2 Works

Metabolomics data for: Microbiome study in irradiated mice treated with a promising radiation countermeasure, BIO 300

Amrita Cheema, Yaoxiang Li, Jatinder Singh, Ryan Johnson, Michael Girgis, Stephen Wise, Oluseyi Fatanmi, Michael Kaytor & Vijay Singh
The mammalian gut harbors a very complex and diverse microbiota that play an important role in the intestinal homeostasis and host health. Exposure to radiation results in dysbiosis of the gut microbiota leading to detrimental pathophysiological changes to the host. To alleviate the effects of irradiation, several candidate countermeasures are under investigation. BIO 300 is a promising candidate under advanced development. The aim of this study was to investigate the effects of BIO 300 on...

Alterations of brain metabolites in adults with HIV: a systematic meta-analysis of MRS studies

Xiong Jiang
Objective. A meta-analysis of proton magnetic resonance spectroscopy (MRS) studies to investigate alterations in brain metabolites in people with HIV (PWH), as well as their relationship with combination antiretroviral therapy (cART) and cognitive impairment. Methods. The PubMed database was searched for studies published from 1997 to 2020. Twenty-seven studies were identified, which included 1255 PWH and 633 controls. Four metabolites (N-acetyl aspartate (NAA), myo-Inositol (mI), choline (Cho), and glutamatergic metabolites (Glx) from five brain regions...

Registration Year

  • 2021
    2

Resource Types

  • Dataset
    2

Affiliations

  • Georgetown University Medical Center
    2
  • Humanetics Corporation (United States)
    1
  • Uniformed Services University of the Health Sciences
    1