2 Works

Data from: Placebo effects in trials evaluating 12 selected minimally invasive interventions: a systematic review and meta-analysis

Robin Holtedahl, Jens Ivar Brox & Ole Tjomsland
Objectives: To analyse the impact of placebo effects on outcome in trials of selected minimally invasive procedures and to assess reported adverse events in both trial arms. Design: A systematic review and meta-analysis. Data sources and study selection: We searched MEDLINE and Cochrane library to identify systematic reviews of musculoskeletal, neurological and cardiac conditions published between January 2009 and January 2014 comparing selected minimally invasive with placebo (sham) procedures. We searched MEDLINE for additional randomised...

Data from: On the perplexingly low rate of transport of IgG2 across the human placenta

Helga K. Einarsdottir, Nigel M. Stapleton, Sicco Scherjon, Jan Terje Andersen, Theo Rispens, C. Ellen Van Der Schoot & Gestur Vidarsson
The neonatal receptor, FcRn, mediates both serum half–life extension as well as active transport of maternal IgG to the fetus during pregnancy. Therefore, transport efficiency and half-life go hand-in-hand. However, while the half-life of the human IgG2 subclass is comparable to IgG1, the placental transport of IgG2 is not, with the neonatal IgG1 levels generally exceeding maternal levels at birth, but not for IgG2. We hypothesized that the unique short-hinged structure of IgG2, which enables...

Registration Year

  • 2014

Resource Types

  • Dataset


  • Oslo University Hospital
  • University of Amsterdam