Objective: The purpose of this study was to characterize the functional brain changes involved in THC modulation of chronic neuropathic pain. Methods: Fifteen patients with chronic radicular neuropathic pain participated in a randomized, double-blind, placebo-controlled trial employing a counterbalanced, within-subjects design. Pain assessments and functional resting state brain scans were performed at baseline and after sublingual THC administration. We examined functional connectivity of the anterior cingulate cortex (ACC) and pain related network dynamics using graph...

Objective: This proof-of-concept feasibility trial examined the potential of the Cognitive Orientation to daily Occupational Performance (CO-OP) ApproachTM to augment deep brain stimulation (DBS) outcomes in childhood-onset hyperkinetic movement disorders (HMD) including dystonia and dyskinetic cerebral palsy. Methods: Single case experimental design using multiple baseline as N-of-1 trial comprised of 10 intervention sessions, with replications across participants (n=10). Treatment focused on three participant-selected goals. Transfer was assessed on two additional untreated goals. Individuals enrolled were...