene expression variations that underlie phenotypic differences among individuals. Existing methods for gene-level ASE detection analyze one individual at a time, therefore failing to account for shared information across individuals. Failure to accommodate such shared information not only reduces power, but also makes it difficult to interpret results across individuals. However, when...

Data from: Using genetic relatedness to understand heterogeneous distributions of urban rat-associated pathogens

Kaylee Byers, Tom Booker, Matthew Combs, Chelsea Himsworth, Jason Munshi-South, David Patrick & Michael Whitlock
Urban Norway rats (Rattus norvegicus) carry several pathogens transmissible to people. However, pathogen prevalence can vary across fine spatial scales (i.e., by city block). Using a population genomics approach, we sought to describe rat movement patterns across an urban landscape, and to evaluate whether these patterns align with pathogen distributions. We genotyped 605 rats from a single neighborhood in Vancouver, Canada and used 1,495 genome-wide single nucleotide polymorphisms to identify parent-offspring and sibling relationships using...

Registration Year

  • 2020

Resource Types

  • Dataset


  • Columbia University
  • Stanford University
  • Princeton University
  • The Ohio State University
  • University of Georgia
  • New York University
  • Fordham University
  • Biodiversity Research Center, Academia Sinica
  • University of California Los Angeles
  • Northwestern University