33 Works

Data from: The role of plasma and urine metabolomics in identifying new biomarkers in severe newborn asphyxia: a study of asphyxiated newborn pigs following cardiopulmonary resuscitation

Daniel Sachse, Anne Lee Solevåg, Jens Petter Berg & Britt Nakstad
Background: Optimizing resuscitation is important to prevent morbidity and mortality from perinatal asphyxia. The metabolism of cells and tissues is severely disturbed during asphyxia and resuscitation, and metabolomic analyses provide a snapshot of many small molecular weight metabolites in body fluids or tissues. In this study metabolomics profiles were studied in newborn pigs that were asphyxiated and resuscitated using different protocols to identify biomarkers for subject characterization, intervention effects and possibly prognosis. Methods: A total...

Data from: BsRADseq: screening DNA methylation in natural populations of non-model species

Emiliano Trucchi, Anna B. Mazzarella, Gregor D. Gilfillan, Maria T. Lorenzo, Peter Schönswetter & Ovidiu Paun
Epigenetic modifications are expected to occur at a much faster rate than genetic mutations, potentially causing isolated populations to stochastically drift apart, or if they are subjected to different selective regimes, to directionally diverge. A high level of genome-wide epigenetic divergence between individuals occupying distinct habitats is therefore predicted. Here, we introduce bisulfite-converted restriction site associated DNA sequencing (bsRADseq), an approach to quantify the level of DNA methylation differentiation across multiple individuals. This reduced representation...

Data from: Evidence accumulation and choice maintenance are dissociated in human perceptual decision making

Mads Lund Pedersen, Tor Endestad & Guido Biele
Perceptual decision making in monkeys relies on decision neurons, which accumulate evidence and maintain choices until a response is given. In humans, several brain regions have been proposed to accumulate evidence, but it is unknown if these regions also maintain choices. To test if accumulator regions in humans also maintain decisions we compared delayed and self-paced responses during a face/house discrimination decision making task. Computational modeling and fMRI results revealed dissociated processes of evidence accumulation...

Stabilizing group treatment for childhood-abuse related PTSD: a randomized controlled trial

Harald Bækkelund, Ida Karlsrud, Asle Hoffart & Espen Ajo Arnevik
Background: Patients with PTSD related to childhood-abuse often experience additional problems such as emotional dysregulation and interpersonal difficulties. Psychotherapy focused on stabilization of symptoms, emotion-regulation, and skills training has been suggested as a treatment for this patient population, either as preparation for further treatment or as a stand-alone intervention. Objective: The present study tests the efficacy of treatment using a group-protocol for stabilizing treatment delivered adjunct with conventional individual therapy. Methods: In a delayed-treatment design...

Data from: Placebo effects in trials evaluating 12 selected minimally invasive interventions: a systematic review and meta-analysis

Robin Holtedahl, Jens Ivar Brox & Ole Tjomsland
Objectives: To analyse the impact of placebo effects on outcome in trials of selected minimally invasive procedures and to assess reported adverse events in both trial arms. Design: A systematic review and meta-analysis. Data sources and study selection: We searched MEDLINE and Cochrane library to identify systematic reviews of musculoskeletal, neurological and cardiac conditions published between January 2009 and January 2014 comparing selected minimally invasive with placebo (sham) procedures. We searched MEDLINE for additional randomised...

Stabilizing group treatment for childhood-abuse related PTSD: a randomized controlled trial

Harald Bækkelund, Ida Karlsrud, Asle Hoffart & Espen Ajo Arnevik
Background: Patients with PTSD related to childhood-abuse often experience additional problems such as emotional dysregulation and interpersonal difficulties. Psychotherapy focused on stabilization of symptoms, emotion-regulation, and skills training has been suggested as a treatment for this patient population, either as preparation for further treatment or as a stand-alone intervention. Objective: The present study tests the efficacy of treatment using a group-protocol for stabilizing treatment delivered adjunct with conventional individual therapy. Methods: In a delayed-treatment design...

Intracranial effect of osimertinib in relapsed EGFR-mutated T790M-positive and -negative non-small cell lung cancer patients: results from a phase II study

Inger Johanne Zwicky Eide, Harald Grut, Åslaug Helland, Simon Ekman, Jens Benn Sørensen, Karin Holmskov Hansen, Bjørn Henning Grønberg, Saulius Cicenas, Jussi Pekka Koivunen, Anders Mellemgaard & Odd Terje Brustugun
Osimertinib is effective for relapsed T790M-positive patients with brain metastases. The high brain permeability suggests that also such patients without T790M could benefit. Therefore, we evaluated the effect of osimertinib on brain metastases in both T790M-positive and -negative patients. The TREM-study was an investigator-initiated phase II, single-arm, multi-institutional clinical trial conducted in Northern Europe. Patients with resistance to prior EGFR-TKIs received osimertinib until radiological progression, unacceptable toxicity or death. Baseline brain scans were performed in...

Utility of a three-gene transcriptomic signature in the diagnosis of tuberculosis in a low-endemic hospital setting

Bih Hycenta Chendi, Tracey Jooste, Thomas Jens Scriba, Martin Kidd, Simon Mendelsohn, Kristian Tonby, Gerhard Walzl, Anne M. Dyrhol-Riise & Novel Njweipi Chegou
Host transcriptomic blood signatures have demonstrated diagnostic potential for tuberculosis (TB), requiring further validation across different geographical settings. Discriminating TB from other diseases with similar clinical manifestations is crucial for the development of an accurate immunodiagnostic tool. In this exploratory cohort study, we evaluated the performance of potential blood-based transcriptomic signatures in distinguishing TB disease from non-TB lower respiratory tract infections in hospitalised patients in a TB low-endemic country. Quantitative real-time polymerase chain reaction qPCR)...

Data from: On the perplexingly low rate of transport of IgG2 across the human placenta

Helga K. Einarsdottir, Nigel M. Stapleton, Sicco Scherjon, Jan Terje Andersen, Theo Rispens, C. Ellen Van Der Schoot & Gestur Vidarsson
The neonatal receptor, FcRn, mediates both serum half–life extension as well as active transport of maternal IgG to the fetus during pregnancy. Therefore, transport efficiency and half-life go hand-in-hand. However, while the half-life of the human IgG2 subclass is comparable to IgG1, the placental transport of IgG2 is not, with the neonatal IgG1 levels generally exceeding maternal levels at birth, but not for IgG2. We hypothesized that the unique short-hinged structure of IgG2, which enables...

Intracranial effect of osimertinib in relapsed EGFR-mutated T790M-positive and -negative non-small cell lung cancer patients: results from a phase II study

Inger Johanne Zwicky Eide, Harald Grut, Åslaug Helland, Simon Ekman, Jens Benn Sørensen, Karin Holmskov Hansen, Bjørn Henning Grønberg, Saulius Cicenas, Jussi Pekka Koivunen, Anders Mellemgaard & Odd Terje Brustugun
Osimertinib is effective for relapsed T790M-positive patients with brain metastases. The high brain permeability suggests that also such patients without T790M could benefit. Therefore, we evaluated the effect of osimertinib on brain metastases in both T790M-positive and -negative patients. The TREM-study was an investigator-initiated phase II, single-arm, multi-institutional clinical trial conducted in Northern Europe. Patients with resistance to prior EGFR-TKIs received osimertinib until radiological progression, unacceptable toxicity or death. Baseline brain scans were performed in...

Utility of a three-gene transcriptomic signature in the diagnosis of tuberculosis in a low-endemic hospital setting

Bih Hycenta Chendi, Tracey Jooste, Thomas Jens Scriba, Martin Kidd, Simon Mendelsohn, Kristian Tonby, Gerhard Walzl, Anne M. Dyrhol-Riise & Novel Njweipi Chegou
Host transcriptomic blood signatures have demonstrated diagnostic potential for tuberculosis (TB), requiring further validation across different geographical settings. Discriminating TB from other diseases with similar clinical manifestations is crucial for the development of an accurate immunodiagnostic tool. In this exploratory cohort study, we evaluated the performance of potential blood-based transcriptomic signatures in distinguishing TB disease from non-TB lower respiratory tract infections in hospitalised patients in a TB low-endemic country. Quantitative real-time polymerase chain reaction qPCR)...

Exercise-induced change in circulating NT-proBNP could not distinguish between patients with and without coronary artery disease: the CADENCE study

Joanna Cwikiel, Morten W. Fagerland, Kristian Wachtell, Harald Arnesen, Ingebjørg Seljeflot & Arnljot Flaa
Objective. In patients with chest pain, exercise stress test has a moderate accuracy for coronary artery disease (CAD). Adding a reliable cardiac biomarker to the exercise test could potentially improve the precision of the test. We investigated circulating NT-proBNP levels before and during exercise stress test in patients with and without angiographically verified CAD. We hypothesized that NT-proBNP would give an additive diagnostic value to the exercise stress test. Methods. In patients presenting with symptoms...

Additional file 1 of Laboratory-based and office-based Globorisk scores to predict 10-year risk of cardiovascular diseases among Iranians: results from the Fasa PERSIAN cohort

Leila Jahangiry, Azizallah Dehghan, Mojtaba Farjam, Dagfinn Aune & Fatemeh Rezaei
Additional fale 1.

Additional file 1 of Laboratory-based and office-based Globorisk scores to predict 10-year risk of cardiovascular diseases among Iranians: results from the Fasa PERSIAN cohort

Leila Jahangiry, Azizallah Dehghan, Mojtaba Farjam, Dagfinn Aune & Fatemeh Rezaei
Additional fale 1.

Data from: Serum-free and xenobiotic-free preservation of cultured human limbal epithelial cells

Oeygunn A. Utheim, Rakibul Islam, Torstein Lyberg, Borghild Roald, Jon Roger Eidet, Maria Fideliz De La Paz, Darlene A. Dartt, Sten Raeder, Tor Paaske Utheim & Oeygunn Utheim
Aim/Purpose of the Study: To develop a one-week storage method, without serum and xenobiotics, that would maintain cell viability, morphology, and phenotype of cultured human limbal epithelial sheets. Materials and Methods: Human limbal explants were cultured on intact human amniotic membranes for two weeks. The sheets were stored in a hermetically sealed container at 23°C in either a serum-free medium with selected animal serum-derived compounds (Quantum 286) or a xenobiotic-free medium (Minimal Essential Medium) for...

Data from: Canine mammary tumours are affected by frequent copy number aberrations, including amplification of MYC and loss of PTEN

Kaja S. Borge, Silje Nord, Peter Van Loo, Ole C. Lingjærde, Gjermund Gunnes, Grethe I. G. Alnæs, Hiroko K. Solvang, Torben Lüders, Vessela N. Kristensen, Anne-Lise Børresen-Dale & Frode Lingaas
Background: Copy number aberrations frequently occur during the development of many cancers. Such events affect dosage of involved genes and may cause further genomic instability and progression of cancer. In this survey, canine SNP microarrays were used to study 117 canine mammary tumours from 69 dogs. Results: We found a high occurrence of copy number aberrations in canine mammary tumours, losses being more frequent than gains. Increased frequency of aberrations and loss of heterozygosity were...

Increased signal diversity/complexity of spontaneous EEG, but not evoked EEG responses, in ketamine-induced psychedelic state in humans

Nadine Farnes, Bjørn Juel, Andre Nilsen, Luis Romundstad & Johan Storm
How and to what extent electrical brain activity reflects pharmacologically altered states and contents of consciousness, is not well understood. Therefore, we investigated whether measures of evoked and spontaneous electroencephalographic (EEG) signal diversity are altered by sub-anaesthetic levels of ketamine compared to normal wakefulness, and how these measures relate to subjective experience. High-density 62-channel EEG was used to record spontaneous brain activity and responses evoked by transcranial magnetic stimulation (TMS) in 10 healthy volunteers before...

Additional file 1 of Mendelian randomization analysis of factors related to ovulation and reproductive function and endometrial cancer risk

Shannon D’Urso, Pooja Arumugam, Therese Weider, Liang-Dar Hwang, Tom A. Bond, John P. Kemp, Nicole M. Warrington, David M. Evans, Tracy A. O’Mara & Gunn-Helen Moen
Additional file 1: Table S1. Genome-wide significant independent SNPs for Body Mass Index in women (Pulit 2018). Table S2. Genome-wide significant independent SNPs for Years Ovulating (Hg19). Table S3. Genome-wide significant independent SNPs for age at menarche downloaded from the ReproGen Consortium Website (Perry et al., 2014; Hg19). Table S4. Genome-wide significant independent SNPs for age at menopause downloaded from the ReproGen Consortium Website (Hg19; Day et al., 2015). Table S5. Genome-wide significant independent SNPs...

Lactate receptor HCAR1 regulates neurogenesis and microglia activation after neonatal hypoxia-ischemia

Johanne Egge Rinholm, Lauritz Hagen Kennedy, Emilie Rylund Glesaaen, Vuk Palibrk, Marco Pannone, Wei Wang, Ali Hussein Jafar Al-Jabri, Rajikala Suganthan, Niklas Meyer, Xiaolin Lin, Linda Hildegard Bergersen, Magnar Bjørås, Lauritz Kennedy, Emilie R Glesaaen, Ali Al-Jabri, Marie Landa Austbø, Linda H Bergersen & Johanne E Rinholm
Neonatal cerebral hypoxia-ischemia (HI) is the leading cause of death and disability in newborns with the only current treatment being hypothermia. An increased understanding of the pathways that facilitate tissue repair after HI may aid the development of better treatments. Here, we study the role of lactate receptor HCAR1 in tissue repair after neonatal HI in mice. We show that HCAR1 knockout mice have reduced tissue regeneration compared with wildtype mice. Furthermore, proliferation of neural...

Data from: Apolipoprotein (ApoE) polymorphism is related to differences in potential fertility in women: a case of antagonistic pleiotropy?

Grazyna Jasienska, Peter T. Ellison, Andrzej Galbarczyk, Michal Jasienski, Malgorzata Kalemba-Drozdz, Maria Kapiszewska, Ilona Nenko, Inger Thune & Anna Ziomkiewicz
The alleles that are detrimental to health, especially in older age, are thought to persist in populations because they also confer some benefits for individuals (through antagonistic pleiotropy). The ApoE4 allele at the ApoE locus, encoding apolipoprotein E (ApoE), significantly increases risk of poor health, and yet it is present in many populations at relatively high frequencies. Why has it not been replaced by natural selection with the health-beneficial ApoE3 allele? ApoE is a major...

Data from: Persistent low toxoplasma IgG avidity is common in pregnancy: experience from antenatal testing in Norway

Gry Findal, Babill Stray-Pedersen, Ellen K. Holter, Tone Berge & Pål A. Jenum
The parasite Toxoplasma gondii might harm the fetus if a woman is infected during pregnancy. IgG seroconversion and significant increase in IgG antibody amount in pregnancy indicates maternal infection. Presence of toxoplasma immunoglobulin M (IgM), immunoglobulin G (IgG) and low IgG avidity in a single serum sample indicates possible maternal infection, but positive toxoplasma IgM and low IgG avidity may persist for months and even years. We aimed to evaluate avidity development during pregnancy in...

Data from: Getting to the heart of emotion regulation in youth: the role of interoceptive sensitivity, heart rate variability, and parental psychopathology

Nele A. J. De Witte, Stefan Sütterlin, Caroline Braet & Sven C. Mueller
Emotion regulation and associated autonomic activation develop throughout childhood and adolescence under the influence of the family environment. Specifically, physiological indicators of autonomic nervous system activity such as interoceptive sensitivity and vagally mediated heart rate variability (HRV) can inform on emotion regulation. Although the effect of parental emotion socialization on emotion regulation appears to be influenced by autonomic processes, research on physiological regulation and the influence of parental factors remains scarce. This study investigated the...

Sick leave and return to work after surgery for type II SLAP lesions of the shoulder. A secondary analysis of a randomised sham - controlled study

Jens Ivar Brox, Øystein Skare, Petter Mowinckel, Jostein Skranes Brox, Olav Reikerås & Cecilie Piene Schrøder
Objectives: To compare days on sick leave and assess predictors of return to work following shoulder surgery. Design: A secondary analysis of a randomised controlled trial. Setting: Orthopaedic Department. Participants: 114 patients with type II superior labral tear from anterior to posterior (SLAP) lesions of the shoulder. Interventions: Labral repair, biceps tenodesis or sham surgery. Outcome measures: Sick leave was obtained from national registers for the last year before and two years following surgery. Total...

Registration Year

  • 2022
    15
  • 2021
    4
  • 2020
    4
  • 2016
    3
  • 2015
    5
  • 2014
    2

Resource Types

  • Dataset
    33

Affiliations

  • Oslo University Hospital
    33
  • University of Oslo
    21
  • Imperial College London
    4
  • Karolinska Institute
    4
  • QIMR Berghofer Medical Research Institute
    2
  • Karolinska University Hospital
    2
  • University of Queensland
    2
  • Norwegian Centre for Violence and Traumatic Stress Studies
    2
  • Jahrom University of Medical Sciences
    2
  • Modum Bad – Gordon Johnsens stiftelse
    2