5 Works

Data from: A rat liver transcriptomic point of departure predicts a prospective liver or non-liver apical point of departure

Kamin J. Johnson, Scott S. Auerbach & Eduardo Costa
Identifying a toxicity point of departure (POD) is a required step in human health risk characterization of crop protection molecules, and this POD has historically been derived from apical endpoints across a battery of animal-based toxicology studies. Using rat transcriptome and apical data for 79 molecules obtained from Open TG-GATES (Toxicogenomics Project-Genomics Assisted Toxicity Evaluation System) (632 datasets), the hypothesis was tested that a short-term exposure, transcriptome-based liver biological effect POD (BEPOD) could estimate a...

Data from: Convergent evolution of broadband reflectors underlies metallic colorations in butterflies

Christopher Day, Anna Ren, Arnaud Martin & Joseph Hanly
Supplementary Files for Ren, Day et al. 2020 : Convergent evolution of broadband reflectors underlies metallic coloration in butterflies

Supplemental material from: ESR1 mutations associated with EIS change conformation of ligand receptor complex and alter transcriptome profile

Yin Li, Katherine Hamilton, Lalith Perera, Tianyuan Wang, Artiom Gruzdev, Tanner Jefferson, Austin Zhang, Emilie Mathura, Kevin Gerrish, Laura Wharey, Negin Martin, Jian-Liang Li & Kenneth Korach
Estrogen insensitivity syndrome (EIS) arises from rare mutations in estrogen receptor α (ERα, encoded by ESR1 gene) resulting in the inability of estrogen to exert its biological effects. Due to the rarity, mutations in ESR1 gene and the underlying molecular mechanisms of EIS have not been thoroughly studied. Here, we investigate known ESR1 mutants, Q375H and R394H, associated with EIS patients using in vitro and in vivo systems. Comparison of the transcriptome and DNA methylome...

Supplemental materials for: Peri- and post-pubertal estrogen exposures of female mice optimize uterine responses later in life

Sylvia Hewitt, Marleny Carmona, Grace Foley, Lauren Donoghue, Sydney Lierz, Wipawee Winuthayanon & Kenneth Korach
At birth, all female mice, including those that either lack estrogen receptor α (ERα-knockout) or that express mutated forms of ERα (AF2ERKI), have a hypoplastic uterus. However, uterine growth and development that normally accompanies pubertal maturation does not occur in ERα-knockout or AF2ERKI mice, indicating ERα mediated estrogen signaling is essential for this process. Mice that lack Cyp19 (aromatase, ArKO mice), an enzyme critical for estrogen (E2) synthesis, are unable to make E2, and lack...

Data from: In vivo assessment of respiratory burst inhibition by xenobiotic exposure using larval zebrafish

Jeffrey Yoder, Drake Phelps, Ashley Fletcher, Dori Germolec, Ivan Rodriguez-Nunez, Michele Balik-Meisner, Debra Tokarz & David Reif
Currently assessment of the potential immunotoxicity of a given agent involves a tiered approach for hazard identification and mechanistic studies, including observational studies, evaluation of immune function, and measurement of susceptibility to infectious and neoplastic diseases. These studies generally use costly low-throughput mammalian models. Zebrafish, however, offer an excellent alternative due to their rapid development, ease of maintenance, and homology to mammalian immune system function and development. Larval zebrafish also are a convenient model to...

Registration Year

  • 2020
    5

Resource Types

  • Dataset
    5

Affiliations

  • National Institute of Environmental Health Sciences
    5
  • North Carolina State University
    2
  • Northwestern University
    1
  • George Washington University
    1
  • University of North Carolina at Chapel Hill
    1
  • Washington State University
    1